Protection and pathology in TB: learning from the zebrafish model

The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

(2015) Robert O. Watson et al.   Cell Host & Microbe

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1

(2015) Ruth Wassermann et al.   Cell Host & Microbe

Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis

(2015) Angela C. Collins et al.   Cell Host & Microbe

A CRISPR/Cas9 Vector System for Tissue-Specific Gene Disruption in Zebrafish

(2015) Julien Ablain et al.   DEVELOPMENTAL CELL

The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection

(2015) V. Torraca et al.   Disease Models & Mechanisms

Identification of potential Mycobacterium tuberculosis topoisomerase I inhibitors: A study against active, dormant and resistant tuberculosis

(2015) Jonnalagadda Padma Sridevi et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Adventures within the speckled band: heterogeneity, angiogenesis, and balanced inflammation in the tuberculous granuloma

(2015) Molly A. Matty et al.   IMMUNOLOGICAL REVIEWS

Cytokine and lipid mediator networks in tuberculosis

(2015) Katrin D. Mayer-Barber et al.   IMMUNOLOGICAL REVIEWS

Twenty-eight cases of Mycobacterium marinum infection: retrospective case series and literature review

(2015) Matthew G. Johnson et al.   INFECTION

CpsA, a LytR-CpsA-Psr Family Protein in Mycobacterium marinum, Is Required for Cell Wall Integrity and Virulence

(2015) Qinglan Wang et al.   INFECTION AND IMMUNITY

The Proprotein Convertase Subtilisin/Kexin FurinA Regulates Zebrafish Host Response against Mycobacterium marinum

(2015) Markus J. T. Ojanen et al.   INFECTION AND IMMUNITY

CXCR3 ligands as clinical markers for pulmonary tuberculosis

(2015) K. Lee et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

A Mycobacterial Phosphoribosyltransferase Promotes Bacillary Survival by Inhibiting Oxidative Stress and Autophagy Pathways in Macrophages and Zebrafish

(2015) Soumitra Mohanty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapid reverse genetic screening using CRISPR in zebrafish

(2015) Arish N Shah et al.   NATURE METHODS

Anti-vascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery

(2015) Meenal Datta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo

(2015) Roxane Simeone et al.   PLoS Pathogens

Nanoparticles as Drug Delivery System against Tuberculosis in Zebrafish Embryos: Direct Visualization and Treatment

(2014) Federico Fenaroli et al.   ACS Nano

Testing Tuberculosis Drug Efficacy in a Zebrafish High-Throughput Translational Medicine Screen

(2014) Anita Ordas et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Correlative light and electron microscopy imaging of autophagy in a zebrafish infection model

(2014) Rohola Hosseini et al.   Autophagy

DRAM1 promotes the targeting of mycobacteria to selective autophagy

(2014) Annemarie H Meijer et al.   Autophagy

Host Evasion and Exploitation Schemes of Mycobacterium tuberculosis

(2014) C.J. Cambier et al.   CELL

The DNA Damage-Regulated Autophagy Modulator DRAM1 Links Mycobacterial Recognition via TLR-MYD88 to Autophagic Defense

(2014) Michiel van der Vaart et al.   Cell Host & Microbe

Out with the old, in with the new: reassessing morpholino knockdowns in light of genome editing technology

(2014) S. Schulte-Merker et al.   DEVELOPMENT

Phagocytosis of mycobacteria by zebrafish macrophages is dependent on the scavenger receptor Marco, a key control factor of pro-inflammatory signalling

(2014) Erica L. Benard et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Transient infection of the zebrafish notochord with E. coli induces chronic inflammation

(2014) M. Nguyen-Chi et al.   Disease Models & Mechanisms

Modeling tuberculous meningitis in zebrafish using Mycobacterium marinum

(2014) L. M. van Leeuwen et al.   Disease Models & Mechanisms

Macrophage-pathogen interactions in infectious diseases: new therapeutic insights from the zebrafish host model

(2014) V. Torraca et al.   Disease Models & Mechanisms

Fit for consumption: zebrafish as a model for tuberculosis

(2014) M. R. Cronan et al.   Disease Models & Mechanisms

Towards a new combination therapy for tuberculosis with next generation benzothiazinones

(2014) V. Makarov et al.   EMBO Molecular Medicine

CXCR3 deficiency enhances tumor progression by promoting macrophage M2 polarization in a murine breast cancer model

(2014) Steve Oghumu et al.   IMMUNOLOGY

Monkey Models of Tuberculosis: Lessons Learned

(2014) Juliet C. Peña et al.   INFECTION AND IMMUNITY

CCL2 Shapes Macrophage Polarization by GM-CSF and M-CSF: Identification of CCL2/CCR2-Dependent Gene Expression Profile

(2014) E. Sierra-Filardi et al.   JOURNAL OF IMMUNOLOGY

Verapamil, and Its Metabolite Norverapamil, Inhibit Macrophage-induced, Bacterial Efflux Pump-mediated Tolerance to Multiple Anti-tubercular Drugs

(2014) Kristin N. Adams et al.   JOURNAL OF INFECTIOUS DISEASES

Latent Tuberculosis Infection: Myths, Models, and Molecular Mechanisms

(2014) N. K. Dutta et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk

(2014) Katrin D. Mayer-Barber et al.   NATURE

Mycobacterium marinum MgtC Plays a Role in Phagocytosis but is Dispensable for Intracellular Multiplication

(2014) Claudine Belon et al.   PLoS One

BCG-induced protection: Effects on innate immune memory

(2014) Mihai G. Netea et al.   SEMINARS IN IMMUNOLOGY

Perspectives on host adaptation in response to Mycobacterium tuberculosis: Modulation of inflammation

(2014) Anca Dorhoi et al.   SEMINARS IN IMMUNOLOGY

Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth

(2014) Sarah A. Stanley et al.   PLoS Pathogens

Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer

(2014) Kathrin Buffen et al.   PLoS Pathogens

Adequate Th2-Type Response Associates with Restricted Bacterial Growth in Latent Mycobacterial Infection of Zebrafish

(2014) Milka Marjut Hammarén et al.   PLoS Pathogens

Playing hide-and-seek with host macrophages through the use of mycobacterial cell envelope phthiocerol dimycocerosates and phenolic glycolipids

(2014) Ainhoa Arbues et al.   Frontiers in Cellular and Infection Microbiology

Establishment and Optimization of a High Throughput Setup to Study Staphylococcus epidermidis and Mycobacterium marinum Infection as a Model for Drug Discovery

(2014) Wouter J. Veneman et al.   Jove-Journal of Visualized Experiments

Reverse Translation in Tuberculosis: Neutrophils Provide Clues for Understanding Development of Active Disease

(2014) Anca Dorhoi et al.   Frontiers in Immunology

Take five — Type VII secretion systems of Mycobacteria

(2013) Edith N.G. Houben et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Integration of Chemical and RNAi Multiparametric Profiles Identifies Triggers of Intracellular Mycobacterial Killing

(2013) Varadharajan Sundaramurthy et al.   Cell Host & Microbe

Mannan core branching of lipo(arabino)mannan is required for mycobacterial virulence in the context of innate immunity

(2013) Esther J. M. Stoop et al.   CELLULAR MICROBIOLOGY

Functional analysis of a zebrafish myd88 mutant identifies key transcriptional components of the innate immune system

(2013) M. van der Vaart et al.   Disease Models & Mechanisms

Amphisomes: out of the autophagosome shadow?

(2013) Jana Sanchez-Wandelmer et al.   EMBO JOURNAL

Training innate immunity: the changing concept of immunological memory in innate host defence

(2013) Mihai G. Netea   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Early clearance ofMycobacterium tuberculosis: a new frontier in prevention

(2013) Ayesha J. Verrall et al.   IMMUNOLOGY

Deficiency in Hematopoietic Phosphatase Ptpn6/Shp1 Hyperactivates the Innate Immune System and Impairs Control of Bacterial Infections in Zebrafish Embryos

(2013) Z. Kanwal et al.   JOURNAL OF IMMUNOLOGY

IL-10 Inhibits Mature Fibrotic Granuloma Formation during Mycobacterium tuberculosis Infection

(2013) J. C. Cyktor et al.   JOURNAL OF IMMUNOLOGY

Localized bacterial infection induces systemic activation of neutrophils through Cxcr2 signaling in zebrafish

(2013) Qing Deng et al.   JOURNAL OF LEUKOCYTE BIOLOGY

PPE38 of Mycobacterium marinum Triggers the Cross-Talk of Multiple Pathways Involved in the Host Response, As Revealed by Subcellular Quantitative Proteomics

(2013) Hui Wang et al.   JOURNAL OF PROTEOME RESEARCH

Host-Directed Therapeutics for Tuberculosis: Can We Harness the Host?

(2013) T. R. Hawn et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids

(2013) C. J. Cambier et al.   NATURE

Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing

(2013) Philana Ling Lin et al.   NATURE MEDICINE

Evaluation of the pathogenesis and treatment of Mycobacterium marinum infection in zebrafish

(2013) Kevin Takaki et al.   Nature Protocols

CXCR3 modulates obesity-induced visceral adipose inflammation and systemic insulin resistance

(2013) Jeffrey A. Deiuliis et al.   Obesity

An adult zebrafish model for preclinical tuberculosis vaccine development

(2013) Kaisa E. Oksanen et al.   VACCINE

Host Genotype-Specific Therapies Can Optimize the Inflammatory Response to Mycobacterial Infections

(2012) David M. Tobin et al.   CELL

Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway

(2012) Robert O. Watson et al.   CELL

Neutrophils Exert Protection in the Early Tuberculous Granuloma by Oxidative Killing of Mycobacteria Phagocytosed from Infected Macrophages

(2012) Chao-Tsung Yang et al.   Cell Host & Microbe

ESX-5-deficient Mycobacterium marinum is hypervirulent in adult zebrafish

(2012) Eveline M. Weerdenburg et al.   CELLULAR MICROBIOLOGY

Mycobacterium marinum SecA2 Promotes Stable Granulomas and Induces Tumor Necrosis Factor AlphaIn Vivo

(2012) Brigitte Y. Watkins et al.   INFECTION AND IMMUNITY

An In Vivo Platform for Rapid High-Throughput Antitubercular Drug Discovery

(2012) Kevin Takaki et al.   Cell Reports

Mycobacterium marinum Causes a Latent Infection that Can Be Reactivated by Gamma Irradiation in Adult Zebrafish

(2012) Mataleena Parikka et al.   PLoS Pathogens

Infection of Zebrafish Embryos with Intracellular Bacterial Pathogens

(2012) Erica L. Benard et al.   Jove-Journal of Visualized Experiments

Drug Tolerance in Replicating Mycobacteria Mediated by a Macrophage-Induced Efflux Mechanism

(2011) Kristin N. Adams et al.   CELL

Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component

(2011) E. J. M. Stoop et al.   Disease Models & Mechanisms

Mycobacterium tuberculosis and the intimate discourse of a chronic infection

(2011) David G. Russell   IMMUNOLOGICAL REVIEWS

Strategies of professional phagocytes in vivo: unlike macrophages, neutrophils engulf only surface-associated microbes

(2011) E. Colucci-Guyon et al.   JOURNAL OF CELL SCIENCE

A Mycobacterium marinum TesA mutant defective for major cell wall-associated lipids is highly attenuated in Dictyostelium discoideum and zebrafish embryos

(2011) Laeticia Alibaud et al.   MOLECULAR MICROBIOLOGY

Neutrophils in tuberculosis: friend or foe?

(2011) David M. Lowe et al.   TRENDS IN IMMUNOLOGY

Macrophage-specific gene functions in Spi1-directed innate immunity

(2010) A. Zakrzewska et al.   BLOOD

Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome

(2010) K. B. Walters et al.   BLOOD

The lta4h Locus Modulates Susceptibility to Mycobacterial Infection in Zebrafish and Humans

(2010) David M. Tobin et al.   CELL

Genome-wide Analysis of the Host Intracellular Network that Regulates Survival of Mycobacterium tuberculosis

(2010) Dhiraj Kumar et al.   CELL

Delivery of Cytosolic Components by Autophagic Adaptor Protein p62 Endows Autophagosomes with Unique Antimicrobial Properties

(2010) Marisa Ponpuak et al.   IMMUNITY

Serine protease activity contributes to control of Mycobacterium tuberculosis in hypoxic lung granulomas in mice

(2010) Stephen T. Reece et al.   JOURNAL OF CLINICAL INVESTIGATION

An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis

(2010) Matthew P. R. Berry et al.   NATURE

The Role of the Granuloma in Expansion and Dissemination of Early Tuberculous Infection

(2009) J. Muse Davis et al.   CELL

Neutrophils Are the Predominant Infected Phagocytic Cells in the Airways of Patients With Active Pulmonary TB

(2009) Seok-Yong Eum et al.   CHEST

Deep sequencing of the zebrafish transcriptome response to mycobacterium infection

(2009) Zoltán Hegedűs et al.   MOLECULAR IMMUNOLOGY

Specificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection and the role of innate and adaptive immune components

(2009) Astrid M. van der Sar et al.   MOLECULAR IMMUNOLOGY

Tuberculous Granuloma Induction via Interaction of a Bacterial Secreted Protein with Host Epithelium

(2009) H. E. Volkman et al.   SCIENCE

Monocyte-Mediated Defense Against Microbial Pathogens

(2008) Natalya V. Serbina et al.   Annual Review of Immunology

Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis

(2008) David M. Tobin et al.   CELLULAR MICROBIOLOGY

Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis

(2008) T. P. Stinear et al.   GENOME RESEARCH

Tumor Necrosis Factor Signaling Mediates Resistance to Mycobacteria by Inhibiting Bacterial Growth and Macrophage Death

(2008) Hilary Clay et al.   IMMUNITY

Macrophage and T Cell Dynamics during the Development and Disintegration of Mycobacterial Granulomas

(2008) Jackson G. Egen et al.   IMMUNITY

Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2and LXA4in the induction of macrophage death

(2008) Minjian Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Trafficking of SuperinfectingMycobacteriumOrganisms into Established Granulomas Occurs in Mammals and Is Independent of the Erp and ESX‐1 Mycobacterial Virulence Loci

(2008) Christine L. Cosma et al.   JOURNAL OF INFECTIOUS DISEASES