Pro- and antitumor effects of mitochondrial reactive oxygen species

Mitochondrial potassium channels in cell death

(2018) Vanessa Checchetto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

G1P3 (IFI6), a mitochondrial localised antiapoptotic protein, promotes metastatic potential of breast cancer cells through mtROS

(2018) Venugopalan Cheriyath et al.   BRITISH JOURNAL OF CANCER

Mitochondria-targeted antioxidant SkQ1 suppresses fibrosarcoma and rhabdomyosarcoma tumour cell growth

(2018) Ekaterina Titova et al.   CELL CYCLE

Vosaroxin induces mitochondrial dysfunction and apoptosis in cervical cancer HeLa cells: Involvement of AMPK/Sirt3/HIF-1 pathway

(2018) Xian-Li Zhao et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Contradictory effects of mitochondria- and non-mitochondria-targeted antioxidants on hepatocarcinogenesis by altering DNA repair in mice

(2018) Bibo Wang et al.   HEPATOLOGY

Helicobacter pylori infection promotes Aquaporin 3 expression via the ROS–HIF-1α–AQP3–ROS loop in stomach mucosa: a potential novel mechanism for cancer pathogenesis

(2018) Jianfei Wen et al.   ONCOGENE

The Role of Mitochondrial H+-ATP Synthase in Cancer

(2018) Pau B. Esparza-Moltó et al.   Frontiers in Oncology

Mitochondria: promising organelle targets for cancer diagnosis and treatment

(2018) Xiao-Shuang Hou et al.   Biomaterials Science

CQ synergistically sensitizes human colorectal cancer cells to SN-38/CPT-11 through lysosomal and mitochondrial apoptotic pathway via p53-ROS cross-talk

(2017) Pinjia Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of redox balance in cancer and T cells

(2017) Hyewon Kong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria Targeted Protein-Ruthenium Photosensitizer for Efficient Photodynamic Applications

(2017) Sabyasachi Chakrabortty et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Mitochondria-Targeted Cryptocyanine-Based Photothermogenic Photosensitizer

(2017) Hyo Sung Jung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer

(2017) Peter W Stacpoole   JNCI-Journal of the National Cancer Institute

Development of Inhibitors Targeting Hypoxia-Inducible Factor 1 and 2 for Cancer Therapy

(2017) Tianchi Yu et al.   YONSEI MEDICAL JOURNAL

Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells

(2017) Farhan Basit et al.   Cell Death & Disease

Biogenic selenium nanoparticles induce ROS-mediated necroptosis in PC-3 cancer cells through TNF activation

(2017) Praveen Sonkusre et al.   JOURNAL OF NANOBIOTECHNOLOGY

Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer

(2017) Peter W Stacpoole   JNCI-Journal of the National Cancer Institute

Acidosis Drives the Reprogramming of Fatty Acid Metabolism in Cancer Cells through Changes in Mitochondrial and Histone Acetylation

(2016) Cyril Corbet et al.   Cell Metabolism

Production of superoxide/hydrogen peroxide by the mitochondrial 2-oxoadipate dehydrogenase complex

(2016) Renata L.S. Goncalves et al.   FREE RADICAL BIOLOGY AND MEDICINE

A PGC1α-mediated transcriptional axis suppresses melanoma metastasis

(2016) Chi Luo et al.   NATURE

The metabolic co-regulator PGC1α suppresses prostate cancer metastasis

(2016) Veronica Torrano et al.   NATURE CELL BIOLOGY

Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth

(2016) Shira L Cramer et al.   NATURE MEDICINE

The Janus-Faced Role of Antioxidants in Cancer Cachexia: New Insights on the Established Concepts

(2016) Mohamad Assi et al.   Oxidative Medicine and Cellular Longevity

Mitochondria-Targeting Magnetic Composite Nanoparticles for Enhanced Phototherapy of Cancer

(2016) Ranran Guo et al.   Small

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

(2015) An S. Tan et al.   Cell Metabolism

Antioxidant Supplementation on Cancer Risk and During Cancer Therapy: An Update

(2015) Tomris Ozben   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment

(2015) Calvin Justus et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Enhanced NIR Radiation-Triggered Hyperthermia by Mitochondrial Targeting

(2015) Hyo Sung Jung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Is There a Role for Oral or Intravenous Ascorbate (Vitamin C) in Treating Patients With Cancer? A Systematic Review

(2015) C. Jacobs et al.   ONCOLOGIST

Antioxidants can increase melanoma metastasis in mice

(2015) Kristell Le Gal et al.   Science Translational Medicine

Down-regulation of oxidative phosphorylation in the liver by expression of the ATPase inhibitory factor 1 induces a tumor-promoter metabolic state

(2015) Fulvio Santacatterina et al.   Oncotarget

Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy

(2015) Laura Poillet-Perez et al.   Redox Biology

Acidosis promotes invasiveness of breast cancer cells through ROS-AKT-NF-κB pathway

(2015) Subash C. Gupta et al.   Oncotarget

A mutation in the mitochondrial protein UQCRB promotes angiogenesis through the generation of mitochondrial reactive oxygen species

(2014) Junghwa Chang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tumor-stroma metabolic relationship based on lactate shuttle can sustain prostate cancer progression

(2014) Patrizia Sanità et al.   BMC CANCER

Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis

(2014) Nicola Aceto et al.   CELL

The antioxidant paradox: what are antioxidants and how should they be used in a therapeutic context for cancer

(2014) Michael Y Bonner et al.   Future Medicinal Chemistry

The 2-Oxoacid Dehydrogenase Complexes in Mitochondria Can Produce Superoxide/Hydrogen Peroxide at Much Higher Rates Than Complex I

(2014) Casey L. Quinlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

The Promise and Perils of Antioxidants for Cancer Patients

(2014) Navdeep S. Chandel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Acidic priming enhances metastatic potential of cancer cells

(2014) Anne Riemann et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2

(2014) W. De Haes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antioxidants Accelerate Lung Cancer Progression in Mice

(2014) V. I. Sayin et al.   Science Translational Medicine

Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival

(2014) Mireille Khacho et al.   Nature Communications

mtDNA germ line variation mediated ROS generates retrograde signaling and induces pro-cancerous metabolic features

(2014) Rajnish Kumar Singh et al.   Scientific Reports

A Mitochondrial Switch Promotes Tumor Metastasis

(2014) Paolo E. Porporato et al.   Cell Reports

Nox2 as a potential target of mitochondrial superoxide and its role in endothelial oxidative stress

(2013) Rafal R. Nazarewicz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Does Scavenging of Mitochondrial Superoxide Attenuate Cancer Prosurvival Signaling Pathways?

(2013) Rafal R. Nazarewicz et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondria-targeted antioxidants for treatment of Parkinson's disease: Preclinical and clinical outcomes

(2013) Huajun Jin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Anoikis molecular pathways and its role in cancer progression

(2013) Paolo Paoli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mammalian SOD2 is exclusively located in mitochondria and not present in peroxisomes

(2013) Srikanth Karnati et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Superoxide radicals have a protective role during H2O2 stress

(2013) Geoffrey W. Thorpe et al.   MOLECULAR BIOLOGY OF THE CELL

Glucose deprivation increases monocarboxylate transporter 1 (MCT1) expression and MCT1-dependent tumor cell migration

(2013) C J De Saedeleer et al.   ONCOGENE

Suppression of Mitochondrial Complex I Influences Cell Metastatic Properties

(2013) Xuelian He et al.   PLoS One

Prognostic Relevance of Cytochrome c Oxidase in Primary Glioblastoma Multiforme

(2013) Corinne E. Griguer et al.   PLoS One

Ras and Rac1, Frequently Mutated in Melanomas, Are Activated by Superoxide Anion, Modulate Dnmt1 Level and Are Causally Related to Melanocyte Malignant Transformation

(2013) Fernanda Molognoni et al.   PLoS One

The Maintenance of Mitochondrial DNA Integrity--Critical Analysis and Update

(2013) M. Alexeyev et al.   Cold Spring Harbor Perspectives in Biology

Manganese superoxide dismutase promotes anoikis resistance and tumor metastasis

(2013) S Kamarajugadda et al.   Cell Death & Disease

Necroptosis modulated by autophagy is a predominant form of melanoma cell death induced by sanguilutine

(2012) Jindřiška Hammerová et al.   BIOLOGICAL CHEMISTRY

Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay

(2012) T. Fiaschi et al.   CANCER RESEARCH

A PGC-1α Isoform Induced by Resistance Training Regulates Skeletal Muscle Hypertrophy

(2012) Jorge L. Ruas et al.   CELL

Impaired Insulin/IGF1 Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS Signal

(2012) Kim Zarse et al.   Cell Metabolism

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity

(2012) Norma Masson et al.   EMBO REPORTS

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death

(2012) Nicholas A Graham et al.   Molecular Systems Biology

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

(2012) Oliver D. K. Maddocks et al.   NATURE

Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia

(2012) Wan Zhang et al.   NATURE CELL BIOLOGY

The diverse role of the PPARγ coactivator 1 family of transcriptional coactivators in cancer

(2012) Geoffrey D. Girnun   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Epigenetic changes induced by oxidative stress in colorectal cancer cells: methylation of tumor suppressor RUNX3

(2012) Kyoung Ah Kang et al.   TUMOR BIOLOGY

A Mutation Threshold Distinguishes the Antitumorigenic Effects of the Mitochondrial Gene MTND1, an Oncojanus Function

(2011) G. Gasparre et al.   CANCER RESEARCH

Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways

(2011) Nadine Rohwer et al.   DRUG RESISTANCE UPDATES

HIF-1α stabilization by mitochondrial ROS promotes Met-dependent invasive growth and vasculogenic mimicry in melanoma cells

(2011) Giuseppina Comito et al.   FREE RADICAL BIOLOGY AND MEDICINE

Vitamin E and the Risk of Prostate Cancer

(2011) Eric A. Klein et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Acquisition of Chemoresistance in Gliomas Is Associated with Increased Mitochondrial Coupling and Decreased ROS Production

(2011) Claudia R. Oliva et al.   PLoS One

Mitochondrial Haplogroups, Control Region Polymorphisms and Malignant Melanoma: A Study in Middle European Caucasians

(2011) Sabine Ebner et al.   PLoS One

Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress

(2011) A. T. Shaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

(2011) D. Anastasiou et al.   SCIENCE

ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy

(2010) Michael Dewaele et al.   Autophagy

Learning from oncocytic tumors: Why choose inefficient mitochondria?

(2010) Giuseppe Gasparre et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

(2010) Anna E. Dikalova et al.   CIRCULATION RESEARCH

Mitochondrial potassium channels and reactive oxygen species

(2010) Dominika Malinska et al.   FEBS LETTERS

Acquisition of Temozolomide Chemoresistance in Gliomas Leads to Remodeling of Mitochondrial Electron Transport Chain

(2010) Claudia R. Oliva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolomic Changes Accompanying Transformation and Acquisition of Metastatic Potential in a Syngeneic Mouse Mammary Tumor Model

(2010) Xin Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular Metabolic Stress: Considering How Cells Respond to Nutrient Excess

(2010) Kathryn E. Wellen et al.   MOLECULAR CELL

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Glutathione, a Key Survival Antioxidant

(2009) Montserrat Marí et al.   ANTIOXIDANTS & REDOX SIGNALING

Extracellular redox status regulates Nrf2 activation through mitochondrial reactive oxygen species

(2009) Barry R. Imhoff et al.   BIOCHEMICAL JOURNAL

Anti- and pro-tumor functions of autophagy

(2009) Eugenia Morselli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Mitochondrial Cytochrome B Gene Mutation Promotes Tumor Growth in Bladder Cancer

(2008) S. Dasgupta et al.   CANCER RESEARCH

Loss of Complex I due to Mitochondrial DNA Mutations in Renal Oncocytoma

(2008) J. A. Mayr et al.   CLINICAL CANCER RESEARCH

Enhanced glycolysis induced by mtDNA mutations does not regulate metastasis

(2008) Kaori Ishikawa et al.   FEBS LETTERS

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Should Supplemental Antioxidant Administration Be Avoided During Chemotherapy and Radiation Therapy?

(2008) B. D. Lawenda et al.   JNCI-Journal of the National Cancer Institute

Mitochondrial DNA mutation stimulates prostate cancer growth in bone stromal environment

(2008) Rebecca S. Arnold et al.   PROSTATE

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE