The Complex Function of Hsp70 in Metastatic Cancer

Hsp70 Translocates into the Plasma Membrane after Stress and Is Released into the Extracellular Environment in a Membrane-Associated Form that Activates Macrophages

(2014) V. L. Vega et al.   JOURNAL OF IMMUNOLOGY

Heat Shock Protein 70, Released from Heat-Stressed Tumor Cells, Initiates Antitumor Immunity by Inducing Tumor Cell Chemokine Production and Activating Dendritic Cells via TLR4 Pathway

(2014) T. Chen et al.   JOURNAL OF IMMUNOLOGY

Invasion potential of H22 hepatocarcinoma cells is increased by HMGB1-induced tumor NF-κB signaling via initiation of HSP70

(2013) WEI GONG et al.   ONCOLOGY REPORTS

Inhibition of HSP70: A challenging anti-cancer strategy

(2012) Anastasia R. Goloudina et al.   CANCER LETTERS

Knockdown of Hop downregulates RhoC expression, and decreases pseudopodia formation and migration in cancer cell lines

(2012) Tarryn Willmer et al.   CANCER LETTERS

Why does cancer therapy lack effective anti-metastasis drugs?

(2012) Georg F. Weber   CANCER LETTERS

The interaction of HspA1A with TLR2 and TLR4 in the response of neutrophils induced by ovarian cancer cells in vitro

(2012) Magdalena Klink et al.   CELL STRESS & CHAPERONES

Heat Shock Proteins (HSPs) Based Anti-Cancer Vaccines

(2012) D.R. Ciocca et al.   CURRENT MOLECULAR MEDICINE

Lysosomal Rerouting of Hsp70 Trafficking as a Potential Immune Activating Tool for Targeting Melanoma

(2012) Kata Juhasz et al.   CURRENT PHARMACEUTICAL DESIGN

Inducible Heat Shock Protein 70 Reduces T Cell Responses and Stimulatory Capacity of Monocyte-derived Dendritic Cells

(2012) Pawel Stocki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HSP90 and HSP70 Proteins Are Essential for Stabilization and Activation of WASF3 Metastasis-promoting Protein

(2012) Yong Teng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anticancer Drugs Cause Release of Exosomes with Heat Shock Proteins from Human Hepatocellular Carcinoma Cells That Elicit Effective Natural Killer Cell Antitumor Responsesin Vitro

(2012) Li-Hong Lv et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The EGF Receptor and HER2 Participate in TNF-α-Dependent MAPK Activation and IL-8 Secretion in Intestinal Epithelial Cells

(2012) Humberto B. Jijon et al.   MEDIATORS OF INFLAMMATION

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Immunotherapeutic Targeting of Membrane Hsp70-Expressing Tumors Using Recombinant Human Granzyme B

(2012) Mathias Gehrmann et al.   PLoS One

HSP70 Enhances Immunosuppressive Function of CD4+CD25+FoxP3+ T Regulatory Cells and Cytotoxicity in CD4+CD25− T Cells

(2012) Julian Wachstein et al.   PLoS One

The anti-inflammatory mechanisms of Hsp70

(2012) Thiago J. Borges et al.   Frontiers in Immunology

The Role of Heat Shock Proteins in Antigen Cross Presentation

(2012) Ayesha Murshid et al.   Frontiers in Immunology

Heat Shock Proteins: Conditional Mediators of Inflammation in Tumor Immunity

(2012) Stuart K. Calderwood et al.   Frontiers in Immunology

BAG3 (BCL2-associated athanogene 3) interacts with MMP-2 to positively regulate invasion by ovarian carcinoma cells

(2011) Miwa Suzuki et al.   CANCER LETTERS

RNAi knockdown of Hop (Hsp70/Hsp90 organising protein) decreases invasion via MMP-2 down regulation

(2011) Naomi Walsh et al.   CANCER LETTERS

Extracellular HSPA1A promotes the growth of hepatocarcinoma by augmenting tumor cell proliferation and apoptosis-resistance

(2011) Feng-Hua Wu et al.   CANCER LETTERS

A case of mistaken identity: HSPs are no DAMPs but DAMPERs

(2011) Willem van Eden et al.   CELL STRESS & CHAPERONES

MMP-9 induces CD44 cleavage and CD44 mediated cell migration in glioblastoma xenograft cells

(2011) Chandramu Chetty et al.   CELLULAR SIGNALLING

Molecular Chaperones as a Common Set of Proteins That Regulate the Invasion Phenotype of Head and Neck Cancer

(2011) C.-C. Chiu et al.   CLINICAL CANCER RESEARCH

Heat shock proteins and cancer vaccines: developments in the past decade and chaperoning in the decade to come

(2011) Ayesha Murshid et al.   Expert Review of Vaccines

A Unique Role for Heat Shock Protein 70 and Its Binding Partner Tissue Transglutaminase in Cancer Cell Migration

(2011) Lindsey K. Boroughs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of HSP70 inhibits cofilin phosphorylation and promotes lymphocyte migration in heat-stressed cells

(2011) J. P. Simard et al.   JOURNAL OF CELL SCIENCE

HSP70 decreases receptor-dependent phosphorylation of Smad2 and blocks TGF-β-induced epithelial-mesenchymal transition

(2011) Yihao Li et al.   Journal of Genetics and Genomics

The C-terminus of Hsp70-Interacting Protein Promotes Met Receptor Degradation

(2011) Kang Won Jang et al.   Journal of Thoracic Oncology

Extracellular Heat Shock Protein (Hsp)70 and Hsp90α Assist in Matrix Metalloproteinase-2 Activation and Breast Cancer Cell Migration and Invasion

(2011) Jessica D. Sims et al.   PLoS One

Inducible Hsp70 in the Regulation of Cancer Cell Survival: Analysis of Chaperone Induction, Expression and Activity

(2011) Elisa Zorzi et al.   Cancers

Role of Endoplasmic Reticulum Stress in Epithelial–Mesenchymal Transition of Alveolar Epithelial Cells

(2010) Qian Zhong et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Inactivation of the WASF3 gene in prostate cancer cells leads to suppression of tumorigenicity and metastases

(2010) Y Teng et al.   BRITISH JOURNAL OF CANCER

Germ cell-specific heat shock protein 70-2 is expressed in cervical carcinoma and is involved in the growth, migration, and invasion of cervical cells

(2010) Manoj Garg et al.   CANCER

Connecting Hsp70, sphingolipid metabolism and lysosomal stability

(2010) Nikolaj H.T. Petersen et al.   CELL CYCLE

The Regulatory Mechanism of Extracellular Hsp90α on Matrix Metalloproteinase-2 Processing and Tumor Angiogenesis

(2010) Xiaomin Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology

(2010) Thomas Kirkegaard et al.   NATURE

Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody

(2010) S. Stangl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy of HSP70 and chelation of lysosomal iron in a non-redox-active form

(2009) Tino Kurz et al.   Autophagy

Heat shock protein 70 is secreted from endothelial cells by a non-classical pathway involving exosomes

(2009) Rui Zhan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A new feature of the stress response: increase in endocytosis mediated by Hsp70

(2009) Virginia L. Vega et al.   CELL STRESS & CHAPERONES

Caught with their PAMPs down? The extracellular signalling actions of molecular chaperones are not due to microbial contaminants

(2009) Brian Henderson et al.   CELL STRESS & CHAPERONES

Silencing of Heat Shock Protein 70 Expression Enhances Radiotherapy Efficacy and Inhibits Cell Invasion in Endometrial Cancer Cell Line

(2009) Xue-lian Du et al.   CROATIAN MEDICAL JOURNAL

Heat-shock protein 70-2 (HSP70-2) expression in bladder urothelial carcinoma is associated with tumour progression and promotes migration and invasion

(2009) Manoj Garg et al.   EUROPEAN JOURNAL OF CANCER

Inhibiting the transcription factor HSF1 as an anticancer strategy

(2009) Luke Whitesell et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Heat shock proteins and immune system

(2009) Min-Fu Tsan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Anti-tumor activity of patient-derived NK cells after cell-based immunotherapy – a case report

(2009) Valeria Milani et al.   Journal of Translational Medicine

Coiled-Coil Tag−Probe System for Quick Labeling of Membrane Receptors in Living Cells

(2008) Yoshiaki Yano et al.   ACS Chemical Biology

Heat shock protein 70 (HSP70) induces cytotoxicity of T-helper cells

(2008) C. Figueiredo et al.   BLOOD

Role of Acetylation and Extracellular Location of Heat Shock Protein 90  in Tumor Cell Invasion

(2008) Y. Yang et al.   CANCER RESEARCH

Lysosomal Cathepsin B Participates in the Podosome-Mediated Extracellular Matrix Degradation and Invasion via Secreted Lysosomes in v-Src Fibroblasts

(2008) C. Tu et al.   CANCER RESEARCH

Redox mechanisms switch on hypoxia-dependent epithelial–mesenchymal transition in cancer cells

(2008) Stefania Cannito et al.   CARCINOGENESIS

Heat shock protein 72 associated with CD44v6 in human colonic adenocarcinoma

(2008) X WANG et al.   CELL BIOLOGY INTERNATIONAL

Guidelines for the nomenclature of the human heat shock proteins

(2008) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

Extracellular HSP70 blocks CD40L-induced apoptosis and tubular formation in endothelial cells

(2008) Seiji Futagami et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Heat Shock Protein Hsp72 Controls Oncogene-Induced Senescence Pathways in Cancer Cells

(2008) V. L. Gabai et al.   MOLECULAR AND CELLULAR BIOLOGY