Simvastatin Suppresses Interleukin Iβ Release in Human Peripheral Blood Mononuclear Cells Stimulated With Cholesterol Crystals

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

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Atorvastatin suppresses NLRP3 inflammasome activation via TLR4/MyD88/NF-κB signaling in PMA-stimulated THP-1 monocytes

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Ticagrelor and Rosuvastatin Have Additive Cardioprotective Effects via Adenosine

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2016 ESC/EAS Guidelines for the Management of Dyslipidaemias

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Human Monocytes Engage an Alternative Inflammasome Pathway

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NLRP3 inflammasome in peripheral blood monocytes of acute coronary syndrome patients and its relationship with statins

(2015) Afrasyab Altaf et al.   CORONARY ARTERY DISEASE

Cytokines in atherosclerosis: Key players in all stages of disease and promising therapeutic targets

(2015) Dipak P. Ramji et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Simvastatin Inhibits Toll-like Receptor 8 (TLR8) Signaling in Primary Human Monocytes and Spontaneous Tumor Necrosis Factor Production from Rheumatoid Synovial Membrane Cultures

(2015) Lisa Mullen et al.   MOLECULAR MEDICINE

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Is immunity a mechanism contributing to statin-induced diabetes?

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3-Hydroxyl-3-methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitor (Statin)-induced 28-kDa Interleukin-1β Interferes with Mature IL-1β Signaling

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Effect of simvastatin or its combination with ezetimibe on Toll-like receptor expression and lipopolysaccharide – Induced cytokine production in monocytes of hypercholesterolemic patients

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HMG-CoA reductase inhibitors activate caspase-1 in human monocytes depending on ATP release and P2X7 activation

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Targeting interleukin-1ß hampers atherosclerosis progression – Is there great promise?

(2011) Andrea Cignarella   ATHEROSCLEROSIS

Monoclonal antibodies targeting IL-1 beta reduce biomarkers of atherosclerosis in vitro and inhibit atherosclerotic plaque formation in Apolipoprotein E-deficient mice

(2011) Vinay Bhaskar et al.   ATHEROSCLEROSIS

C-reactive protein concentration and the vascular benefits of statin therapy: an analysis of 20 536 patients in the Heart Protection Study

(2011) Heart Protection Study Collaborative Group   LANCET

The immune system in atherosclerosis

(2011) Göran K Hansson et al.   NATURE IMMUNOLOGY

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(2011) Israel F. Charo et al.   NATURE REVIEWS DRUG DISCOVERY

Pleiotropic Effects of Statins

(2010) Qian Zhou et al.   CIRCULATION JOURNAL

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

(2010) Kristiina Rajamäki et al.   PLoS One

Inflammation in Atherosclerosis

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Unraveling Pleiotropic Effects Of Statins

(2008) Fatih Arslan et al.   CIRCULATION RESEARCH

Statin synergizes with LPS to induce IL-1β release by THP-1 cells through activation of caspase-1

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