- Home
- Publications
- Publication Search
- Publication Details
Title
Combinational strategies of metformin and chemotherapy in cancers
Authors
Keywords
Metformin, Cancer, Chemotherapeutic agents, Combination therapy
Journal
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Volume 78, Issue 1, Pages 13-26
Publisher
Springer Nature
Online
2016-04-27
DOI
10.1007/s00280-016-3037-3
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Metformin inhibits ovarian cancer growth and increases sensitivity to paclitaxel in mouse models
- (2015) Ernst Lengyel et al. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Metformin synergizes 5-fluorouracil, epirubicin, and cyclophosphamide (FEC) combination therapy through impairing intracellular ATP production and DNA repair in breast cancer stem cells
- (2015) Jaslyn Sian-Siu Soo et al. APOPTOSIS
- Global cancer statistics, 2012
- (2015) Lindsey A. Torre et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Synergistic effects of metformin in combination with EGFR-TKI in the treatment of patients with advanced non-small cell lung cancer and type 2 diabetes
- (2015) Hengyi Chen et al. CANCER LETTERS
- Effect of Metformin, Rapamycin, and Their Combination on Growth and Progression of Prostate Tumors in HiMyc Mice
- (2015) A. Saha et al. Cancer Prevention Research
- (Ir)relevance of Metformin Treatment in Patients with Metastatic Pancreatic Cancer: An Open-Label, Randomized Phase II Trial
- (2015) M. Reni et al. CLINICAL CANCER RESEARCH
- Metformin targets Axl and Tyro3 receptor tyrosine kinases to inhibit cell proliferation and overcome chemoresistance in ovarian cancer cells
- (2015) NAM-YI KIM et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Combined therapeutic effect and molecular mechanisms of metformin and cisplatin in human lung cancer xenografts in nude mice
- (2015) Gang Chen et al. Journal of Cancer Research and Therapeutics
- Combined Use of Metformin and Everolimus Is Synergistic in the Treatment of Breast Cancer Cells
- (2015) Yunshan Wang et al. ONCOLOGY RESEARCH
- No reduced risk of overall, colorectal, lung, breast, and prostate cancer with metformin therapy in diabetic patients: database analyses from Germany and the UK
- (2015) Bernd Kowall et al. PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
- Metformin use improves the survival of diabetic combined small-cell lung cancer patients
- (2015) Fanming Kong et al. TUMOR BIOLOGY
- Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2
- (2015) Wen Yue et al. Oncotarget
- Metformin potentiates rapamycin and cisplatin in gastric cancer in mice
- (2015) Guanzhen Yu et al. Oncotarget
- Metformin Increases Sensitivity of Pancreatic Cancer Cells to Gemcitabine by Reducing CD133+ Cell Populations and Suppressing ERK/P70S6K Signaling
- (2015) Xinqun Chai et al. Scientific Reports
- Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis
- (2015) Takla Griss et al. PLOS BIOLOGY
- Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
- (2015) Enza Lonardo et al. Jove-Journal of Visualized Experiments
- Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts
- (2015) Sílvia Cufí et al. Oncotarget
- Metformin and trametinib have synergistic effects on cell viability and tumor growth in NRAS mutant cancer
- (2015) Igor Vujic et al. Oncotarget
- Metformin and salinomycin as the best combination for the eradication of NSCLC monolayer cells and their alveospheres (cancer stem cells) irrespective of EGFR, KRAS, EML4/ALK and LKB1 status
- (2015) Zhiguang Xiao et al. Oncotarget
- Metformin and erlotinib synergize to inhibit basal breast cancer
- (2015) Ying-Ka Ingar Lau et al. Oncotarget
- Metformin Suppresses Ovarian Cancer Growth and Metastasis with Enhancement of Cisplatin Cytotoxicity In Vivo
- (2015) Ramandeep Rattan et al. NEOPLASIA
- Metformin inhibits the invasion of human hepatocellular carcinoma cells and enhances the chemosensitivity to sorafenib through a downregulation of the ERK/JNK-mediated NF-κB-dependent pathway that reduces uPA and MMP-9 expression
- (2014) Shu-Ching Hsieh et al. AMINO ACIDS
- Metformin inhibits epithelial–mesenchymal transition in prostate cancer cells: Involvement of the tumor suppressor miR30a and its target gene SOX4
- (2014) Jing Zhang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Metformin enhances tamoxifen-mediated tumor growth inhibition in ER-positive breast carcinoma
- (2014) Ji Ma et al. BMC CANCER
- Presurgical Trial of Metformin in Overweight and Obese Patients with Newly Diagnosed Breast Cancer
- (2014) Kevin Kalinsky et al. CANCER INVESTIGATION
- Combined Use of Vitamin D3 and Metformin Exhibits Synergistic Chemopreventive Effects on Colorectal Neoplasia in Rats and Mice
- (2014) W. Li et al. Cancer Prevention Research
- Metformin Sensitizes EGFR-TKI-Resistant Human Lung Cancer Cells In Vitro and In Vivo through Inhibition of IL-6 Signaling and EMT Reversal
- (2014) L. Li et al. CLINICAL CANCER RESEARCH
- Metformin in Chemotherapy-naive Castration-resistant Prostate Cancer: A Multicenter Phase 2 Trial (SAKK 08/09)
- (2014) Christian Rothermundt et al. EUROPEAN UROLOGY
- Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation
- (2014) Floris H. Groenendijk et al. INTERNATIONAL JOURNAL OF CANCER
- Metformin sensitizes chemotherapy by targeting cancer stem cells and the mTOR pathway in esophageal cancer
- (2014) SOICHIRO HONJO et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Metformin synergistically enhances antiproliferative effects of cisplatin and etoposide in NCI-H460 human lung cancer cells
- (2014) Sarah Fernandes Teixeira et al. Jornal Brasileiro de Pneumologia
- Synergistic Simvastatin and Metformin Combination Chemotherapy for Osseous Metastatic Castration-Resistant Prostate Cancer
- (2014) M. A. Babcook et al. MOLECULAR CANCER THERAPEUTICS
- Metformin reverses multidrug resistance in human hepatocellular carcinoma Bel-7402/5-fluorouracil cells
- (2014) SUNBIN LING et al. Molecular Medicine Reports
- Metformin potentiates the anticancer effects of cisplatin under normoxic conditions in vitro
- (2014) TAKASHI UEHARA et al. ONCOLOGY REPORTS
- Is it time to test biguanide metformin in the treatment of melanoma?
- (2014) Michael Cerezo et al. Pigment Cell & Melanoma Research
- Metformin Inhibits the IL-6-Induced Epithelial-Mesenchymal Transition and Lung Adenocarcinoma Growth and Metastasis
- (2014) Zhongquan Zhao et al. PLoS One
- Use of Metformin Alone Is Not Associated with Survival Outcomes of Colorectal Cancer Cell but AMPK Activator AICAR Sensitizes Anticancer Effect of 5-Fluorouracil through AMPK Activation
- (2014) Xinbing Sui et al. PLoS One
- Metformin sensitizes hepatocellular carcinoma to arsenic trioxide-induced apoptosis by downregulating Bcl2 expression
- (2014) Xuejun Yang et al. TUMOR BIOLOGY
- Combination simvastatin and metformin induces G1-phase cell cycle arrest and Ripk1- and Ripk3-dependent necrosis in C4-2B osseous metastatic castration-resistant prostate cancer cells
- (2014) M A Babcook et al. Cell Death & Disease
- Combination of Diane-35 and Metformin to Treat Early Endometrial Carcinoma in PCOS Women with Insulin Resistance
- (2014) Xin Li et al. Journal of Cancer
- Metformin Enhances Cisplatin Cytotoxicity by Suppressing Signal Transducer and Activator of Transcription–3 Activity Independently of the Liver Kinase B1–AMP-Activated Protein Kinase Pathway
- (2013) Chien-Chung Lin et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Update in Hematology and Oncology
- (2013) Reed E. Drews ANNALS OF INTERNAL MEDICINE
- The effect of metformin on apoptosis in a breast cancer presurgical trial
- (2013) M Cazzaniga et al. BRITISH JOURNAL OF CANCER
- Metformin Selectively Targets Tumor-Initiating Cells in ErbB2-Overexpressing Breast Cancer Models
- (2013) P. Zhu et al. Cancer Prevention Research
- Synergistic Effects of Metformin Treatment in Combination with Gefitinib, a Selective EGFR Tyrosine Kinase Inhibitor, in LKB1 Wild-type NSCLC Cell Lines
- (2013) F. Morgillo et al. CLINICAL CANCER RESEARCH
- Activation of mammalian target of rapamycin complex 1 (mTORC1) and Raf/Pyk2 by growth factor-mediated Eph receptor 2 (EphA2) is required for cholangiocarcinoma growth and metastasis
- (2013) Xiang-Dan Cui et al. HEPATOLOGY
- Effect of metformin on residual cells after chemotherapy in a human lung adenocarcinoma cell line
- (2013) SATORU KITAZONO et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Inhibition of p38 MAPK-dependent MutS homologue-2 (MSH2) expression by metformin enhances gefitinib-induced cytotoxicity in human squamous lung cancer cells
- (2013) Jen-Chung Ko et al. LUNG CANCER
- Metformin reverses multidrug resistance and epithelial–mesenchymal transition (EMT) via activating AMP-activated protein kinase (AMPK) in human breast cancer cells
- (2013) Chen Qu et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Effects of Metformin on CD133+ Colorectal Cancer Cells in Diabetic Patients
- (2013) Yanfei Zhang et al. PLoS One
- Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth
- (2013) H. A. Hirsch et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Repositioning metformin for cancer prevention and treatment
- (2013) Brendan J. Quinn et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Metformin-mediated downregulation of p38 mitogen-activated protein kinase-dependent excision repair cross-complementing 1 decreases DNA repair capacity and sensitizes human lung cancer cells to paclitaxel
- (2012) Sheng-Chieh Tseng et al. BIOCHEMICAL PHARMACOLOGY
- Metformin Reduces Endogenous Reactive Oxygen Species and Associated DNA Damage
- (2012) C. Algire et al. Cancer Prevention Research
- AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo
- (2012) Brandon Faubert et al. Cell Metabolism
- AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern
- (2012) D. Grahame Hardie et al. CHEMISTRY & BIOLOGY
- Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway
- (2012) Rabbie K. Hanna et al. GYNECOLOGIC ONCOLOGY
- Targeting metabolism for cancer treatment and prevention: metformin, an old drug with multi-faceted effects
- (2012) M A Pierotti et al. ONCOGENE
- Investigating Metformin for Cancer Prevention and Treatment: The End of the Beginning
- (2012) Michael N. Pollak Cancer Discovery
- 5-Fluorouracil upregulates the activity of Wnt signaling pathway in CD133-positive colon cancer stem-like cells
- (2012) Yan-Hong Deng et al. Chinese Journal of Cancer
- Suppression of Stat3 activity sensitizes gefitinib-resistant non small cell lung cancer cells
- (2011) Huan-Chih Chiu et al. BIOCHEMICAL PHARMACOLOGY
- Metformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell Types
- (2011) D. Iliopoulos et al. CANCER RESEARCH
- EGFR-mutated oncogene-addicted non-small cell lung cancer: Current trends and future prospects
- (2011) Jean-Charles Soria et al. CANCER TREATMENT REVIEWS
- Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo
- (2011) Vladimir N. Anisimov et al. CELL CYCLE
- Potent anti-proliferative effects of metformin on trastuzumab-resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions
- (2011) Bolin Liu et al. CELL CYCLE
- Metformin Amplifies Chemotherapy-Induced AMPK Activation and Antitumoral Growth
- (2011) G. Z. Rocha et al. CLINICAL CANCER RESEARCH
- Clinical Pharmacokinetics of Metformin
- (2011) Garry G. Graham et al. CLINICAL PHARMACOKINETICS
- Combination therapy with vemurafenib (PLX4032/RG7204) and metformin in melanoma cell lines with distinct driver mutations
- (2011) Franziska Niehr et al. Journal of Translational Medicine
- Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells
- (2010) Mahvash Zakikhani et al. BREAST CANCER RESEARCH AND TREATMENT
- The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells
- (2010) Alejandro Vazquez-Martin et al. BREAST CANCER RESEARCH AND TREATMENT
- Metformin inhibits P-glycoprotein expression via the NF-κB pathway and CRE transcriptional activity through AMPK activation
- (2010) Hyung Gyun Kim et al. BRITISH JOURNAL OF PHARMACOLOGY
- Insulin-Mediated Acceleration of Breast Cancer Development and Progression in a Nonobese Model of Type 2 Diabetes
- (2010) R. Novosyadlyy et al. CANCER RESEARCH
- Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells
- (2010) I. Ben Sahra et al. CANCER RESEARCH
- Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT): From cancer stem cells to aging-associated fibrosis
- (2010) Sílvia Cufí et al. CELL CYCLE
- Metformin regulates breast cancer stem cello ntogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status
- (2010) Alejandro Vazquez-Martin et al. CELL CYCLE
- Metformin and cancer: Doses, mechanisms and the dandelion and hormetic phenomena
- (2010) Begoña Martin-Castillo et al. CELL CYCLE
- Comment on: Yang et al. (2010) Associations of Hyperglycemia and Insulin Usage With the Risk of Cancer in Type 2 Diabetes: The Hong Kong Diabetes Registry. Diabetes;59:1254-1260
- (2010) D. Simon et al. DIABETES
- Metformin reduces cisplatin-mediated apoptotic death of cancer cells through AMPK-independent activation of Akt
- (2010) Kristina Janjetovic et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Metformin sensitizes insulin signaling through AMPK-mediated pten down-regulation in preadipocyte 3T3-L1 cells
- (2010) Soo Kyung Lee et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Metformin promotes progesterone receptor expression via inhibition of mammalian target of rapamycin (mTOR) in endometrial cancer cells
- (2010) Ya Xie et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Metformin and reduced risk of hepatocellular carcinoma in diabetic patients with chronic liver disease
- (2010) Valter Donadon et al. LIVER INTERNATIONAL
- Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?
- (2010) I. Ben Sahra et al. MOLECULAR CANCER THERAPEUTICS
- Epithelial-Mesenchymal Transitions in Development and Disease
- (2009) Jean Paul Thiery et al. CELL
- Metformin and Pathologic Complete Responses to Neoadjuvant Chemotherapy in Diabetic Patients With Breast Cancer
- (2009) Sao Jiralerspong et al. JOURNAL OF CLINICAL ONCOLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started