T-Cell Immunotherapies Targeting Histocompatibility and Tumor Antigens in Hematological Malignancies

Mutated nucleophosmin 1 as immunotherapy target in acute myeloid leukemia

(2019) Dyantha I. van der Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer

(2019) Winifred Lo et al.   Cancer Immunology Research

Antigen Targets for the Development of Immunotherapies in Leukemia

(2019) Jens Bauer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lower GVHD and relapse risk in PTCy-based Haploidentical vs Matched Sibling Donor RIC Transplant for Hodgkin Lymphoma

(2019) Sairah Ahmed et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Recipients Receiving Better HLA-Matched Hematopoietic Cell Transplantation Grafts, Uncovered by a Novel HLA Typing Method, Have Superior Survival: A Retrospective Study

(2019) Neema P. Mayor et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Rethinking Thymic Tolerance: Lessons from Mice

(2019) Sarah Inglesfield et al.   TRENDS IN IMMUNOLOGY

Discovery and characterization of actionable tumor antigens

(2019) Grégory Ehx et al.   Genome Medicine

T-cell therapies for T-cell lymphoma

(2019) Keri Toner et al.   CYTOTHERAPY

Updates on CAR T-cell therapy in B-cell malignancies

(2019) Elad Jacoby et al.   IMMUNOLOGICAL REVIEWS

T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant

(2019) Aude G. Chapuis et al.   NATURE MEDICINE

TGFβ Programs Central Memory Differentiation in Ex Vivo–Stimulated Human T Cells

(2019) Amina Dahmani et al.   Cancer Immunology Research

Clinical Relevance of Immunobiology in Umbilical Cord Blood Transplantation

(2019) Hyun Don Yun et al.   Journal of Clinical Medicine

Long-Term Results of Prophylactic Donor Lymphocyte Infusions for Patients with Multiple Myeloma after Allogeneic Stem Cell Transplantation

(2018) Maximilian Gröger et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

A Phase 1 Trial of CNDO-109–Activated Natural Killer Cells in Patients with High-Risk Acute Myeloid Leukemia

(2018) Todd A. Fehniger et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Vaccine therapy in hematologic malignancies

(2018) David Avigan et al.   BLOOD

Low-dose decitabine enhances the effect of PD-1 blockade in colorectal cancer with microsatellite stability by re-modulating the tumor microenvironment

(2018) Ganjun Yu et al.   Cellular & Molecular Immunology

Infusion of cytotoxic T lymphocytes for the treatment of viral infections in hematopoetic stem cell transplant patients

(2018) Katherine A. Baugh et al.   CURRENT OPINION IN INFECTIOUS DISEASES

T Cells Genetically Modified to Express an Anti–B-Cell Maturation Antigen Chimeric Antigen Receptor Cause Remissions of Poor-Prognosis Relapsed Multiple Myeloma

(2018) Jennifer N. Brudno et al.   JOURNAL OF CLINICAL ONCOLOGY

Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden

(2018) Matthew D. Hellmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recent Advances in Targeting CD8 T-Cell Immunity for More Effective Cancer Immunotherapy

(2018) Aurélie Durgeau et al.   Frontiers in Immunology

HLA-Mismatched Microtransplant in Older Patients Newly Diagnosed With Acute Myeloid Leukemia

(2018) Mei Guo et al.   JAMA Oncology

Will CAR T cell therapy have a role in AML? Promises and pitfalls

(2018) Katherine D. Cummins et al.   SEMINARS IN HEMATOLOGY

Predicting Antigen Presentation—What Could We Learn From a Million Peptides?

(2018) David Gfeller et al.   Frontiers in Immunology

Improved accuracy of clinical HLA genotyping by next-generation DNA sequencing affects unrelated donor search results for hematopoietic stem cell transplantation

(2018) Elizabeth S. Allen et al.   HUMAN IMMUNOLOGY

Actively personalized vaccination trial for newly diagnosed glioblastoma

(2018) Norbert Hilf et al.   NATURE

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

(2018) Derin B. Keskin et al.   NATURE

Noncoding regions are the main source of targetable tumor-specific antigens

(2018) Céline M. Laumont et al.   Science Translational Medicine

Comprehensive Genomic Profiling Reveals Diverse but Actionable Molecular Portfolios across Hematologic Malignancies: Implications for Next Generation Clinical Trials

(2018) Natalie Galanina et al.   Cancers

Mass Spectrometry Profiling of HLA-Associated Peptidomes in Mono-allelic Cells Enables More Accurate Epitope Prediction

(2017) Jennifer G. Abelin et al.   IMMUNITY

Update on Aire and thymic negative selection

(2017) Geraldo A. Passos et al.   IMMUNOLOGY

Alloimmune T cells in transplantation

(2017) Susan DeWolf et al.   JOURNAL OF CLINICAL INVESTIGATION

Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

(2017) Ugur Sahin et al.   NATURE

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

An immunogenic personal neoantigen vaccine for patients with melanoma

(2017) Patrick A. Ott et al.   NATURE

DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats

(2017) David Brocks et al.   NATURE GENETICS

CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy

(2017) Terry J Fry et al.   NATURE MEDICINE

The Antigenicity of the Tumor Cell — Context Matters

(2017) Vessela N. Kristensen   NEW ENGLAND JOURNAL OF MEDICINE

The immunopeptidomic landscape of ovarian carcinomas

(2017) Heiko Schuster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunological effects of hypomethylating agents

(2017) Katherine E. Lindblad et al.   Expert Review of Hematology

Graft-versus-Leukemia Effect Following Hematopoietic Stem Cell Transplantation for Leukemia

(2017) Anne M. Dickinson et al.   Frontiers in Immunology

The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy

(2017) Sourav Paul et al.   Frontiers in Immunology

CD4+ T-cell alloreactivity toward mismatched HLA class II alleles early after double umbilical cord blood transplantation

(2016) C. H. J. Lamers et al.   BLOOD

BCR-ABL–specific T-cell therapy in Ph+ALL patients on tyrosine-kinase inhibitors

(2016) Patrizia Comoli et al.   BLOOD

Efficacy of host-dendritic cell vaccinations with or without minor histocompatibility antigen loading, combined with donor lymphocyte infusion in multiple myeloma patients

(2016) R Oostvogels et al.   BONE MARROW TRANSPLANTATION

Prophylactic donor lymphocyte infusion after allogeneic stem cell transplantation for high-risk AML

(2016) F Legrand et al.   BONE MARROW TRANSPLANTATION

T Cells Redirected to a Minor Histocompatibility Antigen Instruct Intratumoral TNFα Expression and Empower Adoptive Cell Therapy for Solid Tumors

(2016) Teresa Manzo et al.   CANCER RESEARCH

Isolation of T-Cell Receptors Specifically Reactive with Mutated Tumor-Associated Antigens from Tumor-Infiltrating Lymphocytes Based on CD137 Expression

(2016) Maria Parkhurst et al.   CLINICAL CANCER RESEARCH

Association of WT1 IgG antibody against WT1 peptide with prolonged survival in glioblastoma multiforme patients vaccinated with WT1 peptide

(2016) Yusuke Oji et al.   INTERNATIONAL JOURNAL OF CANCER

MHC class I–associated peptides derive from selective regions of the human genome

(2016) Hillary Pearson et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteogenomic-based discovery of minor histocompatibility antigens with suitable features for immunotherapy of hematologic cancers

(2016) D P Granados et al.   LEUKEMIA

Loss of the mismatched human leukocyte antigen haplotype in two acute myelogenous leukemia relapses after haploidentical bone marrow transplantation with post-transplantation cyclophosphamide

(2016) S R McCurdy et al.   LEUKEMIA

Role of non-coding sequence variants in cancer

(2016) Ekta Khurana et al.   NATURE REVIEWS GENETICS

T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer

(2016) Eric Tran et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting of cancer neoantigens with donor-derived T cell receptor repertoires

(2016) E. Stronen et al.   SCIENCE

Bone Marrow T Cells and the Integrated Functions of Recirculating and Tissue-Resident Memory T Cells

(2016) Francesca Di Rosa et al.   Frontiers in Immunology

Autosomal Minor Histocompatibility Antigens: How Genetic Variants Create Diversity in Immune Targets

(2016) Marieke Griffioen et al.   Frontiers in Immunology

Allorecognition by T Lymphocytes and Allograft Rejection

(2016) Jose Marino et al.   Frontiers in Immunology

Strategies for the Identification of T Cell–Recognized Tumor Antigens in Hematological Malignancies for Improved Graft-versus-Tumor Responses after Allogeneic Blood and Marrow Transplantation

(2015) Jenny Zilberberg et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts

(2015) David Roulois et al.   CELL

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

(2015) Katherine B. Chiappinelli et al.   CELL

The nature of self for T cells—a systems-level perspective

(2015) Diana P Granados et al.   CURRENT OPINION IN IMMUNOLOGY

Early exposure to interleukin-21 limits rapidly generated anti–Epstein-Barr virus T-cell line differentiation

(2015) Julie Orio et al.   CYTOTHERAPY

Stem cell comparison: what can we learn clinically from unrelated cord blood transplantation as an alternative stem cell source?

(2015) Filippo Milano et al.   CYTOTHERAPY

Defining novel parameters for the optimal priming and expansion of minor histocompatibility antigen-specific T cells in culture

(2015) Valérie Janelle et al.   Journal of Translational Medicine

Mutant MHC class II epitopes drive therapeutic immune responses to cancer

(2015) Sebastian Kreiter et al.   NATURE

NY-ESO-1–specific TCR–engineered T cells mediate sustained antigen-specific antitumor effects in myeloma

(2015) Aaron P Rapoport et al.   NATURE MEDICINE

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells

(2015) B. M. Carreno et al.   SCIENCE

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Adoptive transfer of activated marrow-infiltrating lymphocytes induces measurable antitumor immunity in the bone marrow in multiple myeloma

(2015) Kimberly A. Noonan et al.   Science Translational Medicine

Human Tumor Antigens and Cancer Immunotherapy

(2015) Nathalie Vigneron   Biomed Research International

Neoepitopes of Cancers: Looking Back, Looking Ahead

(2015) P. K. Srivastava   Cancer Immunology Research

Inhibition of Akt signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy

(2014) A. B. van der Waart et al.   BLOOD

Harnessing the power of alloreactivity without triggering graft-versus-host disease: how non-engrafting alloreactive cellular therapy might change the landscape of acute myeloid leukemia treatment

(2014) Elizabeth F. Krakow et al.   BLOOD REVIEWS

A multicentre UK study of GVHD following DLI: Rates of GVHD are high but mortality from GVHD is infrequent

(2014) J J Scarisbrick et al.   BONE MARROW TRANSPLANTATION

Efficient Identification of Mutated Cancer Antigens Recognized by T Cells Associated with Durable Tumor Regressions

(2014) Y.-C. Lu et al.   CLINICAL CANCER RESEARCH

Construction and molecular characterization of a T-cell receptor-like antibody and CAR-T cells specific for minor histocompatibility antigen HA-1H

(2014) Y Inaguma et al.   GENE THERAPY

PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors

(2014) Alena Gros et al.   JOURNAL OF CLINICAL INVESTIGATION

Naive Idiotope-Specific B and T Cells Collaborate Efficiently in the Absence of Dendritic Cells

(2014) J. Jacobsen et al.   JOURNAL OF IMMUNOLOGY

Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing

(2014) Mahesh Yadav et al.   NATURE

Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma

(2014) Alexandra Snyder et al.   NEW ENGLAND JOURNAL OF MEDICINE

Impact of genomic polymorphisms on the repertoire of human MHC class I-associated peptides

(2014) Diana Paola Granados et al.   Nature Communications

5-Azacytidine treatment sensitizes tumor cells to T-cell mediated cytotoxicity and modulates NK cells in patients with myeloid malignancies

(2014) A O Gang et al.   Blood Cancer Journal

High dose interleukin-2 (Aldesleukin) - expert consensus on best management practices-2014

(2014) Janice P Dutcher et al.   Journal for ImmunoTherapy of Cancer

Donor T Cells Administered Over HLA Class II Barriers Mediate Antitumor Immunity without Broad Off-Target Toxicity in a NOD/Scid Mouse Model of Acute Leukemia

(2013) Sanja Stevanović et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma

(2013) G. P. Linette et al.   BLOOD

Uncoupling T-cell expansion from effector differentiation in cell-based immunotherapy

(2013) Joseph G. Crompton et al.   IMMUNOLOGICAL REVIEWS

Sustained Complete Responses in Patients With Lymphoma Receiving Autologous Cytotoxic T Lymphocytes Targeting Epstein-Barr Virus Latent Membrane Proteins

(2013) Catherine M. Bollard et al.   JOURNAL OF CLINICAL ONCOLOGY

Transferred WT1-Reactive CD8+ T Cells Can Mediate Antileukemic Activity and Persist in Post-Transplant Patients

(2013) A. G. Chapuis et al.   Science Translational Medicine

The emergence of WT1-specific T-cell responses following allogeneic T cell-depleted hematopoietic stem cell transplantation and low-dose donor lymphocyte infusions is associated with a graft-vs.- myeloma effect

(2013) Eleanor M Tyler et al.   OncoImmunology

Effect of MHC and non-MHC donor/recipient genetic disparity on the outcome of allogeneic HCT

(2012) E. H. Warren et al.   BLOOD

Generation and administration of HA-1-specific T-cell lines for the treatment of patients with relapsed leukemia after allogeneic stem cell transplantation: a pilot study

(2012) P. Meij et al.   HAEMATOLOGICA

HLA-Mismatched Stem-Cell Microtransplantation As Postremission Therapy for Acute Myeloid Leukemia: Long-Term Follow-Up

(2012) Mei Guo et al.   JOURNAL OF CLINICAL ONCOLOGY

Rapidly Generated Multivirus-specific Cytotoxic T Lymphocytes for the Prophylaxis and Treatment of Viral Infections

(2012) Ulrike Gerdemann et al.   MOLECULAR THERAPY

Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting

(2012) Hirokazu Matsushita et al.   NATURE

T-cell therapy in the treatment of post-transplant lymphoproliferative disease

(2012) Catherine M. Bollard et al.   Nature Reviews Clinical Oncology

Next-generation leukemia immunotherapy

(2011) K. Vincent et al.   BLOOD

Memory T cells from minor histocompatibility antigen-vaccinated and virus-immune donors improve GVL and immune reconstitution

(2011) N. Li et al.   BLOOD

Adoptive immunotherapy with unselected or EBV-specific T cells for biopsy-proven EBV+ lymphomas after allogeneic hematopoietic cell transplantation

(2011) E. Doubrovina et al.   BLOOD

TCR cross-reactivity and allorecognition: new insights into the immunogenetics of allorecognition

(2011) L. J. D’Orsogna et al.   IMMUNOGENETICS

Cytotoxic T Lymphocytes Simultaneously Targeting Multiple Tumor-associated Antigens to Treat EBV Negative Lymphoma

(2011) Ulrike Gerdemann et al.   MOLECULAR THERAPY

A human memory T cell subset with stem cell–like properties

(2011) Luca Gattinoni et al.   NATURE MEDICINE

Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy

(2011) Antonio Di Stasi et al.   NEW ENGLAND JOURNAL OF MEDICINE

High-Throughput Identification of Potential Minor Histocompatibility Antigens by MHC Tetramer-Based Screening: Feasibility and Limitations

(2011) Pleun Hombrink et al.   PLoS One

Graft versus Leukemia Reactivity after Allogeneic Stem Cell Transplantation

(2010) J.H. Frederik Falkenburg et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens

(2010) E. H. Warren et al.   BLOOD

Infusion of HLA-mismatched peripheral blood stem cells improves the outcome of chemotherapy for acute myeloid leukemia in elderly patients

(2010) M. Guo et al.   BLOOD

Concomitant Tumor and Minor Histocompatibility Antigen–Specific Immunity Initiate Rejection and Maintain Remission from Established Spontaneous Solid Tumors

(2010) Rodrigo Hess Michelini et al.   CANCER RESEARCH

Role of donor lymphocyte infusions in relapsed hematological malignancies after stem cell transplantation revisited

(2010) Abhinav Deol et al.   CANCER TREATMENT REVIEWS

Graft-versus-host driven graft-versus-leukemia effect of minor histocompatibility antigen HA-1 in chronic myeloid leukemia patients

(2010) T Mutis et al.   LEUKEMIA

Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy

(2010) Gavin M Bendle et al.   NATURE MEDICINE

Mixed T cell receptor dimers harbor potentially harmful neoreactivity

(2010) M. M. van Loenen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allogeneic T-Cell Therapy for Epstein-Barr Virus-Positive Posttransplant Lymphoproliferative Disease: Long-Term Follow-Up

(2010) Tanzina Haque et al.   TRANSPLANTATION

Relapse risk after umbilical cord blood transplantation: enhanced graft-versus-leukemia effect in recipients of 2 units

(2009) M. R. Verneris et al.   BLOOD

Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients

(2009) H. E. Heslop et al.   BLOOD

Treatment of Chronic Lymphocytic Leukemia with a Hypomethylating Agent Induces Expression of NXF2, an Immunogenic Cancer Testis Antigen

(2009) J. A. Dubovsky et al.   CLINICAL CANCER RESEARCH

Graft-versus-host disease

(2009) James LM Ferrara et al.   LANCET

Donor-recipient mismatch for common gene deletion polymorphisms in graft-versus-host disease

(2009) Steven A McCarroll et al.   NATURE GENETICS

Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

(2009) Luca Gattinoni et al.   NATURE MEDICINE

Targeting haematopoietic-specific minor histocompatibility antigens to distinguish graft-versus-tumour effects from graft-versus-host disease

(2008) Robbert Spaapen et al.   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Graft-versus-host disease causes failure of donor hematopoiesis and lymphopoiesis in interferon-  receptor-deficient hosts

(2008) J.-S. Delisle et al.   BLOOD