Harnessing FOXP3+ regulatory T cells for transplantation tolerance

Clinical Grade Manufacturing of Human Alloantigen-Reactive Regulatory T Cells for Use in Transplantation

(2013) A. L. Putnam et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Prevention of Graft-versus-Host Disease by Adoptive T Regulatory Therapy Is Associated with Active Repression of Peripheral Blood Toll-Like Receptor 5 mRNA Expression

(2013) Birgit Sawitzki et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Adjuvant facilitates tolerance induction to factor VIII in hemophilic mice through a Foxp3-independent mechanism that relies on IL-10

(2013) V. G. Oliveira et al.   BLOOD

"Designed" grafts for HLA-haploidentical stem cell transplantation

(2013) M. F. Martelli et al.   BLOOD

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Induced and thymus-derived Foxp3+regulatory T cells share a common niche

(2013) Yi-Ju Huang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

AMPKα1: A glucose sensor that controls CD8 T-cell memory

(2013) Julia Rolf et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Self-antigen-Driven Activation Induces Instability of Regulatory T Cells during an Inflammatory Autoimmune Response

(2013) Samantha L. Bailey-Bucktrout et al.   IMMUNITY

Foxp3 Transcription Factor Is Proapoptotic and Lethal to Developing Regulatory T Cells unless Counterbalanced by Cytokine Survival Signals

(2013) Xuguang Tai et al.   IMMUNITY

The mTOR pathway and integrating immune regulation

(2013) Stephen P. Cobbold   IMMUNOLOGY

TSC1 regulates the balance between effector and regulatory T cells

(2013) Yoon Park et al.   JOURNAL OF CLINICAL INVESTIGATION

Control of inflammation by integration of environmental cues by regulatory T cells

(2013) Ashutosh Chaudhry et al.   JOURNAL OF CLINICAL INVESTIGATION

Active Demethylation of the Foxp3 Locus Leads to the Generation of Stable Regulatory T Cells within the Thymus

(2013) A. Toker et al.   JOURNAL OF IMMUNOLOGY

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

(2013) Hu Zeng et al.   NATURE

Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch

(2013) Patrick M Gubser et al.   NATURE IMMUNOLOGY

Low-Dose Interleukin-2 Therapy Restores Regulatory T Cell Homeostasis in Patients with Chronic Graft-Versus-Host Disease

(2013) K.-i. Matsuoka et al.   Science Translational Medicine

Sensing the immune microenvironment to coordinate T cell metabolism, differentiation & function

(2013) Emily B. Heikamp et al.   SEMINARS IN IMMUNOLOGY

Ex Vivo Expanded Human Regulatory T Cells Can Prolong Survival of a Human Islet Allograft in a Humanized Mouse Model

(2013) Douglas C. Wu et al.   TRANSPLANTATION

Regulatory T-Cell Therapy in Transplantation: Moving to the Clinic

(2013) Q. Tang et al.   Cold Spring Harbor Perspectives in Medicine

Permanent CNI Treatment for Prevention of Renal Allograft Rejection in Sensitized Hosts Can Be Replaced by Regulatory T Cells

(2012) A. Siepert et al.   AMERICAN JOURNAL OF TRANSPLANTATION

A novel function for FOXP3 in humans: intrinsic regulation of conventional T cells

(2012) A. N. McMurchy et al.   BLOOD

Foxp3 Exploits a Pre-Existent Enhancer Landscape for Regulatory T Cell Lineage Specification

(2012) Robert M. Samstein et al.   CELL

Extrathymic Generation of Regulatory T Cells in Placental Mammals Mitigates Maternal-Fetal Conflict

(2012) Robert M. Samstein et al.   CELL

Plasticity of Foxp3+ T Cells Reflects Promiscuous Foxp3 Expression in Conventional T Cells but Not Reprogramming of Regulatory T Cells

(2012) Takahisa Miyao et al.   IMMUNITY

T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development

(2012) Naganari Ohkura et al.   IMMUNITY

mTOR, metabolism, and the regulation of T-cell differentiation and function

(2012) Adam T. Waickman et al.   IMMUNOLOGICAL REVIEWS

Tryptophan hydroxylase-1 regulates immune tolerance and inflammation

(2012) Elizabeth C. Nowak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Foxp3 Expression Is Required for the Induction of Therapeutic Tissue Tolerance

(2012) F. S. Regateiro et al.   JOURNAL OF IMMUNOLOGY

Extrathymically generated regulatory T cells control mucosal TH2 inflammation

(2012) Steven Z. Josefowicz et al.   NATURE

Therapeutic opportunities for manipulating TReg cells in autoimmunity and cancer

(2012) Harald von Boehmer et al.   NATURE REVIEWS DRUG DISCOVERY

Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion

(2012) M. S. Fassett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Cellular and Molecular Mechanisms of Immuno-Suppression by Human Type 1 Regulatory T Cells

(2012) Silvia Gregori et al.   Frontiers in Immunology

Comparative Genomics Reveals Key Gain-of-Function Events in Foxp3 during Regulatory T Cell Evolution

(2012) Kristian G. Andersen et al.   Frontiers in Immunology

Early Acceptance of Renal Allografts in Mice Is Dependent on Foxp3+ Cells

(2011) Masahiro Miyajima et al.   AMERICAN JOURNAL OF PATHOLOGY

The Potency of Allospecific Tregs Cells Appears to Correlate With T Cell Receptor Functional Avidity

(2011) J. Y. S. Tsang et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

(2011) M. Di Ianni et al.   BLOOD

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

Generation of anti-inflammatory adenosine byleukocytes is regulated by TGF-β

(2011) Frederico S. Regateiro et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Functional type 1 regulatory T cells develop regardless of FOXP3 mutations in patients with IPEX syndrome

(2011) Laura Passerini et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

(2011) Gerritje J.W. van der Windt et al.   IMMUNITY

Sustained suppression by Foxp3+regulatory T cells is vital for infectious transplantation tolerance

(2011) Adrian R. Kendal et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dominant Th2 Differentiation of Human Regulatory T Cells upon Loss of FOXP3 Expression

(2011) L. Hansmann et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

Massive ex Vivo Expansion of Human Natural Regulatory T Cells (Tregs) with Minimal Loss of in Vivo Functional Activity

(2011) K. L. Hippen et al.   Science Translational Medicine

Human Regulatory T Cells with Alloantigen Specificity Are More Potent Inhibitors of Alloimmune Skin Graft Damage than Polyclonal Regulatory T Cells

(2011) P. Sagoo et al.   Science Translational Medicine

Moving to tolerance: Clinical application of T regulatory cells

(2011) Alicia N. McMurchy et al.   SEMINARS IN IMMUNOLOGY

Regulatory T cell plasticity: beyond the controversies

(2011) Shohei Hori   TRENDS IN IMMUNOLOGY

Biomarkers of Transplantation Tolerance: More Hopeful than Helpful?

(2011) Stephen P. Cobbold et al.   Frontiers in Immunology

Connecting the mechanisms of T-cell regulation: dendritic cells as the missing link

(2010) Stephen P. Cobbold et al.   IMMUNOLOGICAL REVIEWS

A Crucial Role for Host APCs in the Induction of Donor CD4+CD25+ Regulatory T Cell-Mediated Suppression of Experimental Graft-versus-Host Disease

(2010) I. Tawara et al.   JOURNAL OF IMMUNOLOGY

The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells

(2010) Guangwei Liu et al.   NATURE IMMUNOLOGY

In vivo prevention of transplant arteriosclerosis by ex vivo–expanded human regulatory T cells

(2010) Satish N Nadig et al.   NATURE MEDICINE

Stability of the Regulatory T Cell Lineage in Vivo

(2010) Y. P. Rubtsov et al.   SCIENCE

Regulatory T cells for the prevention of graft-versus-host disease: Professionals defeat amateurs

(2009) Matthias Edinger   EUROPEAN JOURNAL OF IMMUNOLOGY

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

(2009) Kylie E. Webster et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Depletion of Foxp3+ Cells Leads to Induction of Autoimmunity by Specific Ablation of Regulatory T Cells in Genetically Targeted Mice

(2009) J. Kim et al.   JOURNAL OF IMMUNOLOGY

Infectious tolerance via the consumption of essential amino acids and mTOR signaling

(2009) S. P. Cobbold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterogeneity of natural Foxp3+T cells: A committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity

(2009) Noriko Komatsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD4+T-regulatory cells: toward therapy for human diseases

(2008) Sarah E. Allan et al.   IMMUNOLOGICAL REVIEWS

Induction of antigen-specific regulatory T cells in wild-type mice: Visualization and targets of suppression

(2008) P. Verginis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

(2008) S. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific Immunosuppression with Inducible Foxp3-Transduced Polyclonal T cells

(2008) Kristian G Andersen et al.   PLOS BIOLOGY