A Functional Screen Reveals an Extensive Layer of Transcriptional and Splicing Control Underlying RAS/MAPK Signaling in Drosophila

HAM-2 and HAM-3 are central for the assembly of theNeurospora STRIPAK complex at the nuclear envelope and regulate nuclear accumulation of the MAP kinase MAK-1 in a MAK-2-dependent manner

(2013) Anne Dettmann et al.   MOLECULAR MICROBIOLOGY

Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions

(2013) M. Courcelles et al.   Molecular Systems Biology

SF3B1 Mutations Are Associated with Alternative Splicing in Uveal Melanoma

(2013) S. J. Furney et al.   Cancer Discovery

Nuclear Matrix Factor hnRNP U/SAF-A Exerts a Global Control of Alternative Splicing by Regulating U2 snRNP Maturation

(2012) Rui Xiao et al.   MOLECULAR CELL

A Quantitative, High-Throughput Reverse Genetic Screen Reveals Novel Connections between Pre–mRNA Splicing and 5′ and 3′ End Transcript Determinants

(2012) Laura-Oana Albulescu et al.   PLoS Genetics

The exon junction complex: A splicing factor for long intron containing transcripts?

(2011) Dariel Ashton-Beaucage et al.   FLY

Regulation of alternative splicing by the core spliceosomal machinery

(2011) A. L. Saltzman et al.   GENES & DEVELOPMENT

Strong negative feedback from Erk to Raf confers robustness to MAPK signalling

(2011) R. Fritsche-Guenther et al.   Molecular Systems Biology

Frequent pathway mutations of splicing machinery in myelodysplasia

(2011) Kenichi Yoshida et al.   NATURE

Mapping of signaling networks through synthetic genetic interaction analysis by RNAi

(2011) Thomas Horn et al.   NATURE METHODS

SomaticSF3B1Mutation in Myelodysplasia with Ring Sideroblasts

(2011) E. Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

The emerging role of pre-messenger RNA splicing in stress responses: Sending alternative messages and silent messengers

(2011) Martin Dutertre et al.   RNA Biology

A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint

(2011) S. Kondo et al.   Science Signaling

Proteomic and Functional Genomic Landscape of Receptor Tyrosine Kinase and Ras to Extracellular Signal-Regulated Kinase Signaling

(2011) A. A. Friedman et al.   Science Signaling

Large-Scale Discovery of ERK2 Substrates Identifies ERK-Mediated Transcriptional Regulation by ETV3

(2011) S. M. Carlson et al.   Science Signaling

The Exon Junction Complex Controls the Splicing of mapk and Other Long Intron-Containing Transcripts in Drosophila

(2010) Dariel Ashton-Beaucage et al.   CELL

Exon Junction Complex Subunits Are Required to Splice Drosophila MAP Kinase, a Large Heterochromatic Gene

(2010) Jean-Yves Roignant et al.   CELL

Ras nanoclusters: Combining digital and analog signaling

(2010) Angus Harding et al.   CELL CYCLE

Mechanistic principles of RAF kinase signaling

(2010) Christian M. Udell et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Geminin and Brahma act antagonistically to regulate EGFR–Ras–MAPK signaling in Drosophila

(2010) Anabel Herr et al.   DEVELOPMENTAL BIOLOGY

Global impact of RNA polymerase II elongation inhibition on alternative splicing regulation

(2010) J. Y. Ip et al.   GENOME RESEARCH

Combined Functional Genomic and Proteomic Approaches Identify a PP2A Complex as a Negative Regulator of Hippo Signaling

(2010) Paulo S. Ribeiro et al.   MOLECULAR CELL

Cotranscriptional exon skipping in the genotoxic stress response

(2010) Martin Dutertre et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Digital Genome-Wide ncRNA Expression, Including SnoRNAs, across 11 Human Tissues Using PolyA-Neutral Amplification

(2010) John C. Castle et al.   PLoS One

The Many Pathways of RNA Degradation

(2009) Jonathan Houseley et al.   CELL

Mosaic Genetic Screen for Suppressors of the de2f1 Mutant Phenotype in Drosophila

(2009) A. M. Ambrus et al.   GENETICS

Control of Alternative Splicing by Signal-dependent Degradation of Splicing-regulatory Proteins

(2009) Rebeccah J. Katzenberger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global Effects of Kinase Inhibitors on Signaling Networks Revealed by Quantitative Phosphoproteomics

(2009) Cuiping Pan et al.   MOLECULAR & CELLULAR PROTEOMICS

A dimerization-dependent mechanism drives RAF catalytic activation

(2009) Thanashan Rajakulendran et al.   NATURE

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

(2009) David A. Barbie et al.   NATURE

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

(2009) Charles J. David et al.   NATURE

Cellular stress and RNA splicing

(2009) Giuseppe Biamonti et al.   TRENDS IN BIOCHEMICAL SCIENCES

A Quantitative RNAi Screen for JNK Modifiers Identifies Pvr as a Novel Regulator of Drosophila Immune Signaling

(2009) David Bond et al.   PLoS Pathogens

PDGF/VEGF signaling controls cell size in Drosophila

(2009) David Sims et al.   GENOME BIOLOGY

The FLYWCH transcription factors FLH-1, FLH-2, and FLH-3 repress embryonic expression of microRNA genes in C. elegans

(2008) M. C. Ow et al.   GENES & DEVELOPMENT

The PP2C Alphabet Is a Negative Regulator of Stress-Activated Protein Kinase Signaling in Drosophila

(2008) C. Baril et al.   GENETICS

Mob4 plays a role in spindle focusing in Drosophila S2 cells

(2008) M. A. Trammell et al.   JOURNAL OF CELL SCIENCE

A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein

(2008) Marilyn Goudreault et al.   MOLECULAR & CELLULAR PROTEOMICS

The art and design of genetic screens: RNA interference

(2008) Michael Boutros et al.   NATURE REVIEWS GENETICS

Phosphorylation switches the general splicing repressor SRp38 to a sequence-specific activator

(2008) Ying Feng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tissue-specific splicing factor gene expression signatures

(2008) Ana Rita Grosso et al.   NUCLEIC ACIDS RESEARCH

Signal-Regulated Pre-mRNA Occupancy by the General Splicing Factor U2AF

(2008) Anne Tisserant et al.   PLoS One

C. elegans La-related protein, LARP-1, localizes to germline P bodies and attenuates Ras-MAPK signaling during oogenesis

(2008) K. Nykamp et al.   RNA

Definition of global and transcript-specific mRNA export pathways in metazoans

(2007) N. G. Farny et al.   GENES & DEVELOPMENT