Physiological Notch Signaling Maintains Bone Homeostasis via RBPjk and Hey Upstream of NFATc1

Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis

(2011) Bertrand Isidor et al.   NATURE GENETICS

Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss

(2011) Michael A Simpson et al.   NATURE GENETICS

RBPj -dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development

(2010) Y. Dong et al.   DEVELOPMENT

Osteosclerosis owing to Notch gain of function is solely Rbpj-dependent

(2010) Jianning Tao et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Ubiquitous overexpression of Hey1 transcription factor leads to osteopenia and chondrocyte hypertrophy in bone

(2009) Rishard Salie et al.   BONE

Epidermal Notch1 Loss Promotes Skin Tumorigenesis by Impacting the Stromal Microenvironment

(2009) Shadmehr Demehri et al.   CANCER CELL

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage

(2009) Kameswaran Surendran et al.   DEVELOPMENTAL BIOLOGY

Ligand-Independent Traffic of Notch Buffers Activated Armadillo in Drosophila

(2009) Phil G. T. Sanders et al.   PLOS BIOLOGY

Notch Inhibits Osteoblast Differentiation and Causes Osteopenia

(2008) Stefano Zanotti et al.   ENDOCRINOLOGY

Alternative splicing and expression of human and mouse NFAT genes

(2008) Hanna Vihma et al.   GENOMICS

NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism

(2008) Antonios O. Aliprantis et al.   JOURNAL OF CLINICAL INVESTIGATION

Dimorphic effects of Notch signaling in bone homeostasis

(2008) Feyza Engin et al.   NATURE MEDICINE

Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

(2008) Matthew J Hilton et al.   NATURE MEDICINE