A role for APP in Wnt signalling links synapse loss with β-amyloid production

Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil

(2018) Katherine J. Sellers et al.   Alzheimers & Dementia

A mobile APP for sharing contacts on your cell

(2017) George William Rebeck et al.   JOURNAL OF NEUROCHEMISTRY

The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system

(2017) Lucas J. Sosa et al.   JOURNAL OF NEUROCHEMISTRY

FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system

(2017) K Yalla et al.   MOLECULAR PSYCHIATRY

Not just amyloid: physiological functions of the amyloid precursor protein family

(2017) Ulrike C. Müller et al.   NATURE REVIEWS NEUROSCIENCE

Evidence for opposing roles of Celsr3 and Vangl2 in glutamatergic synapse formation

(2017) Sonal Thakar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent

(2017) Daniela Puzzo et al.   eLife

Increased Dendrite Branching in AβPP/PS1 Mice and Elongation of Dendrite Arbors by Fasudil Administration

(2017) Brian A. Couch et al.   JOURNAL OF ALZHEIMERS DISEASE

Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes

(2016) Marta Pajares et al.   Autophagy

Reversal of Synapse Degeneration by Restoring Wnt Signaling in the Adult Hippocampus

(2016) Aude Marzo et al.   CURRENT BIOLOGY

Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal Degeneration

(2016) E. G. Gentry et al.   JOURNAL OF NEUROSCIENCE

APP Receptor? To Be or Not To Be

(2016) Carole Deyts et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Notch intracellular domain represses CRE-dependent transcription

(2015) Rania Hallaq et al.   CELLULAR SIGNALLING

Activation of the Wnt/β-catenin pathway represses the transcription of the β-amyloid precursor protein cleaving enzyme (BACE1) via binding of T-cell factor-4 to BACE1 promoter

(2015) Callum Parr et al.   FASEB JOURNAL

Deficiency in LRP6-Mediated Wnt Signaling Contributes to Synaptic Abnormalities and Amyloid Pathology in Alzheimer’s Disease

(2014) Chia-Chen Liu et al.   NEURON

Fluorescent labeling of dendritic spines in cell cultures with the carbocyanine dye “DiI”

(2014) Connie Cheng et al.   Frontiers in Neuroanatomy

Loss of Dickkopf-1 Restores Neurogenesis in Old Age and Counteracts Cognitive Decline

(2013) Désirée R.M. Seib et al.   Cell Stem Cell

Rho Kinase Inhibitor Fasudil Protects againstβ-Amyloid-Induced Hippocampal Neurodegeneration in Rats

(2013) Yun Song et al.   CNS Neuroscience & Therapeutics

Pharmacologic Inhibition of ROCK2 Suppresses Amyloid-  Production in an Alzheimer's Disease Mouse Model

(2013) J. H. Herskowitz et al.   JOURNAL OF NEUROSCIENCE

Wnts in action: from synapse formation to synaptic maintenance

(2013) Ellen M. Dickins et al.   Frontiers in Cellular Neuroscience

WNT signaling in neuronal maturation and synaptogenesis

(2013) Silvana B. Rosso et al.   Frontiers in Cellular Neuroscience

Wnts in adult brain: from synaptic plasticity to cognitive deficiencies

(2013) Carolina A. Oliva et al.   Frontiers in Cellular Neuroscience

The Drosophila Homologue of the Amyloid Precursor Protein Is a Conserved Modulator of Wnt PCP Signaling

(2013) Alessia Soldano et al.   PLOS BIOLOGY

The Secreted Wnt Antagonist Dickkopf-1 Is Required for Amyloid  -Mediated Synaptic Loss

(2012) S. A. Purro et al.   JOURNAL OF NEUROSCIENCE

Activation of NMDA Receptors Upregulates A Disintegrin and Metalloproteinase 10 via a Wnt/MAPK Signaling Pathway

(2012) X.-Z. Wan et al.   JOURNAL OF NEUROSCIENCE

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt–PCP–JNK pathway

(2012) R Killick et al.   MOLECULAR PSYCHIATRY

Synaptic changes in Alzheimer’s disease and its models

(2012) J. Pozueta et al.   NEUROSCIENCE

β-Amyloid precursor protein and tau protein levels are differently regulated in human cerebellum compared to brain regions vulnerable to Alzheimer's type neurodegeneration

(2010) Mirsada Čaušević et al.   NEUROSCIENCE LETTERS

Rapid and Direct Transport of Cell Surface APP to the Lysosome defines a novel selective pathway

(2010) Angela Lorenzen et al.   Molecular Brain

Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease

(2009) Ana I. Rojo et al.   GLIA

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE