Review
Pharmacology & Pharmacy
Lais Ribovski, Naomi M. Hamelmann, Jos M. J. Paulusse
Summary: Safe and reliable entry into the brain is crucial for successful treatment of central nervous system disorders, but remains challenging. Nano-sized systems as drug carriers show significant improvements in therapy delivery. Careful design of NP properties is essential for successful brain delivery, affecting the ability to overcome multiple barriers.
Review
Chemistry, Multidisciplinary
Fatemeh Madani, Seyedeh Sara Esnaashari, Thomas J. Webster, Masood Khosravani, Mahdi Adabi
Summary: This review discusses the challenges of delivering drugs through the blood-brain barrier (BBB) in glioblastoma (GBM) treatment and introduces the latest advances in using nanoparticles for this purpose. It also describes the development of drug delivery and combination modalities using natural and synthetic polymer nanoparticles, as well as adjuvant therapies for GBM treatment. Additionally, it explains the receptor-mediated endocytosis agents that exist in brain endothelial capillary cells and emphasizes future research directions.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Instruments & Instrumentation
Bhavana Joshi, Abhijeet Joshi
Summary: The study highlights the potential of using magnetic nanoparticles for targeted brain therapy to overcome the limitations of the blood-brain barrier. Combining drug delivery with contrast imaging functionality can lead to more effective drug delivery and imaging.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Polymer Science
Chad A. Caraway, Hallie Gaitsch, Elizabeth E. Wicks, Anita Kalluri, Navya Kunadi, Betty M. Tyler
Summary: Translating novel therapies for brain cancer is crucial for improving survival rates. Polymeric nanoparticles show promise in delivering chemotherapy drugs to tumor cells and have the potential to be effective in brain tumor therapy.
Article
Pharmacology & Pharmacy
Xinran Zhang, Li Yin Chau, Ho Wan Chan, Jingwen Weng, Ka Wai Wong, Shing Fung Chow, Albert Hee Lum Chow
Summary: The study successfully prepared polymeric IBP nanoparticles using flash nanoprecipitation technology, and found that the nanoparticles could enhance the delivery of IBP into the brain. However, some nanoparticles may face the issue of rapid release into the bloodstream following intravenous administration.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Chemistry, Multidisciplinary
Weisen Zhang, Ami Mehta, Ziqiu Tong, Lars Esser, Nicolas H. Voelcker
Summary: Polymeric nanoparticles have shown great potential in overcoming the blood-brain barrier for effective drug delivery, with their unique properties offering high tunability and ease of synthesis. Careful analysis of their performance in transporting drugs across the blood-brain barrier is essential for successful drug delivery to the central nervous system.
Article
Chemistry, Multidisciplinary
Eric N. Donders, Kai V. Slaughter, Christian Dank, Ahil N. Ganesh, Brian K. Shoichet, Mark Lautens, Molly S. Shoichet
Summary: The pK(a) of colloid-forming drugs can be manipulated to achieve endosomal disruption while avoiding phospholipidosis and minimizing toxicity, leading to the design of drug-rich nanoparticles. By synthesizing ionizable derivatives of fulvestrant analogs, which are lipid-stabilized drug colloids, the pK(a) of these ionizable colloids influenced the mechanism of endosomal and lysosomal disruption. This study establishes a tunable and generalizable strategy for endosomal disruption by manipulating the pK(a) of colloid-forming drugs.
Review
Biotechnology & Applied Microbiology
Annu, Ali Sartaj, Zufika Qamar, Shadab Md, Nabil A. Alhakamy, Sanjula Baboota, Javed Ali
Summary: The blood-brain barrier hinders the delivery of therapeutic molecules to the brain, but nanotechnology, specifically the use of polymeric nanoparticles, shows great potential in overcoming this barrier and targeting therapeutics to the brain, improving intervention for CNS disorders.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Tugce Boztepe, Guillermo R. Castro, Ignacio E. Leon
Summary: Platinum drugs like carboplatin, cisplatin, and oxaliplatin are widely used in cancer treatment but their toxicity limits their application. Recent research focuses on developing new formulations to expand therapeutic options. Advances in drug delivery carriers aim to increase drug stability and reduce toxic effects.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Farzin Firozian, Zahra Arabkhani, Mohammad Mehdi Mahboobian, Mojdeh Mohammadi, Gholamabbas Chehardoli
Summary: The study developed a cationic dextran stearate-glycidyl trimethylammonium chloride (Dex-St-GTMAC) copolymer as a drug carrier to deliver indomethacin to cornea tissues. The prepared polymeric micelles showed sustained drug release and improved penetration of indomethacin into cornea tissues.
Review
Cell Biology
Miguel Pinto, Vera Silva, Sandra Barreiro, Renata Silva, Fernando Remiao, Fernanda Borges, Carlos Fernandes
Summary: Effective drugs for the treatment of neurodegenerative disorders remain a challenge, but the advancement of nanotechnology and nanomedicine offers potential solutions. Polymeric nanoparticles, particularly based on PLGA, have shown success in treating cancer and other diseases, but further research is needed for neurodegenerative disorders.
AGEING RESEARCH REVIEWS
(2022)
Review
Chemistry, Multidisciplinary
Natalia Lopuszynska, Wladyslaw P. Weglarz
Summary: Poor pharmacokinetics and low aqueous solubility combined with rapid clearance from the circulation of drugs result in their limited effectiveness and generally high therapeutic doses. The use of nanocarriers for drug delivery can prevent the rapid degradation of the drug, improve its solubility and stability, enhance distribution and targeting, ensure sustained release, and reduce drug resistance. Nanotechnology enables the combination of therapeutics with biomedical imaging agents to overcome the challenges of disease diagnosis and therapy. This paper presents scientific reports on polymeric nanocarriers for MRI-guided drug delivery, focusing on their contrasting properties and categorizing them into three main groups based on the type of contrast agents.
Review
Biotechnology & Applied Microbiology
Yajing Sun, Qingshan Yang, Xue Xia, Xiaozhe Li, Weimin Ruan, Meng Zheng, Yan Zou, Bingyang Shi
Summary: Researchers are focusing on developing polymeric nanoparticles targeted at mitochondria to enhance the efficiency of cancer therapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
V. Manjusha, M. R. Rajeev, T. S. Anirudhan
Summary: Safe delivery of hydrophobic drugs to the tumor site is a challenging task for the scientific community. In this study, iron oxide nanoparticles coated chitosan with [2-(methacryloyloxy) ethyl] trimethyl ammonium chloride (METAC) (CS-IONPs-METAC-PTX) were developed as a drug carrier for hydrophobic drug delivery. The drug carrier exhibited excellent therapeutic efficacy and selectivity when tested in cell lines, demonstrating its potential for PTX delivery.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Kyoung Nan Kim, Keun Sang Oh, Jiwook Shim, Isabel R. Schlaepfer, Sana D. Karam, Jung-Jae Lee
Summary: Light-sensitive polymeric micelles have been developed as promising drug delivery systems, with the ability to release drugs under UV light. The diazonaphthoquinone (DNQ)-conjugated micellar nanoparticles show high stability and hydrophobicity.
Article
Pharmacology & Pharmacy
Yan-Ting Su, Jian Zhang
Summary: This study aimed to improve the water solubility and stability of cannabidiol (CBD) using micelle technology. CBD-loaded mixed micelles (CBD-M) composed of Poloxamer 407 (P407) and rubusoside (RUB) were successfully prepared and showed significant improvement in solubility and encapsulation efficiency. The CBD-M solution remained stable and maintained the antioxidant activity of CBD after dilution and centrifugation. These findings suggest that CBD-M could serve as a promising formulation for enhanced CBD delivery.
CURRENT DRUG DELIVERY
(2024)