Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair

Safety and efficacy of eculizumab in the prevention of antibody‐mediated rejection in living‐donor kidney transplant recipients requiring desensitization therapy: a randomized trial

(2019) William H. Marks et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Safety and efficacy of eculizumab for the prevention of antibody‐mediated rejection after deceased‐donor kidney transplantation in patients with preformed donor‐specific antibodies

(2019) Denis Glotz et al.   AMERICAN JOURNAL OF TRANSPLANTATION

DNL 104, a Centrally Penetrant RIPK 1 Inhibitor, Inhibits RIP 1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers

(2019) Hendrika W. Grievink et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Peritransplant eculizumab does not prevent delayed graft function in deceased donor kidney transplant recipients: Results of two randomized controlled pilot trials

(2019) Bernd Schröppel et al.   AMERICAN JOURNAL OF TRANSPLANTATION

A phase I/II, double-blind, placebo-controlled study assessing safety and efficacy of C1 esterase inhibitor for prevention of delayed graft function in deceased donor kidney transplant recipients

(2018) Stanley C. Jordan et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Mitochondrial mechanisms and therapeutics in ischaemia reperfusion injury

(2018) Jack L. Martin et al.   PEDIATRIC NEPHROLOGY

Caspase inhibition during cold storage improves graft function and histology in a murine kidney transplant model

(2018) Trevor L. Nydam et al.   TRANSPLANTATION

The therapeutic potential of targeting the endothelial-to-mesenchymal transition

(2018) Shirley Man et al.   ANGIOGENESIS

Transcriptional modulation of the T helper 17/interleukin 17 axis ameliorates renal ischemia-reperfusion injury

(2018) Jae Wook Lee et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Role of endothelial-to-mesenchymal transition induced by TGF-β1 in transplant kidney interstitial fibrosis

(2017) Zijie Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Complement Recognition Pathways in Renal Transplantation

(2017) Christopher L. Nauser et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mitochondria-targeted antioxidant MitoQ reduced renal damage caused by ischemia-reperfusion injury in rodent kidneys: Longitudinal observations of T2 -weighted imaging and dynamic contrast-enhanced MRI

(2017) Xiaoge Liu et al.   MAGNETIC RESONANCE IN MEDICINE

Complement in clinical medicine: Clinical trials, case reports and therapy monitoring

(2017) Daniel Ricklin et al.   MOLECULAR IMMUNOLOGY

Activated Renal Dendritic Cells Cross Present Intrarenal Antigens After Ischemia-Reperfusion Injury

(2017) Sarah L. Snelgrove et al.   TRANSPLANTATION

Hypoxia-Inducible Factor-1α Expression in Kidney Transplant Biopsy Specimens After Reperfusion Is Associated With Early Recovery of Graft Function After Cadaveric Kidney Transplantation

(2017) T. Oda et al.   TRANSPLANTATION PROCEEDINGS

A double-blind randomised controlled investigation into the efficacy of Mirococept (APT070) for preventing ischaemia reperfusion injury in the kidney allograft (EMPIRIKAL): study protocol for a randomised controlled trial

(2017) Theodoros Kassimatis et al.   Trials

Plasma-Derived C1 Esterase Inhibitor for Acute Antibody-Mediated Rejection Following Kidney Transplantation: Results of a Randomized Double-Blind Placebo-Controlled Pilot Study

(2016) R. A. Montgomery et al.   AMERICAN JOURNAL OF TRANSPLANTATION

A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury

(2016) Edward T. Chouchani et al.   Cell Metabolism

A journey through the lectin pathway of complement-MBL and beyond

(2016) Peter Garred et al.   IMMUNOLOGICAL REVIEWS

Collectin-11 detects stress-induced L-fucose pattern to trigger renal epithelial injury

(2016) Conrad A. Farrar et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulatory T cells in kidney disease and transplantation

(2016) Min Hu et al.   KIDNEY INTERNATIONAL

Nonapoptotic cell death in acute kidney injury and transplantation

(2016) Andreas Linkermann   KIDNEY INTERNATIONAL

Protection of mitochondria prevents high-fat diet–induced glomerulopathy and proximal tubular injury

(2016) Hazel H. Szeto et al.   KIDNEY INTERNATIONAL

Autophagy in acute kidney injury

(2016) Gur P. Kaushal et al.   KIDNEY INTERNATIONAL

Depression of Complement Regulatory Factors in Rat and Human Renal Grafts Is Associated with the Progress of Acute T-Cell Mediated Rejection

(2016) Kazuaki Yamanaka et al.   PLoS One

An Overview of Pathways of Regulated Necrosis in Acute Kidney Injury

(2016) Jesper Kers et al.   SEMINARS IN NEPHROLOGY

Targeting Cell Death Pathways for Therapeutic Intervention in Kidney Diseases

(2016) Jay P. Garg et al.   SEMINARS IN NEPHROLOGY

Pharmacological inhibition of MyD88 homodimerization counteracts renal ischemia reperfusion-induced progressive renal injury in vivo and in vitro

(2016) Li-Min Zhang et al.   Scientific Reports

DAMPs activating innate immune responses in sepsis

(2015) Jung-Woo Kang et al.   AGEING RESEARCH REVIEWS

Autophagy and the Kidney: Implications for Ischemia-Reperfusion Injury and Therapy

(2015) Jean-Paul Decuypere et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

The role of the autophagy in myocardial ischemia/reperfusion injury

(2015) Sai Ma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Succinate dehydrogenase inhibition with malonate during reperfusion reduces infarct size by preventing mitochondrial permeability transition

(2015) Laura Valls-Lacalle et al.   CARDIOVASCULAR RESEARCH

The mitochondria-targeted anti-oxidant MitoQ decreases ischemia-reperfusion injury in a murine syngeneic heart transplant model

(2015) Anna J. Dare et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Hypoxia-Inducible Factor-2  Limits Natural Killer T Cell Cytotoxicity in Renal Ischemia/Reperfusion Injury

(2015) J. Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Dendritic Cells in Kidney Transplant Biopsy Samples Are Associated with T Cell Infiltration and Poor Allograft Survival

(2015) I. Batal et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Central Role of CD45RA- Foxp3hi Memory Regulatory T Cells in Clinical Kidney Transplantation Tolerance

(2015) F. Braza et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Worldwide access to treatment for end-stage kidney disease: a systematic review

(2015) Thaminda Liyanage et al.   LANCET

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Complement membrane attack complexes activate noncanonical NF-κB by forming an Akt+NIK+signalosome on Rab5+endosomes

(2015) Dan Jane-wit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protection against renal ischemia–reperfusion injury in vivo by the mitochondria targeted antioxidant MitoQ

(2015) Anna J. Dare et al.   Redox Biology

Autophagy in Renal Ischemia-Reperfusion Injury: Friend or Foe?

(2014) J. P. Decuypere et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Autophagy delays apoptosis in renal tubular epithelial cells in cisplatin cytotoxicity

(2014) Gur P. Kaushal et al.   Autophagy

The enhancer and promoter landscape of human regulatory and conventional T-cell subpopulations

(2014) C. Schmidl et al.   BLOOD

Mannan-binding lectin-associated serine protease 2 is critical for the development of renal ischemia reperfusion injury and mediates tissue injury in the absence of complement C4

(2014) Elham Asgari et al.   FASEB JOURNAL

Complement-dependent NADPH oxidase enzyme activation in renal ischemia/reperfusion injury

(2014) S. Simone et al.   FREE RADICAL BIOLOGY AND MEDICINE

Induction of transplantation tolerance through regulatory cells: from mice to men

(2014) Ivana R. Ferrer et al.   IMMUNOLOGICAL REVIEWS

Harnessing FOXP3+ regulatory T cells for transplantation tolerance

(2014) Herman Waldmann et al.   JOURNAL OF CLINICAL INVESTIGATION

WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

(2014) Hannah C. Dooley et al.   MOLECULAR CELL

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Mesenchymal stromal cell therapy in conditions of renal ischaemia/reperfusion

(2014) P. Erpicum et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Endothelial-to-mesenchymal transition and renal fibrosis in ischaemia/reperfusion injury are mediated by complement anaphylatoxins and Akt pathway

(2014) C. Curci et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Proximal Tubule Epithelial Cell Specific Ablation of the Spermidine/Spermine N1-Acetyltransferase Gene Reduces the Severity of Renal Ischemia/Reperfusion Injury

(2014) Kamyar Zahedi et al.   PLoS One

Innate and adaptive immune responses subsequent to ischemia-reperfusion injury in the kidney

(2014) C. Denecke et al.   PROGRES EN UROLOGIE

mTOR and autophagy: A dynamic relationship governed by nutrients and energy

(2014) E.A. Dunlop et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mechanisms and Consequences of Injury and Repair in Older Organ Transplants

(2014) Bendix R. Slegtenhorst et al.   TRANSPLANTATION

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

Necroptosis in Solid Organ Transplantation: A Missing Link to Immune Activation?

(2013) R. B. Mannon   AMERICAN JOURNAL OF TRANSPLANTATION

Xenon Treatment Protects Against Cold Ischemia Associated Delayed Graft Function and Prolongs Graft Survival in Rats

(2013) H. Zhao et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Donor Simvastatin Treatment Prevents Ischemia-Reperfusion and Acute Kidney Injury by Preserving Microvascular Barrier Function

(2013) R. Tuuminen et al.   AMERICAN JOURNAL OF TRANSPLANTATION

RIPK3-Mediated Necroptosis Promotes Donor Kidney Inflammatory Injury and Reduces Allograft Survival

(2013) A. Lau et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Necroptosis in Immunity and Ischemia-Reperfusion Injury

(2013) A. Linkermann et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Autophagy regulation by nutrient signaling

(2013) Ryan C Russell et al.   CELL RESEARCH

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Alloantibody and Complement Promote T Cell–Mediated Cardiac Allograft Vasculopathy Through Noncanonical Nuclear Factor-κB Signaling in Endothelial Cells

(2013) Dan Jane-wit et al.   CIRCULATION

Randomized, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I, Healthy Subjects Study of Intravenous OPN-305, a Humanized Anti-TLR2 Antibody

(2013) M Reilly et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Acute kidney injury in kidney transplantation

(2013) James E. Cooper et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

A novel strategy for preserving renal grafts in an ex vivo setting: potential for enhancing the marginal donor pool

(2013) Hailin Zhao et al.   FASEB JOURNAL

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

The autophagosome: origins unknown, biogenesis complex

(2013) Christopher A. Lamb et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ischaemia-reperfusion injury: a major protagonist in kidney transplantation

(2013) C. Ponticelli   NEPHROLOGY DIALYSIS TRANSPLANTATION

The Innate Immune System and Transplantation

(2013) C. A. Farrar et al.   Cold Spring Harbor Perspectives in Medicine

Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells

(2012) T. Duhen et al.   BLOOD

Mechanisms of Autophagosome Biogenesis

(2012) David C. Rubinsztein et al.   CURRENT BIOLOGY

Structure and function of collectin liver 1 (CL-L1) and collectin 11 (CL-11, CL-K1)

(2012) Lana Selman et al.   IMMUNOBIOLOGY

Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function

(2012) Eóin N. McNamee et al.   IMMUNOLOGIC RESEARCH

Inhibition of Autophagy Rescues Palmitic Acid-induced Necroptosis of Endothelial Cells

(2012) Muhammad Jadoon Khan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Collectin-11/MASP Complex Formation Triggers Activation of the Lectin Complement Pathway - The Fifth Lectin Pathway Initiation Complex

(2012) Ying Jie Ma et al.   Journal of Innate Immunity

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease

(2012) Helena Erlandsson Harris et al.   Nature Reviews Rheumatology

Toll-Like Receptor 4 in Experimental Kidney Transplantation: Early Mediator of Endogenous Danger Signals

(2012) Tobias Bergler et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Necrostatin-1 Suppresses Autophagy and Apoptosis in Mice Traumatic Brain Injury Model

(2012) Yao-Qi Wang et al.   NEUROCHEMICAL RESEARCH

Hypoxia Inducible Factor 1-Alpha (HIF-1 Alpha) Is Induced during Reperfusion after Renal Ischemia and Is Critical for Proximal Tubule Cell Survival

(2012) Elisa Conde et al.   PLoS One

Mitochondrial pharmacology

(2012) Robin A.J. Smith et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Crosstalk between Complement and Toll-like Receptor Activation in Relation to Donor Brain Death and Renal Ischemia-Reperfusion Injury

(2011) Jeffrey Damman et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Terminal Complement Inhibition Decreases Antibody-Mediated Rejection in Sensitized Renal Transplant Recipients

(2011) M. D. Stegall et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8

(2011) M A Laussmann et al.   CELL DEATH AND DIFFERENTIATION

Cellular pathophysiology of ischemic acute kidney injury

(2011) Joseph V. Bonventre et al.   JOURNAL OF CLINICAL INVESTIGATION

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Cellular and molecular mechanisms of renal fibrosis

(2011) Youhua Liu   Nature Reviews Nephrology

The protective effect of prolyl-hydroxylase inhibition against renal ischaemia requires application prior to ischaemia but is superior to EPO treatment

(2011) Z. Wang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

(2011) Dmitri V. Krysko et al.   TRENDS IN IMMUNOLOGY

Endothelial progenitor cells give rise to pro-angiogenic smooth muscle-like progeny

(2010) Jan-Renier A.J. Moonen et al.   CARDIOVASCULAR RESEARCH

Heat shock protein gp96 and NAD(P)H oxidase 4 play key roles in Toll-like receptor 4-activated apoptosis during renal ischemia/reperfusion injury

(2010) S Ben Mkaddem et al.   CELL DEATH AND DIFFERENTIATION

The role of the Atg1/ULK1 complex in autophagy regulation

(2010) Noboru Mizushima   CURRENT OPINION IN CELL BIOLOGY

The role of PI3P phosphatases in the regulation of autophagy

(2010) Isabelle Vergne et al.   FEBS LETTERS

Toll-like receptor 4 regulates early endothelial activation during ischemic acute kidney injury

(2010) Jianlin Chen et al.   KIDNEY INTERNATIONAL

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Effector T cell plasticity: flexibility in the face of changing circumstances

(2010) Kenneth M Murphy et al.   NATURE IMMUNOLOGY

Is Autophagy in Response to Ischemia and Reperfusion Protective or Detrimental for the Heart?

(2010) Sebastiano Sciarretta et al.   PEDIATRIC CARDIOLOGY

Toll-like receptors 2 and 4 in renal ischemia/reperfusion injury

(2010) Krisztina Rusai et al.   PEDIATRIC NEPHROLOGY

T helper 1, 2 and 17 cell subsets in renal transplant patients with delayed graft function

(2010) Antonia Loverre et al.   TRANSPLANT INTERNATIONAL

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signaling

(2009) S. Wang et al.   Disease Models & Mechanisms

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

(2009) Makoto Miyara et al.   IMMUNITY

HIF in Kidney Disease and Development

(2009) L. Gunaratnam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

siRNA Targeted to p53 Attenuates Ischemic and Cisplatin-Induced Acute Kidney Injury

(2009) B. A. Molitoris et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Regulatory T Cells Suppress Innate Immunity in Kidney Ischemia-Reperfusion Injury

(2009) G. R. Kinsey et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cell Death

(2009) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Role of Toll-Like Receptor 2 in Inflammation and Fibrosis during Progressive Renal Injury

(2009) Jaklien C. Leemans et al.   PLoS One

Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model

(2009) W. M. Bernhardt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation

(2009) B. Kruger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-Like Receptor 2 and Renal Allograft Function

(2008) Kirsten de Groot et al.   AMERICAN JOURNAL OF NEPHROLOGY

The Use of Antibody to Complement Protein C5 for Salvage Treatment of Severe Antibody-Mediated Rejection

(2008) J. E. Locke et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Autophagy: Basic Principles and Relevance to Disease

(2008) Mondira Kundu et al.   Annual Review of Pathology-Mechanisms of Disease

The role of endothelial-to-mesenchymal transition in cancer progression

(2008) S Potenta et al.   BRITISH JOURNAL OF CANCER

The non-haematopoietic biological effects of erythropoietin

(2008) Murat O. Arcasoy   BRITISH JOURNAL OF HAEMATOLOGY

The innate immune response in ischemic acute kidney injury

(2008) Hye Ryoun Jang et al.   CLINICAL IMMUNOLOGY

A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy

(2008) Xueli Yuan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism

(2008) E. Y. W. Chan et al.   MOLECULAR AND CELLULAR BIOLOGY

Biological activities of C1 inhibitor

(2008) Alvin E. Davis et al.   MOLECULAR IMMUNOLOGY

Unknown

(2008) Matthieu Legrand et al.   MOLECULAR MEDICINE

Association between delayed graft function and allograft and patient survival: a systematic review and meta-analysis

(2008) S. G. Yarlagadda et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells

(2008) B. D. Bell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA