JNK contributes to temozolomide resistance of stem-like glioblastoma cells via regulation of MGMT expression

Glycogen synthase kinase 3β inhibition sensitizes human glioblastoma cells to temozolomide by affecting O 6 -methylguanine DNA methyltransferase promoter methylation via c-Myc signaling

(2013) Ilya V. Pyko et al.   CARCINOGENESIS

The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance

(2013) Florian A. Siebzehnrubl et al.   EMBO Molecular Medicine

Type-3 metabotropic glutamate receptors regulate chemoresistance in glioma stem cells and their levels are inversely related to survival in patients with malignant gliomas

(2012) C Ciceroni et al.   CELL DEATH AND DIFFERENTIATION

Selective killing of p53-deficient cancer cells by SP600125

(2012) Mohamed Jemaà et al.   EMBO Molecular Medicine

A negative regulator or just an unconcerned passerby: phosphoinositide 3-kinase signalling in IL-12 production

(2012) K. Miyazawa   JOURNAL OF BIOCHEMISTRY

ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells

(2012) Aditi Nadkarni et al.   JOURNAL OF NEURO-ONCOLOGY

STAT3 Inhibition Overcomes Temozolomide Resistance in Glioblastoma by Downregulating MGMT Expression

(2012) Shinji Kohsaka et al.   MOLECULAR CANCER THERAPEUTICS

c-Jun N-terminal kinase has a pivotal role in the maintenance of self-renewal and tumorigenicity in glioma stem-like cells

(2012) C-H Yoon et al.   ONCOGENE

BMP2 sensitizes glioblastoma stem-like cells to Temozolomide by affecting HIF-1α stability and MGMT expression

(2012) L Persano et al.   Cell Death & Disease

Targeting JNK for therapeutic depletion of stem-like glioblastoma cells

(2012) Ken-ichiro Matsuda et al.   Scientific Reports

Glioma-Initiating Cell Elimination by Metformin Activation of FOXO3 via AMPK

(2012) Atsushi Sato et al.   Stem Cells Translational Medicine

Chemoresistance of glioblastoma cancer stem cells - much more complex than expected

(2011) Dagmar Beier et al.   Molecular Cancer

MEK-ERK Signaling Dictates DNA-Repair Gene MGMT Expression and Temozolomide Resistance of Stem-Like Glioblastoma Cells via the MDM2-p53 Axis

(2011) Atsushi Sato et al.   STEM CELLS

Efficient delivery of liposome-mediated MGMT-siRNA reinforces the cytotoxity of temozolomide in GBM-initiating cells

(2010) T Kato et al.   GENE THERAPY

Advances in the Treatment of Malignant Gliomas

(2010) Mustafa Khasraw et al.   Current Oncology Reports

Autocrine TGF-β Signaling Maintains Tumorigenicity of Glioma-Initiating Cells through Sry-Related HMG-Box Factors

(2009) Hiroaki Ikushima et al.   Cell Stem Cell

Heat Shock Protein 90 Is Important for Sp1 Stability during Mitosis

(2009) Shao-An Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

Inhibition of c-Jun N-terminal kinase enhances temozolomide-induced cytotoxicity in human glioma cells

(2009) Shigeo Ohba et al.   JOURNAL OF NEURO-ONCOLOGY

Correlation of O6-Methylguanine Methyltransferase (MGMT) Promoter Methylation With Clinical Outcomes in Glioblastoma and Clinical Strategies to Modulate MGMT Activity

(2008) Monika E. Hegi et al.   JOURNAL OF CLINICAL ONCOLOGY

Phosphorylation by c-Jun NH2-terminal Kinase 1 Regulates the Stability of Transcription Factor Sp1 during Mitosis

(2008) Jian-Ying Chuang et al.   MOLECULAR BIOLOGY OF THE CELL

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE