Functional Inhibition of Host Histone Deacetylases (HDACs) Enhances in vitro and in vivo Anti-mycobacterial Activity in Human Macrophages and in Zebrafish

HDAC5 promotes Mycoplasma pneumoniae-induced inflammation in macrophages through NF-κB activation

(2019) Yuehua Zhao et al.   LIFE SCIENCES

Histone deacetylase inhibitors impair the host immune response against Mycobacterium tuberculosis infection

(2019) Chuanzhi Zhu et al.   TUBERCULOSIS

Trichostatin A modulates the macrophage phenotype by enhancing autophagy to reduce inflammation during polymicrobial sepsis

(2019) Shu-Nan Cui et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Growth ofMycobacterium tuberculosisin vivo segregates with host macrophage metabolism and ontogeny

(2018) Lu Huang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Histone deacetylase 2 (HDAC2) attenuates lipopolysaccharide (LPS)-induced inflammation by regulating PAI-1 expression

(2018) Wen-Feng Fang et al.   Journal of Inflammation-London

Transcriptional and posttranscriptional repression of histone deacetylases by docosahexaenoic acid in macrophages

(2018) Tho X. Pham et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Mycobacterium tuberculosis infection induces IL-10 gene expression by disturbing histone deacetylase 6 and histonedeacetylase 11 equilibrium in macrophages

(2018) Xiaolei Wang et al.   TUBERCULOSIS

Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials

(2018) Cornelis J. Korbee et al.   Nature Communications

Transcriptional landscape of Mycobacterium tuberculosis infection in macrophages

(2018) Sugata Roy et al.   Scientific Reports

Tuberculosis and the art of macrophage manipulation

(2018) S Upadhyay et al.   Pathogens and Disease

Lysophosphatidylcholine Promotes Phagosome Maturation and Regulates Inflammatory Mediator Production Through the Protein Kinase A–Phosphatidylinositol 3 Kinase–p38 Mitogen-Activated Protein Kinase Signaling Pathway During Mycobacterium tuberculosis Infection in Mouse Macrophages

(2018) Hyo-Ji Lee et al.   Frontiers in Immunology

Ky-2, a hybrid compound histone deacetylase inhibitor, regulated inflammatory response in LPS-driven human macrophages

(2018) Junya Kaneko et al.   CELL BIOLOGY INTERNATIONAL

Histone deacetylase 2 is essential for LPS-induced inflammatory responses in macrophages

(2018) Chenming Wu et al.   IMMUNOLOGY AND CELL BIOLOGY

Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism

(2018) Duco Steven Koenis et al.   Cell Reports

Histone deacetylase 6 inhibitor enhances resistance to Mycobacterium tuberculosis infection through innate and adaptive immunity in mice

(2018) Xiaolei Wang et al.   Pathogens and Disease

The Novel HDAC8 Inhibitor WK2-16 Attenuates Lipopolysaccharide-Activated Matrix Metalloproteinase-9 Expression in Human Monocytic Cells and Improves Hypercytokinemia In Vivo

(2017) Jing-Shiun Jan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulated Polarization of Tumor-Associated Macrophages by miR-145 via Colorectal Cancer–Derived Extracellular Vesicles

(2017) Haruka Shinohara et al.   JOURNAL OF IMMUNOLOGY

Alcohol-induced miR-155 and HDAC11 inhibit negative regulators of the TLR4 pathway and lead to increased LPS responsiveness of Kupffer cells in alcoholic liver disease

(2017) Shashi Bala et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages

(2017) Jennifer L. Guerriero et al.   NATURE

HDAC1-3 inhibitor MS-275 enhances IL10 expression in RAW264.7 macrophages and reduces cigarette smoke-induced airway inflammation in mice

(2017) Niek G. J. Leus et al.   Scientific Reports

mixOmics: An R package for ‘omics feature selection and multiple data integration

(2017) Florian Rohart et al.   PLoS Computational Biology

Epigenetic Regulation of Matrix Metalloproteinase-1 and -3 Expression in Mycobacterium tuberculosis Infection

(2017) Rachel C. Moores et al.   Frontiers in Immunology

Transcriptional networks are associated with resistance to Mycobacterium tuberculosis infection

(2017) Chetan Seshadri et al.   PLoS One

HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity

(2016) Niek G.J. Leus et al.   BIOCHEMICAL PHARMACOLOGY

Overexpression of HDAC6 induces pro-inflammatory responses by regulating ROS-MAPK-NF-κB/AP-1 signaling pathways in macrophages

(2016) Gi Soo Youn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Histone deacetylase 6 negatively regulates NLRP3 inflammasome activation

(2015) Inhwa Hwang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Histone deacetylase 5 regulates the inflammatory response of macrophages

(2015) Lukas Poralla et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6

(2015) Qian Zhang et al.   NATURE

Protection and pathology in TB: learning from the zebrafish model

(2015) Annemarie H. Meijer   Seminars in Immunopathology

Mycobacterial infection induces a specific human innate immune response

(2015) John D. Blischak et al.   Scientific Reports

Phenylbutyrate Is Bacteriostatic against Mycobacterium tuberculosis and Regulates the Macrophage Response to Infection, Synergistically with 25-Hydroxy-Vitamin D₃

(2015) Anna K. Coussens et al.   PLoS Pathogens

Mycobacterium tuberculosis Infection Induces HDAC1-Mediated Suppression of IL-12B Gene Expression in Macrophages

(2015) Aneesh Chandran et al.   Frontiers in Cellular and Infection Microbiology

The DNA Damage-Regulated Autophagy Modulator DRAM1 Links Mycobacterial Recognition via TLR-MYD88 to Autophagic Defense

(2014) Michiel van der Vaart et al.   Cell Host & Microbe

Fit for consumption: zebrafish as a model for tuberculosis

(2014) M. R. Cronan et al.   Disease Models & Mechanisms

Beyond macrophages: the diversity of mononuclear cells in tuberculosis

(2014) Smita Srivastava et al.   IMMUNOLOGICAL REVIEWS

Macrophage Polarization Drives Granuloma Outcome during Mycobacterium tuberculosis Infection

(2014) Simeone Marino et al.   INFECTION AND IMMUNITY

Histone Acetylation and Flagellin Are Essential for Legionella pneumophila-Induced Cytokine Expression

(2014) B. Schmeck et al.   JOURNAL OF IMMUNOLOGY

Macrophage Polarization in Bacterial Infections

(2014) M. Benoit et al.   JOURNAL OF IMMUNOLOGY

Imipramine Exploits Histone Deacetylase 11 To Increase the IL-12/IL-10 Ratio in Macrophages Infected with Antimony-ResistantLeishmania donovaniand Clears Organ Parasites in Experimental Infection

(2014) Sandip Mukherjee et al.   JOURNAL OF IMMUNOLOGY

Glycolysis-dependent histone deacetylase 4 degradation regulates inflammatory cytokine production

(2014) Bin Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Divergent roles of histone deacetylase 6 (HDAC6) and histone deacetylase 11 (HDAC11) on the transcriptional regulation of IL10 in antigen presenting cells

(2014) Fengdong Cheng et al.   MOLECULAR IMMUNOLOGY

HDAC6 Deacetylase Activity Is Critical for Lipopolysaccharide-Induced Activation of Macrophages

(2014) Bing Yan et al.   PLoS One

Pro- and anti-inflammatory cytokines in tuberculosis: A two-edged sword in TB pathogenesis

(2014) Marilena Paola Etna et al.   SEMINARS IN IMMUNOLOGY

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

(2014) E. Seto et al.   Cold Spring Harbor Perspectives in Biology

Tubastatin, a selective histone deacetylase 6 inhibitor shows anti-inflammatory and anti-rheumatic effects

(2013) Santosh Vishwakarma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Histone Deacetylase 7 Promotes Toll-like Receptor 4-dependent Proinflammatory Gene Expression in Macrophages

(2013) Melanie R. Shakespear et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dephosphorylation at a Conserved SP Motif Governs cAMP Sensitivity and Nuclear Localization of Class IIa Histone Deacetylases

(2013) Donald R. Walkinshaw et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type I IFN Inhibits Innate IL-10 Production in Macrophages through Histone Deacetylase 11 by Downregulating MicroRNA-145

(2013) L. Lin et al.   JOURNAL OF IMMUNOLOGY

Opposing HDAC4 nuclear fluxes due to phosphorylation by β-adrenergic activated protein kinase A or by activity or Epac activated CaMKII in skeletal muscle fibres

(2013) Yewei Liu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group

(2013) Mercedes Lobera et al.   Nature Chemical Biology

Evaluation of the pathogenesis and treatment of Mycobacterium marinum infection in zebrafish

(2013) Kevin Takaki et al.   Nature Protocols

Class IIa HDACs repressive activities on MEF2-depedent transcription are associated with poor prognosis of ER+ breast tumors

(2012) Andrea Clocchiatti et al.   FASEB JOURNAL

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages

(2012) X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smoke exposure of human macrophages reduces HDAC3 activity, resulting in enhanced inflammatory cytokine production

(2012) Aaron R. Winkler et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

The role of autophagy in host defence against Mycobacterium tuberculosis infection

(2012) Mário Songane et al.   TUBERCULOSIS

Infection of Zebrafish Embryos with Intracellular Bacterial Pathogens

(2012) Erica L. Benard et al.   Jove-Journal of Visualized Experiments

Bone Marrow–Specific Deficiency of Nuclear Receptor Nur77 Enhances Atherosclerosis

(2011) Anouk A.J. Hamers et al.   CIRCULATION RESEARCH

NR4A1 (Nur77) Deletion Polarizes Macrophages Toward an Inflammatory Phenotype and Increases Atherosclerosis

(2011) Richard N. Hanna et al.   CIRCULATION RESEARCH

Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component

(2011) E. J. M. Stoop et al.   Disease Models & Mechanisms

Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation

(2011) S. E. Mullican et al.   GENES & DEVELOPMENT

HDAC inhibitor MS-275 attenuates the inflammatory reaction in rat experimental autoimmune prostatitis

(2011) Zhi-Yuan Zhang et al.   PROSTATE

Histone deacetylase inhibitors impair innate immune responses to Toll-like receptor agonists and to infection

(2010) T. Roger et al.   BLOOD

The lta4h Locus Modulates Susceptibility to Mycobacterial Infection in Zebrafish and Humans

(2010) David M. Tobin et al.   CELL

Fate Mapping Embryonic Blood in Zebrafish: Multi- and Unipotential Lineages Are Segregated at Gastrulation

(2009) Rachel M. Warga et al.   DEVELOPMENTAL CELL

Multivariate paired data analysis: multilevel PLSDA versus OPLSDA

(2009) Johan A. Westerhuis et al.   Metabolomics

The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance

(2008) Alejandro Villagra et al.   NATURE IMMUNOLOGY