Journal
ONCOIMMUNOLOGY
Volume 2, Issue 7, Pages -Publisher
LANDES BIOSCIENCE
DOI: 10.4161/onci.24963
Keywords
multiple myeloma; allogeneic stem cell transplantation; donor lymphocyte infusion; WT1-specific cytotoxic T cells; graft-vs; -myeloma effect
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The development of T-cell responses specific for myeloma-associated antigens correlates with improved clinical outcomes in multiple myeloma patients undergoing allogeneic T cell-depleted hematopoietic stem cell transplantation and donor lymphocyte infusions. Thus, immunotherapeutic strategies that further increase the frequency of Wilms tumor 1 (WT1)-specific T cells may provide clinical benefits to multiple myeloma patients.
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