Defining novel parameters for the optimal priming and expansion of minor histocompatibility antigen-specific T cells in culture

Adoptive T-cell therapy with hexon-specific Th1 cells as a treatment of refractory adenovirus infection after HSCT

(2015) J. Feucht et al.   BLOOD

Serial Transfer of Single-Cell-Derived Immunocompetence Reveals Stemness of CD8+ Central Memory T Cells

(2014) Patricia Graef et al.   IMMUNITY

Antigen-specific activation and cytokine-facilitated expansion of naive, human CD8+ T cells

(2014) Matthias Wölfl et al.   Nature Protocols

Activity of Broad-Spectrum T Cells as Treatment for AdV, EBV, CMV, BKV, and HHV6 Infections after HSCT

(2014) A. Papadopoulou et al.   Science Translational Medicine

Impact of genomic polymorphisms on the repertoire of human MHC class I-associated peptides

(2014) Diana Paola Granados et al.   Nature Communications

Optimizing the production of suspension cells using the G-Rex “M” series

(2014) Pradip Bajgain et al.   Molecular Therapy-Methods & Clinical Development

Minor Antigen Distribution Predicts Site-Specific Graft-versus-Tumor Activity of Adoptively Transferred, Minor Antigen-Specific CD8 T Cells

(2013) Jessica C. Shand et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Generation of multi-leukemia antigen-specific T cells to enhance the graft-versus-leukemia effect after allogeneic stem cell transplant

(2013) G Weber et al.   LEUKEMIA

Adoptive immunotherapy with antigen-specific T cells during extracorporeal membrane oxygenation (ECMO) for adenovirus-related respiratory failure in a child given haploidentical stem cell transplantation

(2013) Matteo Di Nardo et al.   PEDIATRIC BLOOD & CANCER

Transferred WT1-Reactive CD8+ T Cells Can Mediate Antileukemic Activity and Persist in Post-Transplant Patients

(2013) A. G. Chapuis et al.   Science Translational Medicine

IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors

(2012) N. Cieri et al.   BLOOD

Modulating the differentiation status of ex vivo-cultured anti-tumor T cells using cytokine cocktails

(2012) Shicheng Yang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Generation and administration of HA-1-specific T-cell lines for the treatment of patients with relapsed leukemia after allogeneic stem cell transplantation: a pilot study

(2012) P. Meij et al.   HAEMATOLOGICA

Adoptive Transfer of Epstein-Barr Virus (EBV) Nuclear Antigen 1–Specific T Cells As Treatment for EBV Reactivation and Lymphoproliferative Disorders After Allogeneic Stem-Cell Transplantation

(2012) Vanya Icheva et al.   JOURNAL OF CLINICAL ONCOLOGY

Rapidly Generated Multivirus-specific Cytotoxic T Lymphocytes for the Prophylaxis and Treatment of Viral Infections

(2012) Ulrike Gerdemann et al.   MOLECULAR THERAPY

Transferred melanoma-specific CD8+ T cells persist, mediate tumor regression, and acquire central memory phenotype

(2012) A. G. Chapuis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rat Mesenchymal Stromal Cells Inhibit T Cell Proliferation but Not Cytokine Production Through Inducible Nitric Oxide Synthase

(2012) Severin Zinöcker et al.   Frontiers in Immunology

Next-generation leukemia immunotherapy

(2011) K. Vincent et al.   BLOOD

Exploiting T cells specific for human minor histocompatibility antigens for therapy of leukemia

(2011) Marie Bleakley et al.   IMMUNOLOGY AND CELL BIOLOGY

Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients

(2011) Lukas Baitsch et al.   JOURNAL OF CLINICAL INVESTIGATION

Leukemia-associated minor histocompatibility antigen discovery using T-cell clones isolated by in vitro stimulation of naive CD8+ T cells

(2010) M. Bleakley et al.   BLOOD

Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens

(2010) E. H. Warren et al.   BLOOD

Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjects

(2010) J. J. Melenhorst et al.   BLOOD

Accelerated Production of Antigen-specific T Cells for Preclinical and Clinical Applications Using Gas-permeable Rapid Expansion Cultureware (G-Rex)

(2010) Juan F. Vera et al.   JOURNAL OF IMMUNOTHERAPY

Adoptive transfer and selective reconstitution of streptamer-selected cytomegalovirus-specific CD8+ T cells leads to virus clearance in patients after allogeneic peripheral blood stem cell transplantation

(2010) Anita Schmitt et al.   TRANSFUSION

Coexpression of PD-1, 2B4, CD160 and KLRG1 on Exhausted HCV-Specific CD8+ T Cells Is Linked to Antigen Recognition and T Cell Differentiation

(2010) Bertram Bengsch et al.   PLoS Pathogens

Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes

(2009) P. J. Hanley et al.   BLOOD

MART-1–Specific Melanoma Tumor-Infiltrating Lymphocytes Maintaining CD28 Expression Have Improved Survival and Expansion Capability Following Antigenic Restimulation In Vitro

(2009) Yufeng Li et al.   JOURNAL OF IMMUNOLOGY

IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy

(2008) C. S. Hinrichs et al.   BLOOD

Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungs

(2008) Jodi McGill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Minimally Cultured Tumor-infiltrating Lymphocytes Display Optimal Characteristics for Adoptive Cell Therapy

(2008) Khoi Q. Tran et al.   JOURNAL OF IMMUNOTHERAPY