Glucose transporter 1 in rheumatoid arthritis and autoimmunity

Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1

(2019) Alex J. Freemerman et al.   JOURNAL OF IMMUNOLOGY

Targeting T Cell Activation and Lupus Autoimmune Phenotypes by Inhibiting Glucose Transporters

(2019) Wei Li et al.   Frontiers in Immunology

Inhibition of Glycolysis and Glutaminolysis: An Emerging Drug Discovery Approach to Combat Cancer

(2018) Nicholas S. Akins et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

ICOS Signaling Controls Induction and Maintenance of Collagen-Induced Arthritis

(2018) Vincent Panneton et al.   JOURNAL OF IMMUNOLOGY

Metabolic exhaustion in infection, cancer and autoimmunity

(2018) E. F. McKinney et al.   NATURE IMMUNOLOGY

Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis

(2018) Zhuzhen Zhang et al.   NATURE MEDICINE

Upregulation of Glucose Uptake and Hexokinase Activity of Primary Human CD4+ T Cells in Response to Infection with HIV-1

(2018) Maia Kavanagh Williamson et al.   Viruses-Basel

Inhibition of Glycolysis Reduces Disease Severity in an Autoimmune Model of Rheumatoid Arthritis

(2018) Georges Abboud et al.   Frontiers in Immunology

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

(2018) Marc O. Johnson et al.   CELL

Membrane-enriched solute carrier family 2 member 1 (SLC2A1/GLUT1) in psoriatic keratinocytes confers sensitivity to 2-deoxy-D-glucose (2-DG) treatment

(2018) Xiaoyan Huang et al.   EXPERIMENTAL DERMATOLOGY

Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells

(2018) Seung-Chul Choi et al.   Nature Communications

Glucose metabolism induced by Bmp signaling is essential for murine skeletal development

(2018) Seung-Yon Lee et al.   Nature Communications

Calcium/calmodulin-dependent protein kinase 4 promotes GLUT1-dependent glycolysis in systemic lupus erythematosus

(2018) Tomohiro Koga et al.   Arthritis & Rheumatology

Human Dendritic Cell Subsets Undergo Distinct Metabolic Reprogramming for Immune Response

(2018) Farhan Basit et al.   Frontiers in Immunology

Immunopathogenesis of Rheumatoid Arthritis

(2017) Gary S. Firestein et al.   IMMUNITY

Immunometabolism in early and late stages of rheumatoid arthritis

(2017) Cornelia M. Weyand et al.   Nature Reviews Rheumatology

Fine tuning of immunometabolism for the treatment of rheumatic diseases

(2017) Jillian P. Rhoads et al.   Nature Reviews Rheumatology

Mixing omics: combining genetics and metabolomics to study rheumatic diseases

(2017) Cristina Menni et al.   Nature Reviews Rheumatology

Clinical Value of FDG-PET/CT for the Evaluation of Rheumatic Diseases: Rheumatoid Arthritis, Polymyalgia Rheumatica, and Relapsing Polychondritis

(2017) Kazuo Kubota et al.   SEMINARS IN NUCLEAR MEDICINE

IL-17-mediated mitochondrial dysfunction impairs apoptosis in rheumatoid arthritis synovial fibroblasts through activation of autophagy

(2017) Eun Kyung Kim et al.   Cell Death & Disease

Resolution of TLR2-induced inflammation through manipulation of metabolic pathways in Rheumatoid Arthritis

(2017) Trudy McGarry et al.   Scientific Reports

3-bromopyruvate ameliorate autoimmune arthritis by modulating Th17/Treg cell differentiation and suppressing dendritic cell activation

(2017) Takaichi Okano et al.   Scientific Reports

Dysregulated bioenergetics: a key regulator of joint inflammation

(2016) M Biniecka et al.   ANNALS OF THE RHEUMATIC DISEASES

mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation

(2016) Hu Zeng et al.   IMMUNITY

Immunometabolism and autoimmunity

(2016) Jenny Freitag et al.   IMMUNOLOGY AND CELL BIOLOGY

GC/TOF-MS-based metabolomic profiling in cultured fibroblast-like synoviocytes from rheumatoid arthritis

(2016) Joong Kyong Ahn et al.   JOINT BONE SPINE

GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis

(2016) Amanda Littlewood-Evans et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Prediction of Large Joint Destruction in Patients With Rheumatoid Arthritis Using 18F-FDG PET/CT and Disease Activity Score

(2016) Takahito Suto et al.   MEDICINE

Glucose Transporters at the Blood-Brain Barrier: Function, Regulation and Gateways for Drug Delivery

(2016) Simon G. Patching   MOLECULAR NEUROBIOLOGY

New insights into the immunopathogenesis of systemic lupus erythematosus

(2016) George C. Tsokos et al.   Nature Reviews Rheumatology

Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis

(2016) Ursula Fearon et al.   Nature Reviews Rheumatology

Macrophage heterogeneity in the context of rheumatoid arthritis

(2016) Irina A. Udalova et al.   Nature Reviews Rheumatology

GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters

(2016) Dong Deng et al.   PROTEIN SCIENCE

Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis

(2016) Zhen Yang et al.   Science Translational Medicine

Metabolic pathways in T cell activation and lineage differentiation

(2016) Luís Almeida et al.   SEMINARS IN IMMUNOLOGY

Anticancer agents interacting with membrane glucose transporters

(2016) C. Granchi et al.   MedChemComm

Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes

(2016) Ricard Garcia-Carbonell et al.   Arthritis & Rheumatology

Cell surface Glut1 levels distinguish human CD4 and CD8 T lymphocyte subsets with distinct effector functions

(2016) Gaspard Cretenet et al.   Scientific Reports

A Broken Krebs Cycle in Macrophages

(2015) Luke A.J. O’Neill   IMMUNITY

Hypoxic culture conditions enhance the generation of regulatory T cells

(2015) Thi My Anh Neildez-Nguyen et al.   IMMUNOLOGY

Glucose Oxidation Is Critical for CD4+T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus

(2015) Yiming Yin et al.   JOURNAL OF IMMUNOLOGY

Comprehensive metabolome analyses reveal N-acetylcysteine-responsive accumulation of kynurenine in systemic lupus erythematosus: implications for activation of the mechanistic target of rapamycin

(2015) Andras Perl et al.   Metabolomics

Rheumatoid arthritis therapy reappraisal: strategies, opportunities and challenges

(2015) Josef S. Smolen et al.   Nature Reviews Rheumatology

Energy Metabolism Disorder as a Contributing Factor of Rheumatoid Arthritis: A Comparative Proteomic and Metabolomic Study

(2015) Xin Yu Yang et al.   PLoS One

Normalization of CD4 + T cell metabolism reverses lupus

(2015) Yiming Yin et al.   Science Translational Medicine

Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions

(2015) Clovis S. Palmer et al.   Frontiers in Immunology

Targeting the facilitative glucose transporter GLUT1 inhibits the self-renewal and tumor-initiating capacity of cancer stem cells

(2015) Keita Shibuya et al.   Oncotarget

Differential regulation of GLUT1 and GLUT8 expression by hypoxia in mammary epithelial cells

(2014) Yong Shao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Evaluation of tocilizumab therapy in patients with rheumatoid arthritis based on FDG-PET/CT

(2014) Koichi Okamura et al.   BMC MUSCULOSKELETAL DISORDERS

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

In vivoquantification of mouse autoimmune arthritis by PET/CT

(2014) Smriti Kundu-Raychaudhuri et al.   International Journal of Rheumatic Diseases

Metabolic Reprogramming of Macrophages

(2014) Alex J. Freemerman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways

(2014) S. R. Jacobs et al.   JOURNAL OF IMMUNOLOGY

Metabolic Reprogramming Is Required for Antibody Production That Is Suppressed in Anergic but Exaggerated in Chronically BAFF-Exposed B Cells

(2014) A. Caro-Maldonado et al.   JOURNAL OF IMMUNOLOGY

Roles of glucose transporter-1 and the phosphatidylinositol 3-kinase/protein kinase B pathway in cancer radioresistance (Review)

(2014) JIN FANG et al.   Molecular Medicine Reports

Direct Type I IFN but Not MDA5/TLR3 Activation of Dendritic Cells Is Required for Maturation and Metabolic Shift to Glycolysis after Poly IC Stimulation

(2014) Austin Pantel et al.   PLOS BIOLOGY

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

The Impact of Inflammation on Metabolomic Profiles in Patients With Arthritis

(2013) Stephen P. Young et al.   ARTHRITIS AND RHEUMATISM

Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells

(2013) Zhen Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The SLC2 (GLUT) family of membrane transporters

(2013) Mike Mueckler et al.   MOLECULAR ASPECTS OF MEDICINE

Correlation of 18F-FDG PET/CT assessments with disease activity and markers of inflammation in patients with early rheumatoid arthritis following the initiation of combination therapy with triple oral antirheumatic drugs

(2012) Anne Roivainen et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

PI3 kinase/Akt/HIF-1α pathway is associated with hypoxia-induced epithelial–mesenchymal transition in fibroblast-like synoviocytes of rheumatoid arthritis

(2012) Guo-Qing Li et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo

(2012) Y. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors

(2012) Nunzio Bottini et al.   Nature Reviews Rheumatology

The assessment of biologic treatment in patients with rheumatoid arthritis using FDG-PET/CT

(2012) K. Okamura et al.   RHEUMATOLOGY

Targeting monocytes/macrophages in the treatment of rheumatoid arthritis

(2012) J.-L. Davignon et al.   RHEUMATOLOGY

PET/CT imaging in systemic lupus erythematosus

(2011) Rodolfo Curiel et al.   Annals of the New York Academy of Sciences

Mitochondrial mutagenesis correlates with the local inflammatory environment in arthritis

(2011) Leonard C Harty et al.   ANNALS OF THE RHEUMATIC DISEASES

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

18F-FDG PET as a Tool to Predict the Clinical Outcome of Infliximab Treatment of Rheumatoid Arthritis: An Explorative Study

(2010) E. H. Elzinga et al.   JOURNAL OF NUCLEAR MEDICINE

Will the original glucose transporter isoform please stand up!

(2009) Anthony Carruthers et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Whole-body FDG-PET/CT on rheumatoid arthritis of large joints

(2009) Kazuo Kubota et al.   ANNALS OF NUCLEAR MEDICINE

GLUT1 gene is a potential hypoxic marker in colorectal cancer patients

(2009) Fu-Yen Chung et al.   BMC CANCER

Phosphatidylinostitol-3 kinase and phospholipase C enhance CSF-1-dependent macrophage survival by controlling glucose uptake

(2009) Margaret Chang et al.   CELLULAR SIGNALLING

Hypoxia Prolongs Monocyte/Macrophage Survival and Enhanced Glycolysis Is Associated with Their Maturation under Aerobic Conditions

(2009) J. Roiniotis et al.   JOURNAL OF IMMUNOLOGY

Inflammatory Cytokines and Hypoxia Contribute to 18F-FDG Uptake by Cells Involved in Pannus Formation in Rheumatoid Arthritis

(2009) T. Matsui et al.   JOURNAL OF NUCLEAR MEDICINE

Metalloproteinase Expression in Monocytes and Macrophages and its Relationship to Atherosclerotic Plaque Instability

(2008) Andrew C. Newby   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Glut1 and Glut4 glucose transporters are differentially expressed during perinatal and postnatal erythropoiesis

(2008) A. Montel-Hagen et al.   BLOOD

Erythrocyte Glut1 Triggers Dehydroascorbic Acid Uptake in Mammals Unable to Synthesize Vitamin C

(2008) Amélie Montel-Hagen et al.   CELL