Anti-Angiogenic Effects of Phytochemicals on miRNA Regulating Breast Cancer Progression

Resveratrol as a Tumor-Suppressive Nutraceutical Modulating Tumor Microenvironment and Malignant Behaviors of Cancer

(2019) Youngjin Han et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression

(2019) Marek Samec et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Phytochemicals Targeting VEGF and VEGF-Related Multifactors as Anticancer Therapy

(2019) Amna Parveen et al.   Journal of Clinical Medicine

miR-23b and miR-27b are oncogenic microRNAs in breast cancer: evidence from a CRISPR/Cas9 deletion study

(2019) Bethany N. Hannafon et al.   BMC CANCER

microRNA-21 promotes breast cancer proliferation and metastasis by targeting LZTFL1

(2019) Hui Wang et al.   BMC CANCER

Effects of Curcumin on Vessel Formation Insight into the Pro- and Antiangiogenesis of Curcumin

(2019) Ting-ye Wang et al.   Evidence-based Complementary and Alternative Medicine

Endothelial tip cells in vitro are less glycolytic and have a more flexible response to metabolic stress than non-tip cells

(2019) B. Yetkin-Arik et al.   Scientific Reports

Mir526b and Mir655 Promote Tumour Associated Angiogenesis and Lymphangiogenesis in Breast Cancer

(2019) Stephanie Hunter et al.   Cancers

Breast Cancer Subtypes Present a Differential Production of Reactive Oxygen Species (ROS) and Susceptibility to Antioxidant Treatment

(2019) Fabiola Lilí Sarmiento-Salinas et al.   Frontiers in Oncology

The Diverse Oncogenic and Tumor Suppressor Roles of microRNA-105 in Cancer

(2019) Jie Li et al.   Frontiers in Oncology

Combination of Epigallocatechin-3-gallate and Silibinin: A Novel Approach for Targeting Both Tumor and Endothelial Cells

(2019) Somaye Mirzaaghaei et al.   ACS Omega

miR526b and miR655 Induce Oxidative Stress in Breast Cancer

(2019) Bonita Shin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Triptolide Inhibits Breast Cancer Cell Metastasis Through Inducing the Expression of miR-146a, a Negative Regulator of Rho GTPase

(2019) Qin Liu et al.   ONCOLOGY RESEARCH

Sinomenine restrains breast cancer cells proliferation, migration and invasion via modulation of miR-29/PDCD-4 axis

(2019) Guanglei Gao et al.   Artificial Cells Nanomedicine and Biotechnology

Luteolin exhibits anti-breast cancer property through up-regulating miR-203

(2019) Guanglei Gao et al.   Artificial Cells Nanomedicine and Biotechnology

The Yin-Yang Regulation of Reactive Oxygen Species and MicroRNAs in Cancer

(2019) Kamesh R. Babu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNA Key to Angiogenesis Regulation: MiRNA Biology and Therapy

(2018) Ankit Tiwari et al.   CURRENT CANCER DRUG TARGETS

Endothelial cells promote triple-negative breast cancer cell metastasis via PAI-1 and CCL5 signaling

(2018) Wenwen Zhang et al.   FASEB JOURNAL

Proangiogenic Effect of Metformin in Endothelial Cells Is via Upregulation of VEGFR1/2 and Their Signaling under Hyperglycemia-Hypoxia

(2018) Sherin Bakhashab et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

New insights into the regulatory role of microRNA in tumor angiogenesis and clinical implications

(2018) Ye Wang et al.   Molecular Cancer

Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells

(2018) Wei Yan et al.   NATURE CELL BIOLOGY

microRNA-155 positively regulates glucose metabolism via PIK3R1-FOXO3a-cMYC axis in breast cancer

(2018) Sinae Kim et al.   ONCOGENE

Hypoxia induces miR-153 through the IRE1α-XBP1 pathway to fine tune the HIF1α/VEGFA axis in breast cancer angiogenesis

(2018) Huichun Liang et al.   ONCOGENE

Angiogenic role of miR-20a in breast cancer

(2018) Gines Luengo-Gil et al.   PLoS One

Triptolide inhibits vascular endothelial growth factor‑mediated angiogenesis in human breast cancer cells

(2018) Huantao Liu et al.   Experimental and Therapeutic Medicine

Cardamonin reduces chemotherapy resistance of colon cancer cells via the TSP50/NF‑κB pathway in�vitro

(2018) Sen Lu et al.   Oncology Letters

Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition

(2018) Farid Ahmad Siddiqui et al.   Scientific Reports

Screen for MicroRNA and Drug Interactions in Breast Cancer Cell Lines Points to miR-126 as a Modulator of CDK4/6 and PIK3CA Inhibitors

(2018) Federica Baldassari et al.   Frontiers in Genetics

Glucose-sensing microRNA-21 disrupts ROS homeostasis and impairs antioxidant responses in cellular glucose variability

(2018) Lucia La Sala et al.   Cardiovascular Diabetology

Role of dietary phytochemicals in modulation of miRNA expression: Natural swords combating breast cancer

(2018) Javed Iqbal et al.   Asian Pacific Journal of Tropical Medicine

The “Yin and Yang” of Natural Compounds in Anticancer Therapy of Triple-Negative Breast Cancers

(2018) Elizabeth Varghese et al.   Cancers

AngiomiRs: MicroRNAs driving angiogenesis in cancer (Review)

(2018) Yarely Salinas‑Vera et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Targeting VEGF pathway to normalize the vasculature: an emerging insight in cancer therapy

(2018) Jingbiao Wu et al.   OncoTargets and Therapy

microRNA-23a in Human Cancer: Its Roles, Mechanisms and Therapeutic Relevance

(2018) Ning Wang et al.   Cancers

Flavonoids in Cancer and Apoptosis

(2018) Mariam Abotaleb et al.   Cancers

NRF2 regulates endothelial glycolysis and proliferation with miR-93 and mediates the effects of oxidized phospholipids on endothelial activation

(2017) Suvi M Kuosmanen et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-4530 promotes angiogenesis by targeting VASH1 in breast carcinoma cells

(2017) Tao Zhang et al.   Oncology Letters

MicroRNA-100 shuttled by mesenchymal stem cell-derived exosomes suppresses in vitro angiogenesis through modulating the mTOR/HIF-1α/VEGF signaling axis in breast cancer cells

(2017) Katayoon Pakravan et al.   CELLULAR ONCOLOGY

MiR-23a targets RUNX2 and suppresses ginsenoside Rg1-induced angiogenesis in endothelial cells

(2017) Xiao-Dong Wu et al.   Oncotarget

How Endothelial Cells Adapt Their Metabolism to Form Vessels in Tumors

(2017) Annalisa Zecchin et al.   Frontiers in Immunology

Effects of Evodiamine on the Expression and Secretion of Vascular Endothelial Growth Factor in Human Breast Cancer Cells.

(2017) Paulus S. Wang et al.   BIOLOGY OF REPRODUCTION

MiRNA-21 mediates the antiangiogenic activity of metformin through targeting PTEN and SMAD7 expression and PI3K/AKT pathway

(2017) Mao Luo et al.   Scientific Reports

How glucose, glutamine and fatty acid metabolism shape blood and lymph vessel development

(2017) Laure-Anne Teuwen et al.   DEVELOPMENTAL BIOLOGY

Downregulation of microRNA-206 promotes invasion and angiogenesis of triple negative breast cancer

(2016) Zhongxing Liang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy

(2016) Anna Rita Cantelmo et al.   CANCER CELL

Targeting fatty acid metabolism in cancer and endothelial cells

(2016) Ulrike Harjes et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Soy Isoflavone Genistein-Mediated Downregulation of miR-155 Contributes to the Anticancer Effects of Genistein

(2016) Columba de la Parra et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

ROS and ROS-Mediated Cellular Signaling

(2016) Jixiang Zhang et al.   Oxidative Medicine and Cellular Longevity

Angiogenesis and Antiangiogenesis in Triple-Negative Breast cancer

(2016) Domenico Ribatti et al.   Translational Oncology

miRNA-205 targets VEGFA and FGF2 and regulates resistance to chemotherapeutics in breast cancer

(2016) Y Hu et al.   Cell Death & Disease

The Poly-cistronic miR-23-27-24 Complexes Target Endothelial Cell Junctions: Differential Functional and Molecular Effects of miR-23a and miR-23b

(2016) Jia Li et al.   Molecular Therapy-Nucleic Acids

Overexpression of miR-206 suppresses glycolysis, proliferation and migration in breast cancer cells via PFKFB3 targeting

(2015) Xin Ge et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metastatic breast cancer: the potential of miRNA for diagnosis and treatment monitoring

(2015) Andrew McGuire et al.   CANCER AND METASTASIS REVIEWS

Combination of miR-21 with Circulating Tumor Cells Markers Improve Diagnostic Specificity of Metastatic Breast Cancer

(2015) Xingwang Yang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Luteolin Inhibits Breast Cancer Development and Progression In Vitro and In Vivo by Suppressing Notch Signaling and Regulating MiRNAs

(2015) Da-Wei Sun et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Breast cancer cells promote a notch-dependent mesenchymal phenotype in endothelial cells participating to a pro-tumoral niche

(2015) Pegah Ghiabi et al.   Journal of Translational Medicine

miR-497 suppresses angiogenesis in breast carcinoma by targeting HIF-1α

(2015) ZHIHAO WU et al.   ONCOLOGY REPORTS

MiR-503 inhibited cell proliferation of human breast cancer cells by suppressing CCND1 expression

(2015) Jianting Long et al.   TUMOR BIOLOGY

miR-497 inhibits epithelial mesenchymal transition in breast carcinoma by targeting Slug

(2015) Zhihao Wu et al.   TUMOR BIOLOGY

Genistein-induced mir-23b expression inhibits the growth of breast cancer cells

(2015) Cigir Biray Avci et al.   Wspolczesna Onkologia-Contemporary Oncology

Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness

(2015) Wei Ma et al.   Oncotarget

Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer

(2015) Lacey M. Litchfield et al.   Oncotarget

Metabolic reprogramming of metastatic breast cancer and melanoma by let-7a microRNA

(2015) Anastassia Serguienko et al.   Oncotarget

Overexpression of miRNA-497 inhibits tumor angiogenesis by targeting VEGFR2

(2015) Yingfeng Tu et al.   Scientific Reports

Vascular Normalization Induced by Sinomenine Hydrochloride Results in Suppressed Mammary Tumor Growth and Metastasis

(2015) Huimin Zhang et al.   Scientific Reports

Cardamonin Regulates miR-21 Expression and Suppresses Angiogenesis Induced by Vascular Endothelial Growth Factor

(2015) Fu-Sheng Jiang et al.   Biomed Research International

Modulation of MicroRNAs by Phytochemicals in Cancer: Underlying Mechanisms and Translational Significance

(2015) Sanjeev K. Srivastava et al.   Biomed Research International

MicroRNA miR-98 inhibits tumor angiogenesis and invasion by targeting activin receptor-like kinase-4 and matrix metalloproteinase-11

(2015) Vinayakumar Siragam et al.   Oncotarget

Endothelial PFKFB3 Plays a Critical Role in Angiogenesis

(2014) Yiming Xu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Spanish Mediterranean diet and other dietary patterns and breast cancer risk: case–control EpiGEICAM study

(2014) A Castelló et al.   BRITISH JOURNAL OF CANCER

Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis

(2014) Weiying Zhou et al.   CANCER CELL

VEGF-Targeted Therapy Stably Modulates the Glycolytic Phenotype of Tumor Cells

(2014) M. Curtarello et al.   CANCER RESEARCH

An Overview on Cardamonin

(2014) Luís Moreira Gonçalves et al.   JOURNAL OF MEDICINAL FOOD

High expression of miR-21 in triple-negative breast cancers was correlated with a poor prognosis and promoted tumor cell in vitro proliferation

(2014) Guizhi Dong et al.   MEDICAL ONCOLOGY

Exosomally derived miR-105 destroys tight junctions

(2014) Isabel Lokody   NATURE REVIEWS GENETICS

Methylation and miRNA Effects of Resveratrol on Mammary Tumors vs. Normal Tissue

(2014) Wenyi Qin et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Identification of microRNA-93 as a functional dysregulated miRNA in triple-negative breast cancer

(2014) Jinhua Hu et al.   TUMOR BIOLOGY

Regulation of MicroRNAs by Natural Agents: New Strategies in Cancer Therapies

(2014) Neoh Hun Phuah et al.   Biomed Research International

Prometastatic GPCR CD97 Is a Direct Target of Tumor Suppressor microRNA-126

(2013) Ying Y. Lu et al.   ACS Chemical Biology

MicroRNA-503 targets FGF2 and VEGFA and inhibits tumor angiogenesis and growth

(2013) Bisheng Zhou et al.   CANCER LETTERS

Partial and Transient Reduction of Glycolysis by PFKFB3 Blockade Reduces Pathological Angiogenesis

(2013) Sandra Schoors et al.   Cell Metabolism

MiR-21 is Overexpressed in Response to High Glucose and Protects Endothelial Cells from Apoptosis

(2013) J. Zeng et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

miR-23b regulates cytoskeletal remodeling, motility and metastasis by directly targeting multiple transcripts

(2013) Loredana Pellegrino et al.   NUCLEIC ACIDS RESEARCH

miR-27a regulates endothelial differentiation of breast cancer stem like cells

(2013) W Tang et al.   ONCOGENE

Upregulation of miRNA-155 promotes tumour angiogenesis by targeting VHL and is associated with poor prognosis and triple-negative breast cancer

(2013) W Kong et al.   ONCOGENE

MiR-26a Inhibits Proliferation and Migration of Breast Cancer through Repression of MCL-1

(2013) Jie Gao et al.   PLoS One

Wogonin inhibits tumor angiogenesis via degradation of HIF-1α protein

(2013) Xiuming Song et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

miR-221/222: promising biomarkers for breast cancer

(2013) Wei-Xian Chen et al.   TUMOR BIOLOGY

Tumor Endothelial Cells

(2013) A. C. Dudley   Cold Spring Harbor Perspectives in Medicine

Novel Tissue‐Specific Mechanism of Regulation of Angiogenesis and Cancer Growth in Response to Hyperglycemia

(2013) Sanghamitra Bhattacharyya et al.   Journal of the American Heart Association

Endothelial cell metabolism and implications for cancer therapy

(2012) U Harjes et al.   BRITISH JOURNAL OF CANCER

MicroRNAs Regulate Tumor Angiogenesis Modulated by Endothelial Progenitor Cells

(2012) P. N. Plummer et al.   CANCER RESEARCH

MicroRNA-21 Modulates the Levels of Reactive Oxygen Species by Targeting SOD3 and TNF 

(2012) X. Zhang et al.   CANCER RESEARCH

MiR-145 inhibits tumor angiogenesis and growth by N-RAS and VEGF

(2012) Chao Zou et al.   CELL CYCLE

MiR-93 enhances angiogenesis and metastasis by targeting LATS2

(2012) Ling Fang et al.   CELL CYCLE

Effects of brucine on vascular endothelial growth factor expression and microvessel density in a nude mouse model of bone metastasis due to breast cancer

(2012) Ping Li et al.   Chinese Journal of Integrative Medicine

MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1

(2012) Laisheng Li et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Epigallocatechin Gallate (EGCG) Is the Most Effective Cancer Chemopreventive Polyphenol in Green Tea

(2012) Guang-Jian Du et al.   Nutrients

MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism

(2011) Muhua Yang et al.   BREAST CANCER RESEARCH AND TREATMENT

Metformin induces unique biological and molecular responses in triple negative breast cancer cells

(2011) Bolin Liu et al.   CELL CYCLE

Micro(mi)RNA expression profile of breast cancer epithelial cells treated with the anti-diabetic drug metformin: Induction of the tumor suppressor miRNA let-7a and suppression of the TGFβ-induced oncomiR miRNA-181a

(2011) Cristina Oliveras-Ferraros et al.   CELL CYCLE

GLUT1 expression in malignant tumors and its use as an immunodiagnostic marker

(2011) Kátia C. Carvalho et al.   Clinics

Endothelial-specific intron-derived miR-126 is down-regulated in human breast cancer and targets both VEGFA and PIK3R2

(2011) Ni Zhu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

MiR-21 Induced Angiogenesis through AKT and ERK Activation and HIF-1α Expression

(2011) Ling-Zhi Liu et al.   PLoS One

MicroRNA regulation in angiogenesis

(2011) Andrea Caporali et al.   VASCULAR PHARMACOLOGY

PI3K/AKT/mTOR Pathway in Angiogenesis

(2011) Jayashree Karar et al.   Frontiers in Molecular Neuroscience

Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD

(2010) Esmerina Tili et al.   CARCINOGENESIS

Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes

(2010) Anna Zampetaki et al.   CIRCULATION RESEARCH

miR-20b modulates VEGF expression by targeting HIF-1α and STAT3 in MCF-7 breast cancer cells

(2010) Sandra Cascio et al.   JOURNAL OF CELLULAR PHYSIOLOGY

MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2)

(2010) N. Valeri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AngiomiRs—Key regulators of angiogenesis

(2009) Shusheng Wang et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Matrine suppresses breast cancer cell proliferation and invasion via VEGF-Akt-NF-κB signaling

(2009) Pengfei Yu et al.   CYTOTECHNOLOGY

Curcumin reduces the expression of Bcl-2 by upregulating miR-15a and miR-16 in MCF-7 cells

(2009) Jie Yang et al.   MEDICAL ONCOLOGY

PTEN regulate angiogenesis through PI3K/Akt/VEGF signaling pathway in human pancreatic cancer cells

(2009) Jiachi Ma et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

MicroRNA-21 targets tumor suppressor genes in invasion and metastasis

(2008) Shuomin Zhu et al.   CELL RESEARCH

The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis

(2008) Shusheng Wang et al.   DEVELOPMENTAL CELL

Notch signaling regulates tumor angiogenesis by diverse mechanisms

(2008) J Dufraine et al.   ONCOGENE

MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis

(2008) L.-X. Yan et al.   RNA