Nuclear-accumulated SQSTM1/p62-based ALIS act as microdomains sensing cellular stresses and triggering oxidative stress-induced parthanatos

p62 filaments capture and present ubiquitinated cargos for autophagy

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Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis

(2018) Bernadette Carroll et al.   Nature Communications

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Autophagy: novel applications of nonsteroidal anti-inflammatory drugs for primary cancer

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Nuclear autophagy: An evolutionarily conserved mechanism of nuclear degradation in the cytoplasm

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p62 in Cancer: Signaling Adaptor Beyond Autophagy

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Autophagy Regulates Chromatin Ubiquitination in DNA Damage Response through Elimination of SQSTM1/p62

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p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

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The Selective Autophagy Receptor p62 Forms a Flexible Filamentous Helical Scaffold

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Oxidative Stress, Redox Signaling, and Autophagy: Cell Death Versus Survival

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ROS Function in Redox Signaling and Oxidative Stress

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Poly(ADP-ribose) polymerases in double-strand break repair: Focus on PARP1, PARP2 and PARP3

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Mitophagy is not induced by mitochondrial damage but plays a role in the regulation of cellular autophagic activity

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Critical role of Nrf2 in oxidative stress-induced retinal ganglion cell death

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RNA-Guided Human Genome Engineering via Cas9

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Multiplex Genome Engineering Using CRISPR/Cas Systems

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Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells

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Transient Aggregation of Ubiquitinated Proteins Is a Cytosolic Unfolded Protein Response to Inflammation and Endoplasmic Reticulum Stress

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p62/SQSTM1/A170: Physiology and pathology

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TLR4-mediated autophagy in macrophages is a p62-dependent type of selective autophagy of aggresome-like induced structures (ALIS)

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p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy

(2010) Terje Høyvarde Clausen et al.   Autophagy

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

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Poly(ADP-ribose) signals to mitochondrial AIF: A key event in parthanatos

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Parthanatos, a messenger of death

(2009) Karen Kate David   Frontiers in Bioscience-Landmark

Nucleocytoplasmic Shuttling of p62/SQSTM1 and Its Role in Recruitment of Nuclear Polyubiquitinated Proteins to Promyelocytic Leukemia Bodies

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The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cephalosporin-Induced Neurotoxicity: Clinical Manifestations, Potential Pathogenic Mechanisms, and the Role of Electroencephalographic Monitoring

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Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

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Requirement of Reactive Oxygen Species-dependent Activation of ASK1-p38 MAPK Pathway for Extracellular ATP-induced Apoptosis in Macrophage

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Apoptosis Signal-Regulating Kinase 1 in Stress and Immune Response

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