The Potential Mechanisms of Berberine in the Treatment of Nonalcoholic Fatty Liver Disease

Hepatocellular Carcinoma in the Absence of Cirrhosis in United States Veterans Is Associated With Nonalcoholic Fatty Liver Disease

(2016) Sahil Mittal et al.   Clinical Gastroenterology and Hepatology

Trends in the Burden of Nonalcoholic Fatty Liver Disease in a United States Cohort of Veterans

(2016) Fasiha Kanwal et al.   Clinical Gastroenterology and Hepatology

NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis

(2016) Chi Ma et al.   NATURE

The intersection of nonalcoholic fatty liver disease and obesity

(2016) Jennifer A. Woo Baidal et al.   Science Translational Medicine

Berberine Ameliorates Hepatic Steatosis and Suppresses Liver and Adipose Tissue Inflammation in Mice with Diet-induced Obesity

(2016) Ting Guo et al.   Scientific Reports

Berberine prevents progression from hepatic steatosis to steatohepatitis and fibrosis by reducing endoplasmic reticulum stress

(2016) Zhiguo Zhang et al.   Scientific Reports

Metabolomics Profiling to Investigate the Pharmacologic Mechanisms of Berberine for the Treatment of High-Fat Diet-Induced Nonalcoholic Steatohepatitis

(2015) Jian Li et al.   Evidence-based Complementary and Alternative Medicine

Association of nonalcoholic fatty liver disease (NAFLD) with hepatocellular carcinoma (HCC) in the United States from 2004 to 2009

(2015) Zobair M. Younossi et al.   HEPATOLOGY

Nonalcoholic Fatty Liver Disease

(2015) Mary E. Rinella   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Berberine ameliorates nonalcoholic fatty liver disease by a global modulation of hepatic mRNA and lncRNA expression profiles

(2015) Xinlu Yuan et al.   Journal of Translational Medicine

Starting the battle to control non-alcoholic steatohepatitis

(2015) Vlad Ratziu   LANCET

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease

(2015) Hong-Mei Yan et al.   PLoS One

Inhibition of proprotein convertase subtilisin/kexin type 9: A novel mechanism of berberine and 8-hydroxy dihydroberberine against hyperlipidemia

(2014) De-liang Liu et al.   Chinese Journal of Integrative Medicine

The Role of Oral Antidiabetic Agents and Incretin Mimetics in Type 2 Diabetic Patients with Non-Alcoholic Fatty Liver Disease

(2014) Ioanna Gouni-Berthold et al.   CURRENT PHARMACEUTICAL DESIGN

TheUCP2-866 G>A promoter region polymorphism is associated with nonalcoholic steatohepatitis.

(2014) Roberta Fares et al.   LIVER INTERNATIONAL

Berberine Promotes Glucose Consumption Independently of AMP-Activated Protein Kinase Activation

(2014) Miao Xu et al.   PLoS One

Diabetes and Nonalcoholic Fatty Liver Disease: A Pathogenic Duo

(2013) K. H. Williams et al.   ENDOCRINE REVIEWS

Update on Berberine in Nonalcoholic Fatty Liver Disease

(2013) Yang Liu et al.   Evidence-based Complementary and Alternative Medicine

Effects of berberine on lipid profile in subjects with low cardiovascular risk

(2013) Giuseppe Derosa et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Extrahepatic complications of nonalcoholic fatty liver disease

(2013) Matthew J. Armstrong et al.   HEPATOLOGY

Epidemiology of Hepatocellular Carcinoma

(2013) Sahil Mittal et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Berberine metabolites exhibit triglyceride-lowering effects via activation of AMP-activated protein kinase in Hep G2 cells

(2013) Shijie Cao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Effect of Berberine Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion

(2013) Karina G. Pérez-Rubio et al.   Metabolic Syndrome and Related Disorders

Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: A possible role for SirT3 activation

(2013) João Soeiro Teodoro et al.   MITOCHONDRION

Berberine: New perspectives for old remedies

(2012) Micol Tillhon et al.   BIOCHEMICAL PHARMACOLOGY

Synthesis and structure–activity relationship of berberine analogues in LDLR up-regulation and AMPK activation

(2012) Yan-Xiang Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Berberine Improves Insulin Sensitivity by Inhibiting Fat Store and Adjusting Adipokines Profile in Human Preadipocytes and Metabolic Syndrome Patients

(2012) Jing Yang et al.   Evidence-based Complementary and Alternative Medicine

Berberine and its derivatives: a patent review (2009 – 2012)

(2012) Inder Pal Singh et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

(2012) Naga Chalasani et al.   HEPATOLOGY

Metabolic profile associated with glucose and cholesterol lowering effects of berberine in Sprague–Dawley rats

(2012) Zhangjian Jiang et al.   Metabolomics

Lipid-lowering effect of berberine in human subjects and rats

(2012) Yueshan Hu et al.   PHYTOMEDICINE

Structural Changes of Gut Microbiota during Berberine-Mediated Prevention of Obesity and Insulin Resistance in High-Fat Diet-Fed Rats

(2012) Xu Zhang et al.   PLoS One

Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis

(2011) Ana P. Gomes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

(2011) Yu Li et al.   Cell Metabolism

Effect of berberine on expressions of uncoupling protein-2 mRNA and protein in hepatic tissue of non-alcoholic fatty liver disease in rats

(2011) Qin-he Yang et al.   Chinese Journal of Integrative Medicine

Berberine reducing insulin resistance by up-regulating IRS-2 mRNA expression in nonalcoholic fatty liver disease (NAFLD) rat liver

(2011) Lian-Jun Xing et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Activation of AMPK by berberine promotes adiponectin multimerization in 3T3-L1 adipocytes

(2011) Yun Li et al.   FEBS LETTERS

High prevalence of colorectal neoplasm in patients with non-alcoholic steatohepatitis

(2011) V. W.-S. Wong et al.   GUT

Effect of Vitamin E or Metformin for Treatment of Nonalcoholic Fatty Liver Disease in Children and Adolescents

(2011) Joel E. Lavine   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

DSS induced colitis increases portal LPS levels and enhances hepatic inflammation and fibrogenesis in experimental NASH

(2011) Erwin Gäbele et al.   JOURNAL OF HEPATOLOGY

Berberine Ameliorates Intestinal Epithelial Tight-Junction Damage and Down-regulates Myosin Light Chain Kinase Pathways in a Mouse Model of Endotoxinemia

(2011) Lili Gu et al.   JOURNAL OF INFECTIOUS DISEASES

Human Fatty Liver Disease: Old Questions and New Insights

(2011) J. C. Cohen et al.   SCIENCE

Berberine reduces endoplasmic reticulum stress and improves insulin signal transduction in Hep G2 cells

(2010) Zeng-si Wang et al.   ACTA PHARMACOLOGICA SINICA

From the metabolic syndrome to NAFLD or vice versa?

(2010) Ester Vanni et al.   DIGESTIVE AND LIVER DISEASE

Beneficial effect of berberine on hepatic insulin resistance in diabetic hamsters possibly involves in SREBPs, LXRα and PPARα transcriptional programs

(2010) Xuhan Liu et al.   ENDOCRINE JOURNAL

Berberine: a potential phytochemical with multispectrum therapeutic activities

(2010) Parameswara Rao Vuddanda et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Berberine Inhibits Inflammatory Response and Ameliorates Insulin Resistance in Hepatocytes

(2010) Tianjiong Lou et al.   INFLAMMATION

Berberine reduces methylation of theMTTPpromoter and alleviates fatty liver induced by a high-fat diet in rats

(2010) XinXia Chang et al.   JOURNAL OF LIPID RESEARCH

Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity

(2009) Woo Sik Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metabolic and cardiovascular effects of berberine: from preclinical evidences to clinical trial results

(2009) Arrigo F Cicero et al.   Clinical Lipidology

The effect of berberine in vitro on tight junctions in human Caco-2 intestinal epithelial cells

(2009) Lili Gu et al.   FITOTERAPIA

Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease

(2009) Luca Miele et al.   HEPATOLOGY

Berberine improves free-fatty-acid–induced insulin resistance in L6 myotubes through inhibiting peroxisome proliferator–activated receptor γ and fatty acid transferase expressions

(2009) Yanfeng Chen et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders

(2009) S. K. Kulkarni et al.   PHYTOTHERAPY RESEARCH

Co-administration of berberine and plant stanols synergistically reduces plasma cholesterol in rats

(2008) Xiaoming Jia et al.   ATHEROSCLEROSIS

Selective versus Total Insulin Resistance: A Pathogenic Paradox

(2008) Michael S. Brown et al.   Cell Metabolism

Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I: A Mechanism for the Action of Berberine to Activate AMP-Activated Protein Kinase and Improve Insulin Action

(2008) N. Turner et al.   DIABETES

Berberine reduces insulin resistance through protein kinase C–dependent up-regulation of insulin receptor expression

(2008) Wei-Jia Kong et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Fatty Liver

(2007) Anna Kotronen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY