Comparative Localization and Functional Activity of the Main Hepatobiliary Transporters in HepaRG Cells and Primary Human Hepatocytes

Potency of Individual Bile Acids to Regulate Bile Acid Synthesis and Transport Genes in Primary Human Hepatocyte Cultures

(2014) Jie Liu et al.   TOXICOLOGICAL SCIENCES

Different Dose-Dependent Mechanisms Are Involved in Early Cyclosporine A-Induced Cholestatic Effects in HepaRG Cells

(2014) Ahmad Sharanek et al.   TOXICOLOGICAL SCIENCES

Sandwich-cultured hepatocytes: utility forin vitroexploration of hepatobiliary drug disposition and drug-induced hepatotoxicity

(2013) Tom De Bruyn et al.   Expert Opinion on Drug Metabolism & Toxicology

Drug-Induced Liver Injury: The Role of Drug Metabolism and Transport

(2013) Alberto Corsini et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Comparison of Human Hepatoma HepaRG Cells with Human and Rat Hepatocytes in Uptake Transport Assays in Order to Predict a Risk of Drug Induced Hepatotoxicity

(2013) Monika Szabo et al.   PLoS One

Polarized expression of drug transporters in differentiated human hepatoma HepaRG cells

(2013) Marc Le Vee et al.   TOXICOLOGY IN VITRO

Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells

(2012) Sébastien Anthérieu et al.   HEPATOLOGY

Expression and Transport Function of Drug Uptake Transporters in Differentiated HepaRG Cells

(2012) Naoki Kotani et al.   MOLECULAR PHARMACEUTICS

Endogenous bile acid disposition in rat and human sandwich-cultured hepatocytes

(2012) Tracy L. Marion et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Optimization of the HepaRG cell model for drug metabolism and toxicity studies

(2012) Sébastien Anthérieu et al.   TOXICOLOGY IN VITRO

Automated detection of hepatotoxic compounds in human hepatocytes using HepaRG cells and image-based analysis of mitochondrial dysfunction with JC-1 dye

(2011) K. Pernelle et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Sandwich-cultured hepatocytes: anin vitromodel to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity

(2010) Brandon Swift* et al.   DRUG METABOLISM REVIEWS

Phosphoinositide 3-kinase/protein kinase B signaling pathway is involved in estradiol 17β-d-glucuronide-induced cholestasis: Complementarity with classical protein kinase c

(2010) Andrea C. Boaglio et al.   HEPATOLOGY

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Genetic Determinants of Drug-induced Cholestasis and Intrahepatic Cholestasis of Pregnancy

(2010) Christiane Pauli-Magnus et al.   SEMINARS IN LIVER DISEASE

Oxidative Stress and the Pathogenesis of Cholestasis

(2010) Bryan Copple et al.   SEMINARS IN LIVER DISEASE

Contribution of High Basolateral Bile Salt Efflux to the Lack of Hepatotoxicity in Rat in Response to Drugs Inducing Cholestasis in Human

(2010) Katalin Jemnitz et al.   TOXICOLOGICAL SCIENCES

Stable Expression, Activity, and Inducibility of Cytochromes P450 in Differentiated HepaRG Cells

(2009) S. Antherieu et al.   DRUG METABOLISM AND DISPOSITION

Identification of Novel Specific and General Inhibitors of the Three Major Human ATP-Binding Cassette Transporters P-gp, BCRP and MRP2 Among Registered Drugs

(2009) Pär Matsson et al.   PHARMACEUTICAL RESEARCH

Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation

(2009) Philippe Lefebvre et al.   PHYSIOLOGICAL REVIEWS