Hydrogen-Deuterium Exchange Mass-Spectrometry of Secondary Active Transporters: From Structural Dynamics to Molecular Mechanisms

Dynamic structural biology at the protein membrane interface

(2019) John E. Burke   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrogen-deuterium exchange mass spectrometry of membrane proteins in lipid nanodiscs

(2019) Michelle Redhair et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Magnetic-alignment of polymer macro-nanodiscs enables residual dipolar couplings based high-resolution structural studies by NMR

(2019) Thirupathi Ravula et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Single-particle cryo-EM studies of transmembrane proteins in SMA copolymer nanodiscs

(2019) Chang Sun et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

(2019) Glenn R. Masson et al.   NATURE METHODS

Structure and Dynamics of Membrane Proteins from Solid-State NMR

(2018) Venkata S. Mandala et al.   Annual Review of Biophysics

Membrane transporter research in times of countless structures

(2018) Markus A. Seeger   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Conformational landscapes of membrane proteins delineated by enhanced sampling molecular dynamics simulations

(2018) Tyler J. Harpole et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Single molecule fluorescence for membrane proteins

(2018) Oliver K. Castell et al.   METHODS

Contemporary hydrogen deuterium exchange mass spectrometry

(2018) Irina Oganesyan et al.   METHODS

Structural biology of solute carrier (SLC) membrane transport proteins

(2018) Xiaoyun Bai et al.   MOLECULAR MEMBRANE BIOLOGY

Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT

(2018) Patrick S. Merkle et al.   Science Advances

Key residues controlling bidirectional ion movements in Na+/Ca2+ exchanger

(2018) Liat van Dijk et al.   CELL CALCIUM

Structure-dynamic and functional relationships in a Li+-transporting sodium‑calcium exchanger mutant

(2018) Moshe Giladi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Direct protein-lipid interactions shape the conformational landscape of secondary transporters

(2018) Chloe Martens et al.   Nature Communications

An overview of hydrogen deuterium exchange mass spectrometry (HDX-MS) in drug discovery

(2017) Glenn R. Masson et al.   Expert Opinion on Drug Discovery

Dynamic distinctions in the Na+/Ca2+exchanger adopting the inward- and outward-facing conformational states

(2017) Moshe Giladi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Application of Solution NMR to Structural Studies on α-Helical Integral Membrane Proteins

(2017) Dae-Won Sim et al.   MOLECULES

Assembly of phospholipid nanodiscs of controlled size for structural studies of membrane proteins by NMR

(2017) Franz Hagn et al.   Nature Protocols

Conformational dynamics of a neurotransmitter:sodium symporter in a lipid bilayer

(2017) Suraj Adhikary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligand-induced conformational dynamics of theEscherichia coliNa+/H+antiporter NhaA revealed by hydrogen/deuterium exchange mass spectrometry

(2017) Martin Lorenz Eisinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shared Molecular Mechanisms of Membrane Transporters

(2016) David Drew et al.   Annual Review of Biochemistry

Structure-Based Engineering of Lithium-Transport Capacity in an Archaeal Sodium–Calcium Exchanger

(2016) Bosmat Refaeli et al.   BIOCHEMISTRY

Characterization of the Cation Binding Sites in the NCKX2 Na+/Ca2+-K+ Exchanger

(2016) Hristina Zhekova et al.   BIOCHEMISTRY

Current strategies for protein production and purification enabling membrane protein structural biology

(2016) Aditya Pandey et al.   Biochemistry and Cell Biology

Elevating the alternating-access model

(2016) Renae M Ryan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger

(2016) Jun Liao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Elevating the alternating-access model

(2016) Renae M Ryan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger

(2016) Jun Liao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Asymmetric Preorganization of Inverted Pair Residues in the Sodium-Calcium Exchanger

(2016) Moshe Giladi et al.   Scientific Reports

Analytical Aspects of Hydrogen Exchange Mass Spectrometry

(2015) John R. Engen et al.   Annual Review of Analytical Chemistry

Measuring the Hydrogen/Deuterium Exchange of Proteins at High Spatial Resolution by Mass Spectrometry: Overcoming Gas-Phase Hydrogen/Deuterium Scrambling

(2014) Kasper D. Rand et al.   ACCOUNTS OF CHEMICAL RESEARCH

HDX-MS guided drug discovery: small molecules and biopharmaceuticals

(2014) David P Marciano et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Sodium recognition by the Na+/Ca2+exchanger in the outward-facing conformation

(2014) Fabrizio Marinelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of sugar-bound LacY

(2014) Hemant Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for dynamic mechanism of proton-coupled symport by the peptide transporter POT

(2013) S. Doki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurotransmitter Transporters: Structure Meets Function

(2013) Paul J. Focke et al.   STRUCTURE

CURRENT PROGRESS IN STRUCTURE-BASED RATIONAL DRUG DESIGN MARKS A NEW MINDSET IN DRUG DISCOVERY

(2013) Valère Lounnas et al.   Computational and Structural Biotechnology Journal

Biophysical Limits of Protein–Ligand Binding

(2012) Richard D. Smith et al.   Journal of Chemical Information and Modeling

X-ray structures of LeuT in substrate-free outward-open and apo inward-open states

(2012) Harini Krishnamurthy et al.   NATURE

Structural Insight into the Ion-Exchange Mechanism of the Sodium/Calcium Exchanger

(2012) J. Liao et al.   SCIENCE

Atomistic models of ion and solute transport by the sodium-dependent secondary active transporters

(2011) Igor Zdravkovic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Ion selectivity in channels and transporters

(2011) Benoît Roux et al.   JOURNAL OF GENERAL PHYSIOLOGY

The Alternating-Access Mechanism of MFS Transporters Arises from Inverted-Topology Repeats

(2011) Sebastian Radestock et al.   JOURNAL OF MOLECULAR BIOLOGY

SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation

(2011) A. S. Kristensen et al.   PHARMACOLOGICAL REVIEWS

Hydrogen exchange mass spectrometry: what is it and what can it tell us?

(2010) Sean R. Marcsisin et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

The structural basis of secondary active transport mechanisms

(2010) Lucy R. Forrest et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Hydrogen exchange mass spectrometry for studying protein structure and dynamics

(2010) Lars Konermann et al.   CHEMICAL SOCIETY REVIEWS

Prediction of the human membrane proteome

(2010) Linn Fagerberg et al.   PROTEOMICS

Structures of membrane proteins

(2010) Kutti R. Vinothkumar et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Computational analysis of membrane proteins: the largest class of drug targets

(2009) Yalini Arinaminpathy et al.   DRUG DISCOVERY TODAY

Close Encounters of the Oily Kind: Regulation of Transporters by Lipids

(2009) C. B. Divito et al.   MOLECULAR INTERVENTIONS

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

(2009) R. Palty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA