β-Cell-targeted blockage of PD1 and CTLA4 pathways prevents development of autoimmune diabetes and acute allogeneic islets rejection

Beta cell regeneration after single-round immunological destruction in a mouse model

(2014) Jason M. Tonne et al.   DIABETOLOGIA

M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7

(2014) Xiangwei Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Concise Review: Pluripotent Stem Cell-Based Regenerative Applications for Failingβ-Cell Function

(2014) Sara J. Holditch et al.   Stem Cells Translational Medicine

Death and Dysfunction of Transplanted  -Cells: Lessons Learned From Type 2 Diabetes?

(2013) K. J. Potter et al.   DIABETES

Costimulation Modulation With Abatacept in Patients With Recent-Onset Type 1 Diabetes: Follow-up 1 Year After Cessation of Treatment

(2013) Tihamer Orban et al.   DIABETES CARE

Global gene expression profiling of pancreatic islets in mice during streptozotocin-induced  -cell damage and pancreatic Glp-1 gene therapy

(2013) J. M. Tonne et al.   Disease Models & Mechanisms

Recent Lessons Learned From Prevention and Recent-Onset Type 1 Diabetes Immunotherapy Trials

(2012) Teodora P. Staeva et al.   DIABETES

Improvement in Outcomes of Clinical Islet Transplantation: 1999-2010

(2012) F. B. Barton et al.   DIABETES CARE

Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial

(2011) Nicole Sherry et al.   LANCET

Type 1 Diabetes: Etiology, Immunology, and Therapeutic Strategies

(2011) Tom L. Van Belle et al.   PHYSIOLOGICAL REVIEWS

Unique Cellular and Mitochondrial Defects Mediate FK506-Induced Islet β-Cell Dysfunction

(2011) Nassir Rostambeigi et al.   TRANSPLANTATION

The pattern of inflammatory/anti-inflammatory cytokines and chemokines in type 1 diabetic patients over time

(2010) Antonios Chatzigeorgiou et al.   ANNALS OF MEDICINE

Genetics, pathogenesis and clinical interventions in type 1 diabetes

(2010) Jeffrey A. Bluestone et al.   NATURE

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

(2010) M. A. Curran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal

(2009) Brian T Fife et al.   NATURE IMMUNOLOGY

Prolonged Insulin Independence After Islet Allotransplants in Recipients with Type 1 Diabetes

(2008) M. D. Bellin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The pros and cons of immunomodulatory IL-10 gene therapy with recombinant AAV in a Cftr−/−-dependent allergy mouse model

(2008) C Mueller et al.   GENE THERAPY