The CD14+HLA-DRlo/neg Monocyte: An Immunosuppressive Phenotype That Restrains Responses to Cancer Immunotherapy

Targeting myeloid-derived suppressor cells for cancer immunotherapy

(2018) Yijun Liu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Conditioned media from the renal cell carcinoma cell line 786.O drives human blood monocytes to a monocytic myeloid-derived suppressor cell phenotype

(2018) Shannon L. Okada et al.   CELLULAR IMMUNOLOGY

Blood-based analyses of cancer: Circulating myeloid-derived suppressor cells – is a new era coming?

(2018) Karolina Okla et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Myeloid-derived suppressor cells coming of age

(2018) Filippo Veglia et al.   NATURE IMMUNOLOGY

High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy

(2018) Carsten Krieg et al.   NATURE MEDICINE

SV-BR-1-GM, a Clinically Effective GM-CSF-Secreting Breast Cancer Cell Line, Expresses an Immune Signature and Directly Activates CD4+ T Lymphocytes

(2018) Markus D. Lacher et al.   Frontiers in Immunology

Myeloid-Derived Suppressor Cells Hinder the Anti-Cancer Activity of Immune Checkpoint Inhibitors

(2018) Rebekka Weber et al.   Frontiers in Immunology

Monocytic Myeloid-Derived Suppressor Cells in Chronic Infections

(2018) Anca Dorhoi et al.   Frontiers in Immunology

Post-operative immune suppression is mediated via reversible, Interleukin-10 dependent pathways in circulating monocytes following major abdominal surgery

(2018) Hew D. T. Torrance et al.   PLoS One

Autocrine TGFβ is a Survival Factor for Monocytes and Drives Immunosuppressive Lineage Commitment

(2018) Alba Gonzalez-Junca et al.   Cancer Immunology Research

Targeting both tumour-associated CXCR2+neutrophils and CCR2+macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma

(2017) Timothy M Nywening et al.   GUT

Monocytic myeloid-derived suppressor cells as prognostic factor in chronic myeloid leukaemia patients treated with dasatinib

(2017) Cesarina Giallongo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Immunosuppressive tumor-infiltrating myeloid cells mediate adaptive immune resistance via a PD-1/PD-L1 mechanism in glioblastoma

(2017) Joseph P. Antonios et al.   NEURO-ONCOLOGY

Comprehensive immune profiling reveals substantial immune system alterations in a subset of patients with amyotrophic lateral sclerosis

(2017) Michael P. Gustafson et al.   PLoS One

Ipilimumab treatment decreases monocytic MDSCs and increases CD8 effector memory T cells in long-term survivors with advanced melanoma

(2017) Yago Pico de Coana et al.   Oncotarget

Tumor-associated GM-CSF overexpression induces immunoinhibitory molecules via STAT3 in myeloid-suppressor cells infiltrating liver metastases

(2016) M Thorn et al.   CANCER GENE THERAPY

Toward harmonized phenotyping of human myeloid-derived suppressor cells by flow cytometry: results from an interim study

(2016) Susanna Mandruzzato et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells

(2016) Alan L. Chang et al.   CANCER RESEARCH

Expansion of a BDCA1+CD14+ Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines

(2016) G. Bakdash et al.   CANCER RESEARCH

Baseline Peripheral Blood Biomarkers Associated with Clinical Outcome of Advanced Melanoma Patients Treated with Ipilimumab

(2016) A. Martens et al.   CLINICAL CANCER RESEARCH

Selective Targeting of Myeloid-Derived Suppressor Cells in Cancer Patients Using DS-8273a, an Agonistic TRAIL-R2 Antibody

(2016) George A. Dominguez et al.   CLINICAL CANCER RESEARCH

Targeting Suppressive Myeloid Cells Potentiates Checkpoint Inhibitors to Control Spontaneous Neuroblastoma

(2016) Y. Mao et al.   CLINICAL CANCER RESEARCH

Myeloid cells in peripheral blood mononuclear cell concentrates inhibit the expansion of chimeric antigen receptor T cells

(2016) David F. Stroncek et al.   CYTOTHERAPY

Gemcitabine reduces MDSCs, tregs and TGFβ-1 while restoring the teff/treg ratio in patients with pancreatic cancer

(2016) Emma Eriksson et al.   Journal of Translational Medicine

Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial

(2016) Timothy M Nywening et al.   LANCET ONCOLOGY

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

On the origin of myeloid-derived suppressor cells

(2016) Camilla Rydberg Millrud et al.   Oncotarget

Phase I/II Study of Metastatic Melanoma Patients Treated with Nivolumab Who Had Progressed after Ipilimumab

(2016) J. Weber et al.   Cancer Immunology Research

Regulation of myeloid cells by activated T cells determines the efficacy of PD-1 blockade

(2016) Nina Eissler et al.   OncoImmunology

CD1c-Expression by Monocytes – Implications for the Use of Commercial CD1c+ Dendritic Cell Isolation Kits

(2016) Martine Schrøder et al.   PLoS One

Functional Myeloid-Derived Suppressor Cell Subsets Recover Rapidly after Allogeneic Hematopoietic Stem/Progenitor Cell Transplantation

(2015) Qingdong Guan et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

RORC1 Regulates Tumor-Promoting “Emergency” Granulo-Monocytopoiesis

(2015) Laura Strauss et al.   CANCER CELL

Liver myeloid-derived suppressor cells expand in response to liver metastases in mice and inhibit the anti-tumor efficacy of anti-CEA CAR-T

(2015) Rachel A. Burga et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Immunological factors influencing clinical outcome in lung cancer patients after telomerase peptide vaccination

(2015) Gaute Lund Hansen et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Intratumoral CD14+ Cells and Circulating CD14+HLA-DRlo/neg Monocytes Correlate with Decreased Survival in Patients with Clear Cell Renal Cell Carcinoma

(2015) M. P. Gustafson et al.   CLINICAL CANCER RESEARCH

Myeloid Cells and Related Chronic Inflammatory Factors as Novel Predictive Markers in Melanoma Treatment with Ipilimumab

(2015) C. Gebhardt et al.   CLINICAL CANCER RESEARCH

Myeloid-Derived Suppressor Cells as an Immune Parameter in Patients with Concurrent Sunitinib and Stereotactic Body Radiotherapy

(2015) H.-M. Chen et al.   CLINICAL CANCER RESEARCH

Randomized, Placebo-Controlled, Phase III Trial of Yeast-Derived Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Versus Peptide Vaccination Versus GM-CSF Plus Peptide Vaccination Versus Placebo in Patients With No Evidence of Disease After Complete Surgical Resection of Locally Advanced and/or Stage IV Melanoma: A Trial of the Eastern Cooperative Oncology Group–American College of Radiology Imaging Network Cancer Research Group (E4697)

(2015) David H. Lawson et al.   JOURNAL OF CLINICAL ONCOLOGY

Safety and Survival With GVAX Pancreas Prime and Listeria Monocytogenes–Expressing Mesothelin (CRS-207) Boost Vaccines for Metastatic Pancreatic Cancer

(2015) Dung T. Le et al.   JOURNAL OF CLINICAL ONCOLOGY

Safety and immunologic correlates of Melanoma GVAX, a GM-CSF secreting allogeneic melanoma cell vaccine administered in the adjuvant setting

(2015) Evan J Lipson et al.   Journal of Translational Medicine

Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study

(2015) Nicholas Butowski et al.   NEURO-ONCOLOGY

Myeloid derived suppressor cells—An overview of combat strategies to increase immunotherapy efficacy

(2015) Oana Draghiciu et al.   OncoImmunology

A Method for Identification and Analysis of Non-Overlapping Myeloid Immunophenotypes in Humans

(2015) Michael P. Gustafson et al.   PLoS One

Systemic Monocytic-MDSCs Are Generated from Monocytes and Correlate with Disease Progression in Breast Cancer Patients

(2015) Caroline Bergenfelz et al.   PLoS One

Myeloid-derived suppressor cell heterogeneity in human cancers

(2014) Samantha Solito et al.   Annals of the New York Academy of Sciences

Graft Monocytic Myeloid-Derived Suppressor Cell Content Predicts the Risk of Acute Graft-versus-Host Disease after Allogeneic Transplantation of Granulocyte Colony-Stimulating Factor–Mobilized Peripheral Blood Stem Cells

(2014) Antonio Vendramin et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

CLL-cells induce IDOhi CD14+HLA-DRlo myeloid-derived suppressor cells that inhibit T-cell responses and promote TRegs

(2014) R. Jitschin et al.   BLOOD

Continuous retinoic acid induces the differentiation of mature regulatory monocytes but fails to induce regulatory dendritic cells

(2014) Zachary C VanGundy et al.   BMC IMMUNOLOGY

Correlation between frequencies of blood monocytic myeloid-derived suppressor cells, regulatory T cells and negative prognostic markers in patients with castration-resistant metastatic prostate cancer

(2014) Manja Idorn et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Immune Monitoring of the Circulation and the Tumor Microenvironment in Patients with Regionally Advanced Melanoma Receiving Neoadjuvant Ipilimumab

(2014) Ahmad A. Tarhini et al.   PLoS One

CSF-1 Receptor Signaling in Myeloid Cells

(2014) E. R. Stanley et al.   Cold Spring Harbor Perspectives in Biology

Computational Algorithm-Driven Evaluation of Monocytic Myeloid-Derived Suppressor Cell Frequency for Prediction of Clinical Outcomes

(2014) S. Kitano et al.   Cancer Immunology Research

Evolution of Our Understanding of Myeloid Regulatory Cells: From MDSCs to Mregs

(2014) Masoud H. Manjili et al.   Frontiers in Immunology

Cancer Vaccines in the World of Immune Suppressive Monocytes (CD14+HLA-DRlo/neg Cells): The Gateway to Improved Responses

(2014) Rebecca R. Laborde et al.   Frontiers in Immunology

Rethinking the role of myeloid-derived suppressor cells in adoptive T-cell therapy for cancer

(2014) Ainhoa Arina   OncoImmunology

Vaccination with dendritic cells loaded with allogeneic brain tumor cells for recurrent malignant brain tumors induces a CD4+IL17+ response

(2014) Michael R Olin et al.   Journal for ImmunoTherapy of Cancer

Current status of granulocyte–macrophage colony-stimulating factor in the immunotherapy of melanoma

(2014) Howard L Kaufman et al.   Journal for ImmunoTherapy of Cancer

Myeloid derived suppressor and dendritic cell subsets are related to clinical outcome in prostate cancer patients treated with prostate GVAX and ipilimumab

(2014) Saskia JAM Santegoets et al.   Journal for ImmunoTherapy of Cancer

Frequencies of circulating MDSC correlate with clinical outcome of melanoma patients treated with ipilimumab

(2013) Christiane Meyer et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

GM-CSF Promotes the Immunosuppressive Activity of Glioma-Infiltrating Myeloid Cells through Interleukin-4 Receptor- 

(2013) G. Kohanbash et al.   CANCER RESEARCH

Myeloid-Derived Suppressor Cells Predict Survival of Patients with Advanced Melanoma: Comparison with Regulatory T Cells and NY-ESO-1- or Melan-A-Specific T Cells

(2013) B. Weide et al.   CLINICAL CANCER RESEARCH

Adoptive cytotoxic T lymphocyte therapy triggers a counter-regulatory immunosuppressive mechanismviarecruitment of myeloid-derived suppressor cells

(2013) Akihiro Hosoi et al.   INTERNATIONAL JOURNAL OF CANCER

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Systemic inflammatory response syndrome (SIRS)

(2013) Robert A Balk   Virulence

Untreated Stage IV Melanoma Patients Exhibit Abnormal Monocyte Phenotypes and Decreased Functional Capacity

(2013) R. Chavan et al.   Cancer Immunology Research

Immune monitoring using the predictive power of immune profiles

(2013) Michael P Gustafson et al.   Journal for ImmunoTherapy of Cancer

Clinical Perspectives on Targeting of Myeloid Derived Suppressor Cells in the Treatment of Cancer

(2013) Yana G. Najjar et al.   Frontiers in Oncology

Comparative analysis of monocytic and granulocytic myeloid-derived suppressor cell subsets in patients with gastrointestinal malignancies

(2012) Austin Duffy et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

On the armament and appearances of human myeloid-derived suppressor cells

(2012) Isabel Poschke et al.   CLINICAL IMMUNOLOGY

G-CSF stem cell mobilization in human donors induces polymorphonuclear and mononuclear myeloid-derived suppressor cells

(2012) Ariane Luyckx et al.   CLINICAL IMMUNOLOGY

Inter-laboratory assessment of flow cytometric monocyte HLA-DR expression in clinical samples

(2012) Julie Demaret et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Myeloid-derived suppressor cell measurements in fresh and cryopreserved blood samples

(2012) Athanasios Kotsakis et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Immunosuppressive CD14+HLA-DRlow/neg IDO+ myeloid cells in patients following allogeneic hematopoietic stem cell transplantation

(2012) D Mougiakakos et al.   LEUKEMIA

Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival

(2012) Steffen Walter et al.   NATURE MEDICINE

Association of an increased frequency of CD14+HLA-DRlo/neg monocytes with decreased time to progression in chronic lymphocytic leukaemia (CLL)

(2011) Michael P. Gustafson et al.   BRITISH JOURNAL OF HAEMATOLOGY

Myeloid-derived suppressor cells impair the quality of dendritic cell vaccines

(2011) I. Poschke et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Monocytic CCR2+ Myeloid-Derived Suppressor Cells Promote Immune Escape by Limiting Activated CD8 T-cell Infiltration into the Tumor Microenvironment

(2011) A. M. Lesokhin et al.   CANCER RESEARCH

Circulating and tumor-infiltrating myeloid cell subsets in patients with bladder cancer

(2011) Evgeniy Eruslanov et al.   INTERNATIONAL JOURNAL OF CANCER

Normal human monocytes exposed to glioma cells acquire myeloid-derived suppressor cell-like properties

(2011) Jennifer C. Rodrigues et al.   NEURO-ONCOLOGY

Immunosuppressive CD14+HLA-DRlow/- monocytes in B-cell non-Hodgkin lymphoma

(2010) Y. Lin et al.   BLOOD

Nomenclature of monocytes and dendritic cells in blood

(2010) L. Ziegler-Heitbrock et al.   BLOOD

Immature Immunosuppressive CD14+HLA-DR−/low Cells in Melanoma Patients Are Stat3hi and Overexpress CD80, CD83, and DC-Sign

(2010) Isabel Poschke et al.   CANCER RESEARCH

Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection

(2010) Elias A Said et al.   NATURE MEDICINE

Systemic immune suppression in glioblastoma: the interplay between CD14+HLA-DRlo/neg monocytes, tumor factors, and dexamethasone

(2010) Michael P. Gustafson et al.   NEURO-ONCOLOGY

Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function

(2010) Thomas Condamine et al.   TRENDS IN IMMUNOLOGY

GM-CSF is one of the main breast tumor-derived soluble factors involved in the differentiation of CD11b-Gr1- bone marrow progenitor cells into myeloid-derived suppressor cells

(2009) Johanna K. Morales et al.   BREAST CANCER RESEARCH AND TREATMENT

Cryopreservation Decreases Receptor PD-1 and Ligand PD-L1 Coinhibitory Expression on Peripheral Blood Mononuclear Cell-Derived T Cells and Monocytes

(2009) D. E. Campbell et al.   Clinical and Vaccine Immunology

Effect of Granulocyte/Macrophage Colony-Stimulating Factor on Vaccination with an Allogeneic Whole-Cell Melanoma Vaccine

(2009) M. B. Faries et al.   CLINICAL CANCER RESEARCH

Effect of Granulocyte/Macrophage Colony-Stimulating Factor on Circulating CD8+ and CD4+ T-Cell Responses to a Multipeptide Melanoma Vaccine: Outcome of a Multicenter Randomized Trial

(2009) C. L. Slingluff et al.   CLINICAL CANCER RESEARCH

Gemcitabine directly inhibits myeloid derived suppressor cells in BALB/c mice bearing 4T1 mammary carcinoma and augments expansion of T cells from tumor-bearing mice

(2009) Hanh K. Le et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Longitudinal monocyte Human leukocyte antigen-DR expression is a prognostic marker in critically ill patients with decompensated liver cirrhosis

(2009) Marie-Luise Berres et al.   LIVER INTERNATIONAL

Low HLA-DR expression on CD14+ monocytes of burn victims with sepsis, and the effect of carbachol in vitro

(2008) Hong-ming Yang et al.   BURNS

Interleukin-10-induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes

(2008) Jacques Thibodeau et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A New Population of Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Induces CD4+CD25+Foxp3+ T Cells

(2008) Bastian Hoechst et al.   GASTROENTEROLOGY

Reconstitution of the immune system after hematopoietic stem cell transplantation in humans

(2008) Jan Storek et al.   Seminars in Immunopathology