A Kinome-Wide RNAi Screen in Drosophila Glia Reveals That the RIO Kinases Mediate Cell Proliferation and Survival through TORC2-Akt Signaling in Glioblastoma

A Translation-Like Cycle Is a Quality Control Checkpoint for Maturing 40S Ribosome Subunits

(2012) Bethany S. Strunk et al.   CELL

STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA

(2012) A.-J. Chen et al.   GENES & DEVELOPMENT

Conditional Astroglial Rictor Overexpression Induces Malignant Glioma in Mice

(2012) Tariq Bashir et al.   PLoS One

Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response

(2012) N. J. Szerlip et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human RioK3 is a novel component of cytoplasmic pre-40S pre-ribosomal particles

(2012) Kamila Baumas et al.   RNA Biology

Activation of mTORC2 by Association with the Ribosome

(2011) Vittoria Zinzalla et al.   CELL

Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi

(2011) Ralph A. Neumüller et al.   Cell Stem Cell

Regulation of Drosophila glial cell proliferation by Merlin-Hippo signaling

(2011) B. V. V. G. Reddy et al.   DEVELOPMENT

Phosphorylation of Right Open Reading Frame 2 (Rio2) Protein Kinase by Polo-like Kinase 1 Regulates Mitotic Progression

(2011) Ting Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila

(2011) Rita Sousa-Nunes et al.   NATURE

Identification of novel synergistic targets for rational drug combinations with PI3 kinase inhibitors using siRNA synthetic lethality screening against GBM

(2011) Y.-W. Kim et al.   NEURO-ONCOLOGY

PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

(2011) P. V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

RNAi screening in glioma stem-like cells identifies PFKFB4 as a key molecule important for cancer cell survival

(2011) V Goidts et al.   ONCOGENE

Activation of p53 by Nutlin-3a Induces Apoptosis and Cellular Senescence in Human Glioblastoma Multiforme

(2011) Ruth Villalonga-Planells et al.   PLoS One

The Role of p53 in Ribosomopathies

(2011) Stefano Fumagalli et al.   SEMINARS IN HEMATOLOGY

Oncogenic EGFR Signaling Activates an mTORC2-NF- B Pathway That Promotes Chemotherapy Resistance

(2011) K. Tanaka et al.   Cancer Discovery

Ribosomopathies: human disorders of ribosome dysfunction

(2010) A. Narla et al.   BLOOD

An ARF-Independent c-MYC-Activated Tumor Suppression Pathway Mediated by Ribosomal Protein-Mdm2 Interaction

(2010) Everardo Macias et al.   CANCER CELL

An RNAi Screen Identifies TRRAP as a Regulator of Brain Tumor-Initiating Cell Differentiation

(2010) Heiko Wurdak et al.   Cell Stem Cell

Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma

(2010) M.-d.-M. Inda et al.   GENES & DEVELOPMENT

Chemotherapeutic Drugs Inhibit Ribosome Biogenesis at Various Levels

(2010) Kaspar Burger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo

(2010) H. Hirai et al.   MOLECULAR CANCER THERAPEUTICS

Towards a knowledge-based Human Protein Atlas

(2010) Mathias Uhlen et al.   NATURE BIOTECHNOLOGY

100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future

(2010) Hugo J. Bellen et al.   NATURE REVIEWS NEUROSCIENCE

The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

(2010) D. Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Mutant EGFR is required for maintenance of glioma growth in vivo, and its ablation leads to escape from receptor dependence

(2010) A. Mukasa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM

(2010) W. R. Wiedemeyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mig-6 controls EGFR trafficking and suppresses gliomagenesis

(2010) H. Ying et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Global Protein Kinase and Phosphatase Interaction Network in Yeast

(2010) A. Breitkreutz et al.   SCIENCE

A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene

(2009) Ji Luo et al.   CELL

Glioma Stem Cell Lines Expanded in Adherent Culture Have Tumor-Specific Phenotypes and Are Suitable for Chemical and Genetic Screens

(2009) Steven M. Pollard et al.   Cell Stem Cell

Distinct cytoplasmic maturation steps of 40S ribosomal subunit precursors require hRio2

(2009) Ivo Zemp et al.   JOURNAL OF CELL BIOLOGY

Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells

(2009) G. L. Gallia et al.   MOLECULAR CANCER THERAPEUTICS

Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941

(2009) F. I. Raynaud et al.   MOLECULAR CANCER THERAPEUTICS

Development of a novel mouse glioma model using lentiviral vectors

(2009) Tomotoshi Marumoto et al.   NATURE MEDICINE

Neurosphere Formation Is an Independent Predictor of Clinical Outcome in Malignant Glioma

(2009) Dan R. Laks et al.   STEM CELLS

A Drosophila Model for EGFR-Ras and PI3K-Dependent Human Glioma

(2009) Renee D. Read et al.   PLoS Genetics

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

(2008) A. Y. Choo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antitumor Activity of Rapamycin in a Phase I Trial for Patients with Recurrent PTEN-Deficient Glioblastoma

(2008) Tim F Cloughesy et al.   PLOS MEDICINE