Metabolomics in pharmacology - a delve into the novel field of pharmacometabolomics

2018 FDA drug approvals

(2019) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Tissue Imaging by Mass Spectrometry: A Practical Guide for the Medicinal Chemist

(2019) Robert W. Johnson et al.   ACS Medicinal Chemistry Letters

Liquid chromatography coupled to mass spectrometry for metabolite profiling in the field of drug discovery

(2019) Javier Saurina et al.   Expert Opinion on Drug Discovery

Pharmacomicrobiomics: The Holy Grail to Variability in Drug Response?

(2019) Anukriti Sharma et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Applications of MALDI mass spectrometry imaging for pharmacokinetic studies during drug development

(2019) Masanobu Nishidate et al.   Drug Metabolism and Pharmacokinetics

A longitudinal big data approach for precision health

(2019) Sophia Miryam Schüssler-Fiorenza Rose et al.   NATURE MEDICINE

Emerging Applications of Metabolomics in Clinical Pharmacology

(2019) Huanhuan Pang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pharmacometabolomics of Respiratory Phenotypic Response to Dexamethasone in Preterm Infants at Risk for Bronchopulmonary Dysplasia

(2019) Tamorah Lewis et al.   CTS-Clinical and Translational Science

Reliable identification of prostate cancer using mass spectrometry metabolomic imaging in needle core biopsies

(2019) Nicole Morse et al.   LABORATORY INVESTIGATION

Digital Futures Past — The Long Arc of Big Data in Medicine

(2019) Jeremy A. Greene et al.   NEW ENGLAND JOURNAL OF MEDICINE

Imaging Mass Spectrometry: A New Tool to Assess Molecular Underpinnings of Neurodegeneration

(2019) Kevin Chen et al.   Metabolites

Precision pharmacology: Mass spectrometry imaging and pharmacokinetic drug resistance

(2019) Maria Jove et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Pharmacogenomics

(2019) Dan M Roden et al.   LANCET

Pharmacomicrobiomics informs clinical pharmacogenomics

(2019) Theodora Katsila et al.   PHARMACOGENOMICS

Toward Mass Spectrometry Imaging in the Metabolomics Scale: Increasing Metabolic Coverage Through Multiple On-Tissue Chemical Modifications

(2019) Maria Emilia Dueñas et al.   Frontiers in Plant Science

High spatial resolution imaging of biological tissues using nanospray desorption electrospray ionization mass spectrometry

(2019) Ruichuan Yin et al.   Nature Protocols

Mass spectrometric recommendations for Quan/Qual analysis using liquid-chromatography coupled to quadrupole time-of-flight mass spectrometry

(2018) Anne-Charlotte Dubbelman et al.   ANALYTICA CHIMICA ACTA

Tetrandrine and cancer – An overview on the molecular approach

(2018) Bhagya N. et al.   BIOMEDICINE & PHARMACOTHERAPY

Metabolomics analysis of serum in a rat heroin self-administration model undergoing reinforcement based on 1H-nuclear magnetic resonance spectra

(2018) Tingting Ning et al.   BMC NEUROSCIENCE

Pharmacometabolomics reveals a role for histidine, phenylalanine, and threonine in the development of paclitaxel-induced peripheral neuropathy

(2018) Yihan Sun et al.   BREAST CANCER RESEARCH AND TREATMENT

Urine metabolome analysis by gas chromatography–mass spectrometry (GC–MS): Standardization and optimization of protocols for urea removal and short-term sample storage

(2018) Francesco Palmas et al.   CLINICA CHIMICA ACTA

Preanalytical Processing and Biobanking Procedures of Biological Samples for Metabolomics Research: A White Paper, Community Perspective (for “Precision Medicine and Pharmacometabolomics Task Group”—The Metabolomics Society Initiative)

(2018) Jennifer A. Kirwan et al.   CLINICAL CHEMISTRY

Individualization of Irinotecan Treatment: A Review of Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics

(2018) Femke M. de Man et al.   CLINICAL PHARMACOKINETICS

The Current Status of Drug Discovery and Development as Originated in US Academia: The Influence of Industrial and Academic Collaboration on Drug Discovery and Development

(2018) Tohru Takebe et al.   CTS-Clinical and Translational Science

Mass spectrometry imaging and its application in pharmaceutical research and development: A concise review

(2018) John G. Swales et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Targeted metabolomics analysis reveals the association between maternal folic acid supplementation and fatty acids and amino acids profiles in rat pups

(2018) Zhipeng Liu et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Promises and pitfalls of untargeted metabolomics

(2018) Ilya Gertsman et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Using Metabolomics to Investigate Biomarkers of Drug Addiction

(2018) Reza Ghanbari et al.   TRENDS IN MOLECULAR MEDICINE

Advances in mass spectrometry-based metabolomics for investigation of metabolites

(2018) Jun-Ling Ren et al.   RSC Advances

Pharmacomicrobiomics: a novel route towards personalized medicine?

(2018) Marwah Doestzada et al.   Protein & Cell

Applications of Immunopharmacogenomics: Predicting, Preventing, and Understanding Immune-Mediated Adverse Drug Reactions

(2018) Jason H. Karnes et al.   Annual Review of Pharmacology and Toxicology

Lipopolysaccharide-induced chorioamnionitis and postnatal lung injury: The beneficial effects of L-citrulline in newborn rats

(2018) Arben Dedja et al.   EXPERIMENTAL LUNG RESEARCH

Pharmacometabolomics Reveals Irinotecan Mechanism of Action in Cancer Patients

(2018) Xun Bao et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Developmental Changes in Pharmacokinetics and Pharmacodynamics

(2018) John van den Anker et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacometabolomic prediction of individual differences of gastrointestinal toxicity complicating myelosuppression in rats induced by irinotecan

(2018) Yiqiao Gao et al.   Acta Pharmaceutica Sinica B

Metabolome-wide association study of anti-epileptic drug treatment during pregnancy

(2018) Douglas I. Walker et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Metabolomics Biomarkers: A Strategy Toward Therapeutics Improvement in ALS

(2018) Débora Lanznaster et al.   Frontiers in Neurology

Probiotic supplementation restores normal microbiota composition and function in antibiotic-treated and in caesarean-born infants

(2018) Katri Korpela et al.   Microbiome

Mass spectrometry imaging of the in situ drug release from nanocarriers

(2018) Jinjuan Xue et al.   Science Advances

Strategies for managing multi-patient 3D mass spectrometry imaging data

(2018) D.R.N. Vos et al.   Journal of Proteomics

Multivariate pharmacokinetic/pharmacodynamic (PKPD) analysis with metabolomics shows multiple effects of remoxipride in rats

(2017) W.J. van den Brink et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Metabolite profiling in early clinical drug development: current status and future prospects

(2017) Mike Ufer et al.   Expert Opinion on Drug Metabolism & Toxicology

Clinical metabolomics: a pivotal tool for companion diagnostic development and precision medicine

(2017) Vladimir Tolstikov et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Drug-induced liver injury: recent advances in diagnosis and risk assessment

(2017) Gerd A Kullak-Ublick et al.   GUT

Branched-Chain Amino Acids as Predictors for Individual Differences of Cisplatin Nephrotoxicity in Rats: A Pharmacometabonomics Study

(2017) Pei Zhang et al.   JOURNAL OF PROTEOME RESEARCH

Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery

(2017) Derrick M Chu et al.   NATURE MEDICINE

Drug development in the era of precision medicine

(2017) Sarah A. Dugger et al.   NATURE REVIEWS DRUG DISCOVERY

Metabolomics Analysis of the Osteogenic Differentiation of Umbilical Cord Blood Mesenchymal Stem Cells Reveals Differential Sensitivity to Osteogenic Agents

(2017) Michail E. Klontzas et al.   STEM CELLS AND DEVELOPMENT

Introducing the Microbiome into Precision Medicine

(2017) Thomas M. Kuntz et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Direct infusion mass spectrometry for metabolomic phenotyping of diseases

(2017) Raúl González-Domínguez et al.   Bioanalysis

Identification of key metabolic changes during liver fibrosis progression in rats using a urine and serum metabolomics approach

(2017) Hong Chang et al.   Scientific Reports

Gut dysbiosis following C-section instigates higher colonisation of toxigenic Clostridium perfringens in infants

(2017) R. Nagpal et al.   Beneficial Microbes

A critical assessment of the “sterile womb” and “in utero colonization” hypotheses: implications for research on the pioneer infant microbiome

(2017) Maria Elisa Perez-Muñoz et al.   Microbiome

Enterotypes in the landscape of gut microbial community composition

(2017) Paul I. Costea et al.   Nature Microbiology

Imaging mass spectrometry in drug development and toxicology

(2016) Oskar Karlsson et al.   ARCHIVES OF TOXICOLOGY

Human Foetal Mesenchymal Stem Cells

(2016) Cecilia Götherström   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

Neonatal Maturation of Paracetamol (Acetaminophen) Glucuronidation, Sulfation, and Oxidation Based on a Parent–Metabolite Population Pharmacokinetic Model

(2016) Sarah F. Cook et al.   CLINICAL PHARMACOKINETICS

Pharmacometabolomics in Early-Phase Clinical Development

(2016) T Burt et al.   CTS-Clinical and Translational Science

The diverse and expanding role of mass spectrometry in structural and molecular biology

(2016) Philip Lössl et al.   EMBO JOURNAL

Applied metabolomics in drug discovery

(2016) M. Cuperlovic-Culf et al.   Expert Opinion on Drug Discovery

Metabolic profiling of alcohol consumption in 9778 young adults

(2016) Peter Würtz et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Innovation in the pharmaceutical industry: New estimates of R&D costs

(2016) Joseph A. DiMasi et al.   JOURNAL OF HEALTH ECONOMICS

Recommendations and Standardization of Biomarker Quantification Using NMR-Based Metabolomics with Particular Focus on Urinary Analysis

(2016) Abdul-Hamid Emwas et al.   JOURNAL OF PROTEOME RESEARCH

Metabolomics enables precision medicine: “A White Paper, Community Perspective”

(2016) Richard D. Beger et al.   Metabolomics

Integration of pharmacometabolomics with pharmacokinetics and pharmacodynamics: towards personalized drug therapy

(2016) Vasudev Kantae et al.   Metabolomics

TSPAN5, ERICH3 and selective serotonin reuptake inhibitors in major depressive disorder: pharmacometabolomics-informed pharmacogenomics

(2016) M Gupta et al.   MOLECULAR PSYCHIATRY

Metabolomics: beyond biomarkers and towards mechanisms

(2016) Caroline H. Johnson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chemical derivatization-based LC–MS for metabolomics: advantages and challenges

(2016) Ruiqi Jiang et al.   Bioanalysis

Pharmacometabolomics study identifies circulating spermidine and tryptophan as potential biomarkers associated with the complete pathological response to trastuzumab-paclitaxel neoadjuvant therapy in HER-2 positive breast cancer

(2016) Gianmaria Miolo et al.   Oncotarget

A metabolomics cell-based approach for anticipating and investigating drug-induced liver injury

(2016) Juan Carlos García- Cañaveras et al.   Scientific Reports

Microbial Changes during Pregnancy, Birth, and Infancy

(2016) Meital Nuriel-Ohayon et al.   Frontiers in Microbiology

Metabolomic signatures of drug response phenotypes for ketamine and esketamine in subjects with refractory major depressive disorder: new mechanistic insights for rapid acting antidepressants

(2016) D M Rotroff et al.   Translational Psychiatry

From Metabonomics to Pharmacometabonomics: The Role of Metabolic Profiling in Personalized Medicine

(2016) Jeremy R. Everett   Frontiers in Pharmacology

A guide to the identification of metabolites in NMR-based metabonomics/metabolomics experiments

(2016) Anthony C. Dona et al.   Computational and Structural Biotechnology Journal

Drug localizations in tissue by mass spectrometry imaging

(2015) Ákos Végvári   Biomarkers in Medicine

Microbial programming of health and disease starts during fetal life

(2015) Petya T. Koleva et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Clinical impact of human breast milk metabolomics

(2015) Flaminia Cesare Marincola et al.   CLINICA CHIMICA ACTA

Biomarker Qualification: Toward a Multiple Stakeholder Framework for Biomarker Development, Regulatory Acceptance, and Utilization

(2015) S Amur et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Prospective assessment of autism traits in children exposed to antiepileptic drugs during pregnancy

(2015) Amanda G. Wood et al.   EPILEPSIA

Omics-Based Biomarkers: Application of Metabolomics in Neuropsychiatric Disorders

(2015) Sumit Sethi et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

A New Initiative on Precision Medicine

(2015) Francis S. Collins et al.   NEW ENGLAND JOURNAL OF MEDICINE

PharmGKB summary

(2015) Liudmila L. Mazaleuskaya et al.   Pharmacogenetics and Genomics

Mass spectrometry imaging with laser-induced postionization

(2015) J. Soltwisch et al.   SCIENCE

Dynamics of Infant Gut Microbiota Are Influenced by Delivery Mode and Gestational Duration and Are Associated with Subsequent Adiposity

(2015) Shaillay Dogra et al.   mBio

1H-Nuclear magnetic resonance-based metabolomic analysis of brain in mice with nicotine treatment

(2014) Hongyu Li et al.   BMC NEUROSCIENCE

Imaging Mass Spectrometry in Papillary Thyroid Carcinoma for the Identification and Validation of Biomarker Proteins

(2014) Kyueng-Whan Min et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

The Current State of Drug Discovery and a Potential Role for NMR Metabolomics

(2014) Robert Powers   JOURNAL OF MEDICINAL CHEMISTRY

The metabolic impact of methamphetamine on the systemic metabolism of rats and potential markers of methamphetamine abuse

(2014) Tian Zheng et al.   Molecular BioSystems

The Neurometabolic Fingerprint of Excessive Alcohol Drinking

(2014) Marcus W Meinhardt et al.   NEUROPSYCHOPHARMACOLOGY

Pharmacomicrobiomics: The Impact of Human Microbiome Variations on Systems Pharmacology and Personalized Therapeutics

(2014) Marwa ElRakaiby et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Potential of metabolomics in preclinical and clinical drug development

(2014) Baldeep Kumar et al.   Pharmacological Reports

Strengths and Limitations of 16S rRNA Gene Amplicon Sequencing in Revealing Temporal Microbial Community Dynamics

(2014) Rachel Poretsky et al.   PLoS One

Emerging Biomarkers and Metabolomics for Assessing Toxic Nephropathy and Acute Kidney Injury (AKI) in Neonatology

(2014) M. Mussap et al.   Biomed Research International

The role of metabolomics in neonatal and pediatric laboratory medicine

(2013) Michele Mussap et al.   CLINICA CHIMICA ACTA

Pharmacometabolomics: Implications for Clinical Pharmacology and Systems Pharmacology

(2013) R Kaddurah-Daouk et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery

(2013) Douglas B. Kell et al.   DRUG DISCOVERY TODAY

Evaluating effects of penicillin treatment on the metabolome of rats

(2013) Jinchun Sun et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Metabolomic changes in gastrointestinal tissues after whole body radiation in a murine model

(2013) Sanchita P. Ghosh et al.   Molecular BioSystems

Predicting and Manipulating Cardiac Drug Inactivation by the Human Gut Bacterium Eggerthella lenta

(2013) H. J. Haiser et al.   SCIENCE

The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide

(2013) S. Viaud et al.   SCIENCE

A Guide to Enterotypes across the Human Body: Meta-Analysis of Microbial Community Structures in Human Microbiome Datasets

(2013) Omry Koren et al.   PLoS Computational Biology

Impact of Chemotherapy-Induced Peripheral Neuropathy on Treatment Delivery in Nonmetastatic Breast Cancer

(2013) Rebecca M. Speck et al.   Journal of Oncology Practice

Pharma-metabolomics in Neonatology: is it a Dream or a Fact?

(2012) Vassilios Fanos et al.   CURRENT PHARMACEUTICAL DESIGN

Metabolic phenotype of rats exposed to heroin and potential markers of heroin abuse

(2012) Tian Zheng et al.   DRUG AND ALCOHOL DEPENDENCE

Is poor research the cause of the declining productivity of the pharmaceutical industry? An industry in need of a paradigm shift

(2012) Frank Sams-Dodd   DRUG DISCOVERY TODAY

Longitudinal pharmacometabonomics for predicting patient responses to therapy: drug metabolism, toxicity and efficacy

(2012) Jeremy K Nicholson et al.   Expert Opinion on Drug Metabolism & Toxicology

Human mesenchymal stem cells: A bank perspective on the isolation, characterization and potential of alternative sources for the regeneration of musculoskeletal tissues

(2012) Lorenzo Moroni et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Metabolomic analysis of bronchoalveolar lavage fluid in preterm infants complicated by respiratory distress syndrome: preliminary results

(2012) Adele Fabiano et al.   Journal of Maternal-Fetal & Neonatal Medicine

Pharmaceutical research and metabolomics in the newborn

(2012) Roberto Antonucci et al.   Journal of Maternal-Fetal & Neonatal Medicine

Clinical application of metabolomics in neonatology

(2012) Vassilios Fanos et al.   Journal of Maternal-Fetal & Neonatal Medicine

1H-nuclear magnetic resonance-based metabonomic analysis of brain in rhesus monkeys with morphine treatment and withdrawal intervention

(2012) Yi Deng et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

Metabolomics: the apogee of the omics trilogy

(2012) Gary J. Patti et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Merging pharmacometabolomics with pharmacogenomics using ‘1000 Genomes’ single-nucleotide polymorphism imputation

(2012) Ryan Abo et al.   Pharmacogenetics and Genomics

Metabolomics in neonatology: Fact or fiction?

(2012) V. Fanos et al.   Seminars in Fetal & Neonatal Medicine

A Convenient Strategy for Quantitative Determination of Drug Concentrations in Tissue Homogenates Using a Liquid Chromatography/Tandem Mass Spectrometry Assay for Plasma Samples

(2011) Hao Jiang et al.   ANALYTICAL CHEMISTRY

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Imaging of Intact Tissue Sections: Moving beyond the Microscope

(2011) Erin H. Seeley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Variation in Antibiotic-Induced Microbial Recolonization Impacts on the Host Metabolic Phenotypes of Rats

(2011) Jonathan R. Swann et al.   JOURNAL OF PROTEOME RESEARCH

Enterotypes of the human gut microbiome

(2011) Manimozhiyan Arumugam et al.   NATURE

Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics

(2011) N.C. Kleinstreuer et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Toxicodynamic effects of ciclosporin are reflected by metabolite profiles in the urine of healthy individuals after a single dose

(2010) Jost Klawitter et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

The Application of Metabonomics to Predict Drug-Induced Liver Injury

(2010) T M O'Connell et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Ingenuity pathways analysis of urine metabonomics phenotypes toxicity of gentamicin in multiple organs

(2010) Haitao Lv et al.   Molecular BioSystems

2009 FDA drug approvals

(2010) Bethan Hughes   NATURE REVIEWS DRUG DISCOVERY

How to improve R&D productivity: the pharmaceutical industry's grand challenge

(2010) Steven M. Paul et al.   NATURE REVIEWS DRUG DISCOVERY

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

(2010) M. G. Dominguez-Bello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolomics in Toxicology: Preclinical and Clinical Applications

(2010) D. G. Robertson et al.   TOXICOLOGICAL SCIENCES

Predicting human developmental toxicity of pharmaceuticals using human embryonic stem cells and metabolomics

(2010) Paul R. West et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The enhanced value of combining conventional and “omics” analyses in early assessment of drug-induced hepatobiliary injury

(2010) Heidrun Ellinger-Ziegelbauer et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Pattern Recognition Analysis for the Prediction of Adverse Effects by Nonsteroidal Anti-Inflammatory Drugs Using1H NMR-Based Metabolomics in Rats

(2009) So Young Um et al.   ANALYTICAL CHEMISTRY

A systems biology approach to understanding elevated serum alanine transaminase levels in a clinical trial with ximelagatran

(2009) Ulf Andersson et al.   BIOMARKERS

Pharmacometabolomics of docetaxel-treated human MCF7 breast cancer cells provides evidence of varying cellular responses at high and low doses

(2009) Mathilde Bayet-Robert et al.   BREAST CANCER RESEARCH AND TREATMENT

Serum Metabolomics Reveals Irreversible Inhibition of Fatty Acid β-Oxidation through the Suppression of PPARα Activation as a Contributing Mechanism of Acetaminophen-Induced Hepatotoxicity

(2009) Chi Chen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Probiotics prevent IgE-associated allergy until age 5 years in cesarean-delivered children but not in the total cohort

(2009) Mikael Kuitunen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Imaging Mass Spectrometry for Visualization of Drug and Endogenous Metabolite Distribution: Toward In Situ Pharmacometabolomes

(2009) Yuki Sugiura et al.   Journal of Neuroimmune Pharmacology

Association of Immunosuppressant-Induced Protein Changes in the Rat Kidney with Changes in Urine Metabolite Patterns: A Proteo-Metabonomic Study

(2009) Jost Klawitter et al.   JOURNAL OF PROTEOME RESEARCH

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

(2009) Arun Sreekumar et al.   NATURE

2008 FDA drug approvals

(2009) Bethan Hughes   NATURE REVIEWS DRUG DISCOVERY

Lessons from 60 years of pharmaceutical innovation

(2009) Bernard Munos   NATURE REVIEWS DRUG DISCOVERY

Metabolomic Profiling of Drug Responses in Acute Myeloid Leukaemia Cell Lines

(2009) Stefano Tiziani et al.   PLoS One

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

(2009) W. R. Wikoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drugs, bugs, and personalized medicine: Pharmacometabonomics enters the ring

(2009) I. D. Wilson   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism

(2009) T. A. Clayton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of Metabolomics Biomarkers for Early Detection of Nephrotoxicity

(2009) Kurt J. Boudonck et al.   TOXICOLOGIC PATHOLOGY

Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity

(2009) Richard D. Beger et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The FDA Critical Path Initiative and Its Influence on New Drug Development

(2008) Janet Woodcock et al.   Annual Review of Medicine

Caesarean delivery and risk of atopy and allergic disesase: meta-analyses

(2008) P. Bager et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Metabonomic analysis identifies molecular changes associated with the pathophysiology and drug treatment of bipolar disorder

(2008) M J Lan et al.   MOLECULAR PSYCHIATRY

Desorption electrospray ionization mass spectrometry: Imaging drugs and metabolites in tissues

(2008) J. M. Wiseman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Applications of Metabolomics in Drug Discovery and Development

(2008) David S Wishart   Drugs in research & development