MiRNA-21 mediates the antiangiogenic activity of metformin through targeting PTEN and SMAD7 expression and PI3K/AKT pathway

Metformin-mediated increase in DICER1 regulates microRNA expression and cellular senescence

(2016) Nicole Noren Hooten et al.   AGING CELL

AKT in cancer: new molecular insights and advances in drug development

(2016) Prabhjot S. Mundi et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Metformin improves the angiogenic functions of endothelial progenitor cells via activating AMPK/eNOS pathway in diabetic mice

(2016) Jia-Wen Yu et al.   Cardiovascular Diabetology

Metformin is a novel suppressor for transforming growth factor (TGF)-β1

(2016) Han Xiao et al.   Scientific Reports

Up-regulation of MicroRNA-21 Mediates Isoflurane-induced Protection of Cardiomyocytes

(2015) Jessica M. Olson et al.   ANESTHESIOLOGY

Roundabout4 Suppresses Glioma-Induced Endothelial Cell Proliferation, Migration and Tube Formation in Vitro by Inhibiting VEGR2-Mediated PI3K/AKT and FAK Signaling Pathways

(2015) Heng Cai et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

MicroRNAs: Key regulators of endothelial progenitor cell functions

(2015) Kai Qu et al.   CLINICA CHIMICA ACTA

miR-21 promotes renal fibrosis in diabetic nephropathy by targeting PTEN and SMAD7

(2015) A. D. McClelland et al.   CLINICAL SCIENCE

Association between metformin therapy and incidence, recurrence and mortality of prostate cancer: evidence from a meta-analysis

(2015) Dan Deng et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

A New Role for an Old Drug: Metformin Targets MicroRNAs in Treating Diabetes and Cancer

(2015) Joseph Yi Zhou et al.   DRUG DEVELOPMENT RESEARCH

Involvement of MEK/ERK1/2 and PI3K/Akt Pathways in the Refractory Behavior of GH3B6 Pituitary Tumor Cells to the Inhibitory Effect of TGFβ1

(2015) Juan Pablo Petiti et al.   ENDOCRINOLOGY

Metformin-Derived Growth Inhibition in Renal Cell Carcinoma Depends on miR-21-Mediated PTEN Expression

(2015) Charis Kalogirou et al.   UROLOGIA INTERNATIONALIS

Paradoxic effects of metformin on endothelial cells and angiogenesis

(2014) Katiuscia Dallaglio et al.   CARCINOGENESIS

MiR-152 reduces human umbilical vein endothelial cell proliferation and migration by targeting ADAM17

(2014) Yang Wu et al.   FEBS LETTERS

miRDB: an online resource for microRNA target prediction and functional annotations

(2014) Nathan Wong et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-21 Regulates hTERT via PTEN in Hypertrophic Scar Fibroblasts

(2014) Hua-Yu Zhu et al.   PLoS One

Metformin-Induced Killing of Triple-Negative Breast Cancer Cells Is Mediated by Reduction in Fatty Acid Synthase via miRNA-193b

(2014) Reema S. Wahdan-Alaswad et al.   Hormones & Cancer

miR-21 is a key therapeutic target for renal injury in a mouse model of type 2 diabetes

(2013) X. Zhong et al.   DIABETOLOGIA

MicroRNA-21 mediates the rapamycin-induced suppression of endothelial proliferation and migration

(2013) Chongying Jin et al.   FEBS LETTERS

MicroRNA-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer

(2013) Hongping Xia et al.   HEPATOLOGY

PAI-1–regulated miR-21 defines a novel age-associated fibrogenic pathway in muscular dystrophy

(2012) Esther Ardite et al.   JOURNAL OF CELL BIOLOGY

MicroRNA-21: a ubiquitously expressed pro-survival factor in cancer and other diseases

(2011) Si Li et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Angiogenesis

(2011) D. R. Senger et al.   Cold Spring Harbor Perspectives in Biology

Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells

(2010) Mahvash Zakikhani et al.   BREAST CANCER RESEARCH AND TREATMENT

MicroRNA-21 in Cardiovascular Disease

(2010) Yunhui Cheng et al.   Journal of Cardiovascular Translational Research