Lipotoxicity: Effects of Dietary Saturated and Transfatty Acids

Saturated fat stimulates obesity and hepatic steatosis and affects gut microbiota composition by an enhanced overflow of dietary fat to the distal intestine

(2012) Nicole de Wit et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Trans fatty acid intake is associated with insulin sensitivity but independently of inflammation

(2012) C.T. Angelieri et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

The effect of weight loss magnitude on pro-/anti-inflammatory adipokines and carotid intima-media thickness in obese adolescents engaged in interdisciplinary weight loss therapy

(2012) Deborah C. L. Masquio et al.   CLINICAL ENDOCRINOLOGY

Lipid-Induced Insulin Resistance Is Not Mediated by Impaired Transcapillary Transport of Insulin and Glucose in Humans

(2012) J. Szendroedi et al.   DIABETES

Increased Toll-Like Receptor Activity in Patients With Metabolic Syndrome

(2012) I. Jialal et al.   DIABETES CARE

Relationship of Insulin Sensitivity, Insulin Secretion, and Adiposity With Insulin Clearance in a Multiethnic Population: The Insulin Resistance Atherosclerosis Study

(2012) C. Lorenzo et al.   DIABETES CARE

Prevalence of Prediabetes and Diabetes and Metabolic Profile of Patients With Nonalcoholic Fatty Liver Disease (NAFLD)

(2012) C. Ortiz-Lopez et al.   DIABETES CARE

Long-term effects of aerobic plus resistance training on the adipokines and neuropeptides in nonalcoholic fatty liver disease obese adolescents

(2012) Aline de Piano et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Role of Obesity and Lipotoxicity in the Development of Nonalcoholic Steatohepatitis: Pathophysiology and Clinical Implications

(2012) Kenneth Cusi   GASTROENTEROLOGY

Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways

(2012) Shurong Huang et al.   JOURNAL OF LIPID RESEARCH

Nonalcoholic fatty liver disease as a pro-resolution defective disorder

(2012) Undurti N. Das   NUTRITION

Long-term interdisciplinary therapy reduces endotoxin level and insulin resistance in obese adolescents

(2012) Fábio S Lira et al.   Nutrition Journal

IRE1  Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2

(2012) J.-P. Upton et al.   SCIENCE

Chronic Consumption of trans-Fat-Rich Diet Increases Hepatic Cholesterol Levels and Impairs Muscle Insulin Sensitivity without Leading to Hepatic Steatosis and Hypertriglyceridemia in Female Fischer Rats

(2011) Shanmugam M. Jeyakumar et al.   ANNALS OF NUTRITION AND METABOLISM

Interaction Between Obesity and the Gut Microbiota: Relevance in Nutrition

(2011) Nathalie M. Delzenne et al.   Annual Review of Nutrition

Inhibitory Effect of Unsaturated Fatty Acids on Saturated Fatty Acid-Induced Apoptosis in Human Pancreatic β-Cells: Activation of Caspases and ER Stress Induction

(2011) Vlasta Němcová-Fürstová et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Both adiponectin and interleukin-10 inhibit LPS-induced activation of the NF-κB pathway in 3T3-L1 adipocytes

(2011) Fábio Santos Lira et al.   CYTOKINE

Diacerhein Improves Glucose Tolerance and Insulin Sensitivity in Mice on a High-Fat Diet

(2011) Natália Tobar et al.   ENDOCRINOLOGY

The Role of PAI-1 and Adiponectin on the Inflammatory State and Energy Balance in Obese Adolescents with Metabolic Syndrome

(2011) Flavia Campos Corgosinho et al.   INFLAMMATION

Reactive oxygen and mechanisms of inflammatory liver injury: Present concepts

(2011) Hartmut Jaeschke   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Nonalcoholic fatty liver in Asia: Firmly entrenched and rapidly gaining ground

(2011) Shivakumar Chitturi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

A High Intake of trans Fatty Acids Has Little Effect on Markers of Inflammation and Oxidative Stress in Humans

(2011) Liesbeth A. Smit et al.   JOURNAL OF NUTRITION

Acute and chronic saturated fatty acid treatment as a key instigator of the TLR-mediated inflammatory response in human adipose tissue, in vitro

(2011) Elham M. Youssef-Elabd et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Mechanisms of Lipotoxicity in NAFLD and Clinical Implications

(2011) Samar H Ibrahim et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

A palatable hyperlipidic diet causes obesity and affects brain glucose metabolism in rats

(2011) Debora Estadella et al.   Lipids in Health and Disease

Effect of α-linolenic acid on endoplasmic reticulum stress-mediated apoptosis of palmitic acid lipotoxicity in primary rat hepatocytes

(2011) Yong Zhang et al.   Lipids in Health and Disease

The intake of high fat diet with different trans fatty acid levels differentially induces oxidative stress and non alcoholic fatty liver disease (NAFLD) in rats

(2011) Madiha Dhibi et al.   Nutrition & Metabolism

Hyperleptinemia in obese adolescents deregulates neuropeptides during weight loss

(2011) Ana R. Dâmaso et al.   PEPTIDES

Trans Fatty Acids Induce Vascular Inflammation and Reduce Vascular Nitric Oxide Production in Endothelial Cells

(2011) Naomi G. Iwata et al.   PLoS One

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

The role of nutritional profile in the orexigenic neuropeptide secretion in nonalcoholic fatty liver disease obese adolescents

(2010) Aline de Piano et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Gender-specific differences in adipose distribution and adipocytokines influence adolescent nonalcoholic fatty liver disease

(2010) Oyekoya T. Ayonrinde et al.   HEPATOLOGY

Improvement in HOMA-IR is an independent predictor of reduced carotid intima-media thickness in obese adolescents participating in an interdisciplinary weight-loss program

(2010) Priscila de Lima Sanches et al.   HYPERTENSION RESEARCH

Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice

(2010) Noriyuki Obara et al.   JOURNAL OF HEPATOLOGY

A defect in Δ6 and Δ5 desaturases may be a factor in the initiation and progression of insulin resistance, the metabolic syndrome and ischemic heart disease in South Asians

(2010) Undurti N Das   Lipids in Health and Disease

Toll-Like Receptor Signaling Pathways—Therapeutic Opportunities

(2010) Jiankun Zhu et al.   MEDIATORS OF INFLAMMATION

TNF-α transiently induces endoplasmic reticulum stress and an incomplete unfolded protein response in the hypothalamus

(2010) R.G. Denis et al.   NEUROSCIENCE

Effect of a High Intake of Conjugated Linoleic Acid on Lipoprotein Levels in Healthy Human Subjects

(2010) Anne J. Wanders et al.   PLoS One

Review: Treatment options for nonalcoholic fatty liver disease

(2010) Brian Lam et al.   Therapeutic Advances in Gastroenterology

Metabolism and secretory function of white adipose tissue: effect of dietary fat

(2009) Cláudia M. Oller do Nascimento et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

[RETRACTION]Translational research into gut microbiota: new horizons in obesity treatment

(2009) Daniela M. Tsukumo et al.   Arquivos Brasileiros de Endocrinologia e Metabologia

Lipid homeostasis, lipotoxicity and the metabolic syndrome

(2009) Roger H. Unger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells

(2008) Maria L. Watson et al.   BIOCHEMICAL JOURNAL

Are saturated fatty acids and insulin resistance associated with fatty liver in obese children?

(2008) Dimitrios Papandreou et al.   CLINICAL NUTRITION

Saturated Fatty Acid-Mediated Inflammation and Insulin Resistance in Adipose Tissue: Mechanisms of Action and Implications

(2008) Arion Kennedy et al.   JOURNAL OF NUTRITION

Hydrogenated fat diet intake during pregnancy and lactation modifies the PAI-1 gene expression in white adipose tissue of offspring in adult life

(2008) Luciana P Pisani et al.   Lipids in Health and Disease

Lipid signalling in disease

(2008) Matthias P. Wymann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nutritional assessment and hepatic fatty acid composition in non-alcoholic fatty liver disease (NAFLD): A cross-sectional study

(2007) Johane P. Allard et al.   JOURNAL OF HEPATOLOGY