Insulin secretion from beta cells within intact islets: Location matters

The secretory deficit in islets from db/db mice is mainly due to a loss of responding beta cells

(2014) Oanh H. Do et al.   DIABETOLOGIA

Insulin secretion from beta cells in intact mouse islets is targeted towards the vasculature

(2014) Jiun T. Low et al.   DIABETOLOGIA

New insights into the role of connexins in pancreatic islet function and diabetes

(2014) Nikki L. Farnsworth et al.   FEBS LETTERS

Glucose principally regulates insulin secretion in mouse islets by controlling the numbers of granule fusion events per cell

(2013) Jiun T. Low et al.   DIABETOLOGIA

Altered Pancreatic Islet Function and Morphology in Mice Lacking the Beta-Cell Surface Protein Neuroligin-2

(2013) Charles Zhang et al.   PLoS One

Is Dynamic Autocrine Insulin Signaling Possible? A Mathematical Model Predicts Picomolar Concentrations of Extracellular Monomeric Insulin within Human Pancreatic Islets

(2013) Minghu Wang et al.   PLoS One

Diabetes Mellitus and the β Cell: The Last Ten Years

(2012) Frances M. Ashcroft et al.   CELL

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

The Presynaptic Active Zone

(2012) Thomas C. Südhof   NEURON

Donor Islet Endothelial Cells in Pancreatic Islet Revascularization

(2011) D. Nyqvist et al.   DIABETES

Multivesicular exocytosis in rat pancreatic beta cells

(2011) M. B. Hoppa et al.   DIABETOLOGIA

Vesicle-associated Membrane Protein 8 (VAMP8) Is a SNARE (SolubleN-Ethylmaleimide-sensitive Factor Attachment Protein Receptor) Selectively Required for Sequential Granule-to-granule Fusion

(2011) Natasha Behrendorff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamics of insulin secretion and the clinical implications for obesity and diabetes

(2011) Susumu Seino et al.   JOURNAL OF CLINICAL INVESTIGATION

Gap junctions and other mechanisms of cell-cell communication regulate basal insulin secretion in the pancreatic islet

(2011) R. K. P. Benninger et al.   JOURNAL OF PHYSIOLOGY-LONDON

Type 2 diabetes across generations: from pathophysiology to prevention and management

(2011) Christopher J Nolan et al.   LANCET

Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells

(2011) Colin A. Leech et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Rim2α Determines Docking and Priming States in Insulin Granule Exocytosis

(2010) Takao Yasuda et al.   Cell Metabolism

Class IA Phosphatidylinositol 3-Kinase in Pancreatic β Cells Controls Insulin Secretion by Multiple Mechanisms

(2010) Kazuma Kaneko et al.   Cell Metabolism

Chronic Palmitate Exposure Inhibits Insulin Secretion by Dissociation of Ca2+ Channels from Secretory Granules

(2009) Michael B. Hoppa et al.   Cell Metabolism

Segmentation of the Pathophysiological Stages of Diabetic Changes in the db/db Mouse

(2009) Masaki Yamazaki et al.   Journal of Toxicologic Pathology

Gap Junction Coupling and Calcium Waves in the Pancreatic Islet

(2008) Richard K.P. Benninger et al.   BIOPHYSICAL JOURNAL

Somatostatin Secreted by Islet  -Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function

(2008) A. C. Hauge-Evans et al.   DIABETES

Real-time, multidimensional in vivo imaging used to investigate blood flow in mouse pancreatic islets

(2008) Lara R. Nyman et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuroligins and neurexins link synaptic function to cognitive disease

(2008) Thomas C. Südhof   NATURE