Metabolite profiling in early clinical drug development: current status and future prospects

Strategies for metabolite profiling based on liquid chromatography

(2017) Javier Saurina et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

An evaluation of human ADME and mass balance studies using regular or low doses of radiocarbon

(2016) A.F. Roffel et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Metabolomics: beyond biomarkers and towards mechanisms

(2016) Caroline H. Johnson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

From Metabonomics to Pharmacometabonomics: The Role of Metabolic Profiling in Personalized Medicine

(2016) Jeremy R. Everett   Frontiers in Pharmacology

A high-performance liquid chromatography – tandem mass spectrometry – based targeted metabolomics kidney dysfunction marker panel in human urine

(2015) Jacek Klepacki et al.   CLINICA CHIMICA ACTA

Pediatric microdose and microtracer studies using14C in Europe

(2015) MA Turner et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Cost-effectiveness Analysis of Microdose Clinical Trials in Drug Development

(2013) Naoe Yamane et al.   Drug Metabolism and Pharmacokinetics

Radiolabeled Absorption, Distribution, Metabolism, and Excretion Studies in Drug Development: Why, When, and How?

(2012) Natalia Penner et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Pharma-metabolomics in Neonatology: is it a Dream or a Fact?

(2012) Vassilios Fanos et al.   CURRENT PHARMACEUTICAL DESIGN

Microdosing: A Critical Assessment of Human Data

(2012) Malcolm Rowland   JOURNAL OF PHARMACEUTICAL SCIENCES

Comparative pharmacokinetics between a microdose and therapeutic dose for clarithromycin, sumatriptan, propafenone, paracetamol (acetaminophen), and phenobarbital in human volunteers

(2011) Graham Lappin et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Microdosing: current and the future

(2010) Graham Lappin   Bioanalysis

The utility of microdosing over the past 5 years

(2008) Graham Lappin et al.   Expert Opinion on Drug Metabolism & Toxicology