Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials
Authors
Keywords
-
Journal
Nature Communications
Volume 9, Issue 1, Pages -
Publisher
Springer Nature
Online
2018-01-18
DOI
10.1038/s41467-017-02777-6
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Host-directed therapies for bacterial and viral infections
- (2017) Stefan H. E. Kaufmann et al. NATURE REVIEWS DRUG DISCOVERY
- Efficacy and safety of dovitinib in pretreated patients with advanced squamous non-small cell lung cancer withFGFR1amplification: A single-arm, phase 2 study
- (2016) Sung Hee Lim et al. CANCER
- Randomized, open-label phase 2 study comparing frontline dovitinib versus sorafenib in patients with advanced hepatocellular carcinoma
- (2016) Ann-Lii Cheng et al. HEPATOLOGY
- A phase I trial of the aurora kinase inhibitor, ENMD-2076, in patients with relapsed or refractory acute myeloid leukemia or chronic myelomonocytic leukemia
- (2016) Karen W. L. Yee et al. INVESTIGATIONAL NEW DRUGS
- Phase I trial of dovitinib (TKI258) in recurrent glioblastoma
- (2016) Niklas Schäfer et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- KEGG: new perspectives on genomes, pathways, diseases and drugs
- (2016) Minoru Kanehisa et al. NUCLEIC ACIDS RESEARCH
- Ion Channel Blockers as Antimicrobial Agents, Efflux Inhibitors, and Enhancers of Macrophage Killing Activity against Drug Resistant Mycobacterium tuberculosis
- (2016) Diana Machado et al. PLoS One
- New tricks for old dogs: countering antibiotic resistance in tuberculosis with host-directed therapeutics
- (2015) Thomas R. Hawn et al. IMMUNOLOGICAL REVIEWS
- Receptor tyrosine kinase inhibitors: Are they real tumor killers?
- (2015) Andreas K.A. Gaumann et al. INTERNATIONAL JOURNAL OF CANCER
- A phase II study of AT9283, an aurora kinase inhibitor, in patients with relapsed or refractory multiple myeloma: NCIC clinical trials group IND.191
- (2015) Annette E. Hay et al. LEUKEMIA & LYMPHOMA
- Host-directed drug therapy for tuberculosis
- (2015) Reto Guler et al. Nature Chemical Biology
- Anti-vascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery
- (2015) Meenal Datta et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phenylbutyrate Is Bacteriostatic against Mycobacterium tuberculosis and Regulates the Macrophage Response to Infection, Synergistically with 25-Hydroxy-Vitamin D₃
- (2015) Anna K. Coussens et al. PLoS Pathogens
- Significant Effects of Oral Phenylbutyrate and Vitamin D3 Adjunctive Therapy in Pulmonary Tuberculosis: A Randomized Controlled Trial
- (2015) Akhirunnesa Mily et al. PLoS One
- A Phase I Trial of AT9283 (a Selective Inhibitor of Aurora Kinases) in Children and Adolescents with Solid Tumors: A Cancer Research UK Study
- (2014) L. Moreno et al. CLINICAL CANCER RESEARCH
- Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion
- (2014) M. Schiebler et al. EMBO Molecular Medicine
- Simvastatin increases the in vivo activity of the first-line tuberculosis regimen
- (2014) C. Skerry et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk
- (2014) Katrin D. Mayer-Barber et al. NATURE
- Interception of host angiogenic signalling limits mycobacterial growth
- (2014) Stefan H. Oehlers et al. NATURE
- STRING v10: protein–protein interaction networks, integrated over the tree of life
- (2014) Damian Szklarczyk et al. NUCLEIC ACIDS RESEARCH
- Metformin as adjunct antituberculosis therapy
- (2014) A. Singhal et al. Science Translational Medicine
- Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth
- (2014) Sarah A. Stanley et al. PLoS Pathogens
- Pathogenicity of Mycobacterium tuberculosis Is Expressed by Regulating Metabolic Thresholds of the Host Macrophage
- (2014) Parul Mehrotra et al. PLoS Pathogens
- Protein kinase C pharmacology: refining the toolbox
- (2013) Alyssa X. Wu-zhang et al. BIOCHEMICAL JOURNAL
- Integration of Chemical and RNAi Multiparametric Profiles Identifies Triggers of Intracellular Mycobacterial Killing
- (2013) Varadharajan Sundaramurthy et al. Cell Host & Microbe
- Dual inhibition of Src family kinases and Aurora kinases by SU6656 modulates CTGF (connective tissue growth factor) expression in an ERK-dependent manner
- (2013) Iwona Cicha et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Estimating Dopamine D2 Receptor Occupancy for Doses of 8 Antipsychotics
- (2013) Irene M. Lako et al. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
- Ibuprofen Therapy Resulted in Significantly Decreased Tissue Bacillary Loads and Increased Survival in a New Murine Experimental Model of Active Tuberculosis
- (2013) Cristina Vilaplana et al. JOURNAL OF INFECTIOUS DISEASES
- The knowns and unknowns of the immunopathogenesis of tuberculosis [State of the art]
- (2012) T. H. M. Ottenhoff INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
- Nerve growth factor: from the early discoveries to the potential clinical use
- (2012) Luigi Aloe et al. Journal of Translational Medicine
- New pathways of protective and pathological host defense to mycobacteria
- (2012) Tom H.M. Ottenhoff TRENDS IN MICROBIOLOGY
- Phosphodiesterase-4 Inhibition Combined with Isoniazid Treatment of Rabbits with Pulmonary Tuberculosis Reduces Macrophage Activation and Lung Pathology
- (2011) Selvakumar Subbian et al. AMERICAN JOURNAL OF PATHOLOGY
- Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers
- (2011) Reza Ehsanian et al. Cell Communication and Signaling
- Imatinib-Sensitive Tyrosine Kinases Regulate Mycobacterial Pathogenesis and Represent Therapeutic Targets against Tuberculosis
- (2011) Ruth J. Napier et al. Cell Host & Microbe
- HIV-1/Mycobacterium tuberculosisCoinfection Immunology: How Does HIV-1 Exacerbate Tuberculosis?
- (2011) Collin R. Diedrich et al. INFECTION AND IMMUNITY
- Tuberculosis
- (2011) Stephen D Lawn et al. LANCET
- Phosphodiesterase 4 Inhibition Reduces Innate Immunity and Improves Isoniazid Clearance of Mycobacterium tuberculosis in the Lungs of Infected Mice
- (2011) Mi-Sun Koo et al. PLoS One
- Phosphodiesterase-4 Inhibition Alters Gene Expression and Improves Isoniazid – Mediated Clearance of Mycobacterium tuberculosis in Rabbit Lungs
- (2011) Selvakumar Subbian et al. PLoS Pathogens
- Genome-wide Analysis of the Host Intracellular Network that Regulates Survival of Mycobacterium tuberculosis
- (2010) Dhiraj Kumar et al. CELL
- Cell Signaling by Receptor Tyrosine Kinases
- (2010) Mark A. Lemmon et al. CELL
- Assessment of the In vivo Antitumor Effects of ENMD-2076, a Novel Multitargeted Kinase Inhibitor, against Primary and Cell Line-Derived Human Colorectal Cancer Xenograft Models
- (2010) J. J. Tentler et al. CLINICAL CANCER RESEARCH
- Epidemiology and Challenges to the Elimination of Global Tuberculosis
- (2010) Mandeep S. Jassal et al. CLINICAL INFECTIOUS DISEASES
- The chemical biology of new drugs in the development for tuberculosis
- (2010) Clifton E Barry et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Identification of Host-Dependent Survival Factors for Intracellular Mycobacterium tuberculosis through an siRNA Screen
- (2010) Shilpi Jayaswal et al. PLoS Pathogens
- Overcoming the global crisis: “Yes, we can”, but also for TB … ?
- (2009) Tom H. M. Ottenhoff EUROPEAN JOURNAL OF IMMUNOLOGY
- Synthetic EthR inhibitors boost antituberculous activity of ethionamide
- (2009) Nicolas Willand et al. NATURE MEDICINE
- The pharmacology of sigma-1 receptors
- (2009) Tangui Maurice et al. PHARMACOLOGY & THERAPEUTICS
- Mutations at the BLK locus linked to maturity onset diabetes of the young and -cell dysfunction
- (2009) M. Borowiec et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis
- (2009) V. Makarov et al. SCIENCE
- High Content Screening Identifies Decaprenyl-Phosphoribose 2′ Epimerase as a Target for Intracellular Antimycobacterial Inhibitors
- (2009) Thierry Christophe et al. PLoS Pathogens
- The Biology of Neurotrophins, Signalling Pathways, and Functional Peptide Mimetics of Neurotrophins and their Receptors
- (2008) Stephen Skaper CNS & Neurological Disorders-Drug Targets
- Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity†
- (2008) Steven Howard et al. JOURNAL OF MEDICINAL CHEMISTRY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started