trans-Fatty acids facilitate DNA damage-induced apoptosis through the mitochondrial JNK-Sab-ROS positive feedback loop

New insights into the role and mechanism of c-Jun-N-terminal kinase signaling in the pathobiology of liver diseases

(2018) Sanda Win et al.   HEPATOLOGY

Sab concentrations indicate chemotherapeutic susceptibility in ovarian cancer cell lines

(2018) Iru Paudel et al.   BIOCHEMICAL JOURNAL

The Regulation of JNK Signaling Pathways in Cell Death through the Interplay with Mitochondrial SAB and Upstream Post-Translational Effects

(2018) Sanda Win et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nuclear-accumulated SQSTM1/p62-based ALIS act as microdomains sensing cellular stresses and triggering oxidative stress-induced parthanatos

(2018) Takuya Noguchi et al.   Cell Death & Disease

1-Pyrroline-5-carboxylate released by prostate Cancer cell inhibit T cell proliferation and function by targeting SHP1/cytochrome c oxidoreductase/ROS Axis

(2018) Yutao Yan et al.   Journal for ImmunoTherapy of Cancer

trans-Fatty acids promote proinflammatory signaling and cell death by stimulating the apoptosis signal-regulating kinase 1 (ASK1)-p38 pathway

(2017) Yusuke Hirata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma trans -Fatty Acid Concentrations Continue to Be Associated with Serum Lipid and Lipoprotein Concentrations among US Adults after Reductions in trans -Fatty Acid Intake

(2017) Quanhe Yang et al.   JOURNAL OF NUTRITION

MLK3 phosphorylation by ERK1/2 is required for oxidative stress-induced invasion of colorectal cancer cells

(2017) A L Schroyer et al.   ONCOGENE

Sab mediates mitochondrial dysfunction involved in imatinib mesylate-induced cardiotoxicity

(2017) Tara P. Chambers et al.   TOXICOLOGY

TRIM48 Promotes ASK1 Activation and Cell Death through Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator PRMT1

(2017) Yusuke Hirata et al.   Cell Reports

Mitochondria-meditated pathways of organ failure upon inflammation

(2017) Andrey V. Kozlov et al.   Redox Biology

c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src

(2016) Sanda Win et al.   HEPATOLOGY

Rapamycin ameliorates cadmium-induced activation of MAPK pathway and neuronal apoptosis by preventing mitochondrial ROS inactivation of PP2A

(2016) Chong Xu et al.   NEUROPHARMACOLOGY

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

(2016) Linda S. Steelman et al.   Aging-US

Sub-chronic administration of LY294002 sensitizes cervical cancer cells to chemotherapy by enhancing mitochondrial JNK signaling

(2015) Tara P. Chambers et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Serum Trans-Fatty Acid Concentration Is Elevated in Young Patients With Coronary Artery Disease in Japan

(2015) Kenta Mori et al.   CIRCULATION JOURNAL

Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity

(2015) Sanda Win et al.   JOURNAL OF HEPATOLOGY

The role of DNA damage and repair in atherosclerosis: A review

(2015) Nikunj R. Shah et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The roles of c-Jun NH2-terminal kinases (JNKs) in obesity and insulin resistance

(2015) Martin Pal et al.   JOURNAL OF PHYSIOLOGY-LONDON

Trans-fatty acid promotes thrombus formation in mice by aggravating antithrombogenic endothelial functions via Toll-like receptors

(2015) Kensuke Kondo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Requirement of JNK1 for endothelial cell injury in atherogenesis

(2014) Narges Amini et al.   ATHEROSCLEROSIS

CRISPRdirect: software for designing CRISPR/Cas guide RNA with reduced off-target sites

(2014) Yuki Naito et al.   BIOINFORMATICS

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

DNA Damage and Its Links to Neurodegeneration

(2014) Ram Madabhushi et al.   NEURON

JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death

(2014) S Win et al.   Cell Death & Disease

Lipotoxicity: Effects of Dietary Saturated and Transfatty Acids

(2013) Débora Estadella et al.   MEDIATORS OF INFLAMMATION

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Omega-6 polyunsaturated fatty acids prevent atherosclerosis development in LDLr-KO mice, in spite of displaying a pro-inflammatory profile similar to trans fatty acids

(2012) Roberta M. Machado et al.   ATHEROSCLEROSIS

Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components

(2012) Masato Ogura et al.   BIOCHEMICAL JOURNAL

DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis

(2012) Wynand P. Roos et al.   CANCER LETTERS

Src kinases are important regulators of mitochondrial functions

(2012) Etienne Hebert-Chatelain   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Blocking c-Jun N-terminal Kinase (JNK) Translocation to the Mitochondria Prevents 6-Hydroxydopamine-induced Toxicityin Vitroandin Vivo

(2012) Jeremy W. Chambers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of JNK Mitochondrial Localization and Signaling Is Protective against Ischemia/Reperfusion Injury in Rats

(2012) Jeremy W. Chambers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redox regulation of MAPK phosphatase 1 controls monocyte migration and macrophage recruitment

(2012) H. S. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Inhibition of Mitochondrial JNK Signaling Achieved Using Peptide Mimicry of the Sab Kinase Interacting Motif-1 (KIM1)

(2011) Jeremy W. Chambers et al.   ACS Chemical Biology

NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-α Feedforward Signaling

(2011) Sharon Biton et al.   CELL

c-Jun N-terminal Kinase (JNK)-dependent Acute Liver Injury from Acetaminophen or Tumor Necrosis Factor (TNF) Requires Mitochondrial Sab Protein Expression in Mice

(2011) Sanda Win et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial c-Jun N-terminal Kinase (JNK) Signaling Initiates Physiological Changes Resulting in Amplification of Reactive Oxygen Species Generation

(2011) Jeremy W. Chambers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trans Fatty Acids Induce Vascular Inflammation and Reduce Vascular Nitric Oxide Production in Endothelial Cells

(2011) Naomi G. Iwata et al.   PLoS One

Effects of Protocatechuic Acid on Trans Fat Induced Hepatic Steatosis in Mice

(2010) Wen-Hu Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

JNK: A Stress-Activated Protein Kinase Therapeutic Strategies and Involvement in Alzheimer’s and Various Neurodegenerative Abnormalities

(2010) Sidharth Mehan et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The Role of JNK Proteins in Metabolism

(2010) S. N. Vallerie et al.   Science Translational Medicine

n-3 Fatty acids prevent whereas trans-fatty acids induce vascular inflammation and sudden cardiac death

(2009) Rafat A. Siddiqui et al.   BRITISH JOURNAL OF NUTRITION

trans-Fatty acids in the diet stimulate atherosclerosis

(2009) Chantal M.C. Bassett et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Trans fatty acids: effects on metabolic syndrome, heart disease and diabetes

(2009) Renata Micha et al.   Nature Reviews Endocrinology

Metabolic Implications of Dietary Trans-fatty Acids

(2009) Suzanne E. Dorfman et al.   Obesity

Requirement of Reactive Oxygen Species-dependent Activation of ASK1-p38 MAPK Pathway for Extracellular ATP-induced Apoptosis in Macrophage

(2008) Takuya Noguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caenorhabditis elegans mboa-7, a Member of the MBOAT Family, Is Required for Selective Incorporation of Polyunsaturated Fatty Acids into Phosphatidylinositol

(2007) Hyeon-Cheol Lee et al.   MOLECULAR BIOLOGY OF THE CELL