The Multiple Roles and Therapeutic Potential of Molecular Chaperones in Prostate Cancer
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The Multiple Roles and Therapeutic Potential of Molecular Chaperones in Prostate Cancer
Authors
Keywords
-
Journal
Cancers
Volume 11, Issue 8, Pages 1194
Publisher
MDPI AG
Online
2019-08-19
DOI
10.3390/cancers11081194
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Molecular chaperones and protein quality control: an introduction to the JBC Reviews thematic series
- (2019) Johannes Buchner JOURNAL OF BIOLOGICAL CHEMISTRY
- The Role of Heat Shock Proteins in Regulating Receptor Signal Transduction
- (2019) John Michael Streicher MOLECULAR PHARMACOLOGY
- Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer
- (2018) Michael A. Moses et al. CANCER RESEARCH
- Molecular cloning, cellular expression and characterization of Arabian camel ( Camelus dromedarius ) endoplasmin
- (2018) Abdullah Hoter et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- TRAP1 Regulation of Cancer Metabolism: Dual Role as Oncogene or Tumor Suppressor
- (2018) Danilo Matassa et al. Genes
- The HSP90 Family: Structure, Regulation, Function, and Implications in Health and Disease
- (2018) Abdullah Hoter et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Role of Androgen Receptor in Prostate Cancer: A Review
- (2018) Kazutoshi Fujita et al. World Journal of Mens Health
- HSP27, ALDH6A1 and Prohibitin Act as a Trio-biomarker to Predict Survival in Late Metastatic Prostate Cancer
- (2018) SUNG YONG CHO et al. ANTICANCER RESEARCH
- GRP78 modulates cell adhesion markers in prostate Cancer and multiple myeloma cell lines
- (2018) Christopher N. Cultrara et al. BMC CANCER
- Small heat shock proteins: Simplicity meets complexity
- (2018) Martin Haslbeck et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery of a Potent Grp94 Selective Inhibitor with Anti-Inflammatory Efficacy in a Mouse Model of Ulcerative Colitis
- (2018) Fen Jiang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Targeting Heat Shock Proteins in Cancer: A Promising Therapeutic Approach
- (2017) et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A randomized phase 2 study of a HSP27 targeting antisense, apatorsen with prednisone versus prednisone alone, in patients with metastatic castration resistant prostate cancer
- (2017) Evan Y. Yu et al. INVESTIGATIONAL NEW DRUGS
- Custirsen in combination with docetaxel and prednisone for patients with metastatic castration-resistant prostate cancer (SYNERGY trial): a phase 3, multicentre, open-label, randomised trial
- (2017) Kim N Chi et al. LANCET ONCOLOGY
- Custirsen (OGX-011) combined with cabazitaxel and prednisone versus cabazitaxel and prednisone alone in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel (AFFINITY): a randomised, open-label, international, phase 3 trial
- (2017) Tomasz M Beer et al. LANCET ONCOLOGY
- The HSP90 chaperone machinery
- (2017) Florian H. Schopf et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Heat shock proteins and cancer: intracellular chaperones or extracellular signalling ligands?
- (2017) Stuart K. Calderwood PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Sensitization of lung cancer cells by altered dimerization of HSP27
- (2017) Byeol Choi et al. Oncotarget
- The Chaperone TRAP1 As a Modulator of the Mitochondrial Adaptations in Cancer Cells
- (2017) Ionica Masgras et al. Frontiers in Oncology
- Phase I trial of OGX-427, a 2'methoxyethyl antisense oligonucleotide (ASO), against heat shock protein 27 (Hsp27): Final results.
- (2017) S. J. Hotte et al. JOURNAL OF CLINICAL ONCOLOGY
- Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma
- (2017) Andrew R. Stothert et al. Scientific Reports
- A phase I dose-escalation study of apatorsen (OGX-427), an antisense inhibitor targeting heat shock protein 27 (Hsp27), in patients with castration-resistant prostate cancer and other advanced cancers
- (2016) K. N. Chi et al. ANNALS OF ONCOLOGY
- Mechanisms of Hsp90 regulation
- (2016) C. Prodromou BIOCHEMICAL JOURNAL
- The human HSP70 family of chaperones: where do we stand?
- (2016) Jürgen Radons CELL STRESS & CHAPERONES
- One-Carbon Metabolism in Prostate Cancer: The Role of Androgen Signaling
- (2016) Joshua Corbin et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Endoplasmic Reticulum-resident Heat Shock Protein 90 (HSP90) Isoform Glucose-regulated Protein 94 (GRP94) Regulates Cell Polarity and Cancer Cell Migration by Affecting Intracellular Transport
- (2016) Suman Ghosh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Transgenic Expression of the Mitochondrial Chaperone TNFR-associated Protein 1 (TRAP1) Accelerates Prostate Cancer Development
- (2016) Sofia Lisanti et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Neuroendocrine prostate cancer (NEPCa) increased the neighboring PCa chemoresistance via altering the PTHrP/p38/Hsp27/androgen receptor (AR)/p21 signals
- (2016) Y Cui et al. ONCOGENE
- Heat Shock Proteins Promote Cancer: It's a Protection Racket
- (2016) Stuart K. Calderwood et al. TRENDS IN BIOCHEMICAL SCIENCES
- Overcoming HSP27-mediated resistance by altered dimerization of HSP27 using small molecules
- (2016) Jee Hye Kim et al. Oncotarget
- New HSP27 inhibitors efficiently suppress drug resistance development in cancer cells
- (2016) Jörg C. Heinrich et al. Oncotarget
- Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha (SGTA) Ablation Limits Offspring Viability and Growth in Mice
- (2016) Lisa K. Philp et al. Scientific Reports
- siRNA Lipid Nanoparticle Potently Silences Clusterin and Delays Progression When Combined with Androgen Receptor Cotargeting in Enzalutamide-Resistant Prostate Cancer
- (2015) Y. Yamamoto et al. CLINICAL CANCER RESEARCH
- Synthesis and biological evaluation of novel myrtucommulones and structural analogues that target mPGES-1 and 5-lipoxygenase
- (2015) Katja Wiechmann et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Mechanistic Asymmetry in Hsp90 Dimers
- (2015) Julia M. Flynn et al. JOURNAL OF MOLECULAR BIOLOGY
- Glucose-regulated protein 78 mediates the anticancer efficacy of shikonin in hormone-refractory prostate cancer cells
- (2015) Li-Jen Kuo et al. TUMOR BIOLOGY
- The Endoplasmic Reticulum Chaperone GRP170: From Immunobiology to Cancer Therapeutics
- (2015) Hongxia Wang et al. Frontiers in Oncology
- 60KDa chaperonin (HSP60) is over-expressed during colorectal carcinogenesis
- (2015) F Cappello et al. EUROPEAN JOURNAL OF HISTOCHEMISTRY
- Posttranslational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors
- (2015) Kristin Beebe et al. Oncotarget
- Heat shock protein 27 regulates human prostate cancer cell motility and metastatic progression
- (2015) Eric A. Voll et al. Oncotarget
- Abstract 2433:In vitroandin vivoantitumor activity of the next generation HSP90 inhibitor, AT13387, in both hormone-sensitive and castration-resistant prostate cancer models.
- (2014) Roberta Ferraldeschi et al. CANCER RESEARCH
- Ganetespib and HSP90: Translating Preclinical Hypotheses into Clinical Promise
- (2014) D. A. Proia et al. CANCER RESEARCH
- Suppression of Heat Shock Protein 27 Using OGX-427 Induces Endoplasmic Reticulum Stress and Potentiates Heat Shock Protein 90 Inhibitors to Delay Castrate-resistant Prostate Cancer
- (2014) François Lamoureux et al. EUROPEAN UROLOGY
- HSP27, 70 and 90, anti-apoptotic proteins, in clinical cancer therapy
- (2014) XIAOXIA WANG et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Targeting heat shock proteins in metastatic castration-resistant prostate cancer
- (2014) Arun A. Azad et al. Nature Reviews Urology
- Correction: The Prostate Specific Membrane Antigen Regulates the Expression of IL-6 and CCL5 in Prostate Tumour Cells by Activating the MAPK Pathways1
- (2014) Marco Colombatti et al. PLoS One
- Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation
- (2013) Y Zhang et al. BRITISH JOURNAL OF CANCER
- Novel Hsp90 inhibitor NVP-AUY922 radiosensitizes prostate cancer cells
- (2013) Nishant Gandhi et al. CANCER BIOLOGY & THERAPY
- Hsp27 Regulates Epithelial Mesenchymal Transition, Metastasis, and Circulating Tumor Cells in Prostate Cancer
- (2013) M. Shiota et al. CANCER RESEARCH
- Cotargeting Androgen Receptor and Clusterin Delays Castrate-Resistant Prostate Cancer Progression by Inhibiting Adaptive Stress Response and AR Stability
- (2013) H. Matsumoto et al. CANCER RESEARCH
- The HSP70 family and cancer
- (2013) M. E. Murphy CARCINOGENESIS
- The promise of heat shock protein inhibitors in the treatment of castration resistant prostate cancer
- (2013) Joseph Ischia et al. CURRENT OPINION IN UROLOGY
- PXD101 potentiates hormonal therapy and prevents the onset of castration-resistant phenotype modulating androgen receptor, HSP90, and CRM1 in preclinical models of prostate cancer
- (2013) Giovanni Luca Gravina et al. ENDOCRINE-RELATED CANCER
- Hsp60 chaperonopathies and chaperonotherapy: targets and agents
- (2013) Francesco Cappello et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Contributions of co-chaperones and post-translational modifications towards Hsp90 drug sensitivity
- (2013) Annerleim Walton-Diaz et al. Future Medicinal Chemistry
- Knockdown of the cochaperone SGTA results in the suppression of androgen and PI3K/Akt signaling and inhibition of prostate cancer cell proliferation
- (2013) Andrew P. Trotta et al. INTERNATIONAL JOURNAL OF CANCER
- HSP60 Predicts Survival in Advanced Serous Ovarian Cancer
- (2013) Elisabet Hjerpe et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- Novel Interaction between the Co-chaperone Cdc37 and Rho GTPase Exchange Factor Vav3 Promotes Androgen Receptor Activity and Prostate Cancer Growth
- (2013) Fayi Wu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Gedunin Inactivates the Co-chaperone p23 Protein Causing Cancer Cell Death by Apoptosis
- (2013) Chaitanya A. Patwardhan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PSMA/PSA RATIO EVALUATED BY IMMUNOHISTOCHEMISTRY MAY IMPROVE DIAGNOSIS OF PROSTATE CANCER
- (2013) Awatef Ben Jemaa et al. JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY
- Mini-review: Foldosome regulation of androgen receptor action in prostate cancer
- (2013) Laia Querol Cano et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules
- (2013) Anand Ramteke et al. MOLECULAR CARCINOGENESIS
- Discriminatory Role of Detergent-Resistant Membranes in the Dimerization and Endocytosis of Prostate-Specific Membrane Antigen
- (2013) Sonja Schmidt et al. PLoS One
- Combination of Rapamycin, CI-1040, and 17-AAG Inhibits Metastatic Capacity of Prostate Cancer via Slug Inhibition
- (2013) Guanxiong Ding et al. PLoS One
- Extracellular Hsp90 mediates an NF-κB dependent inflammatory stromal program: Implications for the prostate tumor microenvironment
- (2013) JE Bohonowych et al. PROSTATE
- Androgen receptor splice variants are resistant to inhibitors of Hsp90 and FKBP52, which alter androgen receptor activity and expression
- (2013) Ayesha A. Shafi et al. STEROIDS
- SGTA: A New Player in the Molecular Co-Chaperone Game
- (2013) Lisa K. Philp et al. Hormones & Cancer
- Structure, Function and Regulation of the Hsp90 Machinery
- (2013) Johannes Buchner et al. Biomedical Journal
- Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update
- (2012) Daniel R. Ciocca et al. ARCHIVES OF TOXICOLOGY
- Novobiocin analogues with second-generation noviose surrogates
- (2012) Huiping Zhao et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Clusterin Mediates TGF- -Induced Epithelial-Mesenchymal Transition and Metastasis via Twist1 in Prostate Cancer Cells
- (2012) M. Shiota et al. CANCER RESEARCH
- Release of the glucose-regulated protein 94 by baby hamster kidney cells
- (2012) Yulia Evdokimovskaya et al. CELL BIOCHEMISTRY AND FUNCTION
- Combined inhibition of Wee1 and Hsp90 activates intrinsic apoptosis in cancer cells
- (2012) Aki Iwai et al. CELL CYCLE
- Evidence for Efficacy of New Hsp90 Inhibitors Revealed by Ex Vivo Culture of Human Prostate Tumors
- (2012) M. M. Centenera et al. CLINICAL CANCER RESEARCH
- Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?
- (2012) L. Neckers et al. CLINICAL CANCER RESEARCH
- Screening for prostate cancer: an updated review
- (2012) Gustavo Nader Marta et al. Expert Review of Anticancer Therapy
- Custirsen (OGX-011): a second-generation antisense inhibitor of clusterin in development for the treatment of prostate cancer
- (2012) Robert Zielinski et al. Future Oncology
- Small heat shock proteins in cancer therapy and prognosis
- (2012) Amina Zoubeidi et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Potent activity of the Hsp90 inhibitor ganetespib in prostate cancer cells irrespective of androgen receptor status or variant receptor expression
- (2012) SUQIN HE et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- HSP90 and HSP70 Proteins Are Essential for Stabilization and Activation of WASF3 Metastasis-promoting Protein
- (2012) Yong Teng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Secreted Hsp90 Is a Novel Regulator of the Epithelial to Mesenchymal Transition (EMT) in Prostate Cancer
- (2012) Michael W. Hance et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dual inhibition of chaperoning process by taxifolin: Molecular dynamics simulation study
- (2012) Sharad Verma et al. JOURNAL OF MOLECULAR GRAPHICS & MODELLING
- Cotargeting Stress-Activated Hsp27 and Autophagy as a Combinatorial Strategy to Amplify Endoplasmic Reticular Stress in Prostate Cancer
- (2012) M. Kumano et al. MOLECULAR CANCER THERAPEUTICS
- Role of the HSP90-Associated Cochaperone p23 in Enhancing Activity of the Androgen Receptor and Significance for Prostate Cancer
- (2012) Vikash Reebye et al. MOLECULAR ENDOCRINOLOGY
- Targeting TCTP as a New Therapeutic Strategy in Castration-resistant Prostate Cancer
- (2012) Virginie Baylot et al. MOLECULAR THERAPY
- GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer
- (2012) N Li et al. ONCOGENE
- The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities
- (2011) Jurre Hageman et al. BIOCHEMICAL JOURNAL
- Hsp90 inhibitors and drug resistance in cancer: The potential benefits of combination therapies of Hsp90 inhibitors and other anti-cancer drugs
- (2011) Xiangyi Lu et al. BIOCHEMICAL PHARMACOLOGY
- Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells
- (2011) Jeffery D Eskew et al. BMC CANCER
- Clusterin Inhibition Using OGX-011 Synergistically Enhances Hsp90 Inhibitor Activity by Suppressing the Heat Shock Response in Castrate-Resistant Prostate Cancer
- (2011) F. Lamoureux et al. CANCER RESEARCH
- Hsp27 silencing coordinately inhibits proliferation and promotes Fas-induced apoptosis by regulating the PEA-15 molecular switch
- (2011) N Hayashi et al. CELL DEATH AND DIFFERENTIATION
- A Novel HSP90 Inhibitor Delays Castrate-Resistant Prostate Cancer without Altering Serum PSA Levels and Inhibits Osteoclastogenesis
- (2011) F. Lamoureux et al. CLINICAL CANCER RESEARCH
- Altered Cross-Linking of HSP27 by Zerumbone as a Novel Strategy for Overcoming HSP27-Mediated Radioresistance
- (2011) Seo-Hyun Choi et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- mda-7/IL-24 differentially regulates soluble and nuclear clusterin in prostate cancer
- (2011) Sujit K. Bhutia et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Heat shock protein-60 expression was significantly correlated with the prognosis of lung adenocarcinoma
- (2011) Xin Xu et al. JOURNAL OF SURGICAL ONCOLOGY
- Clusterin Is a Critical Downstream Mediator of Stress-Induced YB-1 Transactivation in Prostate Cancer
- (2011) M. Shiota et al. MOLECULAR CANCER RESEARCH
- Molecular chaperones in protein folding and proteostasis
- (2011) F. Ulrich Hartl et al. NATURE
- Large Potentials of Small Heat Shock Proteins
- (2011) Evgeny V. Mymrikov et al. PHYSIOLOGICAL REVIEWS
- A Novel Extracellular Hsp90 Mediated Co-Receptor Function for LRP1 Regulates EphA2 Dependent Glioblastoma Cell Invasion
- (2011) Udhayakumar Gopal et al. PLoS One
- Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells
- (2011) J. T. De Leon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hsp90 inhibitor 17-AAG inhibits progression of LuCaP35 xenograft prostate tumors to castration resistance
- (2011) Katherine J. O'Malley et al. PROSTATE
- Small heat shock proteins and α-crystallins: dynamic proteins with flexible functions
- (2011) Eman Basha et al. TRENDS IN BIOCHEMICAL SCIENCES
- Targeting heat shock proteins in cancer
- (2010) Gaëtan Jego et al. CANCER LETTERS
- Hsp27 Promotes Insulin-Like Growth Factor-I Survival Signaling in Prostate Cancer via p90Rsk-Dependent Phosphorylation and Inactivation of BAD
- (2010) A. Zoubeidi et al. CANCER RESEARCH
- Preclinical Characterization of Mitochondria-Targeted Small Molecule Hsp90 Inhibitors, Gamitrinibs, in Advanced Prostate Cancer
- (2010) B. H. Kang et al. CLINICAL CANCER RESEARCH
- Independent evolution of the core domain and its flanking sequences in small heat shock proteins
- (2010) Thomas Kriehuber et al. FASEB JOURNAL
- The heat shock factor family and adaptation to proteotoxic stress
- (2010) Mitsuaki Fujimoto et al. FEBS Journal
- Randomized Phase II Study of Docetaxel and Prednisone With or Without OGX-011 in Patients With Metastatic Castration-Resistant Prostate Cancer
- (2010) Kim N. Chi et al. JOURNAL OF CLINICAL ONCOLOGY
- Identification of HSP60 as a Primary Target ofo-Carboranylphenoxyacetanilide, an HIF-1α Inhibitor
- (2010) Hyun Seung Ban et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Heat Shock Protein 27 Is Required for Sex Steroid Receptor Trafficking to and Functioning at the Plasma Membrane
- (2010) M. Razandi et al. MOLECULAR AND CELLULAR BIOLOGY
- Induction of Clusterin by AKT--Role in Cytoprotection against Docetaxel in Prostate Tumor Cells
- (2010) B. Zhong et al. MOLECULAR CANCER THERAPEUTICS
- Asymmetric Activation of the Hsp90 Dimer by Its Cochaperone Aha1
- (2010) Marco Retzlaff et al. MOLECULAR CELL
- Swe1Wee1-Dependent Tyrosine Phosphorylation of Hsp90 Regulates Distinct Facets of Chaperone Function
- (2010) Mehdi Mollapour et al. MOLECULAR CELL
- Heat shock factors: integrators of cell stress, development and lifespan
- (2010) Malin Åkerfelt et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Detecting soluble Clusterin in in-vitro and in-vivo models of prostate cancer
- (2010) F. Girard et al. NEOPLASMA
- Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E
- (2010) C Andrieu et al. ONCOGENE
- Immunohistochemical Expression of Hsp60 Correlates With Tumor Progression and Hormone Resistance in Prostate Cancer
- (2010) Carolina Castilla et al. UROLOGY
- Cytoprotective Mitochondrial Chaperone TRAP-1 As a Novel Molecular Target in Localized and Metastatic Prostate Cancer
- (2009) Irwin Leav et al. AMERICAN JOURNAL OF PATHOLOGY
- Phase II, two-stage, single-arm trial of the histone deacetylase inhibitor (HDACi) romidepsin in metastatic castration-resistant prostate cancer (CRPC)
- (2009) L. R. Molife et al. ANNALS OF ONCOLOGY
- Withaferin A targets heat shock protein 90 in pancreatic cancer cells
- (2009) Yanke Yu et al. BIOCHEMICAL PHARMACOLOGY
- 2-phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells
- (2009) A. J. Steele et al. BLOOD
- Inhibition of constitutive and cxc-chemokine-induced NF-κB activity potentiates ansamycin-based HSP90-inhibitor cytotoxicity in castrate-resistant prostate cancer cells
- (2009) A Seaton et al. BRITISH JOURNAL OF CANCER
- Hsp-27 expression at diagnosis predicts poor clinical outcome in prostate cancer independent of ETS-gene rearrangement
- (2009) C S Foster et al. BRITISH JOURNAL OF CANCER
- A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells
- (2009) Andrew J. Massey et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- The Neuroendocrine-Derived Peptide Parathyroid Hormone-Related Protein Promotes Prostate Cancer Cell Growth by Stabilizing the Androgen Receptor
- (2009) J. DaSilva et al. CANCER RESEARCH
- Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology
- (2009) Sergiy Kostenko et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Clusterin silencing in human lung adenocarcinoma cells induces a mesenchymal-to-epithelial transition through modulating the ERK/Slug pathway
- (2009) Teh-Ying Chou et al. CELLULAR SIGNALLING
- Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/α-synuclein complex by Hip
- (2009) Cintia Roodveldt et al. EMBO JOURNAL
- Characterization of Celastrol to Inhibit Hsp90 and Cdc37 Interaction
- (2009) Tao Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Novel Adenosine-Derived Inhibitors of 70 kDa Heat Shock Protein, Discovered Through Structure-Based Design†
- (2009) Douglas S. Williamson et al. JOURNAL OF MEDICINAL CHEMISTRY
- Chemical Manipulation of Hsp70 ATPase Activity Regulates Tau Stability
- (2009) U. K. Jinwal et al. JOURNAL OF NEUROSCIENCE
- Gold compounds as anticancer agents: chemistry, cellular pharmacology, and preclinical studies
- (2009) Stefania Nobili et al. MEDICINAL RESEARCH REVIEWS
- A Small Molecule Inhibitor of Inducible Heat Shock Protein 70
- (2009) J. I-Ju Leu et al. MOLECULAR CELL
- KU135, a Novel Novobiocin-Derived C-Terminal Inhibitor of the 90-kDa Heat Shock Protein, Exerts Potent Antiproliferative Effects in Human Leukemic Cells
- (2009) S. N. Shelton et al. MOLECULAR PHARMACOLOGY
- Transcriptome profiling of a TGF-β-induced epithelial-to-mesenchymal transition reveals extracellular clusterin as a target for therapeutic antibodies
- (2009) A E G Lenferink et al. ONCOGENE
- Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesis
- (2009) H Song et al. ONCOGENE
- Characterization of a novel novobiocin analogue as a putative C-terminal inhibitor of heat shock protein 90 in prostate cancer cells
- (2009) Shawna B. Matthews et al. PROSTATE
- Heat Shock Protein 40: Structural Studies and Their Functional Implications
- (2009) Jingzhi Li et al. PROTEIN AND PEPTIDE LETTERS
- A Novel Class of Small Molecule Inhibitors of Hsp90
- (2008) Fang Yi et al. ACS Chemical Biology
- Heat shock proteins 27, 60 and 70 as prognostic markers of prostate cancer
- (2008) AXEL GLAESSGEN et al. APMIS
- Structural and Functional Diversities between Members of the Human HSPB, HSPH, HSPA, and DNAJ Chaperone Families†
- (2008) Michel J. Vos et al. BIOCHEMISTRY
- Discovery and development of heat shock protein 90 inhibitors
- (2008) Tony Taldone et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Clusterin knockdown using the antisense oligonucleotide OGX-011 re-sensitizes docetaxel-refractory prostate cancer PC-3 cells to chemotherapy
- (2008) Richard D. Sowery et al. BJU INTERNATIONAL
- HDAC6 inhibition enhances 17-AAG-mediated abrogation of hsp90 chaperone function in human leukemia cells
- (2008) R. Rao et al. BLOOD
- hsp70 genes in the human genome: Conservation and differentiation patterns predict a wide array of overlapping and specialized functions
- (2008) Luciano Brocchieri et al. BMC EVOLUTIONARY BIOLOGY
- Dual Targeting of HSC70 and HSP72 Inhibits HSP90 Function and Induces Tumor-Specific Apoptosis
- (2008) Marissa V. Powers et al. CANCER CELL
- Down-regulation of Mammalian Sterile 20-Like Kinase 1 by Heat Shock Protein 70 Mediates Cisplatin Resistance in Prostate Cancer Cells
- (2008) A. Ren et al. CANCER RESEARCH
- Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways
- (2008) T. T. Onder et al. CANCER RESEARCH
- NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis
- (2008) S. A. Eccles et al. CANCER RESEARCH
- Guidelines for the nomenclature of the human heat shock proteins
- (2008) Harm H. Kampinga et al. CELL STRESS & CHAPERONES
- Heat Shock Protein 90 as a Drug Target: Some Like It Hot
- (2008) U. Banerji CLINICAL CANCER RESEARCH
- Clusterin Activates Survival through the Phosphatidylinositol 3-Kinase/Akt Pathway
- (2008) Hayet Ammar et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Heat shock proteins: essential proteins for apoptosis regulation
- (2008) D. Lanneau et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Docetaxel Plus Prednisone or Mitoxantrone Plus Prednisone for Advanced Prostate Cancer: Updated Survival in the TAX 327 Study
- (2008) Dominik R. Berthold et al. JOURNAL OF CLINICAL ONCOLOGY
- Small heat shock proteins in smooth muscle
- (2008) Sonemany Salinthone et al. PHARMACOLOGY & THERAPEUTICS
- Clusterin, a novel modulator of TGF-β signaling, is involved in Smad2/3 stability
- (2007) Kwan-Bok Lee et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Different glycoforms of prostate-specific membrane antigen are intracellularly transported through their association with distinct detergent-resistant membranes
- (2007) Deborah Castelletti et al. BIOCHEMICAL JOURNAL
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started