Glioblastoma cells vampirize WNT from neurons and trigger a JNK/MMP signaling loop that enhances glioblastoma progression and neurodegeneration

miR-129-5p targets Wnt5a to block PKC/ERK/NF-κB and JNK pathways in glioblastoma

(2018) Ailiang Zeng et al.   Cell Death & Disease

PRL-3 is a potential glioblastoma prognostic marker and promotes glioblastoma progression by enhancing MMP7 through the ERK and JNK pathways

(2018) Nan Mu et al.   Theranostics

The Role of Wnt Signal in Glioblastoma Development and Progression: A Possible New Pharmacological Target for the Therapy of This Tumor

(2018) Mariachiara Zuccarini et al.   Genes

A role for APP in Wnt signalling links synapse loss with β-amyloid production

(2018) Christina Elliott et al.   Translational Psychiatry

Overcoming therapeutic resistance in glioblastoma: the way forward

(2017) Satoru Osuka et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor-related neurocognitive dysfunction in patients with diffuse glioma: a systematic review of neurocognitive functioning prior to anti-tumor treatment

(2017) Emma van Kessel et al.   JOURNAL OF NEURO-ONCOLOGY

Tweety-Homolog 1 Drives Brain Colonization of Gliomas

(2017) Erik Jung et al.   JOURNAL OF NEUROSCIENCE

Cortactin Is a Regulator of Activity-Dependent Synaptic Plasticity Controlled by Wingless

(2017) Daniel Alicea et al.   JOURNAL OF NEUROSCIENCE

Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma

(2017) Humsa S. Venkatesh et al.   NATURE

Identification of diverse astrocyte populations and their malignant analogs

(2017) Chia-Ching John Lin et al.   NATURE NEUROSCIENCE

Tumor microtubes convey resistance to surgical lesions and chemotherapy in gliomas

(2017) Sophie Weil et al.   NEURO-ONCOLOGY

Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome

(2017) Alicia Mansilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bi-specific molecule against EGFR and death receptors simultaneously targets proliferation and death pathways in tumors

(2017) Yanni Zhu et al.   Scientific Reports

Both Drosophila matrix metalloproteinases have released and membrane-tethered forms but have different substrates

(2017) Kimberly S. LaFever et al.   Scientific Reports

Probing the canonicity of the Wnt/Wingless signaling pathway

(2017) Alexandra Franz et al.   PLoS Genetics

Drosophilaenhancer-Gal4 lines show ectopic expression during development

(2017) Sergio Casas-Tintó et al.   Royal Society Open Science

Factors influencing neurocognitive function in patients with neuroepithelial tumors

(2017) Jens Gempt et al.   Scientific Reports

Synaptic pathology: A shared mechanism in neurological disease

(2016) Christopher M. Henstridge et al.   AGEING RESEARCH REVIEWS

JNK Pathway Activation Modulates Acquired Resistance to EGFR/HER2–Targeted Therapies

(2016) Simin Manole et al.   CANCER RESEARCH

Reversal of Synapse Degeneration by Restoring Wnt Signaling in the Adult Hippocampus

(2016) Aude Marzo et al.   CURRENT BIOLOGY

Generating Cellular Diversity and Spatial Form: Wnt Signaling and the Evolution of Multicellular Animals

(2016) Kyle M. Loh et al.   DEVELOPMENTAL CELL

Neurocognitive functioning in patients with glioma of the left and right temporal lobes

(2016) Kyle R. Noll et al.   JOURNAL OF NEURO-ONCOLOGY

Clipping the Wings of Glioblastoma: Modulation of WNT as a Novel Therapeutic Strategy

(2016) Abigail K. Suwala et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The role of the Wnt canonical signaling in neurodegenerative diseases

(2016) Rosaliana Libro et al.   LIFE SCIENCES

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Eiger-induced cell death relies on Rac1-dependent endocytosis

(2016) W Ruan et al.   Cell Death & Disease

LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction

(2016) Jay Penney et al.   Nature Communications

Inhibitor of Nicotinamide Phosphoribosyltransferase Sensitizes Glioblastoma Cells to Temozolomide via Activating ROS/JNK Signaling Pathway

(2016) Jun Feng et al.   Biomed Research International

Cognitive Rehabilitation in Patients with Gliomas and Other Brain Tumors: State of the Art

(2016) E. Bergo et al.   Biomed Research International

Targeting MT1-MMP as an ImmunoPET-Based Strategy for Imaging Gliomas

(2016) A. G. de Lucas et al.   PLoS One

Mechanisms regulating glioma invasion

(2015) Ivy Paw et al.   CANCER LETTERS

Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion

(2015) Humsa S. Venkatesh et al.   CELL

The function of RNA-binding proteins at the synapse: implications for neurodegeneration

(2015) Chantelle F. Sephton et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Neurodegeneration in the Brain Tumor Microenvironment: Glutamate in the Limelight

(2015) Nicolai Savaskan et al.   Current Neuropharmacology

Two classes of matrix metalloproteinases reciprocally regulate synaptogenesis

(2015) Mary Lynn Dear et al.   DEVELOPMENT

Toward an effective strategy in glioblastoma treatment. Part I: resistance mechanisms and strategies to overcome resistance of glioblastoma to temozolomide

(2015) Khaled Messaoudi et al.   DRUG DISCOVERY TODAY

Pharmacologic Wnt Inhibition Reduces Proliferation, Survival, and Clonogenicity of Glioblastoma Cells

(2015) Ulf D. Kahlert et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

WNT signaling in glioblastoma and therapeutic opportunities

(2015) Yeri Lee et al.   LABORATORY INVESTIGATION

The Drosophila TNF receptor Grindelwald couples loss of cell polarity and neoplastic growth

(2015) Ditte S. Andersen et al.   NATURE

Brain tumour cells interconnect to a functional and resistant network

(2015) Matthias Osswald et al.   NATURE

SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma

(2015) Stephanie M. Robert et al.   Science Translational Medicine

How the Wnt signaling pathway protects from neurodegeneration: the mitochondrial scenario

(2015) Macarena S. Arrázola et al.   Frontiers in Cellular Neuroscience

Active JNK-dependent secretion of Drosophila Tyrosyl-tRNA synthetase by loser cells recruits haemocytes during cell competition

(2015) Sergio Casas-Tintó et al.   Nature Communications

Loss of Polo ameliorates APP-induced Alzheimer’s disease-like symptoms in Drosophila

(2015) Fei Peng et al.   Scientific Reports

Cytonemes as specialized signaling filopodia

(2014) T. B. Kornberg et al.   DEVELOPMENT

Synaptic abnormalities in a Drosophila model of Alzheimer's disease

(2014) S. D. Mhatre et al.   Disease Models & Mechanisms

Cell types and coincident synapses in the ellipsoid body ofDrosophila

(2014) Alfonso Martín-Peña et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The guanine-exchange factor Ric8a binds to the Ca2+ sensor NCS-1 to regulate synapse number and neurotransmitter release

(2014) J. Romero-Pozuelo et al.   JOURNAL OF CELL SCIENCE

Can we safely target the WNT pathway?

(2014) Michael Kahn   NATURE REVIEWS DRUG DISCOVERY

Beating the odds: extreme long-term survival with glioblastoma

(2014) W. L. Bi et al.   NEURO-ONCOLOGY

Cytoneme-Mediated Contact-Dependent Transport of the Drosophila Decapentaplegic Signaling Protein

(2014) S. Roy et al.   SCIENCE

Wnt signaling in the nervous system and in Alzheimer's disease

(2014) N. C. Inestrosa et al.   Journal of Molecular Cell Biology

Role of the PI3K/AKT Pathway in Modulating Cytoskeleton Rearrangements and Phenotype Switching in Rat Pulmonary Arterial Vascular Smooth Muscle Cells

(2013) Zhiyu Fan et al.   DNA AND CELL BIOLOGY

Cytonemes extend their reach

(2013) Thomas B Kornberg   EMBO JOURNAL

JNK contributes to temozolomide resistance of stem-like glioblastoma cells via regulation of MGMT expression

(2013) MASASHI OKADA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Neurocognitive deficits following primary brain tumor treatment: systematic review of a decade of comparative studies

(2013) Amanda K. Gehrke et al.   JOURNAL OF NEURO-ONCOLOGY

Patterning and growth control by membrane-tethered Wingless

(2013) Cyrille Alexandre et al.   NATURE

Cytonemes are required for the establishment of a normal Hedgehog morphogen gradient in Drosophila epithelia

(2013) Marcus Bischoff et al.   NATURE CELL BIOLOGY

Bypass Mechanisms of Resistance to Receptor Tyrosine Kinase Inhibition in Lung Cancer

(2013) M. J. Niederst et al.   Science Signaling

Wnts in adult brain: from synaptic plasticity to cognitive deficiencies

(2013) Carolina A. Oliva et al.   Frontiers in Cellular Neuroscience

MMP-9 and uPAR regulated glioma cell migration

(2013) Krishna Kumar Veeravalli et al.   Cell Adhesion & Migration

An Aberrant Transcription Factor Network Essential for Wnt Signaling and Stem Cell Maintenance in Glioblastoma

(2013) Esther Rheinbay et al.   Cell Reports

A Kinome-Wide RNAi Screen in Drosophila Glia Reveals That the RIO Kinases Mediate Cell Proliferation and Survival through TORC2-Akt Signaling in Glioblastoma

(2013) Renee D. Read et al.   PLoS Genetics

raw Functions through JNK signaling and cadherin-based adhesion to regulate Drosophila gonad morphogenesis

(2012) Jennifer C. Jemc et al.   DEVELOPMENTAL BIOLOGY

A Versatile ΦC31 Based Reporter System for Measuring AP-1 and Nrf2 Signaling in Drosophila and in Tissue Culture

(2012) Nirmalya Chatterjee et al.   PLoS One

PI3-K/Akt/JNK/NF-κB is essential for MMP-9 expression and outgrowth in human limbal epithelial cells on intact amniotic membrane

(2012) Ching-Yi Cheng et al.   Stem Cell Research

The  -Catenin Destruction Complex

(2012) J. L. Stamos et al.   Cold Spring Harbor Perspectives in Biology

Targeting JNK for therapeutic depletion of stem-like glioblastoma cells

(2012) Ken-ichiro Matsuda et al.   Scientific Reports

Oncogene AEG-1 Promotes Glioma-Induced Neurodegeneration by Increasing Glutamate Excitotoxicity

(2011) S.-G. Lee et al.   CANCER RESEARCH

Drosophila melanogaster as a model system for human brain cancers

(2011) Renee D. Read   GLIA

Matrix Metalloproteinase (MMP)-9 Induced by Wnt Signaling Increases the Proliferation and Migration of Embryonic Neural Stem Cells at Low O2Levels

(2011) Christopher A. Ingraham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurocognitive function in patients with recurrent glioblastoma treated with bevacizumab

(2011) J. S. Wefel et al.   NEURO-ONCOLOGY

Pertuzumab plus Trastuzumab plus Docetaxel for Metastatic Breast Cancer

(2011) José Baselga et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium

(2011) A. Callejo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt-5a signaling is correlated with infiltrative activity in human glioma by inducing cellular migration and MMP-2

(2010) Masayuki Kamino et al.   CANCER SCIENCE

Wnt/beta-Catenin pathway in human glioma: expression pattern and clinical/prognostic correlations

(2010) Ce Liu et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Inhibition of metalloproteinases derived from tumours: new insights in the treatment of human glioblastoma

(2010) P. Gabelloni et al.   NEUROSCIENCE

Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor

(2010) D Ercan et al.   ONCOGENE

Regulation of expression of matrix metalloproteinase-9 by JNK in Raw 264.7 cells: presence of inhibitory factor(s) suppressing MMP-9 induction in serum and conditioned media

(2009) Yun-Song Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Activation of Wnt/β-catenin/Tcf signaling pathway in human astrocytomas

(2009) Gangadhara Reddy Sareddy et al.   NEUROCHEMISTRY INTERNATIONAL

A Drosophila Model for EGFR-Ras and PI3K-Dependent Human Glioma

(2009) Renee D. Read et al.   PLoS Genetics

GFP Reconstitution Across Synaptic Partners (GRASP) Defines Cell Contacts and Synapses in Living Nervous Systems

(2008) Evan H. Feinberg et al.   NEURON

Functional Wnt Signaling Is Increased in Idiopathic Pulmonary Fibrosis

(2008) Melanie Königshoff et al.   PLoS One