Microbial acetylcholinesterase inhibitors for Alzheimer’s therapy: recent trends on extraction, detection, irradiation-assisted production improvement and nano-structured drug delivery

Semi-continuous production of the anticancer drug taxol by Aspergillus fumigatus and Alternaria tenuissima immobilized in calcium alginate beads

(2020) El-Sayed R. El-Sayed et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Solid-state fermentation for enhanced production of selenium nanoparticles by gamma-irradiated Monascus purpureus and their biological evaluation and photocatalytic activities

(2020) El-Sayed R. El-Sayed et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Biosynthesis of zinc oxide nanoparticles with antimicrobial, anticancer, antioxidant and photocatalytic activities by the endophytic Alternaria tenuissima

(2020) H.K. Abdelhakim et al.   JOURNAL OF APPLIED MICROBIOLOGY

Agro‐industrial wastes for production of paclitaxel by irradiated Aspergillus fumigatus under solid‐state fermentation

(2020) E.R. El‐Sayed et al.   JOURNAL OF APPLIED MICROBIOLOGY

Tunable structures of copper substituted cobalt nanoferrites with prospective electrical and magnetic applications

(2019) M. I. A. Abdel Maksoud et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS

Engineered Nanomaterials as Potential Candidates for HIV Treatment: Between Opportunities and Challenges

(2019) M. Abd Elkodous et al.   JOURNAL OF CLUSTER SCIENCE

Nanoemulsions in CNS drug delivery: recent developments, impacts and challenges

(2019) Zahra Karami et al.   DRUG DISCOVERY TODAY

Production and enhancement of the acetylcholinesterase inhibitor, huperzine A, from an endophytic Alternaria brassicae AGF041

(2019) Amira G. Zaki et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Layer-by-layer preparation and characterization of recyclable nanocomposite (CoxNi1−xFe2O4; X = 0.9/SiO2/TiO2)

(2019) M. Abd Elkodous et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS

Fabrication of Ultra-Pure Anisotropic Zinc Oxide Nanoparticles via Simple and Cost-Effective Route: Implications for UTI and EAC Medications

(2019) M. Abd Elkodous et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Therapeutic and diagnostic potential of nanomaterials for enhanced biomedical applications

(2019) M. Abd Elkodous et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

In vivo toxicity evaluation of nanoemulsions for drug delivery

(2019) Mariana Appel Hort et al.   DRUG AND CHEMICAL TOXICOLOGY

Growth dynamics of CBD-assisted CuS nanostructured thin-film: optical, dielectric and novel switchable device applications

(2019) Geetha Govindasamy et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS

Strain improvement and immobilization technique for enhanced production of the anticancer drug paclitaxel by Aspergillus fumigatus and Alternaria tenuissima

(2019) El-Sayed R. El-Sayed et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Liposomes for drug delivery in stroke

(2019) Gisele E. Bruch et al.   BRAIN RESEARCH BULLETIN

Comparison of different uncoated and starch-coated superparamagnetic iron oxide nanoparticles: Implications for stem cell tracking

(2019) Hoda Elkhenany et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Factorial design-optimized and gamma irradiation-assisted fabrication of selenium nanoparticles by chitosan and Pleurotus ostreatus fermented fenugreek for a vigorous in vitro effect against carcinoma cells

(2019) Ahmed I. El-Batal et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The Optimization Design Of Lactoferrin Loaded HupA Nanoemulsion For Targeted Drug Transport Via Intranasal Route

(2019) Yueyao Jiang et al.   International Journal of Nanomedicine

A novel source of the cardiac glycoside digoxin from the endophytic fungus Epicoccum nigrum : isolation, characterization, production enhancement by gamma irradiation mutagenesis and anticancer activity evaluation

(2019) E.R. El‐Sayed et al.   JOURNAL OF APPLIED MICROBIOLOGY

Identification of a Huperzine A-producing endophytic fungus from Phlegmariurus taxifolius

(2019) Olga Lidia Cruz-Miranda et al.   MOLECULAR BIOLOGY REPORTS

Extracellular biosynthesis of cobalt ferrite nanoparticles by Monascus purpureus and their antioxidant, anticancer and antimicrobial activities: Yield enhancement by gamma irradiation

(2019) El-Sayed R. El-Sayed et al.   Materials Science & Engineering C-Materials for Biological Applications

Reliable optoelectronic switchable device implementation by CdS nanowires conjugated bent-core liquid crystal matrix

(2019) S.I. Asiya et al.   ORGANIC ELECTRONICS

Cholinesterases and the fine line between poison and remedy

(2018) Carey N. Pope et al.   BIOCHEMICAL PHARMACOLOGY

Intranasal delivery of Huperzine A to the brain using lactoferrin-conjugated N-trimethylated chitosan surface-modified PLGA nanoparticles for treatment of Alzheimer’s disease

(2018) Qingqing Meng et al.   International Journal of Nanomedicine

Introduction of marine-derived Streptomyces sp. UTMC 1334 as a source of pyrrole derivatives with anti-acetylcholinesterase activity

(2018) Faezeh Almasi et al.   JOURNAL OF APPLIED MICROBIOLOGY

CdS nanowires encapsulated liquid crystal in-plane switching of LCD device

(2018) Kaushik Pal et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS

Synthesis and characterization of metals-substituted cobalt ferrite [M x Co (1-x) Fe 2 O 4 ; (M = Zn, Cu and Mn; x = 0 and 0.5)] nanoparticles as antimicrobial agents and sensors for Anagrelide determination in biological samples

(2018) M.I.A. Abdel Maksoud et al.   Materials Science & Engineering C-Materials for Biological Applications

Biomolecules-mediated synthesis of selenium nanoparticles using Aspergillus oryzae fermented Lupin extract and gamma radiation for hindering the growth of some multidrug-resistant bacteria and pathogenic fungi

(2018) Farag M. Mosallam et al.   MICROBIAL PATHOGENESIS

Adapting liposomes for oral drug delivery

(2018) Haisheng He et al.   Acta Pharmaceutica Sinica B

Soft, Self-Assembly Liquid Crystalline Nanocomposite for Superior Switching

(2018) Kaushik Pal et al.   Electronic Materials Letters

Formulation and characterisation of 1-ethyl-3-methylimidazolium acetate-in-oil microemulsions as the potential vehicle for drug delivery across the skin barrier

(2018) Yeevon Poh et al.   JOURNAL OF MOLECULAR LIQUIDS

Nanotechnology-based drug delivery systems for Alzheimer's disease management: Technical, industrial, and clinical challenges

(2017) Ming Ming Wen et al.   JOURNAL OF CONTROLLED RELEASE

Research Advances and Detection Methodologies for Microbe-Derived Acetylcholinesterase Inhibitors: A Systemic Review

(2017) Jingqian Su et al.   MOLECULES

Strategies for Fermentation Medium Optimization: An In-Depth Review

(2017) Vineeta Singh et al.   Frontiers in Microbiology

Sorokiniol: a new enzymes inhibitory metabolite from fungal endophyte Bipolaris sorokiniana LK12

(2016) Liaqat Ali et al.   BMC MICROBIOLOGY

Cholinesterase inhibitor (Altenuene) from an endophytic fungusAlternaria alternata: optimization, purification and characterization

(2016) J. Bhagat et al.   JOURNAL OF APPLIED MICROBIOLOGY

Progress and perspectives on targeting nanoparticles for brain drug delivery

(2016) Huile Gao   Acta Pharmaceutica Sinica B

The complete mitochondrial genome of huperzine A-producing endophytic fungus Penicillium polonicum

(2016) Xincong Kang et al.   Mitochondrial DNA Part B-Resources

N-Trimethyl Chitosan Chloride-Coated PLGA Nanoparticles Overcoming Multiple Barriers to Oral Insulin Absorption

(2015) Jianyong Sheng et al.   ACS Applied Materials & Interfaces

Active anti-acetylcholinesterase component of secondary metabolites produced by the endophytic fungi of Huperzia serrata

(2015) Zhejian Wang et al.   ELECTRONIC JOURNAL OF BIOTECHNOLOGY

Applications and limitations of lipid nanoparticles in dermal and transdermal drug delivery via the follicular route

(2015) Andreas Lauterbach et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Acetylcholinesterase inhibitory dimeric indole derivatives from the marine actinomycetes Rubrobacter radiotolerans

(2015) Jian Lin Li et al.   FITOTERAPIA

Nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease

(2015) Bruno Fonseca-Santos et al.   International Journal of Nanomedicine

Immobilization technique for enhanced production of the immunosuppressant mycophenolic acid by ultraviolet and gamma-irradiatedPenicillium roqueforti

(2015) A.A. Ismaiel et al.   JOURNAL OF APPLIED MICROBIOLOGY

Avertoxins A–D, Prenyl Asteltoxin Derivatives from Aspergillus versicolor Y10, an Endophytic Fungus of Huperzia serrata

(2015) Mingzi Wang et al.   JOURNAL OF NATURAL PRODUCTS

Lanostanoids with acetylcholinesterase inhibitory activity from the mushroom Haddowia longipes

(2015) Shuang-Shuang Zhang et al.   PHYTOCHEMISTRY

De Novo RNA Sequencing and Transcriptome Analysis of Colletotrichum gloeosporioides ES026 Reveal Genes Related to Biosynthesis of Huperzine A

(2015) Guowei Zhang et al.   PLoS One

Enhancement of taxol production from endophytic fungus Fusarium redolens

(2014) Sanjog Garyali et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Physicochemical characterization techniques for solid lipid nanoparticles: principles and limitations

(2014) Niranjan Kathe et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Solid lipid nanoparticles as vehicles of drugs to the brain: Current state of the art

(2014) Lucia Gastaldi et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Acetylcholinesterase Inhibitors from a Marine Fungus Talaromyces sp. Strain LF458

(2014) Bin Wu et al.   MARINE BIOTECHNOLOGY

A marine sponge associated strain of Bacillus subtilis and other marine bacteria can produce anticholinesterase compounds

(2014) Sony Pandey et al.   Microbial Cell Factories

Bioactive Secondary Metabolites from Phomopsis sp., an Endophytic Fungus from Senna spectabilis

(2014) Vanessa Chapla et al.   MOLECULES

Huperzine A production byPaecilomyces tenuisYS-13, an endophytic fungus isolated fromHuperzia serrata

(2014) Jingqian Su et al.   NATURAL PRODUCT RESEARCH

Identification of a novel endophytic fungus from Huperzia serrata which produces huperzine A

(2014) Shaohua Shu et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Optimization of submerged fermentation conditions for immunosuppressant mycophenolic acid production by Penicillium roqueforti isolated from blue-molded cheeses: enhanced production by ultraviolet and gamma irradiation

(2014) Ahmed A. Ismaiel et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

The global prevalence of dementia: A systematic review and metaanalysis

(2013) Martin Prince et al.   Alzheimers & Dementia

Impact of lipid nanoparticle physical state on particle aggregation and β-carotene degradation: Potential limitations of solid lipid nanoparticles

(2013) Cheng Qian et al.   FOOD RESEARCH INTERNATIONAL

Comparative in vitro and in vivo evaluation of lipid based nanocarriers of Huperzine A

(2013) Pratikkumar A. Patel et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Alkaloids as a source of potential anticholinesterase inhibitors for the treatment of Alzheimer's disease

(2013) Eduardo Luis Konrath et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Secondary Metabolites of a Mangrove Endophytic Fungus Aspergillus terreus (No. GX7-3B) from the South China Sea

(2013) Chun-Mei Deng et al.   Marine Drugs

The Use of Borneol as an Enhancer for Targeting Aprotinin-Conjugated PEG-PLGA Nanoparticles to the Brain

(2013) Lin Zhang et al.   PHARMACEUTICAL RESEARCH

Production of huperzine A and other Lycopodium alkaloids in Huperzia species grown under controlled conditions and in vitro

(2013) Kan’ichiro Ishiuchi et al.   PHYTOCHEMISTRY

A New Anti-acetylcholinesterase α-Pyrone Meroterpene, Arigsugacin I, from Mangrove Endophytic Fungus Penicillium sp. sk5GW1L of Kandelia candel

(2013) Xishan Huang et al.   PLANTA MEDICA

Ethanol and Methanol Can Improve Huperzine A Production from Endophytic Colletotrichum gloeosporioides ES026

(2013) Xin-Mei Zhao et al.   PLoS One

Huperzine A for Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

(2013) Guoyan Yang et al.   PLoS One

Indentification of huperzine A-producing endophytic fungi isolated from Huperzia serrata

(2013) Li-Hui Dong et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Production enhancement of Cyclosporin ‘A’ by Aspergillus terreus through mutation

(2012) Wajiha Irum   AFRICAN JOURNAL OF BIOTECHNOLOGY

Acetylcholinesterase Inhibitory Potential and Insecticidal Activity of an Endophytic Alternaria sp. from Ricinus communis

(2012) Bahaderjeet Singh et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Design of polymeric nanoparticles for biomedical delivery applications

(2012) Mahmoud Elsabahy et al.   CHEMICAL SOCIETY REVIEWS

Geranylphenazinediol, an Acetylcholinesterase Inhibitor Produced by a Streptomyces Species

(2012) Birgit Ohlendorf et al.   JOURNAL OF NATURAL PRODUCTS

Paecilomide, a new acetylcholinesterase inhibitor from Paecilomyces lilacinus

(2012) Ana Paula C. Teles et al.   MICROBIOLOGICAL RESEARCH

Benzopyranones from the Endophytic Fungus Hyalodendriella sp. Ponipodef12 and Their Bioactivities

(2012) Xiangjie Meng et al.   MOLECULES

An Efficient Total Synthesis of (−)-Huperzine A

(2012) Rui Ding et al.   ORGANIC LETTERS

Correction: The Genome of Ganderma lucidum Provide Insights into Triterpense Biosynthesis and Wood Degradation

(2012) Dongbo Liu et al.   PLoS One

Analysis of Genes Expression of Spodoptera exigua Larvae upon AcMNPV Infection

(2012) Jae Young Choi et al.   PLoS One

Colloidal Polymeric Nanoparticles and Brain Drug Delivery

(2012) Najeh Khalil et al.   Current Drug Delivery

Fungal endophytes: unique plant inhabitants with great promises

(2011) Amal Hassan Aly et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Alzheimer's Disease: Emerging Trends in Small Molecule Therapies

(2011) T. Mohamed et al.   CURRENT MEDICINAL CHEMISTRY

Steroids and an oxylipin from an algicolous isolate of Aspergillus flavus

(2011) Ming-Feng Qiao et al.   MAGNETIC RESONANCE IN CHEMISTRY

An Overview on Natural Cholinesterase Inhibitors - A Multi-Targeted Drug Class - and Their Mass Production

(2011) I. Erdogan Orhan et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Genotoxicity of silver nanoparticles evaluated using the Ames test and in vitro micronucleus assay

(2011) Yan Li et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Functionalized Gold Nanoparticles and Their Biomedical Applications

(2011) Pooja Tiwari et al.   Nanomaterials

Comparison of 454-ESTs from Huperzia serrata and Phlegmariurus carinatus reveals putative genes involved in lycopodium alkaloid biosynthesis and developmental regulation

(2010) Hongmei Luo et al.   BMC PLANT BIOLOGY

Preparation, Optimization and Characteristic of Huperzine A Loaded Nanostructured Lipid Carriers

(2010) Chun-Rong Yang et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Enhancing the Delivery of Anti Retroviral Drug “Saquinavir” Across the Blood Brain Barrier Using Nanoparticles

(2010) Supriya D. Mahajan et al.   CURRENT HIV RESEARCH

A novel endophytic Huperzine A-producing fungus, Shiraia sp. Slf14, isolated from Huperzia serrata

(2010) D. Zhu et al.   JOURNAL OF APPLIED MICROBIOLOGY

Isolation and characterization of endophytic huperzine A-producing fungi from Huperzia serrata

(2010) Ya Wang et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Diversity and Antimicrobial and Plant-Growth-Promoting Activities of Endophytic Fungi in Dendrobium loddigesii Rolfe

(2010) Xiao Mei Chen et al.   JOURNAL OF PLANT GROWTH REGULATION

Natural products as a source of Alzheimer's drug leads

(2010) Philip Williams et al.   NATURAL PRODUCT REPORTS

Huperzine alkaloids from Australasian and southeast AsianHuperzia

(2010) Wei-Han Lim et al.   PHARMACEUTICAL BIOLOGY

Endophytic fungus Cladosporium cladosporioides LF70 from Huperzia serrata produces Huperzine A

(2010) Zhi Bin Zhang et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Ultrasound, liposomes, and drug delivery: principles for using ultrasound to control the release of drugs from liposomes

(2009) Avi Schroeder et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Solid lipid nanoparticles: A modern formulation approach in drug delivery system

(2009) S Mukherjee et al.   INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES

Antibody-Conjugated Nanoparticles for Biomedical Applications

(2009) Manuel Arruebo et al.   Journal of Nanomaterials

Total Synthesis of (−)-Huperzine A

(2009) Takahiro Koshiba et al.   ORGANIC LETTERS

Huperzine A exhibits anti-inflammatory and neuroprotective effects in a rat model of transient focal cerebral ischemia

(2008) Zhi-Fei Wang et al.   JOURNAL OF NEUROCHEMISTRY

In vitro production of huperzine A, a promising drug candidate for Alzheimer’s disease

(2008) Xiaoqiang Ma et al.   PHYTOCHEMISTRY

Endophytes: exploiting biodiversity for the improvement of natural product-based drug discovery

(2008) Agata Staniek et al.   Journal of Plant Interactions