Anticancer agents interacting with membrane glucose transporters

Inhibitor Discovery for the Human GLUT1 from Homology Modeling and Virtual Screening

(2016) Peter Man-Un Ung et al.   ACS Chemical Biology

Identification of novel GLUT inhibitors

(2016) Holger Siebeneicher et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Galactose conjugated platinum(II) complex targeting the Warburg effect for treatment of non-small cell lung cancer and colon cancer

(2016) Meng Wu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides

(2016) Khyati Kapoor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The sweet trap in tumors: aerobic glycolysis and potential targets for therapy

(2016) Li Yu et al.   Oncotarget

Salicylketoximes That Target Glucose Transporter 1 Restrict Energy Supply to Lung Cancer Cells

(2015) Carlotta Granchi et al.   ChemMedChem

Triheptanoin dramatically reduces paroxysmal motor disorder in patients with GLUT1 deficiency

(2015) Fanny Mochel et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Melatonin uptake through glucose transporters: a new target for melatonin inhibition of cancer

(2015) David Hevia et al.   JOURNAL OF PINEAL RESEARCH

Xanthohumol impairs glucose uptake by a human first-trimester extravillous trophoblast cell line (HTR-8/SVneo cells) and impacts the process of placentation

(2015) Ana Correia-Branco et al.   MOLECULAR HUMAN REPRODUCTION

Apigenin inhibits the proliferation of adenoid cystic carcinoma via suppression of glucose transporter-1

(2015) JIN FANG et al.   Molecular Medicine Reports

The Chemopreventive Effect of the Dietary Compound Kaempferol on the MCF-7 Human Breast Cancer Cell Line Is Dependent on Inhibition of Glucose Cellular Uptake

(2015) Cláudia Azevedo et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Inhibiting GLUT-1 expression and PI3K/Akt signaling using apigenin improves the radiosensitivity of laryngeal carcinoma in vivo

(2015) YANG-YANG BAO et al.   ONCOLOGY REPORTS

An update on therapeutic opportunities offered by cancer glycolytic metabolism

(2014) Carlotta Granchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting the Warburg effect with a novel glucose transporter inhibitor to overcome gemcitabine resistance in pancreatic cancer cells

(2014) I-Lu Lai et al.   CARCINOGENESIS

EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1

(2014) Shala L. Thomas et al.   CELL CYCLE

Regulation of GLUT Transporters by Flavonoids in Androgen-Sensitive and -Insensitive Prostate Cancer Cells

(2014) Pedro Gonzalez-Menendez et al.   ENDOCRINOLOGY

Differential Expression of Glut 1 mRNA and Protein Levels Correlates with Increased Sensitivity to the Glyco-Conjugated Nitric Oxide Donor (2-glu-SNAP) in Different Tumor Cell Types

(2014) P.R. Subbarayan et al.   JOURNAL OF CHEMOTHERAPY

Crystal structure of the human glucose transporter GLUT1

(2014) Dong Deng et al.   NATURE

Antiartherosclerotic Effects of Plant Flavonoids

(2014) Shamala Salvamani et al.   Biomed Research International

Resolution of the direct interaction with and inhibition of the human GLUT1 hexose transporter by resveratrol from its effect on glucose accumulation

(2013) Mónica Salas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Identifying novel targets in renal cell carcinoma: Design and synthesis of affinity chromatography reagents

(2013) Muriel Bonnet et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Oxime-based inhibitors of glucose transporter 1 displaying antiproliferative effects in cancer cells

(2013) Tiziano Tuccinardi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeted Cancer Therapy with a 2-Deoxyglucose-Based Adriamycin Complex

(2013) J. Cao et al.   CANCER RESEARCH

Therapeutic role of EF24 targeting glucose transporter 1-mediated metabolism and metastasis in ovarian cancer cells

(2013) Dandan Zhang et al.   CANCER SCIENCE

Dual Targeting of the Warburg Effect with a Glucose-Conjugated Lactate Dehydrogenase Inhibitor

(2013) Emilia C. Calvaresi et al.   CHEMBIOCHEM

Highly water-soluble platinum(ii) complexes as GLUT substrates for targeted therapy: improved anticancer efficacy and transporter-mediated cytotoxic properties

(2013) Pengxing Liu et al.   CHEMICAL COMMUNICATIONS

Quercetin and epigallocatechin gallate inhibit glucose uptake and metabolism by breast cancer cells by an estrogen receptor-independent mechanism

(2013) Liliana Moreira et al.   EXPERIMENTAL CELL RESEARCH

A Phase I Dose-Finding Study of Silybin Phosphatidylcholine (Milk Thistle) in Patients With Advanced Hepatocellular Carcinoma

(2013) Abby B. Siegel et al.   INTEGRATIVE CANCER THERAPIES

Constituents of an Extract of Cryptocarya rubra Housed in a Repository with Cytotoxic and Glucose Transport Inhibitory Effects

(2013) Yulin Ren et al.   JOURNAL OF NATURAL PRODUCTS

Daidzein promotes glucose uptake through glucose transporter 4 translocation to plasma membrane in L6 myocytes and improves glucose homeostasis in Type 2 diabetic model mice

(2013) Sun Hee Cheong et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Glucose conjugation for the specific targeting and treatment of cancer

(2013) Emilia C. Calvaresi et al.   Chemical Science

Noncompetitive blocking of human GLUT1 hexose transporter by methylxanthines reveals an exofacial regulatory binding site

(2012) Paola Ojeda et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Graviola: A novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism

(2012) María P. Torres et al.   CANCER LETTERS

Anticancer Agents That Counteract Tumor Glycolysis

(2012) Carlotta Granchi et al.   ChemMedChem

Design, Synthesis, and Preliminary Biological Evaluation of 6-O-Glucose–Azomycin Adducts for Diagnosis and Therapy of Hypoxic Tumors

(2012) Piyush Kumar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of a Novel Class of Glucose Transporter Inhibitors

(2012) Dasheng Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo

(2012) Y. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Hexose Transporter GLUT1 Harbors Several Distinct Regulatory Binding Sites for Flavones and Tyrphostins

(2011) Alejandra Pérez et al.   BIOCHEMISTRY

A New, Convenient Cell-Based Screening Method for Small-Molecule Glycolytic Inhibitors

(2011) Mitsuhiro KITAGAWA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

A Pairwise Chemical Genetic Screen Identifies New Inhibitors of Glucose Transport

(2011) Olesya A. Ulanovskaya et al.   CHEMISTRY & BIOLOGY

Naringenin, a citrus flavonoid, increases muscle cell glucose uptake via AMPK

(2010) Katarzyna Zygmunt et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel inhibitors of basal glucose transport as potential anticancer agents

(2010) Weihe Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Small compound inhibitors of basal glucose transport inhibit cell proliferation and induce apoptosis in cancer cells via glucose-deprivation-like mechanisms

(2010) Yi Liu et al.   CANCER LETTERS

Metabolomic Identification of the Target of the Filopodia Protrusion Inhibitor Glucopiericidin A

(2010) Mitsuhiro Kitagawa et al.   CHEMISTRY & BIOLOGY

Silybin and dehydrosilybin decrease glucose uptake by inhibiting GLUT proteins

(2010) Tianzuo Zhan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cryptocaryone, a Natural Dihydrochalcone, Induces Apoptosis in Human Androgen Independent Prostate Cancer Cells by Death Receptor Clustering in Lipid Raft and Nonraft Compartments

(2010) Yi-Cheng Chen et al.   JOURNAL OF UROLOGY

Endofacial competitive inhibition of the glucose transporter 1 activity by gossypol

(2009) Alejandra Pérez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Phase I clinical and pharmacokinetic study of the glucose-conjugated cytotoxic agent d-19575 (glufosfamide) in patients with solid tumors

(2009) Toshio Shimizu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Structural Evolutions of Salicylaldoximes as Selective Agonists for Estrogen Receptor β

(2009) Filippo Minutolo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phenolic compounds from Cryptocarya konishii: their cytotoxic and tyrosine kinase inhibitory properties

(2009) Fera Kurniadewi et al.   Journal of Natural Medicines

18F-FDG PET and PET/CT in the Evaluation of Cancer Treatment Response

(2009) S. Ben-Haim et al.   JOURNAL OF NUCLEAR MEDICINE

Estrogen receptor β ligands: Recent advances and biomedical applications

(2009) Filippo Minutolo et al.   MEDICINAL RESEARCH REVIEWS

Stimulation of muscle cell glucose uptake by resveratrol through sirtuins and AMPK

(2008) Danna M. Breen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibitory Mechanisms of Flavonoids on Insulin-Stimulated Glucose Uptake in MC3T3-G2/PA6 Adipose Cells

(2008) Masaaki Nomura et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

In vitroandin vivostudy of phloretin-induced apoptosis in human liver cancer cells involving inhibition of type II glucose transporter

(2008) Chih-Hsiung Wu et al.   INTERNATIONAL JOURNAL OF CANCER

Active Compounds fromLagerstroemia speciosa, Insulin-like Glucose Uptake-Stimulatory/Inhibitory and Adipocyte Differentiation-Inhibitory Activities in 3T3-L1 Cells

(2008) Naisheng Bai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Targeting the Delivery of Glycan-Based Paclitaxel Prodrugs to Cancer Cells via Glucose Transporters

(2008) Yih-Shyan Lin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanisms of flavonoid protection against myocardial ischemia–reperfusion injury

(2008) Masoumeh Akhlaghi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death

(2008) T. E. Wood et al.   MOLECULAR CANCER THERAPEUTICS

Apigenin Inhibits the GLUT-1 Glucose Transporter and the Phosphoinositide 3-Kinase/Akt Pathway in Human Pancreatic Cancer Cells

(2008) Laleh G. Melstrom et al.   PANCREAS