The therapeutic potential of targeting the endothelial-to-mesenchymal transition

Celastrol protects TGF-β1-induced endothelial-mesenchymal transition

(2017) Fei Gong et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Beyond organoids: In vitro vasculogenesis and angiogenesis using cells from mammals and zebrafish

(2017) Muhammad Ibrahim et al.   REPRODUCTIVE TOXICOLOGY

Organoid-based epithelial to mesenchymal transition (OEMT) model: from an intestinal fibrosis perspective

(2017) Soojung Hahn et al.   Scientific Reports

Cinacalcet ameliorates aortic calcification in uremic rats via suppression of endothelial-to-mesenchymal transition

(2016) Min wu et al.   ACTA PHARMACOLOGICA SINICA

Matrix metalloproteinase 9 induces endothelial-mesenchymal transition via Notch activation in human kidney glomerular endothelial cells

(2016) Ye Zhao et al.   BMC CELL BIOLOGY

HSPB1 Inhibits the Endothelial-to-Mesenchymal Transition to Suppress Pulmonary Fibrosis and Lung Tumorigenesis

(2016) S.-H. Choi et al.   CANCER RESEARCH

The role of PDGF-B/TGF-β1/neprilysin network in regulating endothelial-to-mesenchymal transition in pulmonary artery remodeling

(2016) Shasha Song et al.   CELLULAR SIGNALLING

FGF2 inhibits endothelial–mesenchymal transition through microRNA-20a-mediated repression of canonical TGF-β signaling

(2016) Ana C. P. Correia et al.   JOURNAL OF CELL SCIENCE

In Brief: Endothelial-to-mesenchymal transition

(2016) Gonzalo Sanchez-Duffhues et al.   JOURNAL OF PATHOLOGY

Hydrogen sulfide suppresses endoplasmic reticulum stress-induced endothelial-to-mesenchymal transition through Src pathway

(2016) Ru Ying et al.   LIFE SCIENCES

Triazole RGD antagonist reverts TGFβ1-induced endothelial-to-mesenchymal transition in endothelial precursor cells

(2016) Francesca Bianchini et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Tumour cell-derived WNT5B modulates in vitro lymphangiogenesis via induction of partial endothelial-mesenchymal transition of lymphatic endothelial cells

(2016) S-H Wang et al.   ONCOGENE

Endothelial-Mesenchymal Transition in Vascular Calcification of Ins2Akita/+ Mice

(2016) Pierre J. Guihard et al.   PLoS One

Notch hyper-activation drives trans-differentiation of hESC-derived endothelium

(2016) David Reichman et al.   Stem Cell Research

Netrin-1 attenuates the progression of renal dysfunction by blocking endothelial-to-mesenchymal transition in the 5/6 nephrectomy rat model

(2016) Jiuxu Bai et al.   BMC Nephrology

Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability

(2016) Solene M. Evrard et al.   Nature Communications

MiR-630 Inhibits Endothelial-Mesenchymal Transition by Targeting Slug in Traumatic Heterotopic Ossification

(2016) Yangbai Sun et al.   Scientific Reports

Blocking protein phosphatase 2A signaling prevents endothelial-to-mesenchymal transition and renal fibrosis: a peptide-based drug therapy

(2016) Yuanjun Deng et al.   Scientific Reports

Endothelial Plasticity: Shifting Phenotypes through Force Feedback

(2016) Guido Krenning et al.   Stem Cells International

Endothelial-Mesenchymal Transition in Regenerative Medicine

(2016) Damian Medici   Stem Cells International

Endothelial to Mesenchymal Transition (EndoMT) in the Pathogenesis of Human Fibrotic Diseases

(2016) Sonsoles Piera-Velazquez et al.   Journal of Clinical Medicine

Stimulation of Transforming Growth Factor-β1-Induced Endothelial-To-Mesenchymal Transition and Tissue Fibrosis by Endothelin-1 (ET-1): A Novel Profibrotic Effect of ET-1

(2016) Peter J. Wermuth et al.   PLoS One

Local and Circulating Endothelial Cells Undergo Endothelial to Mesenchymal Transition (EndMT) in Response to Musculoskeletal Injury

(2016) Shailesh Agarwal et al.   Scientific Reports

Inhibition of Matrix Metalloproteinase Activity Reverses Corneal Endothelial-Mesenchymal Transition

(2015) Wei-Ting Ho et al.   AMERICAN JOURNAL OF PATHOLOGY

MicroRNA signature of inflamed lymphatic endothelium and role of miR-9 in lymphangiogenesis and inflammation

(2015) Sanjukta Chakraborty et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

High-Density Lipoproteins Reduce Endothelial-to-Mesenchymal TransitionSignificance

(2015) Frank Spillmann et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Valvular interstitial cells suppress calcification of valvular endothelial cells

(2015) Jesper Hjortnaes et al.   ATHEROSCLEROSIS

Endothelial-to-mesenchymal transition contributes to fibro-proliferative vascular disease and is modulated by fluid shear stress

(2015) Jan-Renier A.J. Moonen et al.   CARDIOVASCULAR RESEARCH

Protective Effect of Spironolactone on Endothelial-to-Mesenchymal Transition in HUVECs via Notch Pathway

(2015) Xiao Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

MiR-125b is Critical for Fibroblast-to-Myofibroblast Transition and Cardiac Fibrosis

(2015) Varun Nagpal et al.   CIRCULATION

Endothelial-to-Mesenchymal Transition in Pulmonary Hypertension

(2015) B. Ranchoux et al.   CIRCULATION

Serine Protease Activation Essential for Endothelial–Mesenchymal Transition in Vascular CalcificationNovelty and Significance

(2015) Jiayi Yao et al.   CIRCULATION RESEARCH

A Hypoxia-Induced Vascular Endothelial-to-Mesenchymal Transition in Development of Radiation-Induced Pulmonary Fibrosis

(2015) S.-H. Choi et al.   CLINICAL CANCER RESEARCH

MiR-23b and miR-199a impair epithelial-to-mesenchymal transition during atrioventricular endocardial cushion formation

(2015) Fernando Bonet et al.   DEVELOPMENTAL DYNAMICS

Kallistatin inhibits TGF-β-induced endothelial–mesenchymal transition by differential regulation of microRNA-21 and eNOS expression

(2015) Youming Guo et al.   EXPERIMENTAL CELL RESEARCH

MicroRNA-31 is a positive modulator of endothelial-mesenchymal transition and associated secretory phenotype induced by TGF-β

(2015) Akihiro Katsura et al.   GENES TO CELLS

Snail Is a Direct Target of Hypoxia-inducible Factor 1α (HIF1α) in Hypoxia-induced Endothelial to Mesenchymal Transition of Human Coronary Endothelial Cells

(2015) Xingbo Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial-to-mesenchymal transition drives atherosclerosis progression

(2015) Pei-Yu Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Confocal Imaging–Guided Laser Ablation of Basal Cell Carcinomas: An Ex Vivo Study

(2015) Heidy Sierra et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Endothelial-mesenchymal Transition in Systemic Sclerosis Is Induced by Endothelin-1 and Transforming Growth Factor-  and May Be Blocked by Macitentan, a Dual Endothelin-1 Receptor Antagonist

(2015) P. Cipriani et al.   JOURNAL OF RHEUMATOLOGY

Interactions of DPP-4 and integrin β1 influences endothelial-to-mesenchymal transition

(2015) Sen Shi et al.   KIDNEY INTERNATIONAL

Fibulin-1 suppresses endothelial to mesenchymal transition in the proximal outflow tract

(2015) Keerthi Harikrishnan et al.   MECHANISMS OF DEVELOPMENT

C3a and C5a receptor antagonists ameliorate endothelial-myofibroblast transition via the Wnt/β-catenin signaling pathway in diabetic kidney disease

(2015) Ling Li et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

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(2015) Fei Yan et al.   MOLECULAR MEDICINE

Sulindac metabolites decrease cerebrovascular malformations inCCM3-knockout mice

(2015) Luca Bravi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Environmental Influences on Endothelial to Mesenchymal Transition in Developing Implanted Cardiovascular Tissue-Engineered Grafts

(2015) Dimitri E.P. Muylaert et al.   TISSUE ENGINEERING PART B-REVIEWS

Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradation

(2015) G Grassi et al.   Cell Death & Disease

Relaxin inhibits cardiac fibrosis and endothelial–mesenchymal transition via the Notch pathway

(2015) Xi Zhou et al.   Drug Design Development and Therapy

Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis

(2015) Rui-Ming Liu et al.   Redox Biology

Role of Flow-Sensitive microRNAs in Endothelial Dysfunction and Atherosclerosis

(2014) Sandeep Kumar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Losartan inhibits endothelial-to-mesenchymal transformation in mitral valve endothelial cells by blocking transforming growth factor-β-induced phosphorylation of ERK

(2014) Jill Wylie-Sears et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dyssynchronous Pacing Triggers Endothelial-Mesenchymal Transition Through Heterogeneity of Mechanical Stretch in a Canine Model

(2014) JingTing Mai et al.   CIRCULATION JOURNAL

Angiogenic sprouting is regulated by endothelial cell expression of Slug

(2014) K. M. Welch-Reardon et al.   JOURNAL OF CELL SCIENCE

Curtailing Endothelial TGF-  Signaling Is Sufficient to Reduce Endothelial-Mesenchymal Transition and Fibrosis in CKD

(2014) S. Xavier et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Anti-Fibrosis Effect of Scutellarin via Inhibition of Endothelial–Mesenchymal Transition on Isoprenaline-Induced Myocardial Fibrosis in Rats

(2014) Hao Zhou et al.   MOLECULES

Signaling mechanisms of the epithelial-mesenchymal transition

(2014) D. M. Gonzalez et al.   Science Signaling

Glucose Transporter 1-Positive Endothelial Cells in Infantile Hemangioma Exhibit Features of Facultative Stem Cells

(2014) Lan Huang et al.   STEM CELLS

Macrophages commit postnatal endothelium-derived progenitors to angiogenesis and restrict endothelial to mesenchymal transition during muscle regeneration

(2014) P Zordan et al.   Cell Death & Disease

Intramuscular adipogenesis is inhibited by myo-endothelial progenitors with functioning Bmpr1a signalling

(2014) Ping Huang et al.   Nature Communications

MiR-302c inhibits tumor growth of hepatocellular carcinoma by suppressing the endothelial-mesenchymal transition of endothelial cells

(2014) Kai Zhu et al.   Scientific Reports

Endothelial Cells Contribute to Generation of Adult Ventricular Myocytes during Cardiac Homeostasis

(2014) Bryan A. Fioret et al.   Cell Reports

N-acetyl-seryl-aspartyl-lysyl-proline Inhibits Diabetes-Associated Kidney Fibrosis and Endothelial-Mesenchymal Transition

(2014) Takako Nagai et al.   Biomed Research International

Bleomycin induces endothelial mesenchymal transition through activation of mTOR pathway: a possible mechanism contributing to the sclerotherapy of venous malformations

(2013) Wei Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Bmp signaling represses Vegfa to promote outflow tract cushion development

(2013) Y. Bai et al.   DEVELOPMENT

Epicardial HIF signaling regulates vascular precursor cell invasion into the myocardium

(2013) Jiayi Tao et al.   DEVELOPMENTAL BIOLOGY

Interferon-γ promotes vascular remodeling in human microvascular endothelial cells by upregulating endothelin (ET)-1 and transforming growth factor (TGF) β2

(2013) Izabela Chrobak et al.   JOURNAL OF CELLULAR PHYSIOLOGY

microRNA 126 Inhibits the Transition of Endothelial Progenitor Cells to Mesenchymal Cells via the PIK3R2-PI3K/Akt Signalling Pathway

(2013) Junfeng Zhang et al.   PLoS One

Caveolin-1 Deficiency Induces Spontaneous Endothelial-to-Mesenchymal Transition in Murine Pulmonary Endothelial Cells in Vitro

(2012) Zhaodong Li et al.   AMERICAN JOURNAL OF PATHOLOGY

β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis

(2012) Christian Beyer et al.   ANNALS OF THE RHEUMATIC DISEASES

Inflammatory Cytokines Promote Mesenchymal Transformation in Embryonic and Adult Valve Endothelial Cells

(2012) Gretchen J. Mahler et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Kaposi Sarcoma Herpesvirus Promotes Endothelial-to-Mesenchymal Transition through Notch-Dependent Signaling

(2012) P. Gasperini et al.   CANCER RESEARCH

High glucose mediates endothelial-to-chondrocyte transition in human aortic endothelial cells

(2012) Rining Tang et al.   Cardiovascular Diabetology

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

The Vascular Endothelium of the Adipose Tissue Gives Rise to Both White and Brown Fat Cells

(2012) Khanh-Van Tran et al.   Cell Metabolism

Epithelial-to-Mesenchymal and Endothelial-to-Mesenchymal Transition

(2012) Jason C. Kovacic et al.   CIRCULATION

Epithelial-mesenchymal transitions: insights from development

(2012) J. Lim et al.   DEVELOPMENT

IL-1β and TGFβ2 synergistically induce endothelial to mesenchymal transition in an NFκB-dependent manner

(2012) Monika Maleszewska et al.   IMMUNOBIOLOGY

The role of endothelial-mesenchymal transition in development and pathological process

(2012) Feng Lin et al.   IUBMB LIFE

FGF Regulates TGF-β Signaling and Endothelial-to-Mesenchymal Transition via Control of let-7 miRNA Expression

(2012) Pei-Yu Chen et al.   Cell Reports

Inflammation-Induced Endothelial-to-Mesenchymal Transition

(2011) Florian Rieder et al.   AMERICAN JOURNAL OF PATHOLOGY

Transforming Growth Factor-β–Induced Endothelial-to-Mesenchymal Transition Is Partly Mediated by MicroRNA-21

(2011) Regalla Kumarswamy et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Protein kinase Cδ and c-Abl kinase are required for transforming growth factor β induction of endothelial-mesenchymal transition in vitro

(2011) Zhaodong Li et al.   ARTHRITIS AND RHEUMATISM

Transforming growth factor-β2 promotes Snail-mediated endothelial–mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling

(2011) Damian Medici et al.   BIOCHEMICAL JOURNAL

Regulation of endothelial cell plasticity by TGF-β

(2011) Laurens A. van Meeteren et al.   CELL AND TISSUE RESEARCH

Notch Initiates the Endothelial-to-Mesenchymal Transition in the Atrioventricular Canal through Autocrine Activation of Soluble Guanylyl Cyclase

(2011) Alex C.Y. Chang et al.   DEVELOPMENTAL CELL

Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition

(2011) O. Aisagbonhi et al.   Disease Models & Mechanisms

Endothelial mesenchymal transformation mediated by IL-1β-induced FGF-2 in corneal endothelial cells

(2011) Jeong Goo Lee et al.   EXPERIMENTAL EYE RESEARCH

Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?

(2011) Wilhelm Kriz et al.   JOURNAL OF CLINICAL INVESTIGATION

Erratum: Corrigendum: Conversion of vascular endothelial cells into multipotent stem-like cells

(2011) Damian Medici et al.   NATURE MEDICINE

Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve

(2011) K. Balachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial progenitor cells give rise to pro-angiogenic smooth muscle-like progeny

(2010) Jan-Renier A.J. Moonen et al.   CARDIOVASCULAR RESEARCH

Endothelial Cell–Derived Endothelin-1 Promotes Cardiac Fibrosis in Diabetic Hearts Through Stimulation of Endothelial-to-Mesenchymal Transition

(2010) Bambang Widyantoro et al.   CIRCULATION

Blockade of Endothelial-Mesenchymal Transition by a Smad3 Inhibitor Delays the Early Development of Streptozotocin-Induced Diabetic Nephropathy

(2010) J. Li et al.   DIABETES

Conversion of vascular endothelial cells into multipotent stem-like cells

(2010) Damian Medici et al.   NATURE MEDICINE

NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGF 1-induced fibroblast differentiation into myofibroblasts

(2010) N. Amara et al.   THORAX

Oxidative stress and glutathione in TGF-β-mediated fibrogenesis

(2009) R.-M. Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Differential Regulation of Transforming Growth Factor β Signaling Pathways by Notch in Human Endothelial Cells

(2009) YangXin Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Progenitor Cells That Contribute to Heterotopic Skeletogenesis

(2009) Vitali Y Lounev et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease

(2009) Hervé Acloque et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of endothelial-to-mesenchymal transition in cancer progression

(2008) S Potenta et al.   BRITISH JOURNAL OF CANCER

Calcification of Multipotent Prostate Tumor Endothelium

(2008) Andrew C. Dudley et al.   CANCER CELL

Caveolin-1, transforming growth factor-β receptor internalization, and the pathogenesis of systemic sclerosis

(2008) Francesco Del Galdo et al.   CURRENT OPINION IN RHEUMATOLOGY

Signaling via the Tgf-β type I receptor Alk5 in heart development

(2008) Somyoth Sridurongrit et al.   DEVELOPMENTAL BIOLOGY

Mechanotransduction in vascular physiology and atherogenesis

(2008) Cornelia Hahn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY