Is immunity a mechanism contributing to statin-induced diabetes?

PTEN Upregulation May Explain the Development of Insulin Resistance and Type 2 Diabetes with High Dose Statins

(2014) Yochai Birnbaum et al.   CARDIOVASCULAR DRUGS AND THERAPY

Inflammasome activation in response to dead cells and their metabolites

(2014) Hajime Kono et al.   CURRENT OPINION IN IMMUNOLOGY

Statin-Induced Insulin Resistance Through Inflammasome Activation: Sailing Between Scylla and Charybdis

(2014) Patricia Mitchell et al.   DIABETES

Fluvastatin Causes NLRP3 Inflammasome-Mediated Adipose Insulin Resistance

(2014) Brandyn D. Henriksbo et al.   DIABETES

A dysglycaemic effect of statins in diabetes: relevance to clinical practice?

(2014) Daniel I. Swerdlow et al.   DIABETOLOGIA

Immunometabolism: the interface of immune and metabolic responses in disease

(2014) Jonathan D Schertzer et al.   IMMUNOLOGY AND CELL BIOLOGY

AMPK promotes macrophage fatty acid oxidative metabolism to mitigate inflammation: implications for diabetes and cardiovascular disease

(2014) Gregory R Steinberg et al.   IMMUNOLOGY AND CELL BIOLOGY

3-Hydroxyl-3-methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitor (Statin)-induced 28-kDa Interleukin-1β Interferes with Mature IL-1β Signaling

(2014) Facundo Davaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Application of New Cholesterol Guidelines to a Population-Based Sample

(2014) Michael J. Pencina et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bacterial Peptidoglycan Stimulates Adipocyte Lipolysis via NOD1

(2014) Wendy Chi et al.   PLoS One

Higher potency statins and the risk of new diabetes: multicentre, observational study of administrative databases

(2014) C. R. Dormuth et al.   BMJ-British Medical Journal

Interleukin-18 Activates Skeletal Muscle AMPK and Reduces Weight Gain and Insulin Resistance in Mice

(2013) Birgitte Lindegaard et al.   DIABETES

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes

(2013) Tony Jourdan et al.   NATURE MEDICINE

Statins in the primary prevention of cardiovascular disease

(2013) Željko Reiner   Nature Reviews Cardiology

Risk of incident diabetes among patients treated with statins: population based study

(2013) A. A. Carter et al.   BMJ-British Medical Journal

Mechanisms of disease: inflammasome activation and the development of type 2 diabetes

(2013) Ryan W. Grant et al.   Frontiers in Immunology

Inflammation and Lipid Signaling in the Etiology of Insulin Resistance

(2012) Christopher K. Glass et al.   Cell Metabolism

Moving Beyond JUPITER: Will Inhibiting Inflammation Reduce Vascular Event Rates?

(2012) Paul M Ridker   Current Atherosclerosis Reports

Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

(2012) Hye-Mi Lee et al.   DIABETES

Editorial: Macrophage heterogeneity and responses to influenza virus infection

(2012) Suki M. Y. Lee et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Immunometabolism of AMPK in insulin resistance and atherosclerosis

(2012) Morgan D. Fullerton et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Statins: Is It Really Time to Reassess Benefits and Risks?

(2012) Allison B. Goldfine   NEW ENGLAND JOURNAL OF MEDICINE

Statin Treatment Increases Lifespan and Improves Cardiac Health in Drosophila by Decreasing Specific Protein Prenylation

(2012) Stephen R. Spindler et al.   PLoS One

A Small-Molecule Screening Strategy To Identify Suppressors of Statin Myopathy

(2011) Bridget K. Wagner et al.   ACS Chemical Biology

NOD1 Activators Link Innate Immunity to Insulin Resistance

(2011) J. D. Schertzer et al.   DIABETES

Elimination of the NLRP3-ASC Inflammasome Protects against Chronic Obesity-Induced Pancreatic Damage

(2011) Yun-Hee Youm et al.   ENDOCRINOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Diabetes Mellitus, Fasting Glucose, and Risk of Cause-Specific Death

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondrial KATP channels-derived reactive oxygen species activate pro-survival pathway in pravastatin-induced cardioprotection

(2010) Luong Cong Thuc et al.   APOPTOSIS

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

Risk Factors and Drug Interactions Predisposing to Statin-Induced Myopathy

(2010) Yiannis S. Chatzizisis et al.   DRUG SAFETY

NOD2 Activation Induces Muscle Cell-Autonomous Innate Immune Responses and Insulin Resistance

(2010) Akhilesh K. Tamrakar et al.   ENDOCRINOLOGY

Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials

(2010) Naveed Sattar et al.   LANCET

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

Toll-like receptors: linking inflammation to metabolism

(2010) A. Christine Könner et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Long-term trends in use of and expenditures for cardiovascular medications in Canada

(2009) C. A. Jackevicius et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

(2009) Mohamed Lamkanfi et al.   JOURNAL OF CELL BIOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Update on statin-mediated anti-inflammatory activities in atherosclerosis

(2009) Fabrizio Montecucco et al.   Seminars in Immunopathology

Statin-Induced Inhibition of MCF-7 Breast Cancer Cell Proliferation is Related to Cell Cycle Arrest and Apoptotic and Necrotic Cell Death Mediated by an Enhanced Oxidative Stress

(2008) Claudia A. Sánchez et al.   CANCER INVESTIGATION

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes

(2008) Mohamed Lamkanfi et al.   MOLECULAR & CELLULAR PROTEOMICS

Statin synergizes with LPS to induce IL-1β release by THP-1 cells through activation of caspase-1

(2008) Loes M. Kuijk et al.   MOLECULAR IMMUNOLOGY

Large-scale chemical dissection of mitochondrial function

(2008) Bridget K Wagner et al.   NATURE BIOTECHNOLOGY

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

(2008) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Geranylgeranylation but Not GTP-Loading of Rho GTPases Determines T Cell Function

(2008) S. Waiczies et al.   Science Signaling