Article
Plant Sciences
Shuo Zhai, Xiao-Fan Zhang, Fang Lu, Wei-Guo Chen, Xin He, Chun-Feng Zhang, Chong-Zhi Wang, Chun-Su Yuan
Summary: The study demonstrated that GD extract has a protective effect against myocardial infarction by promoting angiogenesis and regulating the VEGF/VEGFR2 signaling pathway, leading to reduced infarct size and enhanced myocardial repair.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jinjuan Fu, Yuanjuan Tang, Zhen Zhang, Lin Tong, Rongchuan Yue, Lin Cai
Summary: In this study, administration of gastrin improved cardiac function in post-MI mice by reducing fibrosis, decreasing cardiomyocyte apoptosis, and increasing angiogenesis in the infarct border zone. In vitro results showed that gastrin activated the PI3K/Akt/VEGF signaling pathway, promoting migration and tube formation of human coronary artery endothelial cells. The protective effect of gastrin was mediated through the CCK2R receptor. These findings highlight the potential of gastrin as a therapeutic target candidate for MI.
MOLECULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Mahmoud E. Youssef, Mahmoud M. El-Mas, Heba M. Abdelrazek, Mona F. El-Azab
Summary: α7-nicotinic acetylcholine receptor-induced angiogenesis alleviates pathological and electrocardiographic signs of myocardial infarction in rats, suggesting a promising therapeutic strategy for ischemic conditions.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Avner Adini, Irit Adini, Etty Grad, Yuval Tal, Haim D. Danenberg, Peter M. Kang, Benjamin D. Matthews, Robert J. D'Amato
Summary: Myocardial infarction (MI) remains a leading cause of death in the western world, with current interventions being limited due to comorbidities or lack of resources. Non-invasive approaches to enhance angiogenesis in ischemic tissues have been ineffective in humans, prompting researchers to develop PR1P, a VEGF binding peptide that improves heart function post-MI in rodents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Qiong Li, Huifang Hou, Meng Li, Xia Yu, Hongbo Zuo, Jianhui Gao, Min Zhang, Zongjin Li, Zhikun Guo
Summary: The research demonstrates the effective role of CD73(+) AD-MSCs in treating myocardial infarction by promoting angiogenesis for accelerating cardiac recovery. This subgroup shows differences in the expression of factors like VEGF compared to other subgroups, suggesting its potential superiority in myocardial repair.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Carly Boye, Sezgi Arpag, Nina Burcus, Cathryn Lundberg, Scott DeClemente, Richard Heller, Michael Francis, Anna Bulysheva
Summary: This study aimed to optimize cardioporation parameters to increase gene expression efficiency by reducing vector size and minimizing ventricular fibrillation. The results demonstrated that the optimized pulsing conditions significantly increased gene expression levels and reduced tissue damage, leading to improved survival rates.
BIOELECTROCHEMISTRY
(2021)
Article
Engineering, Biomedical
Wenxuan Cao, Hong Zhang, Ning Zhou, Runxue Zhou, Xiaojing Zhang, Jia Yin, Jin Deng, Xiang Ao, Chunying Shi
Summary: In this study, a bi-functional EBP-PR1P peptide was designed to bridge VEGF and injectable cardiac extracellular matrix (c-ECM), allowing VEGF to be specifically bound and released by c-ECM. The results demonstrated that VEGF/EBP-PR1P/c-ECM scaffolds promoted angiogenesis, protected cardiomyocytes from apoptosis, and improved cardiac function recovery. The activation of the canonical downstream VEGF-Akt signaling pathway was also observed. These findings suggest that specific VEGF/EBP-PR1P/c-ECM scaffolds serve as a promising delivery system for VEGF in the treatment of myocardial infarction.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Cardiac & Cardiovascular Systems
Cesar Rios-Navarro, Luisa Hueso, Ana Diaz, Victor Marcos-Garces, Clara Bonanad, Amparo Ruiz-Sauri, Jose M. Vila, Maria J. Sanz, Francisco J. Chorro, Laura Piqueras, Vicente Bodi
Summary: The study investigates the role of antiangiogenic isoform VEGF-A(165)b after myocardial infarction (MI) and its potential as a coadjuvant therapy to coronary reperfusion. Blocking VEGF-A(165)b enhances neoangiogenesis, reduces infarct size, and increases ejection fraction in reperfused MI experiments. Higher VEGF-A(165)b levels are associated with worse systolic function both experimentally and clinically.
REVISTA ESPANOLA DE CARDIOLOGIA
(2021)
Article
Plant Sciences
Deng Pan, Lin Xu, Pengfei Chen, Lina Miao, Yi Tian, Dazhuo Shi, Ming Guo
Summary: PQS improves blood glucose, enhances cardiac function, mitigates cardiac damage, and boosts arteriolar density. The angiogenic impact of PQS appears to be, at least partially, due to its modulation of the PKC delta-mediated VEGF/PI3K-Akt/eNOS signaling pathway in rats with diabetes and myocardial infarction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Cell Biology
Chuiyu Kong, Dayin Lyu, Chang He, Rui Li, Qiulun Lu
Summary: Studies have shown that Dioscin significantly improves cardiac function in mouse models of myocardial infarction, reduces cardiac fibrosis and apoptosis, and promotes angiogenesis. Mechanistically, Dioscin enhances the proliferation and migration of hypoxic endothelial cells by up-regulating lncRNA MANTIS, leading to the induction of angiogenesis-related genes. This provides new insights into the cardioprotective effects of Dioscin and its impact on endothelial cell angiogenic activity.
Article
Cardiac & Cardiovascular Systems
Verena Wilmes, Ivan M. Kur, Andreas Weigert, Marcel A. Verhoff, Elise Gradhand, Silke Kauferstein
Summary: This study examines the expression of iNOS and NT production in postmortem human myocardial infarction hearts. The results demonstrate that resident macrophages are the main source of iNOS expression in these hearts, and there is a correlation between iNOS and NT production, indicating the involvement of iNOS in oxidative stress.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Engineering, Environmental
Shu-yi He, Lin-yu Long, Zhi-cun Wang, Wen-qi Liu, Wen Zhang, Cheng Hu, Xiao-feng Wu, Ruiqi Dong, Hong-song Fan, Qing Jiang, Ying-ying Tong, Guang-hua Yang, Li Yang, Yun-bing Wang
Summary: In this study, an injectable self-doping conductive hydrogel was developed for delivering human umbilical cord mesenchymal stem cell secretome to protect cardiac function after myocardial infarction. The conductive hydrogel showed good biocompatibility and conductivity consistent with the natural myocardium, and the secretome was able to promote cell proliferation, migration, and angiogenesis. In a rat MI model, hydrogel injection improved ejection fraction and fraction shortening, and decreased susceptibility to arrhythmia.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Medicinal
Donghwa Kim, Sang Won Choi, Jihee Cho, Jae-Hui Been, Kyoungsun Choi, Wenzhe Jiang, Jaeho Han, Jedo Oh, Changmin Park, Soongyu Choi, Songyi Seo, Koung Li Kim, Wonhee Suh, Sang Kook Lee, Sanghee Kim
Summary: Diabetic retinopathy is a leading cause of blindness associated with excessive angiogenesis. Researchers have developed a novel antiangiogenesis agent by modifying the structure of wondonin marine natural products, resulting in improved bioactivity and selectivity. This compound, 31, shows potential as a lead for developing small-molecule drugs to treat diabetic retinopathy and to uncover new mechanisms of angiogenesis.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Cell Biology
Anais Moyon, Philippe Garrigue, Samantha Fernandez, Fabien Hubert, Laure Balasse, Pauline Brige, Guillaume Hache, Vincent Nail, Marcel Blot-Chabaud, Francoise Dignat-George, Francesca Rochais, Benjamin Guillet
Summary: The study found that Ga-68-sCD146 PET imaging showed higher AMOT expression after myocardial infarction, with significant correlations with heart perfusion, tissue fibrosis, and functional recovery.
Article
Biochemistry & Molecular Biology
Saif Ullah, Taseer Ahmad, Muhammad Ikram, Hafiz Majid Rasheed, Muhammad Ijaz Khan, Taous Khan, Tariq G. Alsahli, Sami I. Alzarea, Musaad Althobaiti, Abdul Jabbar Shah
Summary: Myocardial infarction (MI) is a leading cause of premature death, and protecting the myocardium from ischemia is a key area of research. This study found that 7-hydroxy frullanolide (7-HF) showed potential cardioprotective effects by reducing myocardial injury, preserving tissue histology, and decreasing the release of cardiac biomarkers. Additionally, 7-HF modulated the expression of cardioprotective genes Nrf2 and iNOS, and improved cardiac function.
Article
Biochemistry & Molecular Biology
Rehab E. Abo El Gheit, Reham L. Younis, Mervat H. El-Saka, Marwa N. Emam, Nema A. Soliman, Rehab M. El-Sayed, Yasser Mostafa Hafez, Norhan Ahmed AbuoHashish, Doaa A. Radwan, Howayda E. Khaled, Samar Kamel, Sawsan A. Zaitone, Ghada A. Badawi
Summary: This study investigates the potential role of irisin in protecting against obesity in a postmenopausal rat model. The findings suggest that irisin treatment improves lipid profile and insulin resistance, and increases thermogenic parameters and energy expenditure in skeletal muscle and adipose tissue.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Mohammed Amran, El-Sayed Khafagy, Hatem Mokhtar, Sawsan A. Zaitone, Yasser M. Moustafa, Shadeed Gad
Summary: This study established a simple method to produce additive-free triamcinolone acetonide (TAA) microspheres suitable for pulmonary delivery. The results indicated that additive-free spray-dried TAA microspheres were promising for treating lung diseases.
Article
Cardiac & Cardiovascular Systems
Umar Abdolah Alharbe, Hanad Hassan Alatawi, Palanisamy Amirthalingam, Sultan Mohammed Daghriri, Alanoud Abduallah Alhwiti, Tahani Saud Alenazi, Abdulelah Turki S. Al Ahmare, Sawsan A. Zaitone, Ahmed Aljabri, Ahmed Mohsen Hamdan
Summary: This study compared the risk factors of acute myocardial infarction among Saudi nationals and expatriates and found significant differences, suggesting a potential genetic contribution to the risk factors.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Chemistry, Analytical
Eman A. Abdel Hameed, Zaitona A. Abd El-Naby, Alaa El Gindy, Roshdy E. Saraya, Aisha Nawaf Al Balawi, Sawsan A. Zaitone, Gasser M. Khairy
Summary: Novel green HPLC and HPTLC chromatographic methods were developed for the concurrent determination of moxifloxacin, levofloxacin, and gemifloxacin. Both methods were optimized, validated, and assessed using the Green analytical procedure index (GAPI). The results showed that these methods are suitable for pharmaceutical analysis and detection of cross-contamination during manufacturing processes.
Article
Medicine, Research & Experimental
Hala M. F. Mohammad, Sahar Galal Gouda, Mohamed Ahmed Eladl, Amany Y. Elkazaz, Khaled S. Elbayoumi, Noha E. Farag, Amr Elshormilisy, Buthainah B. Al-Ammash, Ann Hegazy, Sozan M. Abdelkhalig, Abir S. Mohamed, Mohamed El-Dosoky, Sawsan A. Zaitone
Summary: This study investigates the molecular mechanisms leading to DN and the role of LRG1, ALK1, and TGF beta 1 in DN pathologic alterations. It also explores the protective action of metformin against DN and its influence on LRG1 and ALK1/TGF beta 1 induced renal angiogenesis. The results show that metformin has renoprotective effects in a diabetic model, partly mediated by downregulation of LRG1 and TGF beta 1/ALK1-induced renal angiogenesis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Correction
Immunology
Nehal M. Elsherbiny, Eman Ahmed, Ghada Abdel Kader, Yousra Abdel-mottaleb, Mohamed H. ElSayed, Amal M. Youssef, Sawsan A. Zaitone
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Hebatallah Husseini Atteia, Eman Saad Alamri, Nizar Sirag, Nahla Salah Zidan, Raghad Humod Aljohani, Sharifa Alzahrani, Manar Hamed Arafa, Nanies Sameeh Mohammad, Mervat Elsayed Asker, Sawsan A. Zaitone, Amr Tawfik Sakr
Summary: This study investigated the potential of isoliquiritigenin, a bioflavonoid extracted from licorice roots, as a natural activator for soluble Guanylate Cyclase (sGC) in a chronic kidney disease (CKD) rat model. The results showed that isoliquiritigenin dose-dependently improved CKD-related renal and endothelial dysfunction, reduced fibrosis, apoptosis, and calcification, and attenuated inflammation and oxidative stress. These protective effects were associated with the activation of sGC, increased cGMP and its downstream PKG. However, co-treatment with a selective sGC inhibitor antagonized the therapeutic impact of isoliquiritigenin.
Article
Toxicology
Mohammed A. Attia, Nema Soliman, Mohamed Ahmed Eladl, Shymaa E. Bilasy, Taghrid B. El-Abaseri, Howaida S. Ali, Faten Abbas, Dalia Ibrahim, Noura M. S. Osman, Abdullah A. Hashish, Asma Alshahrani, Abir S. Mohamed, Sawsan A. Zaitone
Summary: The current study demonstrated that topiramate has a neuroprotective effect in mouse peripheral diabetic neuropathy and investigated the underlying mechanisms. Treatment with topiramate increased the hotplate latency time and von-Frey test pain threshold, alleviating pain in DN mice. Additionally, topiramate also attenuated axonal degeneration in sciatic nerves and suppressed the expression of GFAP and inflammatory cytokines while enhancing the plasticity of the spinal cord. This study reinforces the neuroprotective role of topiramate and provides insights into its mechanisms in alleviating neuropathy.
TOXICOLOGY MECHANISMS AND METHODS
(2023)
Article
Pharmacology & Pharmacy
Mohamed F. Zaky, Taha M. Hammady, Shadeed Gad, Abdullah Alattar, Reem Alshaman, Ann Hegazy, Sawsan A. Zaitone, Mamdouh Mostafa Ghorab, Mohamed A. Megahed
Summary: Nanostructured lipid carriers (NLCs) have been studied for their potential to enhance the bioavailability and efficacy of drugs, and the surface modification of NLCs with chitosan and PEGylation has been investigated in this study. The results showed that both chitosanization and PEGylation improved the stability, bioavailability, and pharmacodynamic activity of NLCs loaded with apixaban. Chitosan-modified NLCs displayed better stability and enhanced anticoagulant activity, while PEGylated NLCs showed higher absorption profile in rats.
Article
Infectious Diseases
Mohamed F. Ghaly, Marzough Aziz Albalawi, Mahmoud M. Bendary, Ahmed Shahin, Mohamed A. Shaheen, Abeer F. Abu Eleneen, Mohammed M. Ghoneim, Ayman Abo Elmaaty, Mohamed F. M. Elrefai, Sawsan A. Zaitone, Amira I. Abousaty
Summary: The worldwide crises of multi-drug-resistant bacterial infections have led to a search for alternative therapies. Our research group evaluated the antimicrobial activities of the ethanolic extract of Tamarindus indica, a traditional medicine. The extract showed promising antimicrobial activities against multi-drug-resistant pathogens, with confirmed mechanisms of action and antivirulence activities. We hope that pharmaceutical companies can utilize our findings to develop a new formulation of T. indica extract with other antibiotics.
Article
Chemistry, Medicinal
Samah M. M. Elaidy, Mohamed K. K. El-Kherbetawy, Sally Y. Y. Abed, Abdullah Alattar, Reem Alshaman, Mohamed Ahmed Eladl, Eman Saad Alamri, Aisha Nawaf Al Balawi, AbdelNaser Zaid, Amany Y. Y. Elkazzaz, Sozan M. M. Abdelkhalig, Ziad E. E. Hamed, Sawsan A. A. Zaitone
Summary: This study investigated the chemotherapeutic effect of alpha-hederin in combination with cisplatin on Ehrlich solid tumors in mice. The results showed that alpha-hederin significantly enhanced the chemotherapeutic efficacy of cisplatin against Ehrlich solid tumors by suppressing the signaling pathway of SDF1/CXCR4/p-AKT/NF kappa B.
Article
Chemistry, Medicinal
Eman J. Heikal, Rashad M. Kaoud, Shadeed Gad, Hatem I. Mokhtar, Afaf A. Aldahish, Wafa Ali Alzlaiq, Sawsan A. Zaitone, Yasser M. Moustafa, Taha M. Hammady
Summary: This study aimed to develop a pharmaceutical dosage form containing omeprazole and curcumin for treating experimental peptic ulcers. The complex of omeprazole and curcumin was loaded into alginate beads and coated with chitosan for sustained release. The formulated beads showed improved anti-ulcer effectiveness compared to free omeprazole or omeprazole-only-loaded beads. Evaluation: x/10
Article
Polymer Science
Eman J. Heikal, Rashad M. Kaoud, Shadeed Gad, Hatem I. Mokhtar, Abdullah Alattar, Reem Alshaman, Sawsan A. Zaitone, Yasser M. Moustafa, Taha M. Hammady
Summary: This research developed a drug delivery system by coating alginate/chitosan beads with Eudragit (R) S-100 to target the colon and effectively treat colitis. The coated beads showed controlled release of curcumin/mesalamine at different pH levels. The optimized formula demonstrated high entrapment efficiency, swelling, and bead size. It significantly reduced colitis, indicating its potential for treating ulcerative colitis.
Article
Medicine, Research & Experimental
Mohammed H. ElSayed, Khaled S. Elbayoumi, Mohamed Ahmed Eladl, Abeer A. K. Mohamed, Ann Hegazy, Nagla A. El-Sherbeeny, Mohammed A. Attia, Fatma Azzahraa Hisham, Mohamed A. K. Saleh, Abdelhakeem Elaskary, Khaled Morsi, Amna M. A. Mustsafa, Eman T. Enan, Sawsan A. Zaitone
Summary: Diabetic retinopathy (DRET) can lead to vision loss in adults, but there are limited therapeutic options available. This study investigated the neuroprotective effect of memantine, an anti-Alzheimer drug, in experimental DRET and its impact on ROS/TXNIP/NLRP3 signaling cascade. The results demonstrated that memantine attenuated retinal damage and reduced inflammation in DRET.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Reem Alshaman, Mona Qushawy, Hatem I. Mokhtar, Angie M. Ameen, Rehab M. El-Sayed, Eman Saad Alamri, Lamiaa M. Elabbasy, Ahmed M. N. Helaly, Walid F. Elkhatib, Eidah M. Alyahya, Sawsan A. Zaitone
Summary: This study demonstrated that treatment with M-Oil or M-NE improved motor performance in mice with experimental PD, enhanced anti-inflammatory and antioxidant actions, downregulated inflammatory markers and malondialdehyde levels, and improved physical characteristics by formulating M-Oil as M-NE.
FRONTIERS IN PHARMACOLOGY
(2023)
