HSP90 and Co-chaperones: Impact on Tumor Progression and Prospects for Molecular-Targeted Cancer Therapy

Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase

(2019) Blake E. Smith et al.   Nature Communications

17-Aminogeldanamycin selectively diminishes IRE1α-XBP1s pathway activity and cooperatively induces apoptosis with MEK1/2 and BRAFV600E inhibitors in melanoma cells of different genetic subtypes

(2019) Aleksandra Mielczarek-Lewandowska et al.   APOPTOSIS

Emerging roles of exosomal miRNAs in breast cancer drug resistance

(2019) Hamid Najminejad et al.   IUBMB LIFE

Potential drugs used in the antibody-drug conjugate (ADC) architecture for cancer therapy

(2019) Sajad Yaghoubi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Snail-Overexpression Induces Epithelial-mesenchymal Transition and Metabolic Reprogramming in Human Pancreatic Ductal Adenocarcinoma and Non-tumorigenic Ductal Cells

(2019) Menghan Liu et al.   Journal of Clinical Medicine

HSP90 Molecular Chaperones, Metabolic Rewiring, and Epigenetics: Impact on Tumor Progression and Perspective for Anticancer Therapy

(2019) Valentina Condelli et al.   Cells

Inhibiting protein-protein interactions of Hsp90 as a novel approach for targeting cancer

(2019) Sayan Dutta Gupta et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Roles of Extracellular HSPs as Biomarkers in Immune Surveillance and Immune Evasion

(2019) Eman A. Taha et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A novel heat shock protein 90 inhibitor potently targets adrenocortical carcinoma tumor suppression

(2019) Ton Wang et al.   SURGERY

Co-chaperones TIMP2 and AHA1 Competitively Regulate Extracellular HSP90:Client MMP2 Activity and Matrix Proteolysis

(2019) Alexander J. Baker-Williams et al.   Cell Reports

The Multiple Roles and Therapeutic Potential of Molecular Chaperones in Prostate Cancer

(2019) Hoter et al.   Cancers

Hsp90 and Its Co-Chaperones in Neurodegenerative Diseases

(2019) Anastasiia Bohush et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions

(2019) Li Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

High expression of HSP90 is associated with poor prognosis in patients with colorectal cancer

(2019) Shuming Zhang et al.   PeerJ

Novel Hsp90 Inhibitor C086 Potently Inhibits Non-Small Cell Lung Cancer Cells As A Single Agent Or In Combination With Gefitinib

(2019) Liman Wang et al.   Cancer Management and Research

AT-533, a novel Hsp90 inhibitor, inhibits breast cancer growth and HIF-1α/VEGF/VEGFR-2-mediated angiogenesis in vitro and in vivo

(2019) Peng-Chao Zhang et al.   BIOCHEMICAL PHARMACOLOGY

TRIP13 interference inhibits the proliferation and metastasis of thyroid cancer cells through regulating TTC5/p53 pathway and epithelial-mesenchymal transition related genes expression

(2019) Leitao Yu et al.   BIOMEDICINE & PHARMACOTHERAPY

Identification of vibsanin A analog as a novel HSP90 inhibitor

(2019) Kazuki Miura et al.   BIOORGANIC & MEDICINAL CHEMISTRY

TAS-116 inhibits oncogenic KIT signalling on the Golgi in both imatinib-naïve and imatinib-resistant gastrointestinal stromal tumours

(2019) Yurina Saito et al.   BRITISH JOURNAL OF CANCER

Regulation of the Hsp90 system

(2018) Siyuan Sima et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Chaperoning the guardian of the genome. The two-faced role of molecular chaperones in p53 tumor suppressor action

(2018) Bartosz Wawrzynow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

New TRAP1 and Hsp90 chaperone inhibitors with cationic components: Preliminary studies on mitochondrial targeting

(2018) R. Rondanin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting the Hsp90-Cdc37-client protein interaction to disrupt Hsp90 chaperone machinery

(2018) Ting Li et al.   Journal of Hematology & Oncology

Development of a novel Hsp90 inhibitor NCT-50 as a potential anticancer agent for the treatment of non-small cell lung cancer

(2018) Seung Yeob Hyun et al.   Scientific Reports

Chaperome heterogeneity and its implications for cancer study and treatment

(2018) Tai Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of microRNAs regulating the expression of matrix metalloproteinases (MMPs) in breast cancer development, progression, and metastasis

(2018) Mahsa Javadian et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Hsp70–Hsp90 Chaperone Cascade in Protein Folding

(2018) Tania Morán Luengo et al.   TRENDS IN CELL BIOLOGY

Targeting Heat Shock Proteins in Cancer: A Promising Therapeutic Approach

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ganetespib induces G2/M cell cycle arrest and apoptosis in gastric cancer cells through targeting of receptor tyrosine kinase signaling

(2017) Harry Lee et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

First-in-human study of the epichaperome inhibitor PU-H71: clinical results and metabolic profile

(2017) Giovanna Speranza et al.   INVESTIGATIONAL NEW DRUGS

A chemical compound inhibiting the Aha1–Hsp90 chaperone complex

(2017) Sandrine C. Stiegler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rb family proteins enforce the homeostasis of quiescent hematopoietic stem cells by repressing Socs3 expression

(2017) Eunsun Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutant p53 in Cancer: Accumulation, Gain-of-Function, and Therapy

(2017) Xuetian Yue et al.   JOURNAL OF MOLECULAR BIOLOGY

The Plasticity of the Hsp90 Co-chaperone System

(2017) Priyanka Sahasrabudhe et al.   MOLECULAR CELL

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Heat Shock Proteins and Cancer

(2017) Jianming Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Hydrogen sulfide promotes autophagy of hepatocellular carcinoma cells through the PI3K/Akt/mTOR signaling pathway

(2017) Shanshan S Wang et al.   Cell Death & Disease

Development of Heat Shock Protein (Hsp90) Inhibitors To Combat Resistance to Tyrosine Kinase Inhibitors through Hsp90–Kinase Interactions

(2016) Meining Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

The epichaperome is an integrated chaperome network that facilitates tumour survival

(2016) Anna Rodina et al.   NATURE

Preclinical and clinical evaluation of MET functions in cancer cells and in the tumor stroma

(2016) V Finisguerra et al.   ONCOGENE

HSP90 expression and its association with wighteone metabolite response in HER2-positive breast cancer cells

(2016) ZHONG-WEI CAO et al.   Oncology Letters

The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding

(2016) Mark R. Woodford et al.   Nature Communications

The Mechanism of Hsp90 ATPase Stimulation by Aha1

(2016) Annemarie Wolmarans et al.   Scientific Reports

Patient-derived heavy chain antibody targets cell surface HSP90 on breast tumors

(2015) Charan V. Devarakonda et al.   BMC CANCER

Protease-activated receptors (PARs)—biology and role in cancer invasion and metastasis

(2015) Marek Z. Wojtukiewicz et al.   CANCER AND METASTASIS REVIEWS

HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells

(2015) Dae-Hee Lee et al.   CELLULAR SIGNALLING

Protein Folding and Mechanisms of Proteostasis

(2015) José Díaz-Villanueva et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phase I/II Study of HSP90 Inhibitor AUY922 and Erlotinib forEGFR-Mutant Lung Cancer With Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors

(2015) Melissa L. Johnson et al.   JOURNAL OF CLINICAL ONCOLOGY

Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds

(2015) A.R.M. Ruhul Amin et al.   SEMINARS IN CANCER BIOLOGY

Heat Shock Protein 90 is overexpressed in high-risk myelodysplastic syndromes and associated with higher expression and activation of Focal Adhesion Kinase

(2015) Pascale Flandrin-Gresta et al.   Oncotarget

MTOR inhibition enhances NVP-AUY922-induced autophagy-mediated KIT degradation and cytotoxicity in imatinib-resistant gastrointestinal stromal tumors

(2015) Yuan-Shuo Hsueh et al.   Oncotarget

Cruentaren A Binds F1F0 ATP Synthase To Modulate the Hsp90 Protein Folding Machinery

(2014) Jessica A. Hall et al.   ACS Chemical Biology

Combined inhibition of Hsp90 and the proteasome affects NSCLC proteostasis and attenuates cell migration

(2014) Victoria Zismanov et al.   ANTI-CANCER DRUGS

Herbimycin A inhibits cell growth with reversal of epithelial–mesenchymal transition in anaplastic thyroid carcinoma cells

(2014) Si Hyoung Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HSP90 Supports Tumor Growth and Angiogenesis through PRKD2 Protein Stabilization

(2014) N. Azoitei et al.   CANCER RESEARCH

Glucocorticoid Receptor Function Regulated by Coordinated Action of the Hsp90 and Hsp70 Chaperone Cycles

(2014) Elaine Kirschke et al.   CELL

Plasma Levels of Heat Shock Protein 90 Alpha Associated with Lung Cancer Development and Treatment Responses

(2014) Y. Shi et al.   CLINICAL CANCER RESEARCH

Heat shock protein 90β stabilizes focal adhesion kinase and enhances cell migration and invasion in breast cancer cells

(2014) Xiangyang Xiong et al.   EXPERIMENTAL CELL RESEARCH

Hsp90 inhibitor induces autophagy and apoptosis in osteosarcoma cells

(2014) MASAKI MORI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Profiling Hsp90 differential expression and the molecular effects of the Hsp90 inhibitor IPI-504 in high-grade glioma models

(2014) Kaijun Di et al.   JOURNAL OF NEURO-ONCOLOGY

Heat shock protein 90 promotes epithelial to mesenchymal transition, invasion, and migration in colorectal cancer

(2014) Ganji Purnachandra Nagaraju et al.   MOLECULAR CARCINOGENESIS

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of Heat Shock Protein 90 with AUY922 Represses Tumor Growth in a Transgenic Mouse Model of Islet Cell Neoplasms

(2014) Volker Fendrich et al.   NEUROENDOCRINOLOGY

HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer

(2014) R Schulz et al.   Cell Death & Disease

Geldanamycin and Its Derivatives Inhibit the Growth of Myeloma Cells and Reduce the Expression of the MET Receptor

(2014) Artur Jurczyszyn et al.   Journal of Cancer

Antiangiogenic effects of ganetespib in colorectal cancer mediated through inhibition of HIF-1α and STAT-3

(2013) Purnachandra Nagaraju Ganji et al.   ANGIOGENESIS

Molecular Chaperone Functions in Protein Folding and Proteostasis

(2013) Yujin E. Kim et al.   Annual Review of Biochemistry

The Mitochondrial Chaperone TRAP1 Promotes Neoplastic Growth by Inhibiting Succinate Dehydrogenase

(2013) Marco Sciacovelli et al.   Cell Metabolism

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

A Phase I Study of the HSP90 Inhibitor Retaspimycin Hydrochloride (IPI-504) in Patients with Gastrointestinal Stromal Tumors or Soft-Tissue Sarcomas

(2013) A. J. Wagner et al.   CLINICAL CANCER RESEARCH

Cell Survival and Apoptosis Signaling as Therapeutic Target for Cancer: Marine Bioactive Compounds

(2013) Senthilkumar Kalimuthu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human TTC5, a novel tetratricopeptide repeat domain containing gene, activates p53 and inhibits AP-1 pathway

(2013) Ying Xiong et al.   MOLECULAR BIOLOGY REPORTS

The chaperone Hsp90: changing partners for demanding clients

(2013) Alina Röhl et al.   TRENDS IN BIOCHEMICAL SCIENCES

TTC5 is required to prevent apoptosis of acute myeloid leukemia stem cells

(2013) J T Lynch et al.   Cell Death & Disease

The Complex Function of Hsp70 in Metastatic Cancer

(2013) Kata Juhasz et al.   Cancers

Phase II study of the HSP90-inhibitor BIIB021 in gastrointestinal stromal tumors

(2012) M. A. Dickson et al.   ANNALS OF ONCOLOGY

LAMP2A overexpression in breast tumors promotes cancer cell survival via chaperone-mediated autophagy

(2012) Tapas Saha   Autophagy

Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

(2012) L. Neckers et al.   CLINICAL CANCER RESEARCH

Secreted Hsp90 Is a Novel Regulator of the Epithelial to Mesenchymal Transition (EMT) in Prostate Cancer

(2012) Michael W. Hance et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp90 Is Involved in Apoptosis of Candida albicans by Regulating the Calcineurin-Caspase Apoptotic Pathway

(2012) BaoDi Dai et al.   PLoS One

Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity

(2012) S. Tsutsumi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the ATM-Snail pathway promotes breast cancer metastasis

(2012) Mianen Sun et al.   Journal of Molecular Cell Biology

Regulation and Function of Autophagy during Cell Survival and Cell Death

(2012) G. Das et al.   Cold Spring Harbor Perspectives in Biology

The Role of Heat Shock Proteins in Antigen Cross Presentation

(2012) Ayesha Murshid et al.   Frontiers in Immunology

Discovery and development of natural heat shock protein 90 inhibitors in cancer treatment

(2012) Yong Li et al.   Acta Pharmaceutica Sinica B

Macrocycles That Inhibit the Binding between Heat Shock Protein 90 and TPR-Containing Proteins

(2011) Veronica C. Ardi et al.   ACS Chemical Biology

GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum

(2011) Michal Marzec et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Hsp90 chaperone machinery: Conformational dynamics and regulation by co-chaperones

(2011) Jing Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Secreted heat shock protein-90 (Hsp90) in wound healing and cancer

(2011) Wei Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Post-translational modifications of Hsp90 and their contributions to chaperone regulation

(2011) Mehdi Mollapour et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

HSP90 Inhibition Is Effective in Breast Cancer: A Phase II Trial of Tanespimycin (17-AAG) Plus Trastuzumab in Patients with HER2-Positive Metastatic Breast Cancer Progressing on Trastuzumab

(2011) S. Modi et al.   CLINICAL CANCER RESEARCH

Molecular basis for the actions of Hsp90 inhibitors and cancer therapy

(2011) Hiroshi Yamaki et al.   JOURNAL OF ANTIBIOTICS

Heat shock protein 90–mediated inactivation of nuclear factor-κB switches autophagy to apoptosis through becn1 transcriptional inhibition in selenite-induced NB4 cells

(2011) Qian Jiang et al.   MOLECULAR BIOLOGY OF THE CELL

Substrate Binding Drives Large-Scale Conformational Changes in the Hsp90 Molecular Chaperone

(2011) Timothy O. Street et al.   MOLECULAR CELL

Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53

(2011) Franz Hagn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Novel Extracellular Hsp90 Mediated Co-Receptor Function for LRP1 Regulates EphA2 Dependent Glioblastoma Cell Invasion

(2011) Udhayakumar Gopal et al.   PLoS One

Extracellular Heat Shock Protein (Hsp)70 and Hsp90α Assist in Matrix Metalloproteinase-2 Activation and Breast Cancer Cell Migration and Invasion

(2011) Jessica D. Sims et al.   PLoS One

The 4C5 Cell-Impermeable Anti-HSP90 Antibody with Anti-Cancer Activity, Is Composed of a Single Light Chain Dimer

(2011) Katerina Sidera et al.   PLoS One

An Interaction Network Predicted from Public Data as a Discovery Tool: Application to the Hsp90 Molecular Chaperone Machine

(2011) Pablo C. Echeverría et al.   PLoS One

Lifestyle as risk factor for cancer: Evidence from human studies

(2010) Naghma Khan et al.   CANCER LETTERS

Heat Shock Protein 90 Inhibition Depletes LATS1 and LATS2, Two Regulators of the Mammalian Hippo Tumor Suppressor Pathway

(2010) C. J. Huntoon et al.   CANCER RESEARCH

Targeting PI3K/Akt/HSP90 Signaling Sensitizes Gastric Cancer Cells to Deoxycholate-Induced Apoptosis

(2010) Maria J. Redlak et al.   DIGESTIVE DISEASES AND SCIENCES

Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage

(2010) William B Pratt et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Oncophage®(vitespen®) - Heat shock protein peptide complex 96-based vaccines in melanoma: How far we are, how far we can get?

(2010) Alessandra di Pietro et al.   Human vaccines & immunotherapeutics

The Regulatory Mechanism of Extracellular Hsp90α on Matrix Metalloproteinase-2 Processing and Tumor Angiogenesis

(2010) Xiaomin Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual Role of Heat Shock Proteins as Regulators of Apoptosis and Innate Immunity

(2010) Anne-Laure Joly et al.   Journal of Innate Immunity

Hsp90 and co-chaperones twist the functions of diverse client proteins

(2009) Abbey Zuehlke et al.   BIOPOLYMERS

Targeting HSP90 for cancer therapy

(2009) D Mahalingam et al.   BRITISH JOURNAL OF CANCER

Facilitating Akt Clearance via Manipulation of Hsp70 Activity and Levels

(2009) John Koren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain

(2009) Shinji Tsutsumi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

(2009) E. Caldas-Lopes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK

(2008) Y. Okawa et al.   BLOOD

Significance of heat-shock protein (HSP) 90 expression in acute myeloid leukemia cells

(2008) Pascale Flandrin et al.   CELL STRESS & CHAPERONES

Guidelines for the nomenclature of the human heat shock proteins

(2008) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

In vivo degradation of nitric oxide synthase (NOS) and heat shock protein 90 (HSP90) by calpain is modulated by the formation of a NOS-HSP90 heterocomplex

(2008) Monica Averna et al.   FEBS Journal

Identification and characterization of a novel folliculin-interacting protein FNIP2

(2008) Hisashi Hasumi et al.   GENE

A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells

(2008) T. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

Chaperone-dependent stabilization and degradation of p53 mutants

(2008) P Muller et al.   ONCOGENE

The Human TPR Protein TTC4 Is a Putative Hsp90 Co-Chaperone Which Interacts with CDC6 and Shows Alterations in Transformed Cells

(2008) Gilles Crevel et al.   PLoS One