Article
Chemistry, Medicinal
Xiaobo Dong, Lei Wang, Guangrong Song, Xu Cai, Wenxin Wang, Jiaqi Chen, Gesheng Wang
Summary: The study demonstrates that physcion protects neuronal cells against I/R injury by inhibiting the TLR4/NF-kB pathway, reducing inflammatory response and oxidative stress, and decreasing apoptosis, suggesting a promising therapeutic candidate for ischemic stroke.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Carlos Andres Pantanali, Vinicius Rocha-Santos, Marcia Saldanha Kubrusly, Inar Alves Castro, Luiz Augusto Carneiro-D'Albuquerque, Flavio Henrique Galvao
Summary: Nutraceuticals are bioactive compounds found in food that can improve health, prevent diseases, and support the normal functioning of the human body. They are able to target multiple pathways, acting as antioxidants, anti-inflammatory agents, and immune response and cell death modulators. This study investigated the effect of a nutraceutical solution on liver ischemia-reperfusion injury (IRI), and found that it decreased apoptosis and histologic injury in liver tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Michael A. Fawzy, Sherif A. Maher, Sally M. Bakkar, Mahmoud A. El-Rehany, Moustafa Fathy
Summary: This study demonstrated the protective effect of pantoprazole on renal ischemia/reperfusion injury in rats for the first time, by suppressing apoptosis, reducing pro-inflammatory cytokines levels, and impacting intracellular signaling pathways. Moreover, multiple doses of pantoprazole showed a greater therapeutic effect than a single dose.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Lichen Chen, Jixiang Yuan, Hang Li, Yi Ding, Xuejia Yang, Ziwei Yuan, Zujian Hu, Yuanyuan Gao, Xilong Wang, Hong Lu, Yong Cai, Yongheng Bai, Xiaodong Pan
Summary: Trans-cinnamaldehyde (TCA) extracted from cinnamon bark has anti-inflammatory properties and can attenuate renal ischemia-reperfusion injury (IRI) through inhibiting the JNK/p38 MAPK signaling pathway, thus reducing kidney pathological changes and dysfunction.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Jing Zhang, Xia Cai, Qin Zhang, Xiaozhong Li, Siyuan Li, Jianyong Ma, Wengen Zhu, Xiao Liu, Meilin Wei, Wei Tu, Yunfeng Shen, Jianping Liu, Xiaoyang Lai, Peng Yu
Summary: The study found that hydrogen sulfide can restore the cardioprotection induced by sevoflurane postconditioning in diabetic rats by enhancing and promoting the SIRT1/Nrf2 signaling pathway, thereby mediating mitochondrial dysfunction and oxidative stress.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Yanbin Song, Yunqing Zhang, Zhaofei Wan, Junqiang Pan, Feng Gao, Fei Li, Jing Zhou, Junmin Chen
Summary: This study revealed that CTRP3 alleviates cardiac ischemia/reperfusion injury by elevating LAMP1 and activating the JIP2/JNK signaling pathway, suggesting its potential as a therapeutic target.
Article
Chemistry, Multidisciplinary
Jing-jing Zeng, Han-qing Shi, Fang-fang Ren, Xiao-shan Zhao, Qiao-ying Chen, Dong-juan Wang, Lian-pin Wu, Mao-ping Chu, Teng-fang Lai, Lei Li
Summary: This study investigated the cardioprotective mechanisms of notoginsenoside R1 (NG-R1) in myocardial ischemia/reperfusion (MI/R) injury. The results showed that administration of NG-R1 significantly reduced myocardial infarction area, alleviated myocardial cell damage, and improved cardiac function in MI/R mice. The study also revealed that NG-R1 inhibited apoptosis in cardiomyocytes by suppressing TAK1, JNK, and p38 signaling.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Neurosciences
Shusheng Ge, Liwei Zhang, Xiaoguang Cui, Yuan Li
Summary: This study designs brain-targeted nanomicelles and demonstrates their efficacy in improving activity and mitochondrial function of astrocytes in cerebral ischemia/reperfusion injury models, leading to the alleviation of brain injury.
Article
Medicine, Research & Experimental
Yungang Shan, Deqing Chen, Bo Hu, Guangtao Xu, Wanlu Li, Ye Jin, Xiuhui Jin, Xin Jin, Limin Jin
Summary: The study demonstrated that allicin exerts a protective effect against renal ischemia/reperfusion injury in rats by regulating apoptosis, oxidative stress, and inflammatory response.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Neurosciences
Xulong Yin, Jiahe Wang, Siyuan Yang, Haiying Li, Haitao Shen, Hui Wang, Xiang Li, Gang Chen
Summary: This study investigates the role of Sam50, a barrel protein on the surface of the mitochondrial outer membrane, in cerebral ischemia-reperfusion injury and its underlying mechanisms. The results show that Sam50 plays a vital role in the protection of neurons and mitochondria, which could be a potential target for mitigating ischemia-reperfusion injury.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Chayodom Maneechote, Siripong Palee, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Inhibiting mitochondrial fission and promoting mitochondrial fusion can reduce infarct size and improve left ventricular function in cardiac ischemia-reperfusion injury.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Medicine, Research & Experimental
Baoer Liu, Brice Korkmaz, Patricia Kraft, Tobias Mayer, Alex A. Sayour, Marc A. Grundl, Roxane Domain, Matthias Karck, Gabor Szabo, Sevil Korkmaz-Icoez
Summary: This study demonstrated that the pharmacological inhibition of cathepsin C (CatC) with BI-9740 improves graft function after heart transplantation in rats. By reducing the proteolytic activity of neutrophil elastase, ameliorating histopathological lesions and inflammatory cell infiltration, improvements were observed in both systolic and diastolic function of the transplanted hearts. Additionally, BI-9740 also shortened the graft re-beating time.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Dou Huang, Changwei Chen, Yunxia Zuo, Lei Du, Ting Liu, Geoffrey W. Abbott, Zhaoyang Hu
Summary: This study found that RLIPost reduces pulmonary damage induced by ischemia-reperfusion in both non-diabetic and diabetic rats. The protective mechanism in non-diabetic rats is associated with STAT-3, while in diabetic rats it is independent of STAT-3.
Article
Biochemistry & Molecular Biology
Milomir O. Simovic, Michael J. Falabella, Tuan D. Le, Jurandir J. DalleLucca, Yansong Li
Summary: This study investigated the effects of early administration of DAF on hemorrhage-induced organ damage. The results suggest that DAF treatment can alleviate organ injury and improve metabolic acidosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Weijie Xie, Ting Zhu, Shuxia Zhang, Xiaobo Sun
Summary: This study investigated the regulatory effects and mechanisms of Gypenoside XVII (GP17) on mitochondrial autophagy after cerebral ischemia/reperfusion injury (CIRI). The results showed that GP17 improved mitochondrial damage and combated CIRI through maintaining moderate activation of autophagy, and the modulation of mitochondrial autophagy was associated with crosstalk between the SIRT1-FOXO3A and Hif1a-BNIP3 signaling pathways.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Iru Paudel, Sean M. Hernandez, Gilda M. Portalatin, Tara P. Chambers, Jeremy W. Chambers
BIOCHEMICAL JOURNAL
(2018)
Meeting Abstract
Biophysics
Linjia Su, Jeremy Chambers, Fenfei Leng
BIOPHYSICAL JOURNAL
(2019)
Review
Neurosciences
Maribel Lucero, Ana E. Suarez, Jeremy W. Chambers
CNS NEUROSCIENCE & THERAPEUTICS
(2019)
Article
Oncology
Wenjie Wang, Monica Rodriguez-Silva, Arlet M. Acanda de la Rocha, Aizik L. Wolf, Yanhao Lai, Yuan Liu, William C. Reinhold, Yves Pommier, Jeremy W. Chambers, Yuk-Ching Tse-Dinh
Article
Chemistry, Multidisciplinary
Yunke Wang, Samantha Rakela, Jeremy W. Chambers, Zi-Chun Hua, Mark T. Muller, John L. Nitiss, Yuk-Ching Tse-Dinh, Fenfei Leng
Article
Neurosciences
Meredith K. Loth, Sara R. Guariglia, Diane B. Re, Juan Perez, Vanessa Nunes de Paiva, Jennifer L. Dziedzic, Jeremy W. Chambers, Diana J. Azzam, Tomas R. Guilarte
MOLECULAR NEUROBIOLOGY
(2020)
Article
Chemistry, Medicinal
Michael J. Rishel, Brian C. Bales, Victoria Cotero, Dan E. Meyer, Jeannette C. Roberts, Monica Rodriguez-Silva, Tiberiu M. Siclovan, Jeremy W. Chambers
Summary: Pathological activation of JNK3 in the brain has been linked to neuronal apoptosis, making the development of a PET tracer for visualizing this activation significant for detecting at risk brain regions. Using specific compounds, experiments in a Parkinson's disease mouse model showed that JNK3 activation occurred in multiple brain regions prior to significant neuron loss.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Medicinal
Eddy E. Alfonso, Zifang Deng, Daniel Boaretto, Becky L. Hood, Stefan Vasile, Layton H. Smith, Jeremy W. Chambers, Prem Chapagain, Fenfei Leng
Summary: In this study, a high-throughput screening assay was developed to identify inhibitors targeting bacterial DNA gyrase. 155 new gyrase inhibitors with diverse structures and potent antibacterial activities were discovered, including several gyrase poisons. These findings are significant for the development of drugs against multidrug-resistant bacterial pathogens.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2022)
Article
Chemistry, Analytical
Yarixa L. Cintron-Diaz, Arlet M. Acanda de la Rocha, Anthony Castellanos, Jeremy M. Chambers, Francisco Fernandez-Lima
Article
Multidisciplinary Sciences
Linjia Su, Nadezda Bryan, Sabrina Battista, Juliano Freitas, Alyssa Garabedian, Federica D'Alessio, Miriam Romano, Fabiana Falanga, Alfredo Fusco, Lidia Kos, Jeremy Chambers, Francisco Fernandez-Lima, Prem P. Chapagain, Stefan Vasile, Layton Smith, Fenfei Leng
SCIENTIFIC REPORTS
(2020)
Meeting Abstract
Oncology
Arlet Maria Acanda de la Rocha, Monica Rodriguez-Silva, Sergio Gonzalez-Arias, Jeremy W. Chambers
Meeting Abstract
Cell Biology
M. Rodriguez-Silva, J. W. Chambers
MOLECULAR BIOLOGY OF THE CELL
(2017)
Meeting Abstract
Cell Biology
K. T. Ashourian, J. W. Chambers
MOLECULAR BIOLOGY OF THE CELL
(2017)
Meeting Abstract
Oncology
Wenjie Wang, Monica Rodriguez Silva, Jeremy Chambers, Yuk-Ching Tse-Dinh
Article
Neurosciences
Alejandro O. Sodero, Monica Rodriguez-Silva, Chiara Salio, Marco Sassoe-Pognetto, Jeremy W. Chambers