Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome

Membrane binding of Neuronal Calcium Sensor-1 (NCS1)

(2016) Samuel Lemire et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Structure and Calcium Binding Properties of a Neuronal Calcium-Myristoyl Switch Protein, Visinin-Like Protein 3

(2016) Congmin Li et al.   PLoS One

Fragile X Mental Retardation Protein (FMRP) controls diacylglycerol kinase activity in neurons

(2016) Ricardos Tabet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sense and specificity in neuronal calcium signalling

(2015) Robert D. Burgoyne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions

(2015) Luca Laraia et al.   CHEMISTRY & BIOLOGY

PDE-4 Inhibition Rescues Aberrant Synaptic Plasticity in Drosophila and Mouse Models of Fragile X Syndrome

(2015) C. H. Choi et al.   JOURNAL OF NEUROSCIENCE

Targeted pharmacological treatment of autism spectrum disorders: fragile X and Rett syndromes

(2015) Hansen Wang et al.   Frontiers in Cellular Neuroscience

Hot spot-based design of small-molecule inhibitors for protein–protein interactions

(2014) Wenxing Guo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New insights into the molecular pathophysiology of fragile X syndrome and therapeutic perspectives from the animal model

(2014) Arnau Busquets-Garcia et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The guanine-exchange factor Ric8a binds to the Ca2+ sensor NCS-1 to regulate synapse number and neurotransmitter release

(2014) J. Romero-Pozuelo et al.   JOURNAL OF CELL SCIENCE

Frq2 fromDrosophila melanogaster: cloning, expression, purification, crystallization and preliminary X-ray analysis

(2014) Soledad Baños-Mateos et al.   Acta Crystallographica Section F-Structural Biology Communications

Presynaptic PI3K activity triggers the formation of glutamate receptors at neuromuscular terminals of Drosophila

(2012) S. Jordan-Alvarez et al.   JOURNAL OF CELL SCIENCE

Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics

(2012) Claudia Bagni et al.   JOURNAL OF CLINICAL INVESTIGATION

Drosophila rugose Is a Functional Homolog of Mammalian Neurobeachin and Affects Synaptic Architecture, Brain Morphology, and Associative Learning

(2012) K. Volders et al.   JOURNAL OF NEUROSCIENCE

Learning and Memory Deficits Consequent to Reduction of the Fragile X Mental Retardation Protein Result from Metabotropic Glutamate Receptor-Mediated Inhibition of cAMP Signaling in Drosophila

(2012) A. K. Kanellopoulos et al.   JOURNAL OF NEUROSCIENCE

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Molecular structure and target recognition of neuronal calcium sensor proteins

(2011) James B. Ames et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

N-Acylaminophenothiazines: Neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer’s disease

(2011) Gema C. González-Muñoz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure of a Ca2+-Myristoyl Switch Protein That Controls Activation of a Phosphatidylinositol 4-Kinase in Fission Yeast

(2011) Sunghyuk Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The C-Terminal Tail of Human Neuronal Calcium Sensor 1 Regulates the Conformational Stability of the Ca2+-Activated State

(2011) Pétur O. Heidarsson et al.   JOURNAL OF MOLECULAR BIOLOGY

Fragile X Mental Retardation Protein Regulates New Neuron Differentiation in the Adult Olfactory Bulb

(2011) S. Scotto-Lomassese et al.   JOURNAL OF NEUROSCIENCE

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow’s neuroprotective therapies against neurodegenerative diseases

(2010) Gema C. González-Muñoz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The fragile X mental retardation protein developmentally regulates the strength and fidelity of calcium signaling in Drosophila mushroom body neurons

(2010) Charles R. Tessier et al.   NEUROBIOLOGY OF DISEASE

Phenothiazines inhibit S100A4 function by inducing protein oligomerization

(2010) V. N. Malashkevich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders

(2009) Jeffrey J. Hutsler et al.   BRAIN RESEARCH

Frequenin/NCS-1 and the Ca2+-channel  1-subunit co-regulate synaptic transmission and nerve-terminal growth

(2009) J. S. Dason et al.   JOURNAL OF CELL SCIENCE

Immunocytochemical localization of synaptic proteins to photoreceptor synapses ofDrosophila melanogaster

(2009) Yoshitaka Hamanaka et al.   JOURNAL OF COMPARATIVE NEUROLOGY

A Dual Role for the Adaptor Protein DRK in Drosophila Olfactory Learning and Memory

(2009) A. Moressis et al.   JOURNAL OF NEUROSCIENCE

Temporal requirements of the fragile X mental retardation protein in the regulation of synaptic structure

(2008) C. L. Gatto et al.   DEVELOPMENT

Excess protein synthesis in Drosophila Fragile X mutants impairs long-term memory

(2008) François V Bolduc et al.   NATURE NEUROSCIENCE

The cyclic AMP phenotype of fragile X and autism

(2008) D KELLEY et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Neuralized is expressed in the  /  lobes of adult Drosophila mushroom bodies and facilitates olfactory long-term memory formation

(2008) E. Pavlopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA