Myeloid cells in sepsis-acquired immunodeficiency

The ATP-Binding Cassette Gene ABCF1 Functions as an E2 Ubiquitin-Conjugating Enzyme Controlling Macrophage Polarization to Dampen Lethal Septic Shock

(2019) Hitesh Arora et al.   IMMUNITY

The CD14+HLA-DRlo/neg Monocyte: An Immunosuppressive Phenotype That Restrains Responses to Cancer Immunotherapy

(2019) April E. Mengos et al.   Frontiers in Immunology

Sepsis: Inflammation Is a Necessary Evil

(2019) Christina Nedeva et al.   Frontiers in Cell and Developmental Biology

Sepsis Induces Prolonged Mixed-Lineage Leukemia 1–Mediated Epigenetic Modifications in Bone Marrow and Peripheral Macrophages Impairing Inflammation and Wound Healing

(2019) Frank M. Davis et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Prognostic and predictive enrichment in sepsis

(2019) Natalja L. Stanski et al.   Nature Reviews Nephrology

Poor Outcome Could Be Predicted by Lower Monocyte Human Leukocyte Antigen-DR Expression in Patients with Complicated Intra-Abdominal Infections: A Review

(2019) Evgeni Dimitrov et al.   Surgical Infections

Hard to Remember

(2019) Mihai G. Netea   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Multicentric experience with interferon gamma therapy in sepsis induced immunosuppression. A case series

(2019) Didier Payen et al.   BMC INFECTIOUS DISEASES

Epidemiology of intra-abdominal infection and sepsis in critically ill patients: “AbSeS”, a multinational observational cohort study and ESICM Trials Group Project

(2019) Stijn Blot et al.   INTENSIVE CARE MEDICINE

Inflammatory cytokines and organ dysfunction associate with the aberrant DNA methylome of monocytes in sepsis

(2019) Clara Lorente-Sorolla et al.   Genome Medicine

DAMPs and NETs in Sepsis

(2019) Naomi-Liza Denning et al.   Frontiers in Immunology

Current gaps in sepsis immunology: new opportunities for translational research

(2019) Ignacio Rubio et al.   LANCET INFECTIOUS DISEASES

Macrophages play an essential role in trauma-induced sterile inflammation and tissue repair

(2018) Moritz Peiseler et al.   European Journal of Trauma and Emergency Surgery

Cell-surface signatures of immune dysfunction risk-stratify critically ill patients: INFECT study

(2018) Andrew Conway Morris et al.   INTENSIVE CARE MEDICINE

Long-term reprogramming of the innate immune system

(2018) Jorge Dominguez-Andres et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Myeloid-derived suppressor cells coming of age

(2018) Filippo Veglia et al.   NATURE IMMUNOLOGY

Understanding the Cellular Origin of the Mononuclear Phagocyte System Sheds Light on the Myeloid Postulate of Immune Paralysis in Sepsis

(2018) Lionel Franz Poulin et al.   Frontiers in Immunology

Monocytic Myeloid-Derived Suppressor Cells in Chronic Infections

(2018) Anca Dorhoi et al.   Frontiers in Immunology

Targeting Myeloid-Derived Suppressor Cells to Bypass Tumor-Induced Immunosuppression

(2018) Viktor Fleming et al.   Frontiers in Immunology

Recent advances in endotoxin tolerance

(2018) Dan Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Neutrophils mitigate the systemic host response during endotoxemia in mice

(2018) Anne Jan van der Meer et al.   IMMUNOLOGY

Contribution of Dendritic Cell Responses to Sepsis-Induced Immunosuppression and to Susceptibility to Secondary Pneumonia

(2018) Marwan Bouras et al.   Frontiers in Immunology

Local Modulation of Antigen-Presenting Cell Development after Resolution of Pneumonia Induces Long-Term Susceptibility to Secondary Infections

(2017) Antoine Roquilly et al.   IMMUNITY

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

(2017) Andrew Rhodes et al.   INTENSIVE CARE MEDICINE

Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014

(2017) Chanu Rhee et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Essential Neuroscience in Immunology

(2017) Sangeeta S. Chavan et al.   JOURNAL OF IMMUNOLOGY

Frontline Science: Myeloid cell-specific deletion of Cebpb decreases sepsis-induced immunosuppression in mice

(2017) Melissa B. McPeak et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Nivolumab plus interferon-γ in the treatment of intractable mucormycosis

(2017) David Grimaldi et al.   LANCET INFECTIOUS DISEASES

Advances in the understanding and treatment of sepsis-induced immunosuppression

(2017) Fabienne Venet et al.   Nature Reviews Nephrology

Recognizing Sepsis as a Global Health Priority — A WHO Resolution

(2017) Konrad Reinhart et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multilateral Functional Alterations of Human Neutrophils in Sepsis

(2017) Akira Endo et al.   SHOCK

Intracellular S100A9 Promotes Myeloid-Derived Suppressor Cells during Late Sepsis

(2017) Jun Dai et al.   Frontiers in Immunology

Potentially Inadvertent Immunomodulation: Norepinephrine Use in Sepsis

(2016) Roeland F. Stolk et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations

(2016) Carolin Fleischmann et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance

(2016) Boris Novakovic et al.   CELL

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

(2016) Rob J.W. Arts et al.   Cell Metabolism

Incidence, Risk Factors, and Attributable Mortality of Secondary Infections in the Intensive Care Unit After Admission for Sepsis

(2016) Lonneke A. van Vught et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sepsis-induced immune dysfunction: can immune therapies reduce mortality?

(2016) Matthew J. Delano et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular metabolism of myeloid cells in sepsis

(2016) Rob J. W. Arts et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Frontline Science: Defects in immune function in patients with sepsis are associated with PD-1 or PD-L1 expression and can be restored by antibodies targeting PD-1 or PD-L1

(2016) Andriani C. Patera et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Molecular mechanisms of innate memory and tolerance to LPS

(2016) John J. Seeley et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Sepsis-induced expansion of granulocytic myeloid-derived suppressor cells promotes tumour growth through Toll-like receptor 4

(2016) Jean-François Llitjos et al.   JOURNAL OF PATHOLOGY

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

(2016) Shih-Chin Cheng et al.   NATURE IMMUNOLOGY

Trained immunity: A program of innate immune memory in health and disease

(2016) M. G. Netea et al.   SCIENCE

Past, Present, and Future of Augmentation of Monocyte Function in the Surgical Patient

(2016) Norman Galbraith et al.   Surgical Infections

The Significance and Challenges of Monocyte Impairment: For the Ill Patient and the Surgeon

(2016) Norman Galbraith et al.   Surgical Infections

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

Myeloid-Derived Suppressor Cells in Bacterial Infections

(2016) Michael Ost et al.   Frontiers in Cellular and Infection Microbiology

Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study

(2016) Emma E Davenport et al.   Lancet Respiratory Medicine

Up-regulation of Programmed Cell Death 1 Ligand 1 on Neutrophils May Be Involved in Sepsis-induced Immunosuppression

(2015) Jia-Feng Wang et al.   ANESTHESIOLOGY

Immature myeloid Gr-1+ CD11b+ cells from lipopolysaccharide-immunosuppressed mice acquire inhibitory activity in the bone marrow and migrate to lymph nodes to exert their suppressive function

(2015) V. I. Landoni et al.   CLINICAL SCIENCE

Sepsis-induced immune alterations monitoring by flow cytometry as a promising tool for individualized therapy

(2015) Guillaume Monneret et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Innate immune system favors emergency monopoiesis at the expense of DC-differentiation to control systemic bacterial infection in mice

(2015) Karina A. Pasquevich et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human Monocytes Undergo Functional Re-programming during Sepsis Mediated by Hypoxia-Inducible Factor-1α

(2015) Irina N. Shalova et al.   IMMUNITY

Marked alterations of neutrophil functions during sepsis-induced immunosuppression

(2015) Julie Demaret et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A Review of GM-CSF Therapy in Sepsis

(2015) Brittany Mathias et al.   MEDICINE

The role of dendritic cell alterations in susceptibility to hospital-acquired infections during critical-illness related immunosuppression

(2015) Antoine Roquilly et al.   MOLECULAR IMMUNOLOGY

Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series

(2014) Corine E Delsing et al.   BMC INFECTIOUS DISEASES

Circulating Immature Granulocytes With T-Cell Killing Functions Predict Sepsis Deterioration*

(2014) Estelle Guérin et al.   CRITICAL CARE MEDICINE

Modulation of dendritic cell antigen presentation by pathogens, tissue damage and secondary inflammatory signals

(2014) Javier Vega-Ramos et al.   CURRENT OPINION IN PHARMACOLOGY

Sepsis: Current Dogma and New Perspectives

(2014) Clifford S. Deutschman et al.   IMMUNITY

Hospital Deaths in Patients With Sepsis From 2 Independent Cohorts

(2014) Vincent Liu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Mortality Related to Severe Sepsis and Septic Shock Among Critically Ill Patients in Australia and New Zealand, 2000-2012

(2014) Kirsi-Maija Kaukonen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Enhanced Dendritic Cell Survival Attenuates Lipopolysaccharide-Induced Immunosuppression and Increases Resistance to Lethal Endotoxic Shock

(2014) E. L. Gautier et al.   JOURNAL OF IMMUNOLOGY

Prophylactic Treatment with Fms-Like Tyrosine Kinase-3 Ligand after Burn Injury Enhances Global Immune Responses to Infection

(2014) J. Bohannon et al.   JOURNAL OF IMMUNOLOGY

Dendritic Cells Modulate Lung Response to Pseudomonas aeruginosa in a Murine Model of Sepsis-Induced Immune Dysfunction

(2014) F. Pene et al.   JOURNAL OF IMMUNOLOGY

A high frequency of MDSCs in sepsis patients, with the granulocytic subtype dominating in gram-positive cases

(2014) Helena Janols et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Parallels between Cancer and Infectious Disease

(2014) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Assessment of the worldwide burden of critical illness: the Intensive Care Over Nations (ICON) audit

(2014) Jean-Louis Vincent et al.   Lancet Respiratory Medicine

Immune Effects of Interferon Gamma in Persistent Staphylococcal Sepsis

(2013) Marek Nalos et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Benchmarking the Incidence and Mortality of Severe Sepsis in the United States*

(2013) David F. Gaieski et al.   CRITICAL CARE MEDICINE

Innate Immune Functions of Immature Neutrophils in Patients With Sepsis and Severe Systemic Inflammatory Response Syndrome*

(2013) Geneviève Drifte et al.   CRITICAL CARE MEDICINE

Monitoring the immune response in sepsis: a rational approach to administration of immunoadjuvant therapies

(2013) Fabienne Venet et al.   CURRENT OPINION IN IMMUNOLOGY

Toll-like receptor-4 agonist in post-haemorrhage pneumonia: role of dendritic and natural killer cells

(2013) Antoine Roquilly et al.   EUROPEAN RESPIRATORY JOURNAL

Identification of B7-H1 as a Novel Mediator of the Innate Immune/Proinflammatory Response as well as a Possible Myeloid Cell Prognostic Biomarker in Sepsis

(2013) X. Huang et al.   JOURNAL OF IMMUNOLOGY

Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach

(2013) Richard S Hotchkiss et al.   LANCET INFECTIOUS DISEASES

Identification of Biomarkers of Response to IFNg during Endotoxin Tolerance: Application to Septic Shock

(2013) Florence Allantaz-Frager et al.   PLoS One

The current understanding of sepsis and research priorities for the future

(2013) Steven M Opal   Virulence

Host innate immune responses to sepsis

(2013) Willem Joost Wiersinga et al.   Virulence

Reversal of Immunoparalysis in HumansIn Vivo

(2012) Jenneke Leentjens et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Retraction notice to “Myeloid-derived suppressor cells accumulate in the liver site after sepsis to induce immunosuppression” Cellular Immunology 279 (2012) 12–20

(2012) Dongping Ren et al.   CELLULAR IMMUNOLOGY

Treatment with Fms-like tyrosine kinase 3 ligand reverses lung dendritic cell immunoparalysis and ameliorates zymosan-induced secondary lung injury in mice

(2012) H. W. Wang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The function of neutrophils in sepsis

(2012) Melissa A. Kovach et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Myeloid-Derived Suppressor Cells Evolve during Sepsis and Can Enhance or Attenuate the Systemic Inflammatory Response

(2012) Laura Brudecki et al.   INFECTION AND IMMUNITY

Neutrophil-Mediated Inhibition of Proinflammatory Cytokine Responses

(2012) M. S. Gresnigt et al.   JOURNAL OF IMMUNOLOGY

TLR3 agonist improves survival to secondary pneumonia in a double injury model

(2012) Christopher G. Davis et al.   JOURNAL OF SURGICAL RESEARCH

Human Monocytes Differentiate into Dendritic Cells Subsets that Induce Anergic and Regulatory T Cells in Sepsis

(2012) Valérie Faivre et al.   PLoS One

The danger theory: 20 years later

(2012) Thomas Pradeu et al.   Frontiers in Immunology

Epigenetic regulation of immune cell functions during post-septic immunosuppression

(2011) William F. Carson et al.   Epigenetics

Profound and persistent decrease of circulating dendritic cells is associated with ICU-acquired infection in patients with septic shock

(2011) D. Grimaldi et al.   INTENSIVE CARE MEDICINE

Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure

(2011) Jonathan S. Boomer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1

(2011) Janesh Pillay et al.   JOURNAL OF CLINICAL INVESTIGATION

Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprogramming during acute systemic inflammation

(2011) Charles E. McCall et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Altered Phenotype of Blood Dendritic Cells in Patients with Acute Pneumonia

(2011) Katharina Dreschler et al.   RESPIRATION

Neutrophils are significant producers of IL-10 during sepsis

(2010) Kevin R. Kasten et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Flow cytometric analysis of peripheral blood dendritic cells in patients with severe sepsis

(2010) Francesca Riccardi et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome

(2010) Mark W. Hall et al.   INTENSIVE CARE MEDICINE

Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock

(2010) Caroline Landelle et al.   INTENSIVE CARE MEDICINE

Modulation of Dendritic Cell Differentiation in the Bone Marrow Mediates Sustained Immunosuppression after Polymicrobial Sepsis

(2010) E. Pastille et al.   JOURNAL OF IMMUNOLOGY

CpG-ODN and MPLA Prevent Mortality in a Murine Model of Post-Hemorrhage-Staphyloccocus aureus Pneumonia

(2010) Antoine Roquilly et al.   PLoS One

Granulocyte–Macrophage Colony-stimulating Factor to Reverse Sepsis-associated Immunosuppression

(2009) Christian Meisel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Macroscopic Postmortem Findings in 235 Surgical Intensive Care Patients with Sepsis

(2009) Christian Torgersen et al.   ANESTHESIA AND ANALGESIA

Circulating dendritic cells following burn

(2009) N. D’Arpa et al.   BURNS

Endotoxin tolerance: new mechanisms, molecules and clinical significance

(2009) Subhra K. Biswas et al.   TRENDS IN IMMUNOLOGY

Unknown

(2008) Guillaume Monneret et al.   MOLECULAR MEDICINE