Macrophages play an essential role in trauma-induced sterile inflammation and tissue repair

Admission circulating monocytes level is an independent predictor of outcome in traumatic brain injury

(2018) Zhiqi Li et al.   BRAIN INJURY

The biology of serous cavity macrophages

(2018) Calum C. Bain et al.   CELLULAR IMMUNOLOGY

Mechanisms controlling nucleic acid-sensing Toll-like receptors

(2018) Kensuke Miyake et al.   INTERNATIONAL IMMUNOLOGY

Innate immune responses to trauma

(2018) Markus Huber-Lang et al.   NATURE IMMUNOLOGY

iNKT Cells Orchestrate a Switch from Inflammation to Resolution of Sterile Liver Injury

(2017) Pei Xiong Liew et al.   IMMUNITY

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

(2017) Alexander V. Misharin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Visualizing the function and fate of neutrophils in sterile injury and repair

(2017) Jing Wang et al.   SCIENCE

Tissue-specific contribution of macrophages to wound healing

(2017) Carlos M. Minutti et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Increased circulating M2-like monocytes in patients with breast cancer

(2017) Boke Zhang et al.   TUMOR BIOLOGY

Monocyte Conversion During Inflammation and InjuryHighlights

(2016) Rachel M. Kratofil et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair

(2016) Jing Wang et al.   CELL

Transition from inflammation to proliferation: a critical step during wound healing

(2016) Ning Xu Landén et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Innate Immune Cell Trafficking and Function During Sterile Inflammation of the Liver

(2016) Braedon McDonald et al.   GASTROENTEROLOGY

Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice

(2016) Bruna Araujo David et al.   GASTROENTEROLOGY

Chemokine (C-C motif) receptor 2-positive monocytes aggravate the early phase of acetaminophen-induced acute liver injury

(2016) Jana C. Mossanen et al.   HEPATOLOGY

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

Plasma levels of danger-associated molecular patterns are associated with immune suppression in trauma patients

(2016) Kim Timmermans et al.   INTENSIVE CARE MEDICINE

CD163 promotes hematoma absorption and improves neurological functions in patients with intracerebral hemorrhage

(2016) Qun Liu et al.   Neural Regeneration Research

Damage-associated molecular patterns in cancer: a double-edged sword

(2016) C Hernandez et al.   ONCOGENE

Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities

(2016) Calum C. Bain et al.   Nature Communications

Anti-high mobility group box-1 (HMGB1) antibody attenuates delayed cerebral vasospasm and brain injury after subarachnoid hemorrhage in rats

(2016) Jun Haruma et al.   Scientific Reports

CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure

(2015) Benjamin M. Stutchfield et al.   GASTROENTEROLOGY

Liver inflammation abrogates immunological tolerance induced by Kupffer cells

(2015) Felix Heymann et al.   HEPATOLOGY

The global burden of injury: incidence, mortality, disability-adjusted life years and time trends from the Global Burden of Disease study 2013

(2015) Juanita A Haagsma et al.   INJURY PREVENTION

A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+monocytes at a site of sterile injury

(2015) Daniela Dal-Secco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CCR2 Antagonism Alters Brain Macrophage Polarization and Ameliorates Cognitive Dysfunction Induced by Traumatic Brain Injury

(2015) J. M. Morganti et al.   JOURNAL OF NEUROSCIENCE

An anticomplement agent that homes to the damaged brain and promotes recovery after traumatic brain injury in mice

(2015) Marieta M. Ruseva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble Macrophage Biomarkers Indicate Inflammatory Phenotypes in Patients With Knee Osteoarthritis

(2015) Hikmat N. Daghestani et al.   Arthritis & Rheumatology

Revisiting Mouse Peritoneal Macrophages: Heterogeneity, Development, and Function

(2015) Alexandra dos Anjos Cassado et al.   Frontiers in Immunology

Anatomy of a Discovery: M1 and M2 Macrophages

(2015) Charles Dudley Mills   Frontiers in Immunology

DAMPs from Cell Death to New Life

(2015) Emilie Vénéreau et al.   Frontiers in Immunology

Tissue-Specific Signals Control Reversible Program of Localization and Functional Polarization of Macrophages

(2014) Yasutaka Okabe et al.   CELL

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

(2014) David Gosselin et al.   CELL

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function

(2014) Dror S. Shouval et al.   IMMUNITY

Macrophage-Restricted Interleukin-10 Receptor Deficiency, but Not IL-10 Deficiency, Causes Severe Spontaneous Colitis

(2014) Ehud Zigmond et al.   IMMUNITY

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

(2014) Slava Epelman et al.   IMMUNITY

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Origin and Functions of Tissue Macrophages

(2014) Slava Epelman et al.   IMMUNITY

Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival

(2014) Emmanuel L. Gautier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CCR2 Deficiency Impairs Macrophage Infiltration and Improves Cognitive Function after Traumatic Brain Injury

(2014) Christine L. Hsieh et al.   JOURNAL OF NEUROTRAUMA

The systemic immune response to trauma: an overview of pathophysiology and treatment

(2014) Janet M Lord et al.   LANCET

Pulmonary macrophage transplantation therapy

(2014) Takuji Suzuki et al.   NATURE

Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice

(2014) Calum C Bain et al.   NATURE IMMUNOLOGY

Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart

(2014) Kory J. Lavine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Transcription Factor Gata6 Links Tissue Macrophage Phenotype and Proliferative Renewal

(2014) M. Rosas et al.   SCIENCE

M1 and M2 Macrophages: Oracles of Health and Disease

(2013) Charles Mills   CRITICAL REVIEWS IN IMMUNOLOGY

Processes of Sterile Inflammation

(2013) H. Shen et al.   JOURNAL OF IMMUNOLOGY

Identification of a Tissue-Specific, C/EBP -Dependent Pathway of Differentiation for Murine Peritoneal Macrophages

(2013) D. W. Cain et al.   JOURNAL OF IMMUNOLOGY

Activation of NLRP3 Inflammasome in Alveolar Macrophages Contributes to Mechanical Stretch-Induced Lung Inflammation and Injury

(2013) J. Wu et al.   JOURNAL OF IMMUNOLOGY

Macrophage activation and skeletal muscle healing following traumatic injury

(2013) Margaret L Novak et al.   JOURNAL OF PATHOLOGY

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Tissue-resident macrophages

(2013) Luke C Davies et al.   NATURE IMMUNOLOGY

Relevance of Distinct Monocyte Subsets to Clinical Course of Ischemic Stroke Patients

(2013) Muichi Kaito et al.   PLoS One

Ventilator-induced Lung Injury Is Mediated by the NLRP3 Inflammasome

(2012) Maria T. Kuipers et al.   ANESTHESIOLOGY

Comparison between the prognostic value of the white blood cell differential count and morphological parameters of neutrophils and lymphocytes in severely injured patients for 7-day in-hospital mortality

(2012) Siu W. Lam et al.   BIOMARKERS

CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair

(2012) S. Willenborg et al.   BLOOD

Sterile Inflammation in the Liver

(2012) Paul Kubes et al.   GASTROENTEROLOGY

Reversal of Vascular Macrophage Accumulation and Hypertension by a CCR2 Antagonist in Deoxycorticosterone/Salt-Treated Mice

(2012) Christopher T. Chan et al.   HYPERTENSION

CSF-1 signaling mediates recovery from acute kidney injury

(2012) Ming-Zhi Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

(2012) Luke Boulter et al.   NATURE MEDICINE

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Oxidation of HMGB1 Causes Attenuation of Its Pro-Inflammatory Activity and Occurs during Liver Ischemia and Reperfusion

(2012) Anding Liu et al.   PLoS One

Transforming Growth Factor-β, Macrophage Colony-Stimulating Factor and C-Reactive Protein Levels Correlate with CD14highCD16+ Monocyte Induction and Activation in Trauma Patients

(2012) Sonlee D. West et al.   PLoS One

Transcriptomic analyses of murine resolution-phase macrophages

(2011) M. J. Stables et al.   BLOOD

Epidemiology and risk factors of sepsis after multiple trauma: An analysis of 29,829 patients from the Trauma Registry of the German Society for Trauma Surgery*

(2011) Arasch Wafaisade et al.   CRITICAL CARE MEDICINE

Epidemiology of in-hospital trauma deaths

(2011) R. Lefering et al.   European Journal of Trauma and Emergency Surgery

Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function

(2011) James A. Thomas et al.   HEPATOLOGY

Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages

(2011) Anat London et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-25 Induces M2 Macrophages and Reduces Renal Injury in Proteinuric Kidney Disease

(2011) Q. Cao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

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(2011) Christoph Menzel et al.   MOLECULAR MEDICINE

Activation and Regulation of Purinergic P2X Receptor Channels

(2011) C. Coddou et al.   PHARMACOLOGICAL REVIEWS

Absence of Colony Stimulation Factor-1 Receptor Results in Loss of Microglia, Disrupted Brain Development and Olfactory Deficits

(2011) Bryna Erblich et al.   PLoS One

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

Pattern Recognition Receptors and the Innate Immune Response to Viral Infection

(2011) Mikayla R. Thompson et al.   Viruses-Basel

The Sterile Inflammatory Response

(2010) Kenneth L. Rock et al.   Annual Review of Immunology

HMGB proteins: Interactions with DNA and chromatin

(2010) Michal Štros   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Uric acid promotes an acute inflammatory response to sterile cell death in mice

(2010) Hajime Kono et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential Roles of Macrophages in Diverse Phases of Skin Repair

(2010) T. Lucas et al.   JOURNAL OF IMMUNOLOGY

Identification of the Cellular Sensor That Stimulates the Inflammatory Response to Sterile Cell Death

(2010) H. Kono et al.   JOURNAL OF IMMUNOLOGY

HMGB1 Contributes to Kidney Ischemia Reperfusion Injury

(2010) H. Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Monocyte chemoattractant protein-1 deficiency does not affect steatosis or inflammation in livers of mice fed a methionine–choline-deficient diet

(2010) Karen M Kassel et al.   LABORATORY INVESTIGATION

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells

(2010) Woo-Yong Lee et al.   NATURE IMMUNOLOGY

Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection

(2010) Elias A Said et al.   NATURE MEDICINE

Programmed necrosis induced by asbestos in human mesothelial cells causes high-mobility group box 1 protein release and resultant inflammation

(2010) Haining Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two physically, functionally, and developmentally distinct peritoneal macrophage subsets

(2010) E. E. B. Ghosn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Old and new generation lipid mediators in acute inflammation and resolution

(2010) Melanie J. Stables et al.   PROGRESS IN LIPID RESEARCH

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Macrophages: Master Regulators of Inflammation and Fibrosis

(2010) Thomas Wynn et al.   SEMINARS IN LIVER DISEASE

Systemic Inflammation and Liver Injury Following Hemorrhagic Shock and Peripheral Tissue Trauma Involve Functional TLR9 Signaling on Bone Marrow-Derived Cells and Parenchymal Cells

(2010) Roop Gill et al.   SHOCK

Hepatic recruitment of the inflammatory Gr1+monocyte subset upon liver injury promotes hepatic fibrosis

(2009) Karlin Raja Karlmark et al.   HEPATOLOGY

Role of connective tissue growth factor and its interaction with basic fibroblast growth factor and macrophage chemoattractant protein-1 in skin fibrosis

(2009) Sonoko Chujo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

(2009) S. S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

(2009) Ravid Shechter et al.   PLOS MEDICINE

Elie Metchnikoff: Father of natural immunity

(2008) Siamon Gordon   EUROPEAN JOURNAL OF IMMUNOLOGY

Immunology's foundation: the 100-year anniversary of the Nobel Prize to Paul Ehrlich and Elie Metchnikoff

(2008) Stefan H E Kaufmann   NATURE IMMUNOLOGY

Macrophage activation by endogenous danger signals

(2007) X Zhang et al.   JOURNAL OF PATHOLOGY