Journal
GENES
Volume 10, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/genes10050378
Keywords
GADD45; JNK; p38; development; regeneration; imaginal discs
Categories
Funding
- Spanish Ministerio de Economia y Competitividad [BFU2012-36888, BFU2015-67623-P]
- Institucio Catalana de Recerca i Estudis Avancats (via an ICREA Academia award)
Ask authors/readers for more resources
The GADD45 proteins are induced in response to stress and have been implicated in the regulation of several cellular functions, including DNA repair, cell cycle control, senescence, and apoptosis. In this study, we investigate the role of D-GADD45 during Drosophila development and regeneration of the wing imaginal discs. We find that higher expression of D-GADD45 results in JNK-dependent apoptosis, while its temporary expression does not have harmful effects. Moreover, D-GADD45 is required for proper regeneration of wing imaginal discs. Our findings demonstrate that a tight regulation of D-GADD45 levels is required for its correct function both, in development and during the stress response after cell death.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available