Review
Biochemistry & Molecular Biology
Surendra Kumar Sagar
Summary: This review focuses on the function of miR-106b and its downstream targets in cancer, providing insights into how miR-106b regulates cancer cell proliferation, migration, invasion, and metastasis by modulating tumor suppressor genes. The potential of miR-106b as a candidate for detection, diagnosis, and prognosis assessment in different cancer types is highlighted.
Review
Biochemistry & Molecular Biology
Da Young Lee, Jung Nyeo Chun, Minsoo Cho, Insuk So, Ju-Hong Jeon
Summary: E2F8 is a multifaceted transcription factor that is involved in various aspects of cancer development and progression. It has the ability to promote cancer cell proliferation and survival while also exhibiting tumor-suppressing activity. This review highlights the recent progress in understanding the role of E2F8 in human cancers and its implications for developing therapeutic strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Oncology
Antonio Ferreira, Jon C. Aster
Summary: Notch receptors participate in a conserved signaling pathway that has diverse effects on normal cells and is highly dependent on the cellular context and signaling dosage. Notch plays different roles in various types of cancers, acting as either an oncogene or a tumor suppressor and affecting tumor cells and stromal elements in multiple ways. This review provides an overview of the roles of Notch in cancer and discusses the challenges and potential approaches for clinical translation of Notch targeting agents.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Medicine, Research & Experimental
Seyede Fatemeh Hosseini, Setareh Javanshir-giv, Hanieh Soleimani, Homa Mollaei, Farzad Sadri, Zohreh Rezaei
Summary: MicroRNA production in tumorigenesis is dysregulated by various processes, leading to dysfunctional and dysregulated miRNAs. These miRNAs have been identified as potential biomarkers for human cancer, although further evaluation is necessary. The miR-28 family, especially miR-28-5p and miR-28-3p, play essential roles in various cancers and can serve as diagnostic biomarkers for prognosis and early detection of cancers.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Hanieh Shirvani, Jalaledin Ghanavi, Amin Aliabadi, Fatemehsadat Mousavinasab, Mehrdad Talebi, Jamal Majidpoor, Sajad Najafi, Seyyed Mohammad Miryounesi, Seyed Mohsen Aghaei Zarch
Summary: This review discusses the expression levels, target genes, and mechanisms of miR-211 in different cancers, revealing its oncogenic or tumor-suppressive impact on tumorigenesis and cancer development. Additionally, miR-211 may serve as a noninvasive biomarker and therapeutic factor for the diagnosis and treatment of cancer.
CELLULAR SIGNALLING
(2023)
Article
Biochemistry & Molecular Biology
Francisco Alejandro Lagunas-Rangel
Summary: KDM6B is a histone demethylase that can act as a tumor suppressor or an oncogene depending on the cellular context. This study summarizes the role of KDM6B in different oncological contexts, aiming to guide its clinical application.
Review
Pathology
Soudeh Ghafouri-Fard, Arash Safarzadeh, Solmaz Hassani Fard Katiraei, Bashdar Mahmud Hussen, Mohammadreza Hajiesmaeili
Summary: This review article explores the functions of miR-328 in the development of human carcinogenesis and highlights the discrepancies in different studies, which may be attributed to different stages/grades of tumor tissues or other clinical characteristics.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Cell Biology
Songjie Shen, Yu Song, Bin Zhao, Yali Xu, Xinyu Ren, Yidong Zhou, Qiang Sun
Summary: The study identified miR-7641 as a key miRNA in cancer-derived exosomes promoting tumor progression and metastasis via intercellular communication. Exosomal miR-7641 may serve as a non-invasive diagnostic biomarker and potential therapeutic target in breast cancer treatment.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Pathology
Mahmoud A. Elrebehy, Tamer M. Abdelghany, Mostafa M. Elshafey, Maher H. Gomaa, Ahmed S. Doghish
Summary: This study evaluated the expression of miR-509-5p in colorectal cancer (CRC) cell lines and tissues and found a significant reduction compared to normal tissues. Upregulation of miR-509-5p inhibited cell viability and suppressed the expression of SLC7A11. Overexpression of miR-509-5p also increased levels of MDA and iron, suggesting its role in promoting ferroptosis.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Manlio Tolomeo, Antonio Cascio
Summary: STAT3 is a complex regulator of transcription, with constitutive activation reported in many tumors but less frequent somatic mutations in cancer. Oncogenic targets of STAT3 have been identified, and inhibitors have been developed for cancer prevention and treatment. However, data suggest that STAT3 functions are multifaceted and its cellular role is determined by various signals and factors, making targeted therapies tailored to specific tumor types important.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yousef M. Hawsawi, Anwar Shams, Abdulrahman Theyab, Wed A. Abdali, Nahed A. Hussien, Hanan E. Alatwi, Othman R. Alzahrani, Atif Abdulwahab A. Oyouni, Ahmad O. Babalghith, Mousa Alreshidi
Summary: This article reviews the spectrum of full-length BARD1 genes and their different isoforms, highlighting their anticipated associated risk. Additionally, the study emphasizes the role of BARD1 as an oncogene in breast cancer patients and its potential uses as a prognostic/diagnostic biomarker and therapeutic target for cancer susceptibility testing and treatment.
Review
Oncology
Sarah M. Zimmerman, Phyo Nay Lin, George P. Souroullas
Summary: Mutations in chromatin modifying genes frequently occur in many kinds of cancer. Recent studies suggest that non-canonical functions of chromatin modifiers may be equally important and therapeutically actionable in different types of cancer. EZH2, a histone methyltransferase, demonstrates such a dual role in cancer.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Petra Korac, Mariastefania Antica, Maja Matulic
Summary: miR-7 is an ancient miRNA involved in cell signaling pathways, acting primarily as a tumor suppressor by inhibiting cell proliferation and promoting apoptosis. It also has additional roles in cell regulation and protection, with potential for use in biotherapeutics.
Review
Biochemistry & Molecular Biology
Yichen Liu, Qiong Zhao, Tao Xi, Lufeng Zheng, Xiaoman Li
Summary: Metastasis refers to secondary tumor growth at a distant site from the primary tumor, which is closely linked to poor prognosis and mortality. miR-9 plays a dual role as a promoter or suppressor in cancer metastasis and is involved in coordinating multiple steps of the metastatic process. Studying the various mechanisms of miR-9 in regulating metastasis can facilitate further research and potentially inform clinical applications in the future.
Review
Biology
Junaid Ali Shah, Saadullah Khattak, Mohd Ahmar Rauf, Yong Cai, Jingji Jin
Summary: miRNAs are small non-coding RNA transcripts that regulate gene expression in cells, including tumorigenesis. The miR-371-373 genes are found to be abnormally expressed in various cancers and may serve as molecular biomarkers for cancer diagnosis and prevention. Further studies linking miR-371-373 functions to tumorigenesis suggest their potential applications in cancer diagnosis and treatment.
