Regulation of cGAS‐Mediated Immune Responses and Immunotherapy

Novel Approaches to Improve the Efficacy of Immuno-Radiotherapy

(2019) Maxim Shevtsov et al.   Frontiers in Oncology

Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS–STING signalling

(2019) James B. Eaglesham et al.   NATURE

Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity

(2019) Jiang Dai et al.   CELL

An emerging role for calcium signalling in innate and autoimmunity via the cGAS-STING axis

(2019) Sabateeshan Mathavarajah et al.   CYTOKINE & GROWTH FACTOR REVIEWS

A STING to inflammation and autoimmunity

(2019) Vijay Kumar   JOURNAL OF LEUKOCYTE BIOLOGY

SLC19A1 Is an Importer of the Immunotransmitter cGAMP

(2019) Christopher Ritchie et al.   MOLECULAR CELL

RNA viruses promote activation of the NLRP3 inflammasome through cytopathogenic effect-induced potassium efflux

(2019) Leandro Silva da Costa et al.   Cell Death & Disease

Oncolytic virus immunotherapy induces immunogenic cell death and overcomes STING deficiency in melanoma

(2019) Praveen K. Bommareddy et al.   OncoImmunology

Regulation of phosphoribosyl ubiquitination by a calmodulin-dependent glutamylase

(2019) Ninghai Gan et al.   NATURE

HER2 recruits AKT1 to disrupt STING signalling and suppress antiviral defence and antitumour immunity

(2019) Shiying Wu et al.   NATURE CELL BIOLOGY

The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers

(2019) Lili Cao et al.   Cell Host & Microbe

The Diverse Function of PD-1/PD-L Pathway Beyond Cancer

(2019) Weiting Qin et al.   Frontiers in Immunology

Roles of protein kinase R in cancer: Potential as a therapeutic target

(2018) Takao Watanabe et al.   CANCER SCIENCE

Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of Immune Surveillance

(2018) Wen Zhou et al.   CELL

Delicate regulation of the cGAS–MITA-mediated innate immune response

(2018) Wei-Wei Luo et al.   Cellular & Molecular Immunology

Mutations in RNA Polymerase III genes and defective DNA sensing in adults with varicella-zoster virus CNS infection

(2018) Madalina E. Carter-Timofte et al.   GENES AND IMMUNITY

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

(2018) Tuo Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STING-dependent translation inhibition restricts RNA virus replication

(2018) Kate M. Franz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

(2018) Mingjian Du et al.   SCIENCE

cGAS–STING and Cancer: Dichotomous Roles in Tumor Immunity and Development

(2018) Kevin W. Ng et al.   TRENDS IN IMMUNOLOGY

STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection

(2018) Siyuan Ding et al.   Nature Communications

TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing

(2018) Gil Ju Seo et al.   Nature Communications

Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells

(2018) Bartosz Szczesny et al.   Scientific Reports

RINCK-mediated monoubiquitination of cGAS promotes antiviral innate immune responses

(2018) Zhao-Shan Liu et al.   Cell and Bioscience

Pro-inflammation Associated with a Gain-of-Function Mutation (R284S) in the Innate Immune Sensor STING

(2018) Hiroyasu Konno et al.   Cell Reports

Combining Immunotherapy and Radiotherapy for Cancer Treatment: Current Challenges and Future Directions

(2018) Yifan Wang et al.   Frontiers in Pharmacology

The cGas–Sting Signaling Pathway Is Required for the Innate Immune Response Against Ectromelia Virus

(2018) Wen-Yu Cheng et al.   Frontiers in Immunology

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

(2018) Gillian Dunphy et al.   MOLECULAR CELL

PKR Senses Nuclear and Mitochondrial Signals by Interacting with Endogenous Double-Stranded RNAs

(2018) Yoosik Kim et al.   MOLECULAR CELL

Phase separation focuses DNA sensing

(2018) Andrea Ablasser   SCIENCE

Tumor cGAMP Awakens the Natural Killers

(2018) Shriram K. Sundararaman et al.   IMMUNITY

Tumor-Derived cGAMP Triggers a STING-Mediated Interferon Response in Non-tumor Cells to Activate the NK Cell Response

(2018) Assaf Marcus et al.   IMMUNITY

Nuclear cGAS suppresses DNA repair and promotes tumorigenesis

(2018) Haipeng Liu et al.   NATURE

Mechanisms of PARP inhibitor resistance in cancer and insights into the DNA damage response

(2018) Paola Francica et al.   Genome Medicine

The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway

(2018) Lele Zhang et al.   PLoS Pathogens

Innate immunosensing of DNA in cellular senescence

(2018) Selene Glück et al.   CURRENT OPINION IN IMMUNOLOGY

Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection

(2017) Yutao Wang et al.   IMMUNITY

The AIM2 inflammasome: Sensor of pathogens and cellular perturbations

(2017) Jérôme Lugrin et al.   IMMUNOLOGICAL REVIEWS

Promising Targets for Cancer Immunotherapy: TLRs, RLRs, and STING-Mediated Innate Immune Pathways

(2017) Kai Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors

(2017) Tyrel T. Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

Herpes Simplex Virus 1 UL24 Abrogates the DNA Sensing Signal Pathway by Inhibiting NF-κB Activation

(2017) Haiyan Xu et al.   JOURNAL OF VIROLOGY

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders

(2017) Liudmila Andreeva et al.   NATURE

miR-25/93 mediates hypoxia-induced immunosuppression by repressing cGAS

(2017) Min-Zu Wu et al.   NATURE CELL BIOLOGY

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

cGAS drives noncanonical-inflammasome activation in age-related macular degeneration

(2017) Nagaraj Kerur et al.   NATURE MEDICINE

Tumour viruses and innate immunity

(2017) Sharon E. Hopcraft et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

cGAS is essential for the antitumor effect of immune checkpoint blockade

(2017) Hua Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

cGAS is essential for cellular senescence

(2017) Hui Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NOD1 and NOD2: Beyond Peptidoglycan Sensing

(2017) A. Marijke Keestra-Gounder et al.   TRENDS IN IMMUNOLOGY

Evolutionary Origins of cGAS-STING Signaling

(2017) Shally R. Margolis et al.   TRENDS IN IMMUNOLOGY

Interferon-γ-inducible protein 16 (IFI16) is required for the maintenance of Epstein-Barr virus latency

(2017) Gina Pisano et al.   Virology Journal

IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

(2017) K. L. Jønsson et al.   Nature Communications

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

(2017) Jessica F. Almine et al.   Nature Communications

Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

(2017) Jessica Vincent et al.   Nature Communications

Decreased expression of interferon-induced protein 2 (IFIT2) by Wnt/β-catenin signaling confers anti-apoptotic properties to colorectal cancer cells

(2017) Tomoyuki Ohsugi et al.   Oncotarget

Decreased expression of STING predicts poor prognosis in patients with gastric cancer

(2017) Shushu Song et al.   Scientific Reports

Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT

(2017) Stephanie Dabo et al.   Scientific Reports

SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing

(2017) Ye Cui et al.   PLoS Pathogens

The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription

(2017) Baca Chan et al.   PLoS Pathogens

The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response

(2017) Qiang Wang et al.   PLoS Pathogens

Antibody Engineering for Pursuing a Healthier Future

(2017) Abdullah F. U. H. Saeed et al.   Frontiers in Microbiology

Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection

(2017) Sebastian Aguirre et al.   Nature Microbiology

Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells

(2016) Chih-Hang Anthony Tang et al.   CANCER RESEARCH

STING Promotes the Growth of Tumors Characterized by Low Antigenicity via IDO Activation

(2016) Henrique Lemos et al.   CANCER RESEARCH

The cGAS-STING Defense Pathway and Its Counteraction by Viruses

(2016) Zhe Ma et al.   Cell Host & Microbe

Viral evasion of DNA-stimulated innate immune responses

(2016) Maria H Christensen et al.   Cellular & Molecular Immunology

HSV‐1 ICP27 targets the TBK1‐activated STING signalsome to inhibit virus‐induced type I IFN expression

(2016) Maria H Christensen et al.   EMBO JOURNAL

Post-Translational Modification Control of Innate Immunity

(2016) Juan Liu et al.   IMMUNITY

The DNA Structure-Specific Endonuclease MUS81 Mediates DNA Sensor STING-Dependent Host Rejection of Prostate Cancer Cells

(2016) Samantha S.W. Ho et al.   IMMUNITY

Nuclear Innate Immune DNA Sensor IFI16 Is Degraded during Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus (KSHV): Role of IFI16 in Maintenance of KSHV Latency

(2016) Arunava Roy et al.   JOURNAL OF VIROLOGY

Targeted therapy: An elusive cancer target

(2016) Carolyn Brown   NATURE

The microbiome and innate immunity

(2016) Christoph A. Thaiss et al.   NATURE

Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer

(2016) Qing Chen et al.   NATURE

iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING

(2016) Wei-Wei Luo et al.   NATURE IMMUNOLOGY

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity

(2016) Pengyan Xia et al.   NATURE IMMUNOLOGY

EAF2 regulates DNA repair through Ku70/Ku80 in the prostate

(2016) J Ai et al.   ONCOGENE

Structural basis for DNA recognition by STAT6

(2016) Jing Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance

(2016) David H. Munn et al.   TRENDS IN IMMUNOLOGY

Activation of STING requires palmitoylation at the Golgi

(2016) Kojiro Mukai et al.   Nature Communications

Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response

(2016) Tiejun Li et al.   Scientific Reports

The emerging roles of the DDX41 protein in immunity and diseases

(2016) Yan Jiang et al.   Protein & Cell

Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals

(2016) Matthew D Daugherty et al.   eLife

Reprogramming of Melanoma Tumor-Infiltrating Lymphocytes to Induced Pluripotent Stem Cells

(2016) Hidehito Saito et al.   Stem Cells International

Innate Immune Recognition of Cancer

(2015) Seng-Ryong Woo et al.   Annual Review of Immunology

Activated STING enhances Tregs infiltration in the HPV-related carcinogenesis of tongue squamous cells via the c-jun/CCL22 signal

(2015) Ding Liang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Silencing of LRRFIP1 reverses the epithelial–mesenchymal transition via inhibition of the Wnt/β-catenin signaling pathway

(2015) Daisuke Douchi et al.   CANCER LETTERS

Radiotherapy Combined with Novel STING-Targeting Oligonucleotides Results in Regression of Established Tumors

(2015) J. R. Baird et al.   CANCER RESEARCH

Nucleic Acid–Sensing Receptors: Rheostats of Autoimmunity and Autoinflammation

(2015) Shruti Sharma et al.   JOURNAL OF IMMUNOLOGY

Evasion of Innate Cytosolic DNA Sensing by a Gammaherpesvirus Facilitates Establishment of Latent Infection

(2015) Chenglong Sun et al.   JOURNAL OF IMMUNOLOGY

HIV Blocks Interferon Induction in Human Dendritic Cells and Macrophages by Dysregulation of TBK1

(2015) Andrew N. Harman et al.   JOURNAL OF VIROLOGY

Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway

(2015) Sowmya Pattabhi et al.   JOURNAL OF VIROLOGY

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA

(2015) Anna-Maria Herzner et al.   NATURE IMMUNOLOGY

CD47 blockade triggers T cell–mediated destruction of immunogenic tumors

(2015) Xiaojuan Liu et al.   NATURE MEDICINE

Perception of self: distinguishing autoimmunity from autoinflammation

(2015) Tessa S. van Kempen et al.   Nature Reviews Rheumatology

Diverse roles of STING-dependent signaling on the development of cancer

(2015) J Ahn et al.   ONCOGENE

STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity

(2015) Olivier Demaria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

(2015) Daxing Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses

(2015) Zhe Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway

(2015) L. Lau et al.   SCIENCE

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade

(2015) Juan Fu et al.   Science Translational Medicine

New insights into the structural basis of DNA recognition by HINa and HINb domains of IFI16

(2015) Xiangmin Ni et al.   Journal of Molecular Cell Biology

Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis

(2015) Smitha Pillai et al.   Nature Communications

DNA-Damage-Induced Type I Interferon Promotes Senescence and Inhibits Stem Cell Function

(2015) Qiujing Yu et al.   Cell Reports

Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway

(2015) Gil Ju Seo et al.   Cell Reports

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

(2015) Leticia Corrales et al.   Cell Reports

Crosstalk between the cGAS DNA Sensor and Beclin-1 Autophagy Protein Shapes Innate Antimicrobial Immune Responses

(2014) Qiming Liang et al.   Cell Host & Microbe

Emerging roles of interferon-stimulated genes in the innate immune response to hepatitis C virus infection

(2014) Mun-Teng Wong et al.   Cellular & Molecular Immunology

DNA Double-strand Break Repair in a Cellular Context

(2014) A. Shibata et al.   CLINICAL ONCOLOGY

IFI16: At the interphase between innate DNA sensing and genome regulation

(2014) Martin R. Jakobsen et al.   CYTOKINE & GROWTH FACTOR REVIEWS

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

Bacterial Sensor Nod2 Prevents Inflammation of the Small Intestine by Restricting the Expansion of the Commensal Bacteroides vulgatus

(2014) Deepshika Ramanan et al.   IMMUNITY

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

NLRC3, a Member of the NLR Family of Proteins, Is a Negative Regulator of Innate Immune Signaling Induced by the DNA Sensor STING

(2014) Lu Zhang et al.   IMMUNITY

Hepatitis B Virus Polymerase Disrupts K63-Linked Ubiquitination of STING To Block Innate Cytosolic DNA-Sensing Pathways

(2014) Yinghui Liu et al.   JOURNAL OF VIROLOGY

Murine Gammaherpesvirus 68 Encoding Open Reading Frame 11 Targets TANK Binding Kinase 1 To Negatively Regulate the Host Type I Interferon Response

(2014) H.-R. Kang et al.   JOURNAL OF VIROLOGY

Insight into the Mechanism of Inhibition of Adeno-Associated Virus by the Mre11/Rad50/Nbs1 Complex

(2014) Thomas B. Lentz et al.   JOURNAL OF VIROLOGY

Mechanisms of RIG-I-Like Receptor Activation and Manipulation by Viral Pathogens

(2014) M. U. Gack   JOURNAL OF VIROLOGY

Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs

(2014) Lingyin Li et al.   Nature Chemical Biology

Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING

(2014) Xiaomei Wu et al.   NUCLEIC ACIDS RESEARCH

RNF26 Temporally Regulates Virus-Triggered Type I Interferon Induction by Two Distinct Mechanisms

(2014) Yue Qin et al.   PLoS Pathogens

Cyclic Dinucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling

(2013) Hiroyasu Konno et al.   CELL

Human Cytomegalovirus Tegument Protein pUL83 Inhibits IFI16-Mediated DNA Sensing for Immune Evasion

(2013) Tuo Li et al.   Cell Host & Microbe

Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing

(2013) Nadine Gehrke et al.   IMMUNITY

Nuclease Activity of the Human SAMHD1 Protein Implicated in the Aicardi-Goutières Syndrome and HIV-1 Restriction

(2013) Natalia Beloglazova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosome-mediated processing of chromatin in senescence

(2013) Andre Ivanov et al.   JOURNAL OF CELL BIOLOGY

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteasomal Degradation of Herpes Simplex Virus Capsids in Macrophages Releases DNA to the Cytosol for Recognition by DNA Sensors

(2013) K. A. Horan et al.   JOURNAL OF IMMUNOLOGY

Structural mechanism of cytosolic DNA sensing by cGAS

(2013) Filiz Civril et al.   NATURE

Human Papillomavirus (HPV) Upregulates the Cellular Deubiquitinase UCHL1 to Suppress the Keratinocyte's Innate Immune Response

(2013) Rezaul Karim et al.   PLoS Pathogens

Sweeten PAMPs: role of sugar complexed PAMPs in innate immunity and vaccine biology

(2013) Ranjeet Singh Mahla   Frontiers in Immunology

Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding

(2012) Songying Ouyang et al.   IMMUNITY

Recent advances in understanding viral evasion of type I interferon

(2012) Kathryne E. Taylor et al.   IMMUNOLOGY

Microbial recognition and evasion of host immunity

(2012) Michiel J. C. Pel et al.   JOURNAL OF EXPERIMENTAL BOTANY

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response

(2012) Kislay Parvatiyar et al.   NATURE IMMUNOLOGY

Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein

(2012) M. H. Orzalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

(2012) Y. Tanaka et al.   Science Signaling

Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor-2 inhibits type 1 interferon signalling by targeting interferon-stimulated gene factor-3

(2011) M. Mutocheluh et al.   JOURNAL OF GENERAL VIROLOGY

Evasion and Subversion of Interferon-Mediated Antiviral Immunity by Kaposi's Sarcoma-Associated Herpesvirus: an Overview

(2011) N. Sathish et al.   JOURNAL OF VIROLOGY

Inhibition of TANK Binding Kinase 1 by Herpes Simplex Virus 1 Facilitates Productive Infection

(2011) Y. Ma et al.   JOURNAL OF VIROLOGY

The Anti-interferon Activity of Conserved Viral dUTPase ORF54 is Essential for an Effective MHV-68 Infection

(2011) Ronika Sitapara Leang et al.   PLoS Pathogens

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

The DNA-dependent protein kinase (DNA-PK): More than just a case of making ends meet?

(2010) Richard Hill et al.   CELL CYCLE

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a β-catenin-dependent pathway

(2010) Pengyuan Yang et al.   NATURE IMMUNOLOGY

Anti–CTLA-4 Antibody Therapy: Immune Monitoring During Clinical Development of a Novel Immunotherapy

(2010) Margaret K. Callahan et al.   SEMINARS IN ONCOLOGY

ITAM-mediated Signaling by the T-Cell Antigen Receptor

(2010) P. E. Love et al.   Cold Spring Harbor Perspectives in Biology

Chemokine Expression in Melanoma Metastases Associated with CD8+ T-Cell Recruitment

(2009) H. Harlin et al.   CANCER RESEARCH

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

(2009) Yu-Hsin Chiu et al.   CELL

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

The Ubiquitin Ligase RNF5 Regulates Antiviral Responses by Mediating Degradation of the Adaptor Protein MITA

(2009) Bo Zhong et al.   IMMUNITY

The roles of TLRs, RLRs and NLRs in pathogen recognition

(2009) T. Kawai et al.   INTERNATIONAL IMMUNOLOGY

A Kaposi's Sarcoma-Associated Herpesvirus Protein That Forms Inhibitory Complexes with Type I Interferon Receptor Subunits, Jak and STAT Proteins, and Blocks Interferon-Mediated Signal Transduction

(2009) S. A. Bisson et al.   JOURNAL OF VIROLOGY

The EBV-encoded latent membrane proteins, LMP2A and LMP2B, limit the actions of interferon by targeting interferon receptors for degradation

(2009) K M Shah et al.   ONCOGENE

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

(2009) T. Saitoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

SOCS regulation of the JAK/STAT signalling pathway

(2008) Ben A. Croker et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY