Notch Signaling Promotes Osteoclast Maturation and Resorptive Activity

Ubiquitin E3 Ligase LNX2 is Critical for Osteoclastogenesis In Vitro by Regulating M-CSF/RANKL Signaling and Notch2

(2015) Jian Zhou et al.   CALCIFIED TISSUE INTERNATIONAL

Downregulation of Notch Modulators, Tetraspanin 5 and 10, Inhibits Osteoclastogenesis in Vitro

(2014) Jian Zhou et al.   CALCIFIED TISSUE INTERNATIONAL

Regulated Proteolysis of NOTCH2 and NOTCH3 Receptors by ADAM10 and Presenilins

(2014) A. J. Groot et al.   MOLECULAR AND CELLULAR BIOLOGY

Interleukin-3 plays dual roles in osteoclastogenesis by promoting the development of osteoclast progenitors but inhibiting the osteoclastogenic process

(2013) Huixian Hong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IL-11 produced by breast cancer cells augments osteoclastogenesis by sustaining the pool of osteoclast progenitor cells

(2013) Erin M McCoy et al.   BMC CANCER

Osteoclast-Derived Coupling Factors in Bone Remodeling

(2013) Kim Henriksen et al.   CALCIFIED TISSUE INTERNATIONAL

Notch Signaling in Skeletal Stem Cells

(2013) Shan Chen et al.   CALCIFIED TISSUE INTERNATIONAL

Zinc inhibits osteoclast differentiation by suppression of Ca2+-Calcineurin-NFATc1 signaling pathway

(2013) Kwang Park et al.   Cell Communication and Signaling

Defining Single Molecular Forces Required to Activate Integrin and Notch Signaling

(2013) X. Wang et al.   SCIENCE

PKCδ Is Required for Jagged-1 Induction of Human Mesenchymal Stem Cell Osteogenic Differentiation

(2013) Fengchang Zhu et al.   STEM CELLS

Calcium/calmodulin-dependent protein kinase IV (CaMKIV) enhances osteoclast differentiation via the up-regulation of Notch1 protein stability

(2012) Yun-Hee Choi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Molecular Basis of Requirement of Receptor Activator of Nuclear Factor κB Signaling for Interleukin 1-mediated Osteoclastogenesis

(2012) Joel Jules et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Src Links a RANK/ v 3 Integrin Complex to the Osteoclast Cytoskeleton

(2012) T. Izawa et al.   MOLECULAR AND CELLULAR BIOLOGY

Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis

(2012) Kazuhiro Maeda et al.   NATURE MEDICINE

Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes

(2012) Chiyoko Sekine et al.   ARTHRITIS RESEARCH & THERAPY

Neural fate decisions mediated by trans-activation and cis-inhibition in Notch signaling

(2011) Ruiqi Wang et al.   BIOINFORMATICS

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells

(2011) Nilay Sethi et al.   CANCER CELL

Genetic Ablation of CD68 Results in Mice with Increased Bone and Dysfunctional Osteoclasts

(2011) Jason W. Ashley et al.   PLoS One

Receptor Activator of NF-κB (RANK) Cytoplasmic IVVY535–538Motif Plays an Essential Role in Tumor Necrosis Factor-α (TNF)-mediated Osteoclastogenesis

(2010) Joel Jules et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Maslinic acid suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss by regulating RANKL-mediated NF-κB and MAPK signaling pathways

(2010) Chenghai Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Outsmarting a Mastermind

(2009) Katherine A. Jones   DEVELOPMENTAL CELL

Direct inhibition of the NOTCH transcription factor complex

(2009) Raymond E. Moellering et al.   NATURE

Notch is activated in RANKL-induced osteoclast differentiation and resorption

(2008) Li Duan   Frontiers in Bioscience-Landmark

Notch inhibition blocks multiple myeloma cell-induced osteoclast activation

(2008) R Schwarzer et al.   LEUKEMIA

The Association of Notch2 and NF- B Accelerates RANKL-Induced Osteoclastogenesis

(2008) H. Fukushima et al.   MOLECULAR AND CELLULAR BIOLOGY

A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition

(2008) Jemima Cordle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY