Pharmacomicrobiomics: a novel route towards personalized medicine?

Mechanistic and structural insight into promiscuity based metabolism of cardiac drug digoxin by gut microbial enzyme

(2018) Kundan Kumar et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A High-Carbohydrate, High-Fiber, Low-Fat Diet Results in Weight Loss among Adults at High Risk of Type 2 Diabetes

(2017) Allison C Sylvetsky et al.   JOURNAL OF NUTRITION

Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug

(2017) Hao Wu et al.   NATURE MEDICINE

Gut microbiota modulation of chemotherapy efficacy and toxicity

(2017) James L. Alexander et al.   Nature Reviews Gastroenterology & Hepatology

Chemical transformation of xenobiotics by the human gut microbiota

(2017) Nitzan Koppel et al.   SCIENCE

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

(2017) Bertrand Routy et al.   SCIENCE

Host Genetics and Gut Microbiome: Challenges and Perspectives

(2017) Alexander Kurilshikov et al.   TRENDS IN IMMUNOLOGY

Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes

(2017) Sebastiaan J. Trietsch et al.   Nature Communications

Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity

(2016) Melanie Schirmer et al.   CELL

Genetic Determinants of the Gut Microbiome in UK Twins

(2016) Julia K. Goodrich et al.   Cell Host & Microbe

Proton Pump Inhibitors Accelerate Endothelial SenescenceNovelty and Significance

(2016) Gautham Yepuri et al.   CIRCULATION RESEARCH

Predicting Drug Extraction in the Human Gut Wall: Assessing Contributions from Drug Metabolizing Enzymes and Transporter Proteins using Preclinical Models

(2016) Sheila Annie Peters et al.   CLINICAL PHARMACOKINETICS

Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota

(2016) Jun Wang et al.   NATURE GENETICS

The effect of host genetics on the gut microbiome

(2016) Marc Jan Bonder et al.   NATURE GENETICS

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

(2016) Hubert Plovier et al.   NATURE MEDICINE

The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism

(2016) Peter Spanogiannopoulos et al.   NATURE REVIEWS MICROBIOLOGY

Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

(2016) Alexandra Zhernakova et al.   SCIENCE

Population-level analysis of gut microbiome variation

(2016) Gwen Falony et al.   SCIENCE

Antibiotics and the Human Gut Microbiome: Dysbioses and Accumulation of Resistances

(2016) M. P. Francino   Frontiers in Microbiology

Culture of previously uncultured members of the human gut microbiota by culturomics

(2016) Jean-Christophe Lagier et al.   Nature Microbiology

Personalized Nutrition by Prediction of Glycemic Responses

(2015) David Zeevi et al.   CELL

The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood LipidsNovelty and Significance

(2015) Jingyuan Fu et al.   CIRCULATION RESEARCH

Dietary Polyphenols Promote Growth of the Gut BacteriumAkkermansia muciniphilaand Attenuate High-Fat Diet–Induced Metabolic Syndrome

(2015) Diana E. Roopchand et al.   DIABETES

Epidemiology of Adverse Drug Reactions in Europe: A Review of Recent Observational Studies

(2015) Jacoline C. Bouvy et al.   DRUG SAFETY

Proton Pump Inhibitors Alter Specific Taxa in the Human Gastrointestinal Microbiome: A Crossover Trial

(2015) Daniel E. Freedberg et al.   GASTROENTEROLOGY

Gut microbiota composition associated with stool consistency

(2015) E F Tigchelaar et al.   GUT

Proton pump inhibitors affect the gut microbiome

(2015) Floris Imhann et al.   GUT

Proton pump inhibitors alter the composition of the gut microbiota

(2015) Matthew A Jackson et al.   GUT

Akkermansia muciniphilaand improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology

(2015) Maria Carlota Dao et al.   GUT

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

(2015) Kristoffer Forslund et al.   NATURE

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy

(2015) A. Sivan et al.   SCIENCE

Cohort profile: LifeLines DEEP, a prospective, general population cohort study in the northern Netherlands: study design and baseline characteristics

(2015) Ettje F Tigchelaar et al.   BMJ Open

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

(2015) Cathie Sudlow et al.   PLOS MEDICINE

The Treg/Th17 Axis: A Dynamic Balance Regulated by the Gut Microbiome

(2015) Sara Omenetti et al.   Frontiers in Immunology

Human Genetics Shape the Gut Microbiome

(2014) Julia K. Goodrich et al.   CELL

The Impact of Proton Pump Inhibitors on the Human Gastrointestinal Microbiome

(2014) Daniel E. Freedberg et al.   CLINICS IN LABORATORY MEDICINE

Cohort Profile: LifeLines, a three-generation cohort study and biobank

(2014) Salome Scholtens et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant

(2014) Takanori Takebe et al.   Nature Protocols

Commensal bacteria protect against food allergen sensitization

(2014) A. T. Stefka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An increase in theAkkermansiaspp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

(2013) Na-Ri Shin et al.   GUT

Colonic bacterial metabolism of corticosteroids

(2013) Vipul Yadav et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

(2013) Koji Atarashi et al.   NATURE

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

(2013) A. Everard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Predicting and Manipulating Cardiac Drug Inactivation by the Human Gut Bacterium Eggerthella lenta

(2013) H. J. Haiser et al.   SCIENCE

Gut Pharmacomicrobiomics: the tip of an iceberg of complex interactions between drugs and gut-associated microbes

(2013) Rama Saad et al.   Gut Pathogens

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

Multiple NSAID-Induced Hits Injure the Small Intestine: Underlying Mechanisms and Novel Strategies

(2012) Urs A. Boelsterli et al.   TOXICOLOGICAL SCIENCES

Relating human genetic variation to variation in drug responses

(2012) Ashraf G. Madian et al.   TRENDS IN GENETICS

Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic Obese and Diet-Induced Leptin-Resistant Mice

(2011) Amandine Everard et al.   DIABETES

Efficient Generation of Functional Hepatocytes From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by HNF4α Transduction

(2011) Kazuo Takayama et al.   MOLECULAR THERAPY

Enteric Microbiome Metabolites Correlate with Response to Simvastatin Treatment

(2011) Rima Kaddurah-Daouk et al.   PLoS One

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors

(2010) A. K. Benson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

(2010) B. D. Wallace et al.   SCIENCE

Present status and strategy of NSAIDs-induced small bowel injury

(2009) Kazuhide Higuchi et al.   JOURNAL OF GASTROENTEROLOGY

Review: Chemotherapy-induced diarrhea: pathophysiology, frequency and guideline-based management

(2009) Alexander Stein et al.   Therapeutic Advances in Medical Oncology

Distribution of β-glucosidase and β-glucuronidase activity and of β-glucuronidase gene gus in human colonic bacteria

(2008) Marta Dabek et al.   FEMS MICROBIOLOGY ECOLOGY

Mendelian Randomisation and Causal Inference in Observational Epidemiology

(2008) Nuala A Sheehan et al.   PLOS MEDICINE