Article
Biochemistry & Molecular Biology
Kerry T. Sun, Tark Patel, Sang-Gyun Kang, Allan Yarahmady, Mahalashmi Srinivasan, Olivier Julien, Jonathan Heras, Sue-Ann Mok
Summary: The accumulation of tau fibrils is linked to neurodegenerative diseases, and the structure of tau fibrils can vary in different tauopathies. Certain tauopathies are associated with mutations in the tau protein, and these mutations can impact the structure of the fibrils.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Mohammad Nasir Uddin, Montasir Elahi, Shotaro Shimonaka, Soichiro Kakuta, Koichi Ishiguro, Yumiko Motoi, Nobutaka Hattori
Summary: The study found that lithium can reduce tau protein aggregation by promoting autophagy and influencing IMPase in a strain-specific manner.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Hariharakrishnan Chidambaram, Subashchandrabose Chinnathambi
Summary: Alzheimer's disease is characterized by the accumulation of Tau protein in cells, and cysteine residues play a crucial role in this aggregation process. In this study, it was found that even cysteine mutant Tau can aggregate to form filaments under in-vitro conditions, although with a delayed aggregation compared to wild-type Tau.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Multidisciplinary Sciences
Melina Theoni Gyparaki, Arian Arab, Elena M. Sorokina, Adriana N. Santiago-Ruiz, Christopher H. Bohrer, Jie Xiao, Melike Lakadamyali
Summary: The study found that tau forms small oligomers on microtubules ex vivo, which are different from those found in cells exhibiting tau aggregation and could be precursors of aggregated tau in pathology. Using an unsupervised shape classification algorithm that was developed, different tau phosphorylation states were associated with distinct tau aggregate species. The research elucidates tau's nanoscale composition under nonaggregated and aggregated conditions ex vivo.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Neurosciences
Galina Limorenko, Hilal A. Lashuel
Summary: The study explores the effects of heparin on Tau aggregation and provides new insights into its role in Tauopathies. The review calls for a reassessment of approaches to studying Tau aggregation mechanisms, development of better diagnostic tools to enhance understanding of Tauopathies, and more effective means for drug development.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Chemistry, Multidisciplinary
Amaruka Hazari, Michael R. Sawaya, Maria Sajimon, Niko Vlahakis, Jose Rodriguez, David Eisenberg, Jevgenij A. Raskatov
Summary: Five new crystal structures of rippled sheets derived from amyloid beta and amylin have been reported, providing insights into the molecular structures of toxic peptides in Alzheimer's disease and type II diabetes, and offering a structural basis for targeted therapies.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Pharmacology & Pharmacy
Johanna Giovannini, Willy Smeralda, Marie Jouanne, Jana Sopkova-de Oliveira Santos, Marco Catto, Anne Sophie Voisin-Chiret
Summary: Tauopathies are neurodegenerative disorders characterized by the accumulation of abnormal tau protein in the brain, with Alzheimer's disease being the most common form. The pathophysiological mechanisms of AD are still not fully understood, and there is currently no curative treatment available. Therefore, targeting tau protein aggregation has become an important focus for therapeutic approaches.
DRUG DISCOVERY TODAY
(2022)
Article
Biochemistry & Molecular Biology
Francesca Parolini, Roberto Tira, Carlo Giorgio Barracchia, Francesca Munari, Stefano Capaldi, Mariaina D'Onofrio, Michael Assfalg
Summary: The formation of biomolecular condensates plays a crucial role in neuronal physiology and neurodegeneration. This study reveals that ubiquitination can regulate the behavior of tau protein during condensate formation and potentially influence the physiological and pathological states of tau in cellular condensates.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Analytical
Chang Liu, Yuanting Li, Yuxin Luo, Ying Zhang, Tianshu Zhou, Jingjing Deng
Summary: This study explores the spectral changes of blue-color-emissive and red-color-emissive ZnO submicron particles towards different tau species to construct a lab-on-a-ZnO-submicron-particle sensor array. Using principal component analysis, the sensor array can differentiate and quantitatively detect different tau species simultaneously. The study demonstrates the potential application of the sensor array in monitoring the dynamic changes of tau441% in cerebrospinal fluid during Alzheimer's disease onset and provides valuable insights for early diagnosis and therapy.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ying-Ying Gao, Tao Zhong, Li-Qiang Wang, Na Zhang, Yan Zeng, Ji-Ying Hu, Hai-Bin Dang, Jie Chen, Yi Liang
Summary: Zinc promotes liquid-liquid phase separation and aggregation of full-length Tau, resulting in the formation of stress granules and interaction with G3BP1, leading to increased Tau filaments and neuronal toxicity. Additionally, zinc aggravates mitochondrial damage and reactive oxygen species production induced by Tau aggregation, further deteriorating the pathogenesis of Alzheimer's disease.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Neurosciences
Engie Prifti, Eleni N. Tsakiri, Ergina Vourkou, George Stamatakis, Martina Samiotaki, Katerina Papanikolopoulou
Summary: The study revealed that the two cysteine residues of Tau protein, Cys-322 and Cys-291, play different roles in Tau aggregation and toxicity, with Cys-322 being critical for Tau toxicity and dysfunction.
JOURNAL OF NEUROSCIENCE
(2021)
Correction
Clinical Neurology
Woo Shik Shin, Jing Di, Qin Cao, Binsen Li, Paul M. Seidler, Kevin A. Murray, Gal Bitan, Lin Jiang
Summary: The paper has been amended and the updated version can be accessed through the original article.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Mantas Ziaunys, Kamile Mikalauskaite, Lukas Krasauskas, Vytautas Smirnovas
Summary: Protein aggregation into amyloid fibrils plays a role in neurodegenerative diseases such as Alzheimer's and Parkinson's. Despite significant research, the process remains poorly understood, hindering the development of treatments. Recent reports of cross-interactions between amyloidogenic proteins, including Tau and prion, have further complicated the process. This study observed a conformation-specific association between Tau and prion fibrils, increasing their aggregate formation and amyloid binding capacity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Antonio J. Figueira, Guilherme G. Moreira, Joana Saavedra, Isabel Cardoso, Claudio M. Gomes
Summary: The hallmark of Alzheimer's disease (AD) includes the aggregation of amyloid-beta (A beta), tau, and neuroinflammation. In this study, the researchers found that S100B protein, which is upregulated in AD, can inhibit the aggregation of A beta 42, and this activity is dependent on Ca2+ binding. They also discovered that S100B exists in tetrameric form, and tetrameric S100B is more effective in inhibiting A beta 42 aggregation. These findings highlight the importance of S100B protein in regulating AD proteotoxicity.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dahbia Yatoui, Philipp O. Tsvetkov, Romain La Rocca, Viktoriia E. Baksheeva, Diane Allegro, Gilles Breuzard, Geraldine Ferracci, Deborah Byrne, Francois Devred
Summary: Researchers have identified three zinc binding sites on Tau protein and found that zinc binding to these sites plays an important role in aggregation. Particularly, lack of zinc binding to the high affinity site in the repeat region prevents Tau protein from aggregating.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Ruihao Li, Xiaochun Hu, Fangjian Shang, Wenjing Wu, Haijun Zhang, Yixuan Wang, Jiawei Pan, Shuo Shi, Chunyan Dong
Summary: This study successfully constructed a new multifunctional nanoplatform (M-17AAG-AIPH) for the treatment of TNBC through mild-temperature photothermal therapy and oxygen-independent cytotoxic free radicals.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Multidisciplinary
Xiaochun Hu, Ruihao Li, Wenjing Wu, Kang Fang, Zhounan Zhu, Yixuan Wang, Lulu Zhou, Mengyao Chen, Chunyan Dong, Shuo Shi
Summary: This study successfully developed a nanotheranostics that promotes the synergistic effect of chemotherapy/ferroptosis/immunomodulation in cancer. The nanotheranostics utilize the characteristics of drug prodrug and metal-organic frameworks to achieve controllable chemotherapy and ferroptosis in the tumor microenvironment.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Yiming Rao, Ting Fan, Lulu Zhou, Kang Fang, Yanting Sun, Xiaochun Hu, Anqi Wang, Ruihao Li, Zhounan Zhu, Chunyan Dong, Shuo Shi
Summary: A pH-sensitive nanoplatform is designed to enhance the therapeutic effect of chemodynamic therapy by increasing intracellular H2O2 and acidity. The nanoplatform releases loaded TAM and ICG under acidic conditions and increases the content of O2 and H2O2 through a synergistic effect. It also promotes the collapse of nanoparticles and the accumulation of intracellular H2O2 through a positive circulation. In addition, the nanoplatform combines photothermal therapy and starvation therapy with chemodynamic therapy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Engineering, Biomedical
Xiaochun Hu, Hui Li, Ruihao Li, Sufeng Qiang, Mengyao Chen, Shuo Shi, Chunyan Dong
Summary: Chemotherapy is still the main strategy for cancer treatment, but chemo-resistance and side effects limit its efficacy. In this study, an intelligent nanoplatform based on dendritic mesoporous organosilica nanoparticles (DMON) was developed for responsive drug release. The nanoplatform enabled a combined therapy (chemo/photothermal/photodynamic therapy), efficiently killing cancer cells and inhibiting tumor growth. Minimal systemic toxicity was observed in vivo, highlighting the potential of this nanoplatform for targeted and controlled chemotherapy drug delivery.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Yanting Sun, Kang Fang, Xiaochun Hu, Jingxian Yang, Zhengyang Jiang, Lei Feng, Ruihao Li, Yiming Rao, Shuo Shi, Chunyan Dong
Summary: In this report, a smart G-quadruplex hydrogel named HMI@GEL was constructed for breast cancer treatment. This platform exhibited excellent characteristics of NIR-light-triggered and persistent drug delivery to maintain high intratumoral concentration of metformin. The combination of PTT and synergistically enhanced PDT as well as the activated tumour immunotherapy achieved remarkable apoptosis and necrosis.
MATERIALS TODAY BIO
(2022)
Article
Chemistry, Analytical
Ying Tu, Keke Chai, Junjie Wu, Yuan Hu, Shuo Shi, Danjing Yang, Tianming Yao
Summary: The aggregation of Tau proteins is closely related to the progression and severity of Alzheimer's disease. Developing selective imaging probes for Tau aggregates is challenging. This study designed three new fluorescent dyes and demonstrated the importance of side chain substitution in improving the selectivity of Tau probes.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Cell & Tissue Engineering
Pingting Ye, Lei Feng, Dan Zhang, Ruihao Li, Yixuan Wen, Xiaohan Tong, Shuo Shi, Chunyan Dong
Summary: Research shows that metformin can promote autophagy in hBMSCs and delay cellular senescence within a low concentration range, providing potential benefits for clinical stem cell therapy.
STEM CELLS INTERNATIONAL
(2023)
Article
Biochemical Research Methods
Xiaochun Hu, Guanghua Wang, Kang Fang, Ruihao Li, Chunyan Dong, Shuo Shi, Hui Li
Summary: Nanozymes, as nanomaterials with enzyme-mimetic catalytic properties, have attracted considerable attention in the field of biological detection. This study successfully prepared Fe-TCPP MOFs, which exhibited peroxidase (POD) activity by catalyzing H2O2 to produce ·OH. By combining Fe-TCPP with glucose oxidase (GOx), a cascade reaction was built, enabling the selective and sensitive detection of glucose with a limit of detection of 0.12 μM. Furthermore, a portable hydrogel (Fe-TCPP@GEL) encapsulating Fe-TCPP MOFs, GOx, and TMB was developed, allowing for easy colorimetric detection of glucose when paired with a smartphone.
ANALYTICAL BIOCHEMISTRY
(2023)
Review
Chemistry, Inorganic & Nuclear
Chunhui Wang, Xinda Yang, Chunyan Dong, Keke Chai, Juan Ruan, Shuo Shi
Summary: Copper is an essential micronutrient that plays a crucial role in promoting metabolism and maintaining basic biological functions. The imbalance of copper levels can have negative effects on cell function and metabolism. Therefore, copper-related agents have gained attention in the field of cancer therapy as a means to inhibit proliferation or induce cell death. This review provides a comprehensive summary of the recent developments in copper-related agents for cancer treatment, focusing on copper depletion and supplementation strategies. The challenges and future directions in the development of copper-related anticancer agents are also discussed.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Analytical
Ying Tu, Junjie Wu, Keke Chai, Xiaochun Hu, Yuan Hu, Shuo Shi, Tianming Yao
Summary: A turn-on unlabeled colorimetric aptasensor based on aptamer-polythymine (polyT)polyadenine (polyA)-gold nanoparticles (pA-pT-apt@AuNPs) was developed for highly sensitive and specific detection of amyloid- beta(1-40) oligomers (A beta 40-O), which is valuable for the early diagnosis of Alzheimer's disease (AD).
Article
Engineering, Biomedical
Kang Fang, Yanting Sun, Jingxian Yang, Xiaochun Hu, Mengyao Chen, Ruihao Li, Xinda Yang, Ting Fan, Junjie Wu, Xiaohan Tong, Chunyan Dong, Shuo Shi
Summary: An acid and glutathione (GSH) dual-controlled nanoplatform is designed to strengthen the antitumor efficacy and avoid toxicity to normal cells of cisplatin and triptolide through the synergy of 1+1 apoptosis and 1+1 ferroptosis. The nanosystem shows superior specificity and therapeutic outcomes while reducing the toxicity to normal cells/tissues.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Anqi Wang, Xinda Yang, Ruihao Li, Lujing Shao, Wenrong Zhao, Xiaochun Hu, Kang Fang, Keke Chai, Shuo Shi, Chunyan Dong
Summary: An immunomodulatory nanoplatform was engineered to eradicate triple-negative breast cancer tumors through a combination of immunotherapy, chemotherapy, and photothermal therapy. The nanoplatform maximally activated dendritic cells, boosted the immune response, and reversed the immunosuppressive tumor microenvironment, resulting in enhanced tumor killing effects.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Xiaochun Hu, Wenrong Zhao, Ruihao Li, Keke Chai, Fangjian Shang, Shuo Shi, Chunyan Dong
Summary: In this study, a multifunctional nanoplatform (MCDGF) was developed to improve the stability of DSF and enhance its anticancer effects through a cascade reaction. The nanoplatform integrated chemotherapy, starvation therapy, photothermal therapy, and immunotherapy to synergistically eliminate cancer cells and regulate the tumor immune microenvironment. This promising strategy holds potential for the clinical treatment of breast cancer using DSF.
Article
Chemistry, Multidisciplinary
Mohamed Nabeel Mattath, Haibin Zhang, Debasis Ghosh, Thimmaiah Govindaraju, Shuo Shi
Summary: Biocomputing, using DNAs as its primary building blocks, is the most promising alternative for next-generation molecular computers. DNA nanoclusters (NCs) have unique self-assembly properties and programmability, making them promising candidates for biosensing applications. Thymine overhang-modified DNA-templated NCs are chemosensing ensembles capable of driving elementary and complex logic operations. These NCs can also be used for advanced DNA logic devices and error detection.
Review
Materials Science, Multidisciplinary
Mengyao Chen, Chunyan Dong, Shuo Shi
Summary: This review summarizes the research progress of Mn-based nanomaterials and their applications in ROS-mediated cancer therapy. Mn, as an important transition-metal element, plays a key role in cancer treatment. Mn-based nanomaterials have been widely used in ROS-mediated cancer therapy, serving as an ideal nanoplatform.
ACS MATERIALS LETTERS
(2022)